Experimental and Morphologic Investigations on Reversible and Irreversible Hypothalamic Compression in the Rabbit

  • H. E. Clar
  • L. Gerhard
  • V. Reinhardt
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 6)


Intracranial space-occupying lesions causing direct or indirect compression of the hypothalamic structures are apt to produce severe disturbances of endocrine and general hypothalamic regulations. Neurosurgical experience confirms the important role dysregulations play for operative and postoperative survival and care. This is true also for procedures performed on the hypothalamic structures proper. Therefore an experimental study of this clinical and morphologic diencephalic syndrome appeared to be of value. Since previous investigations (4, 6, 8, 10) did not deal with clinical problems, we tried to develop an experimental model which imitates a hypothalamic space occupying lesion in the rabbit, so as to study acute and chronical hypothalamic dysfunction.


Cresyl Violet Chronic Lesion Anterior Hypothalamus Blood Brain Barrier Function Blood Brain Barrier Dysfunction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • H. E. Clar
  • L. Gerhard
  • V. Reinhardt

There are no affiliations available

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