Placental Changes in Gestational Diabetes

Conference paper


The placenta of the diabetic woman has been the focus of considerable pathological interest. This is due largely to the belief, almost certainly a mistaken one, that placental damage or “insufficiency” plays a role in the relatively high perinatal mortality rate in diabetic pregnancies. Numerous investigations at both the light and electron microscopic level have yielded results which have been not only inconsistent, but often contradictory (Kloos, 1952; Knopp, 1955; Burstein et al. , 1957; Horky, 1964, 1965; Lister, 1965; Driscoll, 1965, 1975; Okudaira et al. , 1966; Liebhart, 1968a, 1968b, 1971, 1973; Widmaier, 1970; Emmrich and Godel, 1972a, 1972b, 1972c; Emmrich et al. , 1974a, 1974b, 1975; Hoelzl et al. , 1975; Jacomo et al. , 1976). The root of this failure to achieve a consensus lies in the methodological defects from which many of these studies have suffered. These include a failure to compare the placentae examined with those from uncomplicated pregnancies of the same gestational length and the consideration as a homogenous group of placentae from both prematurely terminating and full term pregnancies. The inclusion of placentae from still-births without any account being taken of the changes that occur in the placentae after fetal death and the failure to separate those placentae from diabetic women with superimposed pre-eclampsia from those of diabetic women whose pregnancies were uncomplicated have also added to the lack of agreement.


Gestational Diabetes Rough Endoplasmic Reticulum Diabetic Woman Diabetic Pregnancy Cytotrophoblastic Cell 
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© Springer-Verlag Berlin Heidelberg 1979

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  • H. Fox

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