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Anti-Inflammatory Drugs pp 740–766Cite as

A Critical Comparison of the Evaluation of Anti-Inflammatory Therapy in Animal Models and Man

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

This chapter is purposely written from the point of view of the practising clinician in the hope that it may illustrate some of the difficulties in moving from in vitro or animal models of inflammation to the human organism and of assessing the clinical action of anti-inflammatory agents. It is primarily concerned only with the inflammation of arthritis and associated conditions which invariably form the major indication for this form of therapy.

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References

  • American Rheumatism Association: 1958 Revision of diagnostic criteria for rheumatoid arthritis. Arthr. and Rheum. 2, 16–20 (1959)

    Article  Google Scholar 

  • Ansell, B.M., Bywaters, E.G.L.: Alternate day corticosteroid therapy in juvenile chronic polyarthritis. J. Rheum. 1, 176–186 (1974)

    PubMed  CAS  Google Scholar 

  • Backlund, L., Tiselius, P.: Objective measurements of joint stiffness in rheumatoid arthritis. Acta. rheum. scand. 13, 275–288 (1967)

    PubMed  CAS  Google Scholar 

  • Beck, F.J., Whitehouse, M. W.: Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism. Biochem. Pharmacol. 22, 2453–2468 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Boardman, P.J., Hart, F.D.: Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis. Brit. med. J. (1967) IV, 264–268

    Article  Google Scholar 

  • Chalmers, I.M., Bell, M.A., Buchanan, W.W.: Effect of flurbiprofen on the metabolism of antipyr-ine in man. Ann. rheum. Dis. 32, 58–61 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Chen, W., Vrindten, P.A., Dayton, P.C., Burns, J.J.: Accelerated amidopyrine metabolism in human subjects pretreated with phenylbutazone. Life Sci. 1, 35–42 (1962)

    Article  CAS  Google Scholar 

  • Cohen, A.S., Reynolds, W.E., Franklyn, E.C., Kulka, J.P., Roper, M.W., Shulman, L.E, Wallace, S.L.: Preliminary criteria for the classification of systemic lupus erythematosus. Bull, rheum. Dis. 21, 643–647 (1971)

    Google Scholar 

  • Collins, A.J., Ring, E.F.J., Cosh, J.A., Bacon, P.A.: Quantitation of thermography in arthritis using multi-isothermal analysis. Ann. rheum. Dis. 33, 113–115 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Co-Operating Clinics Committee of American Rheumatism Association: A controlled trial of cyclophosphamide in rheumatoid arthritis. New Engl. J. Med. 283, 883–889 (1970)

    Article  Google Scholar 

  • Dick, W.C.: The use of radioisotopes in normal and diseased joints. Semin. Arthr. Rheum. 1, 301–325 (1972)

    Article  CAS  Google Scholar 

  • Dick, W.C., Fowler, P.F.: Personal Communication (1976)

    Google Scholar 

  • Dickson, R.A., Nicolle, F.V.: The assessment of the rheumatoid hand. In: Holt, P.J.L. (Ed.): Current topics of Connective Tissue Diseases, pp. 95–114. London: Churchill Livingstone 1975

    Google Scholar 

  • Duthie, J.J.R., Thompson, M., Weir, M., Fletcher, W.B.: Medical and social aspects of the treatment of rheumatoid arthritis. Ann. rheum. Dis. 14, 133–149 (1955)

    Article  PubMed  CAS  Google Scholar 

  • Empire Rheumatism Council: Gold therapy in rheumatoid arthritis—a report of a multicentre trial. Ann. rheum. Dis. 19, 95–119 (1960)

    Article  Google Scholar 

  • Feinstein, A.R.: The need for humanised science in evaluating medication. Lancet (1972)II,421–423

    Google Scholar 

  • Feinstein, A.R.: Clinical biostatics. XIX. Ambiguity and abuse in the twelve different concepts of ‘control’. Clin. Pharmacol. Ther. 14, 112–122 (1973)

    PubMed  CAS  Google Scholar 

  • Froland, S.S., Natvig, J.B., Hoyeraal, H.M., Kass, E.: The principle of immunopotentation in rheumatoid arthritis treatment: effect of transfer factor. Scand. J. Immunol. 3, 223–228 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Gelehrter, T.D.: Enzyme induction. New Engl. J. Med. 294, 522–526, 588–595, 646–651 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, M.A., Arnett, F.C., Bias, W.B., Shulman, L.E.: Histocompatibility antigens in systemic lupus erythematosus. Arthr. Rheum. 19, 129–132 (1976)

    Article  CAS  Google Scholar 

  • Hawkins, C.F., Holt, P.J.L.: The Cuffdolorimeter. Proc. roy. Soc. Med. 59 (Suppl.), 95–96 (1966)

    PubMed  Google Scholar 

  • Haydu, G.G., Goldschmidt, L., Drymiotis, A.D.: Effect of imipramine on the rheumatoid factor titre of psychotic patients with depressive symptomatology. Ann. rheum. Dis. 33, 273–275 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Holt, P.J.L., How, M.J., Long, V.J.W., Hawkins, C.F.: Mucopolysaccharides in synovial fluid: effect of aspirin and indomethacin on hyaluronic acid. Ann. rheum. Dis. 27, 264–270 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Horvath, S.M., Hollander, J.L.: Intra-articular temperature as a measure of joint reaction. J. clin. Invest. 28, 469–473 (1949)

    Article  Google Scholar 

  • Hughes, G.R.V.: Significance of anti DNA antibodies in systemic lupus erythematosus. Lancet (1971)II,861–864

    Google Scholar 

  • Huskisson, E.C.: Measurement of pain. Lancet (1974)II,1127–1131

    Google Scholar 

  • Huskisson, E.C., Dieppe, P.A., Scott, J., Trapnell, J., Balme, H.W., Milloughby, D.A.: Immunsti-mulant therapy with levamisole for rheumatoid arthritis. Lancet (1976)I, 393–395

    Google Scholar 

  • Koch-Weser & Sellers, E.M.: Binding of drugs to serum albumin. New Engl. J. Med. 294, 311–315, 526–531 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Lansbury, J.: Report of a three year study on the systemic and articular indices in rheumatoid arthritis. Arthr. Rheum. 1, 505–522 (1958)

    Article  CAS  Google Scholar 

  • Lee, P., Baxter, A., Dick, W.C., Webb, J.: An assessment of grip strength measurements in rheumatoid arthritis. Scand. J. Rheum. 3, 17–23 (1974 a)

    Article  PubMed  CAS  Google Scholar 

  • Lee, P., Kennedy, A.C., Anderson, J., Buchanan, W.W.: The therapeutic benefits of hospital inpatient treatment in rheumatoid arthritis. Quart. J. Med. 43, 203–214 (1974 b)

    Google Scholar 

  • Levi, A.J., Sherlock, S., Walker, D.: Phenylbutazone and isoniazide metabolism in patients with liver disease in relation to previous drug therapy. Lancet (1968)I, 1275–1279

    Google Scholar 

  • McCarty, D.J., Gatter, R.A., Steele, A.D.: A twenty pound dolorimeter for quantitation of articular tenderness. Arthr. Rheum. 11, 696–697 (1968)

    Article  Google Scholar 

  • Mc Conkey, B., Crockson, R.A., Crockson, A.P., Williamson, A.R.: The effect of some anti-inflammatory drugs on the acute phase proteins in rheumatoid arthritis. Quart. J. Med. 42, 785–791 (1973)

    CAS  Google Scholar 

  • Maini, R.N., Scott, J.T., Roffe, L.M., Hamblin, A.S., Dumonde, D.C: Preliminary experience of transfer factor in rheumatoid arthritis: clinical and immunological studies. In: Dumonde, D.C. (Ed.): Infection and Immunology in the Rheumatic Disease, pp.579–589. London: Blackwell 1976

    Google Scholar 

  • Medical Research Council and Nuffield Foundation: A comparison or cortisone and aspirin in the treatment of early cases of rheumatoid arthritis. Brit. med. J. (1954)I, 1223–1227

    Google Scholar 

  • Moertel, C.G., Taylor, W.F., Roth, A., Tyce, F.A.J.: Who responds to sugar pills? Mayo Clin. Proc. 51, 96–100(1976)

    PubMed  CAS  Google Scholar 

  • Ritchie, D.M., Boyle, J.A., Mclnnes, J.H., Jasani, M.K., Dalakos, T.C., Grieveson, P., Buchanan, W.W.: Clinical studies with an articular index for assessment of joint tenderness in patients with rheumatoid arthritis. Quart. J. Med. 37, 393–406 (1968)

    PubMed  CAS  Google Scholar 

  • Russell, A.S., Sturge, R.A., Smith, M.A.: Serum transaminases during salicylate therapy. Brit, med. J. (1971)II, 428–429

    Google Scholar 

  • Savage, O.: Measurements in rheumatoid arthritis. Proc. roy. Soc. Med. 59 (Suppl.), 85–88 (1966)

    PubMed  Google Scholar 

  • Seaman, W.E., Ishak, K.C., Plotz, P.H.: Aspirin induced hepatoxicity in patients with systemic lupus erythematosus. Ann. intern. Med. 80, 1–8 (1974)

    PubMed  CAS  Google Scholar 

  • Steinbrocker, O., Traeger, C.H., Batteman, R.C.: Therapeutic criteria in rheumatoid arthritis. J. Amer. med. Ass. 140, 659–662 (1949)

    CAS  Google Scholar 

  • Swezey, R.L.: Essentials of physical management and rehabilitation in arthritis. Semin. Arthr. Rheum. 3, 349 (1974)

    Article  CAS  Google Scholar 

  • Talal, N.: Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthr. Rheum. 13, 887–894 (1970)

    Article  CAS  Google Scholar 

  • Traut, E.F., Passarell, E. W.: Placebos in the evaluation of treatment in rheumatic disease. Illinois med. J. 115, 181–198(1959)

    CAS  Google Scholar 

  • Verrier-Jones, J., Cumming, R.H., Bucknall, R.C., Asplin, C.M., Fraser, I.D., Bothomley, J., Davis, P., Hamblin,T.J.: Plasmophoresis in the management of acute systemic lupus erythematosus? Lancet (1976)I, 709–711

    Google Scholar 

  • Versey, J.M.B., Hobbs, J.R., Holt, P.J.L.: Complement metabolism in rheumatoid arthritis. 1. Longtudinal studies. Ann. rheum. Dis. 32, 357–564 (1973)

    Google Scholar 

  • Wright, V.: Some observations on diurnal variations of grip. Clin. Sci. 18, 17–23 (1959)

    PubMed  CAS  Google Scholar 

  • Wright, V., Dowson, D., Longfield, M.D.: Joint stiffness—its characterisation and significance. Biomed.Engng 4, 8(1969)

    CAS  Google Scholar 

  • Wright, V., Johns, R.J.: Physical factors concerned with the stiffness of normal and diseased joints. Bull. John Hopk. Hosp. 106, 215–231 (1961)

    Google Scholar 

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Authors
  1. P. J. L. Holt
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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© 1979 Springer-Verlag Berlin Heidelberg

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Holt, P.J.L. (1979). A Critical Comparison of the Evaluation of Anti-Inflammatory Therapy in Animal Models and Man. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-66891-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66893-7

  • Online ISBN: 978-3-642-66891-3

  • eBook Packages: Springer Book Archive

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