Is Posterior-Hypophysial Corticotropin Involved in Neurogenic Stress?

  • C. Mialhe
  • B. Briaud
  • B. Koch
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


By disconnecting the pituitary from the central nervous system (CNS), FORTIER (1951) distinguished between two categories of stress: neurogenic and systemic, according to whether they act at the hypothalamo-pituitary level through the CNS, or through the circulatory system. Neurogenic stress may be characterized by: (1) the necessity of an intact neural input to the hypothalamus, (2) a fast ACTH response and, (3) a great sensitivity to the circulating corticosteroid levels (cf. review by MIALHE and BRIAUD, 1977).


Anterior Pituitary ACTH Activity ACTH Content ACTH Molecule Neurointermediate Lobe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. BROWNSTEIN, M.J., PALKOVITZ, M., SAAVEDRA, J.M., KIZER, J.S.: Distribution of hypothalamic hormones and neurotransmitters within the diencephalon. In: Frontiers in Neuroendocrinology. Martini, L., Gannong, W.F. (eds.). New York: Raven Press, 1976, pp. 1–23Google Scholar
  2. FISCHER, J.L., MORIARTY, C.M.: Control of bioactive corticotropin release from the neuro-intermediate lobe of the rat pituitary in vitro. Endocrinology 100, 1047–1054 (1977)PubMedCrossRefGoogle Scholar
  3. FORTIER, C.: Dual control of adrenocorticotrophin release. Endocrinology 49, 782–788 (1951)PubMedCrossRefGoogle Scholar
  4. GREER, M.A., ALLEN, C.F., PATON, P., ALLEN, J.P.: Evidence that the pars intermedia and pars nervosa of the pituitary do not secrete functionally significant quantities of ACTH. Endocrinology 96, 718–724 (1975)PubMedCrossRefGoogle Scholar
  5. KRAICER, J., GOSBEE, J.L., BENCOSME, S.A.: Pars intermedia and pars distalis: two sites of ACTH production in the rat hypophysis. Neuroendocrinology 11, 156–176 (1973)PubMedCrossRefGoogle Scholar
  6. KRAICER, J., MORRIS, A.R.: In vitro release of ACTH from dispersed rat pars intermedia cells: effect of secretagogues. Neuroendocrinology 20, 79–96 (1976)PubMedCrossRefGoogle Scholar
  7. MIALHE, C., BRIAUD, B.: Possible involvement of pars intermedia of the rat pituitary in neurogenic stress. In: Frontiers of Hormone Research. Van Wimersma Greindanus (ed.). Basel: Karger, 1977, pp. 193–199Google Scholar
  8. MIALHE-VOLOSS, C.: Posthypophyse et activité corticotrope. Acta Endocrinol. Copenh. 35, Suppl. pp. 1–96 (1958)Google Scholar
  9. SCOTT, A.P., RATCLIFFE, J.G., REES, L.H., LANDON, J., BENNETT, H.P., LOWRY, P.J., MCMARTIN, C.: Pituitary peptide. Nature (New Biol.) 244, 65–67 (1973)Google Scholar
  10. SMELIK, P.G., GAARENSTROOM, J.H., KONI JNENDIJK, W., DE WIED, D.: Evaluation of the rôle of the posterior lobe of the hypophysis in the reflex secretion of corticotrophin. Acta Physiol. Pharmacol. Neerl. 11, 20–33 (1962)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • C. Mialhe
  • B. Briaud
  • B. Koch

There are no affiliations available

Personalised recommendations