Abstract
Disturbances of heme biosynthesis differ from most other metabolic diseases in that they involve a pathway essential to life. Heme (Feprotoporphyrin IX) functions as a prosthetic group for hemoglobin, myoglobin, mitochondrial and microsomal cytochromes, catalase, peroxidases, and tryptophan pyrrolase. Important physiologic functions of heme are transport of oxygen, activation of oxygen, and the transfer of electrons to oxygen. All cells with aerobic metabolism are presumed to be able to synthesize heme.
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Meyer, U.A. (1978). Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias. In: Doss, M. (eds) Diagnosis and Therapy of Porphyrias and Lead Intoxication. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67002-2_1
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DOI: https://doi.org/10.1007/978-3-642-67002-2_1
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