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Immunologic Phenomena Induced by Cryosurgery

  • R. J. Ablin
  • P. D. Guinan

Abstract

Until recently, cryosurgery of benign and malignant neoplasms had been utilized in the majority of cases in an anecdotal manner, the primary objective being palliation of readily accessible lesions, generally following their unsuccessful treatment by radiation, surgery, or both. In spite of early trepidations, continued interest in the therapeutic applications of cryosurgery have led to improvement in design and development. A major impetus to this increased application may have been the observation that in situ freezing of tissues constitutes an antigenic stimulus comparable to that obtained through the parenteral administration of antigen — and hence the term “cryoimmunology” (80). Followed shortly by reports of the remission of metastases following cryoprostatectomy (15, 19, 81), destruction of secondary tumors occurring beyond the freezing site prompted continuing investigation of the possible development of an immunologic response by the host against tumor and of the applicability of ultimately directing this response toward the therapeutic management of malignancy.

Keywords

Prostatic Cancer Prostatic Carcinoma Prostatic Cancer Patient Immunologic Responsiveness Prostatic Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ABLIN, R.J.: Distribution of rabbit IgG in the accessory sexual gland tissues of the male rabbit. J. Reprod. Fertil. 30, 201–205 (1972)PubMedCrossRefGoogle Scholar
  2. 2.
    ABLIN, R.J.: Immunologic studies of the rabbit coagulating gland and its secretions. Biol. Reprod. 8, 327–334 (1973b)PubMedGoogle Scholar
  3. 3.
    ABLIN, R.J.: Cryostimulation — An explanation of the mechanism of in situ autosensitization (Abstract). Biol. Reprod. 9, 100 (1973a)Google Scholar
  4. 4.
    ABLIN, R.J.: Immunological surveillance and α-globulin. Isr. J. Med. Sci. 9, 480–483 (1973c)PubMedGoogle Scholar
  5. 5.
    ABLIN, R.J.: Immunological Aspects of the Development and Advances of Cryosurgery of the Prostate. In: Cryosurgery in urology. REUTER, H.J. (ed.), pp. 4–23. Int. Symp. Stuttgart 1973, Stuttgart: Georg Thieme 1974aGoogle Scholar
  6. 6.
    ABLIN, R.J.: Cryo-immunotherapy: Clinical and Experimental Considerations of the Nature of the Immune Response. In: Symposium on the normal and abnormal growth of the prostate. GOLAND, M. (ed.), pp. 788–832. San Antonio, 1973. Springfield, Illinois: C.C. Thomas 1974bGoogle Scholar
  7. 7.
    ABLIN, R.J.: Immunologic properties of sex accessory tissue components. In: Male accessory sex organs. Structure and function in mammals. BRANDES, D. (ed.), pp. 432–467. New York: Academic Press 1974cGoogle Scholar
  8. 8.
    ABLIN, R.J.: Cryosurgery of the rabbit prostate. Comparison of the immune response of immature and mature bucks. Cryobiology 11, 416–432 (1974d)PubMedCrossRefGoogle Scholar
  9. 9.
    ABLIN, R.J.: Immunologic aspects of malignancy: Factors of concern in the prospective candidate for immunotherapy. Allergol. Immunopathol. 3, 105–108 (1975)Google Scholar
  10. 10.
    ABLIN, R.J.: Immunobiology of the Prostate. In: Urologic pathology: the prostate. TANNENBAUM, M. (ed.), pp. 33–98. Philadelphia: Lea & FebigerGoogle Scholar
  11. 11.
    ABLIN, R.J.: Handbook of cryosurgery. New York: Marcel Dekker, 1978Google Scholar
  12. 12.
    ABLIN, R.J. and the Cryoimmunotherapeutic Study Group: Cryo-sensitivity: Factors influencing the development of an immunologic reponse following cryosurgery of the prostate. Urology 5, 317–321 (1975)CrossRefGoogle Scholar
  13. 13.
    ABLIN, R.J., REDDY, K.P.: Cryosurgery of the monkey (Macaque) prostate. II. Apparent immunopathologic alterations following cryostimulation. Cryobiology 14, 205–214 (1977)PubMedCrossRefGoogle Scholar
  14. 14.
    ABLIN, R.J., SOANES, W.A.: Experimental production of autoimmune aspermatogenic orchitis In the rabbit in consequence of in situ freezing of the testis. Eur. Surg. Res. 4, 98–106 (1972)PubMedCrossRefGoogle Scholar
  15. 15.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Immunologic studies of the prostate: A review. Int. Surg. 52, 8–21 (1969a)PubMedGoogle Scholar
  16. 16.
    ABLIN, R.J., PFEIFFER, L., GONDER, M.J., SOANES, W.A.: Precipitating antibody in the sera of patients treated cryosurgerically for carcinoma of the prostate. Exp. Med. Surg. 27, 406–410 (1969b)PubMedGoogle Scholar
  17. 17.
    ABLIN, R.J., BRONSON, P., SOANES, W.A.: Immunoglobulin G: Identification of rabbit IgG in coagulo-prostatic fluid by gel diffusion precipitation and Immunoelectrophoresis. Indian J. Exp. Biol. 8, 185–196 (1970a)PubMedGoogle Scholar
  18. 18.
    ABLIN, R.J., BRONSON, P., SOANES, W.A., WITEBSKY, E.: Tissue and species-specific antigens of normal human prostatic tissue. J. Immunol. 104, 1329–1339 (1970b)PubMedGoogle Scholar
  19. 19.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate. Cryobiology 8, 271–279 (1971a)CrossRefGoogle Scholar
  20. 20.
    ABLIN, R.J., WITBSKY, E., JAGODZINSKI, R.V., SOANES, W.A.: Secondary immunologic response as a consequence of the in situ freezing of rabbit male adnexal glands tissues of reproduction. Exp. Med. Surg. 23, 72–88 (1971b)Google Scholar
  21. 21.
    ABLIN, R.J., SOANES, W.A., BRONSON, P.M., GONDER, M.J.: Serum proteins in patients with benign and malignant diseases of the prostate. Neoplasma 18, 271–276 (1971c)PubMedGoogle Scholar
  22. 22.
    ABLIN, R.J., SOANES, W.A., DANAHER, J.: Immunohistologic studies of carcinoma of the prostate II. Antibodies to prostatic tissue. Z. Immunol. Forsch. 142, 432–438 (1972a)Google Scholar
  23. 23.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Alterations of serum proteins in patients with prostatic cancer following cryoprostat-ectomy (Abstract). Clin. Res. 20, 882 (1972b)Google Scholar
  24. 24.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Elution of in vivo bound antiprostatic epithelial antibodies following multiple cryotherapy of carcinoma of prostate. Urology 2, 276–279 (1973a)PubMedCrossRefGoogle Scholar
  25. 25.
    ABLIN, R.J., GONDER, M.J., SOANES, W.A.: Serum proteins in prostatic cancer. I. Relationship between clinical stage and level. J. Urol. 110, 238–241 (1973b)PubMedGoogle Scholar
  26. 26.
    ABLIN, R.J., BRUNS, G.R., GUINAN, P.D., BUSH, I.M.: Migration-inhibitory effect of serum from patients with prostatic cancer. Oncology 30, 423–428 (1974)PubMedCrossRefGoogle Scholar
  27. 27.
    ABLIN, R.J., BARNES, G.W., STOLL, H.W.: Cryostimulation. Androgenic and ontogenic dependence of the immune response following in situ autosensitization (Abstract). Cryobiology 12, 571 (1975a)Google Scholar
  28. 28.
    ABLIN, R.J., GUINAN, P.D., BRUNS, G.R., SADOUGHI, N., BUSH, I.M.: Serum proteins in prostic cancer. II. Effect on in vitro cell-mediated immunologic responsiveness. Urology 6, 22–29 (1975b)PubMedCrossRefGoogle Scholar
  29. 29.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Alterations of host resistance following surgery: Serum immunoglobulins following cryosurgery (Abstract). Clin. Res. 23, 286A (1975c)Google Scholar
  30. 30.
    ABLIN, R.J., GONDER, M.J., SOANES, W.A.: Alterations of alpha2-globulin and the clinical response in patients with prostatic cancer following cryotherapy. Oncology 32, 127–144 (1975d)PubMedCrossRefGoogle Scholar
  31. 31.
    ABLIN, R.J., JAGODZINSKI, R.V., PROX (KOSTRZEWSKI) C., WILLIAMS, R.W., GONDER, M.J., SOANES, W.A.: Cryosurgery of the monkey (Macaque) prostate. I. Humoral immunologic responsiveness following cryostimulation. Cryobiology 13, 47–53 (1976a)PubMedCrossRefGoogle Scholar
  32. 32.
    ABLIN, R.J., MARROW, C., BRUNS, G.R., JOHN, T., GUINAN, P.D., SADOUGHI, N., BUSH, I.M.: Evaluation of cellular immunologic responsiveness in the clinical management of patients with prostatic cancer. III. Inhibition of leukocyte migration. Urol. Int. 31, 444–458 (1976b)PubMedCrossRefGoogle Scholar
  33. 33.
    ABLIN, R.J., BRUNS, G.R., AL SHEIK, H., GUINAN, P.D., BUSH, I.M.: Hormonal therapy and alteration of lymphocyte proliferation. J. Lab. Clin. Med. 87, 227–231 (1976c)PubMedGoogle Scholar
  34. 34.
    ABLIN, R.J.: Serum proteins in prostatic cancer. VI. Reduction of the suppressive (‘blocking’?) properties of serum from patients with prostatic cancer on cell-mediated immunologic responsiveness following cryosurgery. Urol. Int. 32, 65–73 (1977a)PubMedCrossRefGoogle Scholar
  35. 35.
    ABLIN, R.J., SOANES, W.A., GONDER, M.J.: Serum proteins in prostatic cancer. V. Alterations in immunoglobulins and clinical responsiveness following cryoprostatectomy. Urol. Int. 32, 56–64 (1977b)PubMedCrossRefGoogle Scholar
  36. 36.
    ABLIN, R. J., SADOUGHI, N., GUINAN, P., BRUNS, G.R., BUSH, I.M.: Biphasic effect of cryosurgery of the prostate on lymphocyte proliferation. Cryobiology 14, 60–67 (1977c)PubMedCrossRefGoogle Scholar
  37. 37.
    ABLIN, R.J., BRUNS, G.R., GUINAN, P.D., SADOUGHI, N., AL SHEIK, H., BUSH, I.M.: Alterations in host responsiveness in patients with prostatic cancer following cryosurgery or transurethral resection. Am. Surg. 43, 144–150 (1977d)PubMedGoogle Scholar
  38. 38.
    ABLIN, R.J., BHATTI, R.A., GUINAN, P.D.: Tumor-associated antigens and immunity in prostatic carcinoma. This volume, pp. 65–80Google Scholar
  39. 39.
    BALDWIN, R.W., PRICE, M.R., ROBINS, R.A.: Significance of serum factors modifying cellular immune responses to growing tumors. Br. J. Cancer 28, (Suppl. I), 37–47 (1973)Google Scholar
  40. 40.
    BARNES, G.W.: The antigenic nature of male accessory glands of reproduction. Biol. Reprod. 6, 384–421 (1972)PubMedGoogle Scholar
  41. 41.
    BARNES, G.W., ABLIN, R.J., STOLL, H.W.: Autoimmunization by the intra-abdominal release of rabbit male accessory glands secretions. (Abstract). Cryobiology 12, 572 (1975)CrossRefGoogle Scholar
  42. 42.
    BLACKWOOD, C.E., COOPER, I.S.: Response of experimental tumor systems to cryosurgery. Cryobiology 9, 508–515 (1972)PubMedCrossRefGoogle Scholar
  43. 43.
    BRONSON, P., ABLIN, R.J., SOANES, W.A.: Evaluation of the freeze-thaw alteration of rabbit male urogenital tissue antigens by double diffusion gel precipitation. Cryobiology 6, 401–403 (1970)PubMedCrossRefGoogle Scholar
  44. 44.
    CALAMS, J.A., FLANAGAN, M.J., McDONALD, J.H.: Rapid freezing of the prostate: An experimental study. J. Urol. 96, 512–518 (1966)PubMedGoogle Scholar
  45. 45.
    CAMUS, L., GLEY, E.: Action coagulante de liquide de la prostate extreme du herisson sur le contenue des vescules seminales. C.R. Acad. Sci. 128, 1417 (1899)Google Scholar
  46. 46.
    COGGIN, J.H., AMBROSE, K.R., DIERLAM, P.J., ANDERSON, N.G.: Proposed mechanisms by which autochthonous neoplasms escape immune rejection. Cancer Res. 34, 2093–2101 (1974)Google Scholar
  47. 47.
    COOPER, A.J., FRASER, J.D.: Autoallergic Responses Induced by Cryoablation of Normal Kidney Tissue. In: Cryoimmunology. SIMATOS, D., STRONG, D.M., TURC, J.M. (eds.), pp. 261–266. Paris: INSERM Publ. 1976Google Scholar
  48. 48.
    CURRIE, G.A., ALEXANDER, P.: Spontaneous shedding of TSTA by viable sarcoma cells: Its possible role in facilitating metastatic spread. Br. J. Cancer 29, 72–75 (1974)PubMedCrossRefGoogle Scholar
  49. 49.
    CURRIE, G.A., BASHAM, C.: Serum mediated inhibition of the immunological reactions of the patient to his tumour: A possible role for cirulating antigen. Br. J. Cancer 26, 427–438 (1972)PubMedCrossRefGoogle Scholar
  50. 50.
    DRYLIE, D.M., JORDAN, W.P., ROBBINS, J.B.: Immunologic consequences of cryosurgery. I. Serum proteins. Invest. Urol. 5, 619–626 (1968)PubMedGoogle Scholar
  51. 51.
    EHRLICH, R.M., TANNENBAUM, M., ROBERTS, M., LATTIMER, J.K.: Experimental prostate cryosurgery: a study utilizing radioautography and electron microscopy. J. Urol. 101, 890–897 (1969)PubMedGoogle Scholar
  52. 52.
    FARACI, R.P., BAGLEY, D.H., MARRONE, J., BEAZLEY, R.M.: In vitro demonstration of cryosurgical augmentation of tumor immunity. Surgery 77, 433–438 (1975)PubMedGoogle Scholar
  53. 53.
    FLOCKS, R.H., NELSON, C.M.K., BOATMAN, D.L.: Perineal cryosurgery for prostatic carcinoma. J. Urol. 108, 933–935 (1972)PubMedGoogle Scholar
  54. 54.
    FLOCKS, R.H., O’DONOGHUE, E.P.N., MILLEMAN, L.A., GULP, D.A.: Management of stage prostatic carcinoma. In: Symposium on the prostate. FLOCKS, R.H., SCOTT, W.W. (eds.), pp. 163–179. Urol. Clin. No. Amer. Philadelphia: W.B. Saunders Co. 1975Google Scholar
  55. 55.
    FONTANA, G., PUGLIESE, A., SAVOIA, D., CAUDA, F.: Immunological Aspects of Cryosurgery of the Prostate. In: Proceedings III Internation Congress of Cryosurgery. TRAMOYERES C.A. (ed.) Valencia 1978Google Scholar
  56. 56.
    FREUND, J., THOMPSON, G.E.: Toxic effects of fluid from the coagulating gland of the guinea pig. Proc. Soc. Exp. Biol. Med. 94, 350 (1957)PubMedGoogle Scholar
  57. 57.
    GERBER, J., JABLONSKI, K., OSADA, J., DOBRYSZYCKA, W.: Biochemical blood studies in patients with carcinoma of the ovaries during treatment with preparation C-2 83. I. Behavior of serum protein fractions. Arch. Immunol. Ther. Exp. 19, 861–868 (1971)Google Scholar
  58. 58.
    GONDER, M.J., SOANES, W.A., SMITH, V.: Experimental prostate cryosurgery. Invest. Urol. 1, 610–619 (1964)PubMedGoogle Scholar
  59. 59.
    GURSEL, E., FINGERHUT, B., VEENEMA, R.J.: Cellular Response to Immunotherapy and Cryotherapy in Rat Bladder Tumor.Google Scholar
  60. 60.
    GURSEL, E., ROBERTS, M., VEENEMA, R.J.: Regression of prostatic cancer following sequential cryotherapy to the prostate. J. Urol. 108, 928–932 (1972b)PubMedGoogle Scholar
  61. 61.
    GURSEL, E.O., ROBERTS, M.S., VEENEMA, R.J.: Cryotherapy in advanced prostatic cancer. Urology 1, 392–396 (1973a)PubMedCrossRefGoogle Scholar
  62. 62.
    GURSEL, E.O., MEGALLI, M.R., ROBERTS, M.S., VEENEMA, F.J.: Effects of cryotherapy on serum immunoglobulins in patients with prostate cancer. XVI Congress of the International Society of Urology. Vol. 2, pp. 286–290. 1973bGoogle Scholar
  63. 63.
    HANSEN, R.I., WANSTRUP, J.: Cryoprostatectomy: Histological changes elucidated by serial biopsies. Scand. J. Urol. Nephrol. 7, 100–104 (1973)PubMedCrossRefGoogle Scholar
  64. 64.
    HORAN, A.H., Sequential cryotherapy for prostatic carcinoma: Does it palliate the bone pane? Conn. Med. 39, 81–83 (1975)PubMedGoogle Scholar
  65. 65.
    HELPAP, B., GROULS, V.: Evidence of a Primary Immunological Response After Cryosurgical Lesions. In: Antibody response to cryotherapy. ABLIN, R.J. (ed.). To be publishedGoogle Scholar
  66. 66.
    HELPAP, B., GROULS, V., YAMASHITZ, K., BREINING, H.: The proliferative response of the spleen in cryosurgery. Cryobiology 13, 54–60 (1976)PubMedCrossRefGoogle Scholar
  67. 67.
    JAGODZINSKI, R., YANTORNO, C., SHULMAN, S.: An experimental system for the production of antibodies in response to cryosurgical procedures. Cryobiology 3, 446–463 (1967)CrossRefGoogle Scholar
  68. 68.
    KANETAKE, H.: Cryoimmunologic investigations of the rabbit kidney. Invest. Urol. 14, 373–377 (1977)PubMedGoogle Scholar
  69. 69.
    MASER, M.D., JAHODZINSKI, R.M., SOANES, W.A., GONDER, M.J.: Cytological changes in the secretory epithelium of the canine prostate after freezing and thawing. Cryobiology 6, 105–115 (1969)PubMedCrossRefGoogle Scholar
  70. 70.
    McPHEDRAN, P., FINCH, S.C., NEMERSON, Y.R., BARNES, M.G.: Alpha2-globulin “spike” in renal carcinoma. Ann. Int. Med. 76, 439–441 (1972)PubMedGoogle Scholar
  71. 71.
    MYERS, R.S., HAMMOND, W.G., KETCHAM, A.S.: Tumor-specific transplantation immunity after cryosurgery. J. Surg. Oncol. 1, 241–246 (1969)PubMedCrossRefGoogle Scholar
  72. 72.
    NAGAYAMA, T., MIYAUCHI, T., AIKAWA, H., TAKAGI, T., ISHIGURO, K.: Cryosurgery of urinary bladder tumor and immune response. In: Proceedings Third International Symposium. Detection and Prevention of Cancer. NIEBURGS, H.E. (ed.). New York: Marcel Dekker, Inc. 1977Google Scholar
  73. 73.
    NEEL, H.B., KETCHAM, A.S., HAMMOND, W.G.: Cryosurgery of SV40 prostatic transplant tumors. Int. Surg. 57, 61–66 (1972)PubMedGoogle Scholar
  74. 74.
    OLIARO, T.: International Congress of Cryosurgery. The Second Session. Minerva Med. 65, 3679–3713 (1974)Google Scholar
  75. 75.
    REUTER, H.J.: Cryosurgery in urology. Int. Symp. in Stuttgart 1973. Stuttgart: Georg Thieme 1974Google Scholar
  76. 76.
    RIGGI, G.: The Effect of Cryonecrosis on Immunitary Resistance to Syngeneic Tumours. In: Antibody response to cryotherapy. ABLIN, R.J. (ed.). To be publishedGoogle Scholar
  77. 77.
    SCHWEIZER, K., LYMBEROPOULOS, S., BREINING, H.: Immunological studies after cryosurgical tumor treatment. Minerva Med. 65, 3658 (1974)PubMedGoogle Scholar
  78. 78.
    SESIA, G., FERRANDO, U., LAUDI, M., SGUAZZI, A.: La cryotherapie dans les obstructions prostatiques (à propos de 120 cas). J. Urol. Nephrol. 75, 121–139 (1969)Google Scholar
  79. 79.
    SHULMAN, S.: Experimental cryosurgery and antibody response. J. Cryosurg. 2, 90–96 (1969)Google Scholar
  80. 80.
    SHULMAN, S., YANTORNO, C., BRONSON, P.: Cryoimmunology: A method of immunization to autologous tissue. Proc. Soc. Exp. Biol. Med. 124, 658–661 (1967)PubMedGoogle Scholar
  81. 81.
    SOANES, W.A., ABLIN, R.J., GONDER, M.J.: Remission of metastatic lesions following cryosurgery in prostatic cancer: Immunologic considerations. J. Urol. 104, 154–159 (1970)PubMedGoogle Scholar
  82. 82.
    STOLL, H.W., ANSELL, J.S., BARNES, M.S., BARNES, G.W.: The autoimmune response to male reproductive tissues of rabbits. III. Effects of testosterone and estrogen on cryoimmunogenic and immunochemical expressions of the central accessory glands. Invest. Urol. 12, 236–245 (1974a)PubMedGoogle Scholar
  83. 83.
    STOLL, H.W., BARNES, G.W., ANSELL, J.S.: The autoimmune response to male reproductive tissues of rabbits. I. Simplified cryosurgical procedures for inducing antibody to accessory tissue. Invest. Urol. 12, 108–115 (1974b)Google Scholar
  84. 84.
    STOLL, H.W., BARNES, G.W., ANSELL, J.S.: The autoimmune response to male reproductive tissues of rabbits. II. The secondary response as an indicator of cryosentitization to accessory tissue. Invest. Urol. 12, 116–122 (1974c)PubMedGoogle Scholar
  85. 85.
    SUGA, S., TAMURA, Z.: Analysis of serum protein changes in patients with advances gastric cancer special reference to alpha-globulin fractions. Cancer Res. 32, 426–429 (1972)PubMedGoogle Scholar
  86. 86.
    SUNDERMAN, E.W., SUNDERMAN, F.W., Jr.: Serum proteins and dys-proteinemias. Philadelphia: J.P. Lippincott Co. 1964Google Scholar
  87. 87.
    VOTTERO-CIMA, E., VIDES, M.A., SHULMAN, S., YANTORNO, C.: Tissue-specific antigens and autoantigens in the early developing rabbit male reproductive accessory glands. Ann. Immunol. Inst. Pasteur 126C, 629–637 (1975)Google Scholar
  88. 88.
    ZAPPI, E., NEMIROVSKY, M. SHULMAN, S.: Contralateral epididymo-orchitis after cryo-injury to the male rabbit gonad. Immunology 25, 891–899 (1973)PubMedGoogle Scholar
  89. 89.
    ZAPPI, E., NEMIROVSKY, M., SHULMAN, S.: Cellular and humoral responses of autosensitized rabbits to a testis cryo-injury. Immunology 26, 477–488 (1974)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • R. J. Ablin
    • 1
  • P. D. Guinan
    • 1
  1. 1.Division of ImmunologyCook County HospitalChicagoUSA

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