Evidence Supporting a Physiological Role for Endogenous C-Type Virus in the Immune System

  • J. F. DeLamarter
  • J. Stoye
  • G. Schumann
  • C. Moroni
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 23)

Abstract

The discovery that sequences coding for C-type viruses were endogenous to the genome of a variety of vertebrates raised several important questions. Principal among these were the relationship of endogenous viruses to oncogenic C-type viruses and their putative function during normal differentiation and development of their host cells. Recently a possible link between endogenous virus expression and the development of spontaneous leukemia has been proposed by the work of Hartley and Rowe with AKR mice [1]. Reasons for the retention and expression of these viruses in normal cells, however, have been lacking.

Keywords

Leukemia Bromodeoxyuridine Midine 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • J. F. DeLamarter
    • 1
  • J. Stoye
    • 1
  • G. Schumann
    • 2
  • C. Moroni
    • 1
  1. 1.Friedrich-Miescher-InstitutBaselSwitzerland
  2. 2.Research Department, Pharmaceuticals DivisionCiba-Geigy LimitedBaselSwitzerland

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