Abstract
4-hydroxybutyric acid (4-HB) is used in the practice of anesthesia, as a sedative in the Intensive Care Unit and as a hypnotic drug in psychiatry (20). It was observed that when after an intravenous bolus injection in the time course of surgery a small dosis was given repeatedly, this resulted in a very prolonged sleeping time in the recovery room.
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Vree, T.B., Damsma, J., van den Bogert, A.G., van der Kleijn, E. (1978). Pharmacokinetics of 4-Hydroxybutyric Acid in Man, Rhesus Monkey and Dog. In: Frey, R. (eds) Neue Untersuchungen mit Gamma-Hydroxibuttersäure. Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66925-5_3
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DOI: https://doi.org/10.1007/978-3-642-66925-5_3
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