Chemistry and Pharmacology of Dobutamine
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More than 9 years ago I realized that there was no agent that would effectively and selectively increase the contractility of the heart. Although we had the digitalis glycosides for many years, their ability to increase cardiac contractility is small relative to a catecholamine acting on the β1-receptor of the myocardium. In addition to their great efficacy, the catecholamines have the advantage of immediate onset and quick termination of action which makes it possible to precisely control the amount of stimulation with intravenous infusion. For these reasons we narrowed our search for a selective inotropic agent to the catecholamines.
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