Evidence Supporting a Physiological Role for Endogenous C-Type Virus in the Immune System

  • J. F. DeLamarter
  • J. Stoye
  • G. Schumann
  • C. Moroni
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 23)


The discovery that sequences coding for C-type viruses were endogenous to the genome of a variety of vertebrates raised several important questions. Principal among these were the relationship of endogenous viruses to oncogenic C-type viruses and their putative function during normal differentiation and development of their host cells. Recently a possible link between endogenous virus expression and the development of spontaneous leukemia has been proposed by the work of Hartley and Rowe with AKR mice [1]. Reasons for the retention and expression of these viruses in normal cells, however, have been lacking.


Viral Antigen Viral Sequence Viral Transcript Endogenous Virus Murine Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • J. F. DeLamarter
    • 1
  • J. Stoye
    • 1
  • G. Schumann
    • 2
  • C. Moroni
    • 1
  1. 1.Friedrich-Miescher-InstitutBaselSwitzerland
  2. 2.Research Department, Pharmaceuticals DivisionCiba-Geigy LimitedBaselSwitzerland

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