Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment

  • Marios Marselos
  • Riitta Törrönen
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 1)


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a contaminant of some herbicides, is an extremely potent enzyme inducer. Male albino rats of two genetically different substrains developed for the inducibility (RR) and non-inducibility (rr) of aldehyde dehydrogenase by phenobarbital were given TCDD 80 μg/kg as a single dose 6 days before analysis. rr-Animals having no induction of the hepatic soluble high-Km aldehyde dehydrogenase by phenobarbital showed an approximate 25-fold increase in activity after TCDD treatment. The increase in aldehyde dehydrogenase activity could be detected only when measured with a millimolar substrate concentration. The aldehyde dehydrogenase activity in serum was increased 3-fold after TCDD administration in both substrains.


Aldehyde Dehydrogenase Aliphatic Aldehyde Environmental Health Perspective TCDD Treatment Toxicological Aspect 
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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Marios Marselos
    • 1
  • Riitta Törrönen
    • 1
  1. 1.Department of PhysiologyUniversity of KuopioKuopio 10Finland

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