The Virus as the Etiologic Agent of Infectious Mononucleosis

  • G. Henle
  • W. Henle


The world-wide distribution and high incidence of antibodies to the Epstein-Barr virus (EBV) (see Chap. 4) strongly suggested that the virus might be the unsuspected cause of a common disease, besides its association with two rare malignancies i.e., Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC). Consequently, numerous paired acute-phase and convalescent sera from patients with unidentifiable infections of presumably viral origin were examined for an emergence or increase in titer of antibodies to EBV. While these efforts in search of a disease caused by the virus were initially unrewarding, they prepared the stage for what appeared to be a fortuitous observation and led to the identification of EBV as the long-sought cause of infectious mononucleosis (IM).


Infectious Mononucleosis Lymphoid Cell Line Phosphonoacetic Acid Throat Washing Acute Infectious Mononucleosis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • G. Henle
    • 1
  • W. Henle
    • 1
  1. 1.Division of Virology, The Joseph Stokes, Jr. Research Institute at The Children’s Hospital of Philadelphia, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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