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Cytostats with Effects in Chronic Inflammation

  • Chapter
Anti-Inflammatory Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

A number of toxic agents happen to exhibit therapeutic side-effects including the suppression of inflammatory disease. Obviously, those used in the clinic have a tolerable therapeutic index. The acceptability of some of these toxic drugs may be due to any one or more of the following reasons: (1) they have a reversible effect on cell populations that turn over slowly; (2) they mainly delete cells from populations with a high rate of generation; (3) their toxicity is not incompatible with maintenance of cell vitality.

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Authors
  1. K. Brune
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  2. M. W. Whitehouse
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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Brune, K., Whitehouse, M.W. (1979). Cytostats with Effects in Chronic Inflammation. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-66891-3_17

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