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The Role of Pregnancy-Specific B1-Glycoprotein in the Management of Pregnancies Complicated by Diabetes

  • M. S. Beebeejaun
  • V. Jandial
  • C. M. Towler
  • H. W. Sutherland
  • C. H. W. Horne
Conference paper

Abstract

Pregnancy specific ß1-glycoprotein (PS6G) (synonyms; SP1, PAPP-C and TBG) is a trophoblastic product which was described independently by Tatarinov and Masyukevich (1970), Bohn (1971) and Lin et al. (1974). Being a trophoblast product, it may have a role in assessing placental function. Chard (1974) has proposed that for a constituent of maternal blood to be a useful indicator of placental function, four criteria must be fulfilled. PS6G appears to meet these criteria since (1) it is not normally present in non-pregnant subjects; (2) it shows only a small day-to-day variation; (3) its plasma half life is relatively short (about 30-40 h); and (4) the plasma concentrations are sufficiently high to allow their measurements by simple, rapid techniques.

Keywords

Birth Weight Fetal Weight Normal Birth Weight Placental Weight Diabetic Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • M. S. Beebeejaun
  • V. Jandial
  • C. M. Towler
  • H. W. Sutherland
  • C. H. W. Horne

There are no affiliations available

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