Evidence Supporting a Physiological Role for Endogenous C-Type Virus in the Immune System
The discovery that sequences coding for C-type viruses were endogenous to the genome of a variety of vertebrates raised several important questions. Principal among these were the relationship of endogenous viruses to oncogenic C-type viruses and their putative function during normal differentiation and development of their host cells. Recently a possible link between endogenous virus expression and the development of spontaneous leukemia has been proposed by the work of Hartley and Rowe with AKR mice . Reasons for the retention and expression of these viruses in normal cells, however, have been lacking.
KeywordsLeukemia Bromodeoxyuridine Midine
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