Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment

  • Marios Marselos
  • Riitta Törrönen
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 1)

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a contaminant of some herbicides, is an extremely potent enzyme inducer. Male albino rats of two genetically different substrains developed for the inducibility (RR) and non-inducibility (rr) of aldehyde dehydrogenase by phenobarbital were given TCDD 80 μg/kg as a single dose 6 days before analysis. rr-Animals having no induction of the hepatic soluble high-Km aldehyde dehydrogenase by phenobarbital showed an approximate 25-fold increase in activity after TCDD treatment. The increase in aldehyde dehydrogenase activity could be detected only when measured with a millimolar substrate concentration. The aldehyde dehydrogenase activity in serum was increased 3-fold after TCDD administration in both substrains.

Keywords

Acetone Propionaldehyde Aldehyde NADH Phenobarbital 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deitrich, R.A.: Science 171, 334 (1971)CrossRefGoogle Scholar
  2. Lucier, G.W., McDaniel, O.S., Hook, G.E.R., Fowler, B., Sonawane, B.R., Faeder, E.: Environmental Health Perspectives 5, 199 (1971)Google Scholar
  3. Marselos, M.: Acta pharmacologica et toxicologica 39, 186 (1976)PubMedCrossRefGoogle Scholar
  4. Marselos, M., Eriksson, K., Hänninen, O.: Medical Biology 53, 224 (1975)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Marios Marselos
    • 1
  • Riitta Törrönen
    • 1
  1. 1.Department of PhysiologyUniversity of KuopioKuopio 10Finland

Personalised recommendations