Assessment of Digoxin Action by a Pharmacodynamic Biochemical Method

  • D. G. Grahame-Smith
  • J. K. Aronson
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Abstract

The sequence of events occurring between the administration of digoxin and its therapeutic effect is very complex. The generalities of this sequence which can be applied to any drug are depicted in Figure 20.1.

Keywords

Toxicity Adenosine Anemia Glycoside Digoxin 

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References

  1. Aronson, J.K., Grahame-Smith, D.G., Hallis, K.F., Hibble, A., Wigley, F.: Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response. Br. J. Clin. Pharmacol. (in press) (1977)Google Scholar
  2. Astrup, J.: Sodium and potassium in human red cells: Variations among centrifuged cells. Scand. J. Clin. Lab. Invest. 33, 231–237 (1974)PubMedCrossRefGoogle Scholar
  3. Cohen, I., Dant, J., Noble, D.: The influence of extracellular potassium ions on the action of ouabain in membrane currents in sheep Purkinjee fibres. J. Physiol. (Lond.) 249, 42–43 (1975)Google Scholar
  4. Grahame-Smith, D.G., Everest, M.S.: Measurement of digoxin in plasma and its use in the diagnosis of digoxin intoxication. Br. Med. J. 1969/i, 286CrossRefGoogle Scholar
  5. Ingelfinger, J., Goldman, P.: The serum digitalis concentration — does it diagnose digitalis toxicity. N. Engl. J. Med. 294, 867–870 (1976)PubMedCrossRefGoogle Scholar
  6. Love, W.D., Burch, G.E.: A comparison of 42potassium, 86rubidium, and 134caesium as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J. Lab. Clin. Med. 41, 351–362 (1953)PubMedGoogle Scholar
  7. Schatzmann, H.J.: Herzglycoside als Hemmstoffe für aktiven Kalium und Natriumtransport durch die Erythrocytenmembran. Helv. Physiol. Acta 11, 346–354 (1953)Google Scholar
  8. Schwartz, A., Lindenmayer, G.E., Allen, J.C.: The sodium-potassium adenosine triphosphatase: pharmacological, physiological and behavioural aspects. Pharmacol. Rev. 27, 3–134 (1975)PubMedGoogle Scholar
  9. Wang, C.H., Willis, D.L.: In: Radiotracer Methodology in Biological Science. New Jersey: Prentice-Hall 1965, p. 31Google Scholar
  10. Chan, Sanslone: Arch. Biochem. Biophys. 134, 48 (1969)PubMedCrossRefGoogle Scholar
  11. Greeff, K.: Eur. J. Pharmacol. 37, 89 (1976)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • D. G. Grahame-Smith
  • J. K. Aronson

There are no affiliations available

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