Malignant hyperthermia occurs as a complication in general anesthesia, usually (or always) on the basis of a hereditary predisposition. The first indication of an impending attack is frequently an unexplained tachycardia. There is often muscle rigidity, hyperventilation, and fever, which may reach extreme degrees; about two-thirds of the cases are fatal. The syndrome has most often occurred after administration of halothane and other halogenated anesthetics (Aldrete and Britt, 1978).
KeywordsHypertrophic Cardiomyopathy Malignant Hyperthermia Joint Hypermobility Muscle Rigidity Caffeine Concentration
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- Huckell, V. F., Staniloff, H. M., McLaughlin, P. R., Britt, B. A., Morch, J. E.: Cardiovascular manifestations of normothermic malignant hyperthermia. In: Second International Symposium on Malignant Hyperthermia, J.A. Aldrete, B.A. Britt, eds. New York, San Francisco, London: Grune & Stratton 1978Google Scholar