Abstract
Griseofulvin is a highly effective fungistatic drug, which can be used to induce a pronounced disturbance of porphyrin metabolism in mice. The disturbance is characterized by high levels of free erythrocytic protoporphyrin, high values of porphyrins in the liver, and by increas ed protoporphyrin and coproporphyrin excretion in the feces (2). As shown in previous studies, protoporphyrin and coproporphyrin accumulation in the liver precedes free protoporphyrin increase in the erythro cytes. This is evidence of the liver’s decisive part in the genesis of the disease (6). The detected increase in the activity of δ-aminolevulinic acid synthetase (ALAS) and decrease in hepatic ferrochelatas activity suggest a slowing down of the transformation of fast-developing protoporphyrin into heme - a fact that may help explain the accumulation of protoporphyrin.
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Janoušek, V., Dobiáš, J., Chlumská, A., Klein, O., Paulová, M. (1978). Biochemical and Morphologic Changes in Early Phases of Experimental Protoporphyria. In: Doss, M. (eds) Diagnosis and Therapy of Porphyrias and Lead Intoxication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67002-2_44
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DOI: https://doi.org/10.1007/978-3-642-67002-2_44
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