Skip to main content
SpringerLink
Log in

Allgemeine Pathologie des Binde- und Stützgewebes

  • Chapter
Pathogenese

Zusammenfassung

Die Bezeichnung »Bindegewebe« entstammt der Auffassung, die Hauptaufgabe dieses faserigen Gewebes bestünde im Zusammenhalten (»Binden«) der Zellen, Gewebeteile, Organe und Körperteile. Diese mechanische Teilfunktion ist unbestritten; insbesondere gilt sie für die sehr reißfesten Sehnen und Faszien, die man als straffes Bindegewebe bezeichnet. Stützaufgaben erfüllen das für Gelenke und andere Knochenverbindungen geeignete, druck-, biegungs- und torsionselastische Knorpelgewebe sowie das einem Verbundbau aus kol-lagenen Fasern und Apatitkristallen vergleichbare Knochengewebe. Man erkannte immer mehr, daß insbesondere das an sauren Mukopolysacchariden (Glykosaminoglykanen) reichere lockere Bindegewebe im Innern der Organe im Dienst der Homöostase, der Speicherung und des Austausches von Proteinbestandteilen, Kohlenhydraten, Lipiden und vor allem Elektrolyten sowie des Stofftransports zwischen Gefäßen und Parenchymzellen steht. Überdies bietet das Bindegewebe den Boden für entzündliche Vorgänge (S. 1243) und besorgt Reparaturleistungen verschiedener Art. Wahrscheinlich geht die Bedeutung des Bindegewebes noch erheblich über das bisher Gesagte hinaus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Galambos, J. T., Hollingsworth, M. A., Falek, A., Warren, W. D.: The rate of synthesis of glycosaminoglycans and collagen by fibroblasts cultured from adult human liver biopsies. J. Clin. Invest. 60, 107 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Ivey, J. L., Wright, D. R., Tashjian, A. H.: Bone resorption in organ culture. J. Clin. Invest 58, 1327 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Kewley, M. A., Williams, G., Steven, F. S.: Studies of elastic tissue formation in the developing bovine ligamentum nuchae. J. Pathol. 124, 95 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Layman, D.L., Titus, J. L.: Synthesis of type I collagen by human smooth muscle cells in vitro. Lab. Invest. 33, 103 (1975)

    PubMed  CAS  Google Scholar 

  • McDougal, J. S., Azar, H. A.: Tritiated proline in macrophages. Arch. Pathol. 93, 13 (1972)

    PubMed  CAS  Google Scholar 

  • Mohr, W., Wild, A.: The proliferation of chondrocytes and pannus in adjuvant arthritis. Virchows Arch. [Cell Pathol] 25, 1 (1977)

    CAS  Google Scholar 

  • Nagle, R. B., Kneiser, M. R., Bulger, R. E., Benditt, E. P.: Induction of smooth muscle characteristics in renal interstitial fibroblasts during obstructive nephropathy. Lab. Invest. 29, 422 (1973)

    Google Scholar 

  • Ryan, G. B., Cliff, W. J., Gabbiani, G., Irle, C., Statkov, P. R., Majno, G.: Myofibroblasts in an avascular fibrous tissue. Lab. Invest. 29, 197 (1973)

    PubMed  CAS  Google Scholar 

  • Tonna, E. A., Pentel, L.: Chondrogenic cell formation via osteogenic cell progeny transformation. Lab. Invest. 27, 418 (1972)

    PubMed  CAS  Google Scholar 

  • Weiser, G.: Neurofibrom und Perineuralzelle. Virchows Arch. [Pathol. Anat] 379, 73 (1978)

    Article  Google Scholar 

  • Zucker-Franklin, D., Grusky, G., Marcus, A.: Transformation of monocytes into »fat« cells. Lab. Invest. 38, 620 (1978)

    PubMed  CAS  Google Scholar 

  • Cleary, E. G., Cliff, W. J.: The substructure of elastin. Exp. Mol. Pathol. 28, 227 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Engfeldt, B., Hjerpe, A.: Glyco-saminoglycans und proteoglycans of human bone tissue at different stages of mineralization. Acta Pathol. Microbiol. Scand. [A] 84, 95 (1976)

    CAS  Google Scholar 

  • Grant, M. E., Prockop, D. J.: The biosynthesis of collagen. N. Engl. J. Med. 286, 194 (I), 242– (II), 291– (III) (1972)

    Article  PubMed  Google Scholar 

  • Krane, S. M., Kantrowitz, F. G., Byrne, M., Pinnell, S. R., Singer, F. R.: Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J. Clin. Invest. 59, 819 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Longacre, J. J. (ed.): The ultrastructure of collagen. Springfield: Thomas 1976

    Google Scholar 

  • Nevo, Z., Michaeli, D., Daentl, D. L.: Examination of core protein of proteoglycans. I. Abnormal PG in auriculoepiphyseal dysplasia. Exp. Mol. Pathol. 28, 247 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, E. R., Adamy, L.: Effect of ascorbic acid on arylsulfatase activities and sulfated proteoglycan metabolism in chondrocyte cultures. J. Clin. Invest. 60, 96 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Seyer, J. M., Hutcheson, E. T., Kang, A. H.: Collagen polymorphism in normal and cirrhotic human liver. J. Clin. Invest. 59, 241 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Cooper, R. R., Pedrini-Mille, A., Ponsetti, I. V.: Metaphyseal dysostosis. A rough surfaced andoplasmic reticulum storage defect. Lab. Invest. 28, 119 (1973)

    PubMed  CAS  Google Scholar 

  • McKusick, V. A.: Heritable disorders of connective tissue. St. Louis: Mosby 1972

    Google Scholar 

  • Martinez-Hernandez, A., Huffer, W. E., Neldner, K., Gordon, S., Reeve, E. B.: Resolution and repair of elastic tissue calcification in pseudoxanthoma elasticum. Arch. Pathol. Lab. Med. 102, 303 (1978)

    PubMed  CAS  Google Scholar 

  • Maynard, J. A., Cooper, R. R., Ponsetti, I. V.: A unique rough surfaced endoplasmic reticulum inclusion in pseudo-achondroplasia. Lab. Invest. 26, 40 (1972)

    PubMed  CAS  Google Scholar 

  • Pope, F. M., Martin, G. R., Lichtenstein, J. R., Penttinen, R., Gerson, B., Rowe, D.W., McKusick, V. A.: Patients with Ehlers-Danlos syndrome Type IV lack type III collagen. Proc. Natl. Acad. Sci. USA 72, 1314 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Saruk, M., Eisenstein, R.: Aortic lesion in Marfan syndrome. The ultrastructure of cystic medial degeneration. Arch. Pathol. Lab. Med. 101, 74 (1977)

    PubMed  CAS  Google Scholar 

  • Trelstad, R. L., Rubin, D., Gross, J.: Osteogenesis imperfecta congenita. Evidence for a generalized molecular disorder of collagen. Lab. Invest. 36, 501 (1977)

    PubMed  CAS  Google Scholar 

  • S. auch Literatur zu Alkaptonurie (S. 892) und Mukopolysaccha-ridosen (S. 964).

    Google Scholar 

  • Buddecke, E., Fricke, R., Hartmann, F., Muir, H., Kühn, K. (eds.): Connective tissues. Berlin, Heidelberg, New York: Springer 1974

    Google Scholar 

  • Bonfiglio, T. A., Schenk, E. A.: Lipid deposits in pulmonary connective tissue. Arch. Pathol. 97, 48 (1974)

    PubMed  CAS  Google Scholar 

  • Brady, A. H.: Collagenase in scleroderma. J. Clin. Invest. 56, 1175 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Collins, J. F., Durnin, L. S., Johanson, W. G.: Papain-induced lung injury: alterations in connective tissue metabolism without emphysema. Exp. Mol. Pathol. 29, 29 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Hayes, J. A., Korthy, A., Snider, G. L.: The pathology of elastase-induced panacinar emphysema in hamsters. J. Pathol. 117, 1 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Kindblom, L.-G., Möller-Nielsen, J.: Diffuse lipomatosis in the leg after poliomyelitis. Acta Pathol. Microbiol. Scand. [A] 83, 339 (1975)

    CAS  Google Scholar 

  • Mathews, M. B.: Connective tissue. Buddecke, E., Fricke, R., Hartmann, F., Muir, H., Kühn, K. (eds.). Berlin, Heidelberg, New York: Springer 1975

    Chapter  Google Scholar 

  • Sarkar, K., Uhthoff, H. K.: Ultrastructural localization of calcium in calcifying tendinitis. Arch. Pathol. Lab. Med. 102, 266 (1978)

    PubMed  CAS  Google Scholar 

  • Schuster, G. S., McKinney, R. V., Dirksen, T. R., Bustos, S. E.: Effect of β-aminopropionitrile on lipid metabolism of bone cell cultures: biochemistry and morphology. Exp. Mol. Pathol. 28, 267 (1978)

    Article  Google Scholar 

  • Gabbiani, G., Le Lous, M., Bailey, A. J., Bazin, S., Delauney, A.: Collagen and myofibroblasts of granulation tissue. A chemical, ultrastructural and immunologic study. Virchows Arch. [Cell Pathol.] 21, 133 (1976)

    CAS  Google Scholar 

  • Hansen, T. M.: Collagen development in granulation tissue as compared with collagen of skin and aorta from injured and non-injured rats. Acta Pathol. Microbiol. Scand. [A] 83, 721 (1975)

    CAS  Google Scholar 

  • Remberger, K., Gay, S., Fietzek, P. P.: Immunhistochemische Untersuchungen zur Kollagencha-rakterisierung in Leberzirrhosen. Virchows Arch. [Pathol. An-at.] 367, 231 (1975)

    Article  CAS  Google Scholar 

  • Ruiz-Torres, A., Kürten, I., Rosenstock, M.: The dynamics of collagen deposition in liver damaged by CCl4. Beitr. Pathol. 158, 287 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Feiner, H., Kaye, G. I.: Ultrastructural evidence of myofibroblasts in circumscribed fibromatosis. Arch. Pathol. Lab. Med. 100, 265 (1976)

    PubMed  CAS  Google Scholar 

  • Gabbiani, G., Majno, G.: Dupuytren’s con-tracture: fibroblast contraction? An ultrastructural study. Am. J. Pathol. 66, 131 (1972)

    PubMed  CAS  Google Scholar 

  • Mende, S., Völpel, M., Rotthauwe, L: Idiopathic retroperitoneal fibrosis (Ormond’s disease) with unusual extension involving the brain. Beitr. Pathol. 153, 80 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Meister, P., Brückmann, F.-W., Konrad, E.: Nodular fasciitis (Analysis of 100 cases and review of the literature). Pathol. Res. Pract. 162 133 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Bariety, J., Callard, P.: Striated membranous structures in renal glomerular tufts. An electron microscopy study of 340 human renal biopsies. Lab. Invest. 32, 636 (1975)

    PubMed  CAS  Google Scholar 

  • Bendayan, M., Sandborn, E., Rasio, E.: Studies of the capillary basal lamina. II. Preparation, chemical composition and metabolic properties. Lab. Invest. 32, 768 (1975)

    PubMed  CAS  Google Scholar 

  • Lin, J. H., Duffy, J. L., Roginsky, M. S. : Microcirculation in diabetes mellitus. A study of gingival biopsies. Human Pathol. 6, 77 (1975)

    Article  CAS  Google Scholar 

  • Martin, S. A., Kissane, J. M.: Polypoid change of the glomerular basement membrane. Arch. Pathol. 99, 249 (1975)

    PubMed  CAS  Google Scholar 

  • Romen, W., Bannasch, P., Aterman, K.: Toxic glomerulosclerosis — morphology and pathogenesis. Virchows Arch. [Cell Pathol.] 19, 205 (1975)

    CAS  Google Scholar 

  • Romen, W., Schultze, B., Hempel, K.: Synthesis of glomerular basement membrane in the rat kidney. Autoradiographic studies with the light and electron microscope. Virchows Arch. [Cell Pathol.] 20, 125 (1976)

    CAS  Google Scholar 

  • S. zudem Literatur zu Diabetes mellitus (S. 933), Kalziumstoffwechsel (S. 814) und Glomerulonephritiden (S. 766).

    Google Scholar 

  • Barrie, H. J.: Intra-articular loose bodies regarded as organ cultures in vivo. J. Pathol. 125, 163 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Ghadially, F. N., Thomas, I., Oryschak, A. F., Lalonde, J.-M.: Long-term results of superficial defects in articular cartilage: a scanning electron-microsope study. J. Pathol. 121, 213 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Ghadially, J. A., Ghadially, F. N.: Evidence of cartilage flow in deep defects in articular cartilage. Virchows Arch. [Cell Pathol.] 18, 193 (1975)

    CAS  Google Scholar 

  • Huffer, W. E.: Degradation of chondromucoprotein by macrophage enzymes. Lab. Invest. 29, 304 (1973)

    PubMed  CAS  Google Scholar 

  • Meachim, G.: The state of knee meniscal fibrocartilage in Liverpool necropsies. J. Pathol. 119, 167 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Minns, R. J., Steven, F. S., Hardinge, K.: Osteoarthrotic articular cartilage lesions of the femoral head observed in the scanning electron microscope. J. Pathol. 122, 63 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Quintarelli, G., Ippolito, E., Rodén, L.: Age- dependent changes on the state of aggregation of cartilage matrix. Lab. Invest. 32, 111 (1975)

    PubMed  CAS  Google Scholar 

  • Sapolsky, A. I., Keiser, H., Howell, D. S., Woessner, J. F.: Metallo-proteases of human articular cartilage that digest cartilage proteoglycan at neutral and acid pH. J. Clin. Invest. 58, 1030 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Stougård, J.: The calcified cartilage and the subchondral bone under normal and abnormal conditions. Acta Pathol. Microbiol. Scand. [A] 82, 182 (1974)

    Google Scholar 

  • Armstrong, J. R.: Lumbar disc lesions. Baltimore: Williams & Wilkins 1965

    Google Scholar 

  • Utsinger, P. D., Resnick, S., Shapiro, R.: Diffuse skeletal abnormalities in Forestier disease. Arch. Int. Med. 136, 763 (1976)

    Article  CAS  Google Scholar 

  • Wolf, E., Stern, S.: Costosternal syndrome. Arch. Int. Med. 136, 189 (1976)

    Article  CAS  Google Scholar 

  • Anderson, C., Danylchuk, K. D.: Scanning electron microscopic observations on bone. Arch. Pathol. Lab. Med. 101, 19 (1977)

    PubMed  CAS  Google Scholar 

  • Bonucci, E., Lo Cascio, V., Adami, S., Cominacini, L., Galvanini, G., Scuro, A.: The ultrastructure of bone cells and bone matrix in human primary hyperparathyroidism. Virchows Arch. [Pathol. Anat.] 379, 11 (1978)

    Article  CAS  Google Scholar 

  • Delling, G., Donath, K.: Morphometrische, elektronenmikroskopische und physikalisch-chemische Untersuchungen über die experimentelle Osteoporose bei chronischer Azidose. Virchows Arch. [Pathol. Anat.] 358, 321 (1973)

    Article  CAS  Google Scholar 

  • Krempien, B., Geiger, G., Ritz, E.: Structural changes of cortical bone in secondary hyperparathyreoidism. Replacement of lamellar bone by woven bone. Virchows Arch. [Pathol. Anat.] 366, 249 (1975)

    Article  CAS  Google Scholar 

  • Krempien, B., Manegold, Ch., Ritz, E., Bommer, J.: The influence of immobilization on osteocyte morphology. Osteocyte differential count and electron microscopical studies. Virchows Arch. [Pathol. Anat.] 370, 55 (1976)

    Article  CAS  Google Scholar 

  • Krempien, B., Ritz, E., Beck, U., Keilbach, H.: Osteopathy in maintenance hemodialysis. Micromorphometric and microradiographic studies with correlations to serum parathyroid hormone and calcitonin levels. Virchows Arch. [Pathol. Anat.] 357, 257 (1972)

    Article  CAS  Google Scholar 

  • Larsson, A., Larsson, S.-E.: The effects of ethylene-1-hydroxy-1,1-diphosphonate on cellular transformation and organic matrix of the epiphyseal growth plate of the rat — a light microscopic and ultrastructural study. Acta Pathol. Microbiol. Scand. [A] 86, 211 (1978)

    CAS  Google Scholar 

  • Meisen, F., Meisen, B., Mosekilde, L.: An evaluation of the quantitative parameters applied in bone histology. Acta Pathol. Microbiol. Scand. [A] 86, 63 (1978)

    Google Scholar 

  • Mosekilde, L., Meisen, F.: Morphometric and dynamic studies of bone changes in hypothyroidism. Acta Path. Microbiol. Scand. [A] 86, 56 (1978)

    CAS  Google Scholar 

  • Mundy, G. R., Shapiro, J. L., Bandelin, J. G., Canalis, E. M., Raisz, L. G.: Direct stimulation of bone resorption by thyroid hormones. J. Clin. Invest. 58, 529 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Olah, A. J.: Quantitative relations between osteoblasts and osteoid in primary hyperparathyroidism, intestinal malabsorption and renal osteodystrophy. Virchows Arch. Pathol. Anat. 358, 301 (1973)

    Article  CAS  Google Scholar 

  • Rosenquist, J. B.: Skeletal fluorosis in immobilized extremities. Acta Pathol. Microbiol. Scand. 83, 678 (1975)

    CAS  Google Scholar 

  • Russell, J.E., Termine, J. D., Avioli, L. V.: Experimental renal osteodystrophy. The response to 25-hydroxycholecalciferol and dichloromethylene diphosphate therapy. J. Clin. Invest. 56, 548 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Seifert, G. (ed.): Knochenpathologie. Verh. Dtsch. Ges. Pathol., 58. Tagung. Stuttgart: Fischer 1974

    Google Scholar 

  • Smith, D. M., Khairi, M. R. A., Johnston, C. C.: The loss of bone mineral with aging and its relationship for risk of fracture. J. Clin. Invest. 56, 311 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Smith, D. M., Khairi, M. R. A., Norton, J., Johnston, C. C.: Age and activity effects on rate of bone mineral loss. J. Clin. Invest. 58, 716 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Weisbrode, S. E., Capen, C. C.: Ultrastructural evaluation of the interaction of glucocorticoids and vitamin D on bone cells in thyroparathyroidectomized rats. Am. J. Pathol. 84, 457 (1976)

    PubMed  CAS  Google Scholar 

  • S. Schrifttum zu Kap. 3 (S. 19), 4 (S. 27) und 62 (S. 275)

    Google Scholar 

  • Barry, H. C.: Paget’s disease of bone. Edinburgh: Livingstone 1969

    Google Scholar 

  • Bourne, G. H. (ed.): The biochemistry and physiology of bone. New York: Academic Press 1971

    Google Scholar 

  • Jaffe, H. L.: Metabolic, degenerative and inflammatory diseases of bones and joints. Philadelphia: Lea & Febiger 1972

    Google Scholar 

  • Frame, B., Parfitt, A. M., Duncan, H. (eds.): Clinical aspects of metabolic bone disease. Amsterdam: Excerpta Medica 1973

    Google Scholar 

  • Rasmussen, H., Bordier, P.: The physiological and cellular basis of metabolic bone disease. Baltimore: Williams & Wilkins 1974

    Google Scholar 

  • S. Schrifttum zu Kap. 85 (S. 321)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathologisches Institut der Universität, Freiburgstr. 30, CH-3010, Bern, Switzerland

    Professor Dr. Hans Cottier

Authors
  1. Professor Dr. Hans Cottier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Cottier, H. (1980). Allgemeine Pathologie des Binde- und Stützgewebes. In: Pathogenese. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67213-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67213-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67214-9

  • Online ISBN: 978-3-642-67213-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation