Plasma-Tissue Distribution of Different Cardiac Glycosides

  • D. Larbig
  • R. Haasis
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Abstract

As shown by other investigators with different methods (Binnion, 1973; Chamberlain, 1973a; Coltart et al., 1972; Doherty et al., 1961,1967; Güllner et al., 1974; Redfors et al., 1973), tissue glycoside concentrations of patients on digoxin maintenance therapy are usually markedly higher than “steady-state” serum concentrations. Since the relationship between steady-state serum glycoside concentration and cardiac effect is still controversial, glycoside concentrations were determined in various human tissues in order to analyze the corrélation between serum concentration and tissue concentration.

Keywords

Creatinine Glycoside Acetyl Digoxin Glycos 

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References

  1. Benthe, H.F., Chempanich, K.: Vergleich der enteralen Wirksamkeit von Digoxin, Acetyldigoxin und Digitoxin. Arzneim. Forsch. 15, 486 (1965)Google Scholar
  2. Binnion, P.F.: Plasma and Myocardial Digoxin Levels in Dogs and Man. Symposium on Digitalis, Oslo, Norway: Gyldendal Norsk Forlag 1973, p. 254Google Scholar
  3. Chamberlain, D.A., White, R.J., Howard, M.R.: Plasma digoxin concentrations in patients with atrial fibrillation. Br. Med. J. 1970, 427Google Scholar
  4. Chamberlain, D.A.: The Ratio Between Myocardial and Plasma Levels of Digoxin. Symposium on Digitalis. Oslo, Norway: Gyldendal Norsk Forlag, 1973a, p. 262Google Scholar
  5. Chamberlain, D.A.: The Influence of Cardiopulmonary Bypass on Plasma Digoxin Cencentrations. Symposium on Digitalis, Oslo, Norway: Gyldendal Norsk Forlag 1973 b, p. 277Google Scholar
  6. Coltart, D.J., Chamberlain, D.A., Howard, M.R., Kettlewell, M.G., Mecer, J.L., Smith, T.W.: Effect of cardiopulmonary bypass on plasma digoxin concentrations. Br. Heart J. 33, 334 (1971)PubMedCrossRefGoogle Scholar
  7. Coltart, J., Howard, M., Chamberlain, D.: Myocardial and skeletal muscle concentrations of digoxin in patients on long-term therapy. Br. Med. J. 2, 318 (1972)PubMedCrossRefGoogle Scholar
  8. Doherty, J.E., Perkins, W.H., Mitchell, G.K.: Tritiated digoxin studies in human subjects. Arch. Intern. Med. 108, 531 (1961)PubMedGoogle Scholar
  9. Doherty, J.E., Perkins, W.H., Flanigan, W.H.: The distribution and concentration of tritiated digoxin in human tissue. Ann. Intern. Med. 66, 116 (1967)PubMedGoogle Scholar
  10. Grant, J.C.B.: A Method of Anatomy, 6th ed. Williams and Wilken, Baltimore, USA: 1958, p. 7Google Scholar
  11. Güllner, H.G., Stinson, E.B., Harrison, D.C., Kalmon, S.H.: Correlation of serum concentrations with heart concentrations of digoxin in human subjects. Circulation 50, 635 (1974)Google Scholar
  12. Haasis, R., Larbig, D., Klenk, H.O.: Glykosidkonzentration im Serum und Urin bei Herzgesunden nach Gabe von β-Methyldigoxin. Klin. Wochenschr. 53, 529 (1975)PubMedCrossRefGoogle Scholar
  13. Haasis, R., Larbig, D.: Vergleichende Untersuchungen der Serumglykosidkonzentrationen bei Glykosidintoxikationen mit extracardialen Nebenwirkungen nach Einnahme von β-Methyldigoxin, β-Acetyldigoxin und Digoxin. Verh. Dtsch. Ges. Inn. Med. 82 (in press) (1976)Google Scholar
  14. Haasis, R., Larbig, D., Stunkat, R., Bader, H., Seboldt, H.: Radioimmunologische Bestimmung der Glykosidkonzentration im menschlichen Gewebe. Klin. Wochenschr. 1, 23 (1977)CrossRefGoogle Scholar
  15. Jusko, W.J., Weintraub, M.: Myocardial distribution of digoxin and renal function Clin. Pharmacol. Ther. 16, 449 (1975)Google Scholar
  16. Larbig, D., Kochsiek, K.: Radioimmunchemische Bestimmungen von Digoxin im menschlichen Serum. Klin. Wochenschr. 49, 1031 (1971)PubMedCrossRefGoogle Scholar
  17. Larbig, D., Kochsiek, K.: Zur radioimmunchemischen Bestimmung von Digoxin und Digoxinderivaten. Dtsch. Med. Wochenschr. 97, 1310 (1972)PubMedCrossRefGoogle Scholar
  18. Marcus, F.J., Kapadia, G.G., Goldsmith, C: Alterations of the body distribution of tritiated digoxin by acute hyperkalemia in the dog. J. Pharmacol. Exp. Ther. 165, 136 (1969)PubMedGoogle Scholar
  19. Redfors, A., Bertler, A., Schüller, H.: The Ratio Between Myocardial and Plasma Levels of Digoxin in Man. Symposium on Digitalis. Oslo, Norway: Gyldendal Norsk Forlag, 1973, p. 265Google Scholar
  20. Rennekamp, H., Rennekamp, Ch., Abshagen, U., v. Bergmann, K.: Pharmacokinetic behaviour of 4’’’ methyldigoxin in man. Naunyn Schmiedebergs. Arch. Pharmakol. 273, 172 (1972)CrossRefGoogle Scholar
  21. Smith, T.W., Haber, E.: Digitalis. Boston, USA: Little, Brown and Company 1974 p. 69Google Scholar
  22. Stoll, R.G., Christensen, M.S., Sakmar, E., Wagner, J.G.: The specifity of the digoxin radioimmunoassay procedure. Res. Com. Chem. Pathol. Pharmacol. 4, 503 (1972)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • D. Larbig
  • R. Haasis

There are no affiliations available

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