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Changes in Liver Tyrosine Aminotransferase after Acute and Chronic Administration of Morphine in the Rat

  • A. Santagostino
  • G. Giagnoni
  • R. Reina
  • C. Spadaro
  • S. Ferri
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 1)

Abstract

Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as μmoles of p-hy-droxyphenylpyruvate/100 mg/h. With chronic administration, a tolerance develops to this enzymatic effect. TAT induction is not evident in pregnant rats, given the narcotic, in which enzyme levels are already initially high. Afer delivery TAT returns to normal levels and it is possible to show both induction and tolerance developing to morphine. Enzyme activity in fetal livers is much lower than that of adult animals: after maternal administration of morphine only a modest TAT increase is seen which is not, however, statistically significant. TAT activity is fully evident in livers of offspring, with much higher mean levels in newborn rats from morphine-treated animals, as a possible consequence of morphine deprivation. In this latter group of newborn rats narcotic administration causes TAT activity to return to levels as high as those of naive animals. On the other hand, morphine administration to the prole of naive rats results in an induction of liver TAT.

Keywords

Fetal Liver Morphine Administration Maternal Treatment Tyrosine Aminotransferase Enzymatic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin 1978

Authors and Affiliations

  • A. Santagostino
    • 1
  • G. Giagnoni
    • 1
  • R. Reina
    • 2
  • C. Spadaro
    • 2
  • S. Ferri
    • 2
  1. 1.Institute of Pharmacology, Faculty of SciencesUniversity of MilanoMilanoItaly
  2. 2.Institute of Pharmacology, Faculty of PharmacyUniversity of CataniaCataniaItaly

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