Abstract
During pregnancy maternal metabolic realignments occur which are related to providing the fetus with the most advantageous nutritional environment. Using a glucose infusion test (GIT) the present study was undertaken to investigate the adaptations of maternal insulin response and insulin sensitivity in relation to normal intravenous glucose tolerance (IVGT) and to chemical gestational diabetes.
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References
Beck, P., Daughaday, W.H.: Human placental lactogen: Studies of its acute metabo lie effect and disposition in normal man. J. Clin. Invest. 46, 103–110 (1967)
Bleicher, S.J., O’Sullivan, J.B., Freinkel, N.B.: Carbohydrate metabolism in pregnancy. V. The inter-relationships of glucose insulin and free fatty acids in late pregnancy and postpartum. N. Engl. J. Med. 271, 866–872 (1964)
Burt, R.L., Davidson, I.W.F.: Insulin half-life and utilisation in normal pregnancy. Obstet. Gynecol. 43, 161–170 (1974)
Burt, R.L., Leake, N.H., Rhyne, A.L.: Glucose tolerance during pregnancy and the puerperium. A modification with observations on serum immunoreactive insulin. Obstet. Gynecol. 33, 634–641 (1969)
Campbell, D.M., Bewsher, P.D., Davidson, J.M., Sutherland, H.W.: Day-to-day variation in fasting plasma glucose and fasting plasma insulin levels. Br.J. Obstet. Gynaecol. 81, 615–621 (1974)
Cerasi, E., Luft, R.: The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol. 55, 278–304 (1967)
Cerasi, E., Luft, R.: Pathogenesis of genetic diabetic mellitus. Further develop ments of a hypothesis. M. Sinai J. Med. NY 40, 334–349 (1973)
Cerasi, E., Warren, J., Luft, R., Felig, P., Hendler, R.: The regulation of splanchnic glucose production in subjects with low insulin response - a compensa tory mechanism in pre-diabetes? Eur. J. Clin. Invest. 3, 193–200 (1973)
Costrini, N.V., Kalkhoff, R.K.: Relative effects of pregnancy. Estradiol and progesterone on plasma insulin and pancreatic islet insulin secretion J. Clin. Invest. 50, 992–999 (1971)
Edstrom, K., Cerasi, E., Luft, R.: Insulin response to glucose infusion during pregnancy. A Prospective study of high and low insulin responders with normal carbohydrate tolerance. Acta Endocrinol. 75, 87–104 (1974)
Fisher, P.M., Hamilton, P.M., Sutherland, H.W., Stowers, J.M.: The effect of pregnancy on intravenous glucose tolerance. Br.J. Obstet. Gynaecol. 81, 285–290 (1974)
Freinkel, N., Herrera, E., Knopp, R.H., Ruder, H.J.: Metabolic realignments in late pregnancy. A clue to diabetogenesis. In: Early diabetes. Supplement I to advances in metabolic disorders. Camerini-Devalos, R., Cole, H.S. (eds.), pp. 205–215. New York: Academic Press 1970
Gross, M.: Effect of pregnancy on carbohydrate metabolism. Clin. Obstet. Gynaecol. 5, 482–496 (1962)
Grumbach, M.M., Kaplan, S.L., Sciarra, J.J., Burr, I.M.: Chorionic growth-hormone-prolactin (C.G.P.): Secretion, disposition, biological activity in man; postulated function as “growth hormone” of second half of pregnancy. Ann. NY Acad. Sci. 148, 501–531 (1968)
Hales, C.N., Randle, P.J.: Immunoassay of insulin with insulin-antibody precipitate. Biochem. J. 88, 137–146 (1963)
Kalkhoff, R.K., Schalch, D.S., Walker, J.L., Beck, P., Kipnis, D.M., Daughaday, W.M.: Diabetogenic factors associated with pregnancy. Trans. Assoc. Am. Physicians 77, 270–280 (1964)
Kemsley, W.F.F.: Body weight at different ages and heights. Ann. Eugenics (London) 16, 316–334 (1951)
Oakley, N.W., Monier, D., Wynn, V.: Diurnal variation in oral glucose tolerance: Insulin and growth hormone changes with special reference to women taking oral contraceptives. Diabetologia 9, 235–238 (1973)
Reaven, G.M., Olefsky, J.M.: The relationship between insulin response during the intravenous glucose tolerance test, rate of fractional glucose removal and the degree of insulin resistance in normal adults. J. Clin. Endocrinol. Metab. 38, 151–154 (1974)
Samaan, N., Yen, S.C.C., Gonzales, D., Pearson, O.H.: Metabolic effects of placental lactogen (HPL) in man. J. Clin. Endocrinol. Metab. 28, 485–491 (1968)
Spellacy, W.N., Goetz, F.C., Greenberg, B.Z., Ells, J.: Plasma insulin in late normal pregnancy. N. Engl. J. Med. 268, 988–991 (1963)
Sutherland, H.W., Fisher, P.M., Stowers, J.M.: Evaluation of maternal carbohydrate metabolism by the intravenous glucose tolerance test. In: Early diabetes in early life. Camerini (ed.), Davalos, R., Cole, H.S., pp. 365–374. New York: Academic Press 1975
Thomson, A.M., Billewicz, W.Z., Hytten, F.E.: The assessment of fetal growth. J. Obstet. Gynaecol. Brit. Cwlth. 75, 903–916 (1968)
Thorell, J.I., Nosslin, B., Sterky, G.: Estimation of the early insulin response to intravenous glucose injection. J. Lab. Clin. Med. 82, 101–110 (1973)
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Fisher, P.M., Sutherland, H.W., Bewsher, P.D. (1979). Insulin Response Studies in Normal Pregnancy and Chemical Gestational Diabetes. In: Sutherland, H.W., Stowers, J.M. (eds) Carbohydrate Metabolism in Pregnancy and the Newborn 1978. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66972-9_3
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DOI: https://doi.org/10.1007/978-3-642-66972-9_3
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