The unravelling of the principles governing synaptic organization presents the neuroscientific community with a complex, multifaceted range of problems. Whatever discipline within the neurosciences is taken as the starting point for the investigation of synaptic organization, it will be impinged upon by related disciplines with their equally relevant contributions. While the present review starts from a morphological base, the dependence of a morphological approach upon other disciplines, particularly neurochemistry, is highlighted. The scope of morphology needed to provide a broad framework within which synaptic organization can be viewed is worked out in some detail.
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