Abstract
Some new factors have to be taken into account when considering the pharmacokinetics of blood concentration-time curves of substances absorbed through the gastrointestinal tract. These are: 1) the amount of substance which can be absorbed varies with gastrointestinal filling and emptying; 2) invasion into the circulation often does not obey the laws of simple concentration gradients; 3) the interposition of organs of active metabolism such as the liver or intestinal mucosa can lead to a partial or complete change in the substance absorbed; 4) counter-regulatory influences may affect substances absorbed in the gastrointestinal tract, particularly foodstuffs.
By W. Kübler, Giessen. Dedicated to Prof. Dr. h. c. Franz Klose, Kiel, on the occasion of his 85th birthday, 21st July, 1972.
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© 1979 Springer-Verlag Berlin Heidelberg
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Gladtke, E., von Hattingberg, H.M. (1979). Pharmacokinetics of Gastrointestinal Absorption. In: Pharmacokinetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67188-3_7
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DOI: https://doi.org/10.1007/978-3-642-67188-3_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09183-7
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