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Oedema and Increased Vascular Permeability

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Anti-Inflammatory Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

No laboratory model using animals can be a perfect duplicate of a human disease. There are always differences of some kind. For a practical result to be achieved, however, such as finding a drug for clinical use, it is not required that the animal model should even remotely resemble the human disease in its superficial aspects. As examples, morphine can be assayed by the curling of a mouse’s tail; digitalis by the vomiting of a pigeon; anesthetics by the membrane resistance of isolated cells; and anti-epileptic drugs by antagonism of electroshock-induced convulsions. Practically, it does not matter whether one measures a side-effect in an assay rather than the desired effect, so long as these vary together in a known manner.

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  1. C. G. Van Arman
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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Van Arman, C.G. (1979). Oedema and Increased Vascular Permeability. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-66891-3_3

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