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Adjuvant Chemo-Immuno-Therapy with LMF+BCG in Node-Negative and Node-Positive Breast Cancer

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Adjuvante zytostatische Chemotherapie

Abstract

Breast Cancer is by far the most common neoplastic disease ofwomen in western industrialized countries. Contrary to public hope and prevailing medical opinion, this tumor is apparently hard to cure, since eventually 60-70% of “radically” resected patients are going to succumb to their disseminated disease within 10 years after surgery [1, 2, 3]. Survival expectancy and mortality have essentially remained unchanged over the past 40 years.

Supported by the Regional Scientific Cancer Program sponsered by the Cancer Leagues of St. Gallen-Appenzell and Thurgau and by the E. E. Schellenberg-Stiftung.

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References

  1. Ross W. L.: The magnitude of the breast cancer problem in the USA. Cancer 24, 1106 (1969)

    Article  PubMed  CAS  Google Scholar 

  2. Brinkley D., Haybittle J. L.: The curability of breast cancer. Lancet 2, 95 (1975)

    Article  PubMed  CAS  Google Scholar 

  3. Cutter S. J., Myers M. H., Green S. B.: Trends in survival rates of patients with cancer. N. Engl. J. Med. 293, 122 (1975)

    Article  Google Scholar 

  4. Fisher, B., Slack N. H., Cavanaugh P. J. et al.: Postoperative radiotherapy in the treatment of breast cancer: results of the NSABP clinical trial. Ann. Surg. 172, 711 (1970)

    Article  PubMed  CAS  Google Scholar 

  5. Stiernswärd J. : Decreased survival related to postoperative radiotherapy in early operable breast cancer? Lancet 2, 1285 (1974)

    Article  Google Scholar 

  6. Fisher B., Ravdin R. G., Ausman R. K., et aI.: Surgical adjuvant chemotherapy in cancer of the breast: results of a decade of cooperative investigation. Ann. Surge 168, 337 (1968)

    Article  CAS  Google Scholar 

  7. Tormey D. C.: Combined chemotherapy and surgery in breast cancer: a review. Cancer 36, 881 (1975)

    Article  PubMed  CAS  Google Scholar 

  8. Fisher B., Carbone P., Economu S. G., et al.: L-PAM in the management of primary breast cancer: a report of early findings. N. EngI. J. Med. 292, 117 (1975)

    Article  CAS  Google Scholar 

  9. Bonadonna G., Brusamolino E., Valagussa P.: Combination chemotherapy as an adjuvant treatment in operable breast cancer. N. Engl. J. Med. 294, 405 (1976)

    Article  PubMed  CAS  Google Scholar 

  10. Mutzner F., Amgwerd, R., Gessner U.: Prognose des lokalen primären Mammakarzinoms unter der bisherigen Therapie. Schweiz. Med. Wschr. 107, 992 (1977)

    PubMed  CAS  Google Scholar 

  11. Sparks F. C., Meyerowitz B. E., Ramming K. P., et al.: Adjuvant Chemotherapy and chemoimmunotherapy for breast cancer, in: Adjuvant therapy of cancer, Salmon S. S., Jones St. E. (ed.). Amsterdam—Oxford—New York: North-Holland Publishing company 1977, p. 109

    Google Scholar 

  12. Schabel F. M. jr.: Concepts for systemic treatment of micrometastases. Cancer 35, 15 (1975)

    Article  PubMed  CAS  Google Scholar 

  13. Sutow W. W., Sullivan M. P.: Childhood cancer — the improving prognosis. Postgraduate Medicine 59, 131 (1976)

    PubMed  CAS  Google Scholar 

  14. Rosenberg S. A., Kaplan H. S.: The management of stages I, II and III Hodgkin’s disease with combined radiotherapy and chemotherapy. Cancer 35, 55 (1975)

    Article  PubMed  CAS  Google Scholar 

  15. Burchenal J. H.: A giant step forward - if! New Engl. J. Med. 291, 1029 (1974)

    Article  PubMed  CAS  Google Scholar 

  16. Bonadonna G., Rossi A., Valagussa, P., et al.: Adjuvant chemotherapy with CMFin breast cancer with positive axillary nodes, in: Salmon S. S., Jones S. E. (ed.): Adjuvant therapy of cancer. Amsterdam—Oxford—New York: North-Holland 1977, p. 83

    Google Scholar 

  17. Fisher B., Redmond C., NSABP investigators: Studies of the national surgical adjuvant breast cancer project, in ibidem as (16)

    Google Scholar 

  18. Canellos G. P., DeVita V. T., Gold G. L., et al.: Cyclical combination chemotherapy for advanced breast carcinoma. Brit. Med. J. 1, 218 (1974)

    Article  PubMed  CAS  Google Scholar 

  19. Donovan A., Powell J., Waterhouse J. A. H., et al.: A prolonged course of cyclophsphamide as an adjunct to mastectomy in the primary treatment of breast carcinoma. Br. J. Surg. 63, 817 (1976)

    Article  PubMed  CAS  Google Scholar 

  20. Nissen-Meyer R., Kjellgren K., Mansson B.: Report from the Scandinavian adjuvant chemotherapy study group. 7th Int. Congress of chemotherapy, Prag 1971, abstract 2/B–6/7

    Google Scholar 

  21. Multicentre Breast Cancer Chemotherapy Group: Multimodal therapy for histological stage-II breast cancer. Lancet 2, 396 (1977)

    Google Scholar 

  22. Swiss Group for Clinical Cancer Research: Adjuvante Chemotherapie zur Metastasenprophylaxe beim operierten Mammakarzinom, Studie SAKK–27/76, unpublished observations 1977

    Google Scholar 

  23. Meakin J. W., AlIt W. E. C., Beale F. A., et al.: Ovarian irradiation and prednisone following surgery for carcinoma of the breast, in ibidem as (16)

    Google Scholar 

  24. Holland J. F.: Major advance in breast cancer therapy. editorial. New Engl. J. Med. 294, 440 (1976)

    Article  CAS  Google Scholar 

  25. Culliton B. J.: Breast cancer: Reports of new therapy are greatly exaggerated. Science 191, 1029 (1976)

    Article  PubMed  CAS  Google Scholar 

  26. Lerner H.: Second malignancies diagnosed in breast cancer patients while receiving adjuvant chemotherapy at the Pensilvania Hospital. Meeting of the American Soc. Clin. Oncol. (1977), Denver, abstract C-295, p. 340

    Google Scholar 

  27. Sadoff, L., Chan P., Tyson S.: Incidence of second primary cancers in breast cancer patients after prolonged thiotepa therapy. Proc. Am. Assoc. Cancer Res./Am. Soc. Clin. Oncol. 15, 145 (1974)

    Google Scholar 

  28. Ravdin R. G., Lewison E. F., Slack N. H., et al.: Results of a clinical trial concerning the worth of prophylactic oophorectomy for breast carcinoma. Surg. GynecoI. Obstet. 131, 1055 (1970)

    CAS  Google Scholar 

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© 1978 Springer-Verlag Berlin Heidelberg

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Senn, H.J. et al. (1978). Adjuvant Chemo-Immuno-Therapy with LMF+BCG in Node-Negative and Node-Positive Breast Cancer. In: Huber, H., Senn, H., Falkensammer, M. (eds) Adjuvante zytostatische Chemotherapie. Hämatologie und Bluttransfusion, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67111-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-67111-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09069-4

  • Online ISBN: 978-3-642-67111-1

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