Therapy for Lead Poisoning

  • N. Graben
  • M. Doss
  • H. A. Klöppel
  • W. Wilhelms
  • R. v. Tiepermann


In industrial lead poisoning, the lead accumulates mainly in the respiratory tract. In contrast to the slow and incomplete absorption of lead via the gastrointestinal tract, inhaled lead is incorporated quickly and in great quantities. Therefore processes during which lead vapor and lead oxides develop (8) result in great lead concentrations. It is known, but often ignored, that welders demolishing steel constructions with a protective coating of paint containing lead are particularly endangered (2). The following presents diagnosis and therapy of three severe cases of lead poisoning in welders.


Lead Concentration Lead Poisoning Excretion Pattern Acute Intermittent Porphyria Urinary Porphyrin 
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  1. 1.
    Beattie, A.D.: Diagnostic and therapeutic uses of D-penicillamine in lead poisoning. Postgrad. Med. J. 50, 17–20 (1974)PubMedGoogle Scholar
  2. 2.
    Brugsch, H.J.: Hazardous lead exposures among structural-steel workers. N. Engl. J. Med. 270, 211–211 (1964)CrossRefGoogle Scholar
  3. 3.
    Chisolm, J.: Chelation therapy in children with subclinical plumbism. Pediatrics 53, 441–443 (1974)PubMedGoogle Scholar
  4. 4.
    Doss, M.: Porphyrins and porphyrin precursors. In: Clinical Biochemistry, Principles and Methods. Curtius, M. Ch., Roth, M. (eds.). Berlin: de Gruyter 1974, Vol. II, pp. 1323–1371Google Scholar
  5. 5.
    Doss, M., Schermuly, E.: Urinary porphyrin excretion pattern and isomer distribution of I and III in human porphyrin disorders. In: Porphyrins in Human Dis-eases. Doss, M. (ed.). Basel: Karger 1976, pp. 189–204Google Scholar
  6. 6.
    Doss, M., v. Tiepermann, R.: Urinary porphyrin profiles in acute lead poisoning: relation and differentiation to acute intermittent porphyria. In: Proc. Toxic Metals Symp. on Clin. Chem. and Chem. Toxicol. Brown, S.S. (ed.). Amsterdam: Elsevier 1977, Vol. I, pp. 183–186Google Scholar
  7. 7.
    Goldberg, A., Smith, J.A., Lochhead, A.C.: Treatment of lead poisoning with oral penicillamine. Br. Med. J. 1963/i, pp. 1270–1275CrossRefGoogle Scholar
  8. 8.
    Kisser, W.: Biochemische Methoden zum Nachweis der Bleivergiftung. Arch. Toxikol. 37, 173–193 (1977)CrossRefGoogle Scholar
  9. 9.
    Lehnert, G., Eschtruch, R., Szadkowski, D., Schaller, K.-H.: Zum Problem der medikamentösen Prophylaxe beruflicher Schwermetallintoxikationen mit D-Penicillamin. Med. Welt 21, 346–353 (1970)Google Scholar
  10. 10.
    Martin, H., Berger, O.: Die gewerbliche Bleiintoxikation als internistisches KrankheitsbiId. Med. Welt 24, 589–592 (1973)PubMedGoogle Scholar
  11. 11.
    Miehlke, K., Jentsch, D.: D-Penicillamin-Therapie bei entzūndlichen rheumatischen Krankheiten. Dtsch. Ärzteblatt 72, 1207–1212 (1975)Google Scholar
  12. 12.
    Moeschlin, S.: Klinik und Therapie der Vergiftungen, 5th ed. Stuttgart: Georg Thieme 1972, pp. 36–56Google Scholar
  13. 13.
    Niemann, G.: Zur Therapie der Bleivergiftung mit D-Penicillamin. Arbeitsmed. Soziaimed. Arbeitshyg. 3, 224–225 (1968)Google Scholar
  14. 14.
    Perings, E., Hauswaldt, Ch., Junge, U., Schulze, F., Schumann, E.: Die Wirkung von D-Penicillamin auf das Knochenmark der Ratte. Verh. Dtsch. Ges. Inn. Med. 80, 1405–1406 (1974)PubMedGoogle Scholar
  15. 15.
    Rat der Europäischen Gemeinschaften: Richtlinien des Rates vom 29.3. 1977 über die biologische Überwachung der Bevölkerung auf Gefährdung durch Blei. Amtsblatt der Europäischen Gemeinschaften, 20. Jahrgang, No. L 105, 28.4.1977 (German Edit.)Google Scholar
  16. 16.
    Schiele, R., Schaller, K.-H., Valentin, H.: Moderne Kriterien zur Diagnostik und Beurteilung chronischer Bleibelastung in der Arbeitswelt. Berufskrankheiten in der Keramischen und Glasindustrie 27, 21–36 (1977)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • N. Graben
    • 1
  • M. Doss
    • 1
  • H. A. Klöppel
    • 2
  • W. Wilhelms
    • 2
  • R. v. Tiepermann
    • 2
  1. 1.Medical Clinic and PolyclinicInstitute for Forensic Medicine of the University Clinic of EssenGermany
  2. 2.Department of Clinical Biochemistry of the Faculty of Human Medicine of Philipp-UniversityMarburg a.d. LahnGermany

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