Toxicological Studies on a New Veterinary Antibiotic Turimycin

  • A. Härtl
  • U. Horn
  • E. Kirchner
  • J. Güttner
  • H. Hoffmann
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 1)

Abstract

Turimycin is a fermentation product of Streptomyces hygroscopicus (DDR W-Patent-Nr. 84 450). It is highly active in vitro against a range of mycoplasma species and gram-positive bacteria. The acute toxicity was determined in mice, rats and dogs. In mice and rats LD50 values ranged from 750 mg/kg intraperitoneally to higher than 3000 mg/kg orally. In a chronic study on dogs oral doses of 50 and 125 mg/kg Turimycin were given daily in capsules for 12 months. The results showed no functional or morphological differences between treated and control animals.

Keywords

Toxicity Fermentation Filtration Pneumonia Streptomyces 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, R.C., Harris, P.N., Lee, C.C., Maze, N., Small, R.N., Worth, H.M.: The Lilly Research Laboratories, Product Registration (1966)Google Scholar
  2. Haupt, I., Fricke, H., Cerna, J., Rychlik, I.: The Journal of Antibiotics 29, 1314 (1976)PubMedGoogle Scholar
  3. Knöll, H., Bradler, G., Fügner, G., Kramer, P., Prauser, H., Forberg, W., Strumpf, E., Fricke, H., Effenberger, W., Thrum, H.: Verfahren zur Gewinnung eines Makrolid-Antibiotikums, DDR-WP No 84450 (1971)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • A. Härtl
    • 1
  • U. Horn
    • 1
  • E. Kirchner
    • 1
  • J. Güttner
    • 1
  • H. Hoffmann
    • 1
  1. 1.Forschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und experimentelle TherapieAkademie der Wissenschaften der DDRJenaGerman Democratic Republic

Personalised recommendations