Snake Venoms pp 213-257 | Cite as

The Three-Dimensional Structure of Postsynaptic Snake Neurotoxins: Consideration of Structure and Function

  • Barbara W. Low
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 52)

Abstract

The structural expression of function in biological systems is three-dimensional at all levels of resolutions. In interactions between single molecules, for examples, between deoxyhemoglobin and oxygen, or between enzymes and their substrates, the relative geometric positioning of the specific groups of atoms and their distances from each other is critical as measured in Ångstroms (10−8cm; 0.10nm) or tenths of an Ångstrom. The proper articulation of the wrist depends on the size, shape, orientation, and placement of more gross segments, but the principle holds. Furthermore, interactions at all levels from macroscopic to molecular are recognized as frequently involving favorable geometric repositioning; that is, in molecular interactions, shifts from inactive to active conformations as, for example, the 12 Å shift of the phenolic OH which accompanies the flip-over swing of Tyr 248 in carboxypeptidase A when substrate binds to enzyme (Quiocho and Lipscomb, 1971). These shifts may be induced in one molecule by the proximity of another with which it interacts.

Keywords

Crystallization Tyrosine Glycine Serine Proline 

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References

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  • Barbara W. Low

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