Malignant hyperthermia occurs as a complication in general anesthesia, usually (or always) on the basis of a hereditary predisposition. The first indication of an impending attack is frequently an unexplained tachycardia. There is often muscle rigidity, hyperventilation, and fever, which may reach extreme degrees; about two-thirds of the cases are fatal. The syndrome has most often occurred after administration of halothane and other halogenated anesthetics (Aldrete and Britt, 1978).


Hypertrophic Cardiomyopathy Malignant Hyperthermia Joint Hypermobility Muscle Rigidity Caffeine Concentration 
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  1. Aldrete, J. A., Britt, B. A.: The Second International Symposium on Malignant Hyperthermia. New York, San Francisco, London: Grune & Stratton 1978Google Scholar
  2. Huckell, V. F., Staniloff, H. M., McLaughlin, P. R., Britt, B. A., Morch, J. E.: Cardiovascular manifestations of normothermic malignant hyperthermia. In: Second International Symposium on Malignant Hyperthermia, J.A. Aldrete, B.A. Britt, eds. New York, San Francisco, London: Grune & Stratton 1978Google Scholar
  3. Kalow, W., Britt, B. A., Richter, A.: The caffeine test of isolated human muscle in relation to malignant hyperthermia. Can. Anaesth. Soc. J. 24, 678–694 (1977)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • W. Kalow
    • 1
  1. 1.Department of PharmacologyUniversity of TorontoTorontoCanada

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