Skip to main content
SpringerLink
Log in
Book cover

Anti-Inflammatory Drugs pp 415–466Cite as

Antagonists of Histamine, 5-Hydroxytryptamine and SRS-A

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

Antihistamines that powerfully and selectively inhibit certain effects of histamine have been known for over 25 years. The effects of histamine that they inhibit are contractile actions on the smooth muscle of the gut, uterus and bronchioles and capillary permeability responses. Some other effects of histamine are highly resistant to these antihistamines and they include stimulation of gastric secretion, relaxation of rat uterus and positive inotropic effects on isolated atria (Loew, 1947; Ashford et al., 1949; Dutta, 1949; Trendelenberg, 1960). Indeed, it has been demonstrated that gastric secretion induced by histamine is enhanced rather than diminished by antihistamines, including mepyramine (Wood, 1948) and triprolidine (Green, 1953), perhaps in consequence of histamine release (Chap. 34, Sect. CIL). Compounds that selectively inhibit histamine-induced gastric secretion and other effects of histamine resistant to the earlier antihistamines were first reported only in 1972 by Black and colleagues. They are referred to as antagonists at H2 receptors, in distinction from the earlier antihistamines whose inhibitory effects at low concentrations characterised a histamine receptor for which Ash and Schild in 1966 had suggested the symbol H1. The distinction between H1 and H2 receptors is already well characterised by studies both of selective agonists (Ash and Schild, 1966; Black et al., 1972) and antagonists (Black et al., 1972, 1973, 1975).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adamson, D.W., Barrett, P.A., Billinghurst, J.W., Green, A.F., Jones, T.S.G.: Geometrical isomers in a series of antihistamines. Nature (Lond.) 168, 204–205 (1951)

    CAS  Google Scholar 

  • Aitken, M.M., Sanford, J.: Modification of acute systemic anaphylaxis in cattle by drugs and by vagotomy. J. comp. Path. 82, 247–256 (1972 a)

    PubMed  CAS  Google Scholar 

  • Aitken, M.M., Sanford, J.: Effects of histamine, 5-hydroxytryptamine and bradykinin on cattle and their modification by antagonists and by vagotomy. J. comp. Path. 82, 257–266 (1972 b)

    PubMed  CAS  Google Scholar 

  • Alberty, J., Takkunen, R.: Der Anteil von Histamin an der anaphylaktischen und der durch einen chemischen Histaminfreisetzer hervorgerufenen vasculären Hautreaktion. Int. Arch. Allergy 10, 285–304(1957)

    PubMed  CAS  Google Scholar 

  • Ankier, S.L, Neat, M.L.: Some studies on acute inflammation induced by dextran in the mouse. Int. Arch. Allergy 42, 264–277 (1972)

    PubMed  CAS  Google Scholar 

  • Ankier, S.L, West, G.B.: Inhibition of the anaphylactoid reaction in rats. Brit. J. Pharmacol. 33, 304–311(1968)

    PubMed  CAS  Google Scholar 

  • Armitage, P., Herxheimer, H., Rosa, L.: Protective action of antihistamines in the anaphylactic microshock of the guinea pig. Brit. J. Pharmacol. 7, 625–632 (1952)

    PubMed  CAS  Google Scholar 

  • Ash, A.S.F., Schild, H.O.: Receptors mediating some actions of histamine. Brit. J. Pharmacol. 27, 427–439 (1966)

    PubMed  CAS  Google Scholar 

  • Ashford, C.A., Heller, H., Smart, G.A.: The action of histamine on hydrochloric acid and pepsin secretion in man. Brit. J. Pharmacol. 4, 153–161 (1949)

    PubMed  CAS  Google Scholar 

  • Augstein, J., Farmer, J.B., Lee, T.B., Sheard, P., Tattersall, M. L.: Selective inhibitor of slow-reacting substance of anaphylaxis. Nature (New Biol.) 245, 215–217 (1973)

    CAS  Google Scholar 

  • Austen, K.F., Humphrey, J.H.: In vitro studies of the mechanism of anaphylaxis. In: Dixon, F. J., Humphrey, J.H. (Eds.): Advances in Immunology, Vol. 3, pp. 1–96. New York-London: Academic Press 1963

    Google Scholar 

  • Aviado, D.M., Sadavongvivad, C.: Pharmacological significance of biogenic amines in the lungs: histamine. Brit. J. Pharmacol. 38, 366–373 (1970)

    CAS  Google Scholar 

  • Bain, W.A.: Discussion on antihistamine drugs. Proc. roy. Soc. Med. 42, 615–625 (1949)

    PubMed  CAS  Google Scholar 

  • Bain, W.A.: The evaluation of drugs in man, with special reference to antihistamines. Analyst. 76, 573–579(1951)

    CAS  Google Scholar 

  • Baumgarten, A., Wilhelm, D.L.: Vascular permeability responses in hypersensitivity: I. The tuberculin reaction. Pathology 1, 301–315 (1969)

    PubMed  CAS  Google Scholar 

  • Beach, V.L., Steinetz, B.G.: Quantative measurement of Evans blue space in tissue of the rat; influence of 5-hydroxytryptamine antagonists and phenelzine on experimental inflammation. J. Pharmacol, exp. Ther. 131, 400–406 (1961)

    CAS  Google Scholar 

  • Becker, E.L., Mota, L, Wong, D.: Inhibition by antihistamines of the vascular permeability increase induced by bradykinin. Brit. J. Pharmacol. 34, 330–336 (1968)

    CAS  Google Scholar 

  • Bein, H.J.: The pharmacology of rauwolfia. Pharmacol. Rev. 8, 435–483 (1956)

    PubMed  CAS  Google Scholar 

  • Beretta, C., Ferrini, R., Glässer, A.H.: 1-Methyl-8-β-carbobenzyloxy-aminomethyl 10 α-ergoline, a potent and long-lasting 5-hydroxytryptamine antagonist. Nature (Lond.) 207, 421–422 (1965)

    CAS  Google Scholar 

  • Bernauer, W., Hahn, F., Giertz, H.: Comparison of the antilethal, broncholytic and antiemphyse-matous activities of mepyramine in anaphylactic, histamine, and anaphylatoxin shock of guinea pigs. Arch. int. Pharmacodyn. 178, 137–151 (1969)

    PubMed  CAS  Google Scholar 

  • Berry, P.A., Collier, H.O.J.: Bronchoconstrictor action and antagonism of a slow reacting substance from anaphylaxis of guinea pig isolated lung. Brit. J. Pharmacol. 23, 201–216 (1964)

    PubMed  CAS  Google Scholar 

  • Bhattacharya, B.K., Lewis, G.P.: The effects of reserpine and compound 48/80 on the release of amines from the mast cells of rats. Brit. J. Pharmacol. 11, 411–416 (1956)

    PubMed  CAS  Google Scholar 

  • Black, J.W., Duncan, W.A.M., Durant, G.J., Ganellin, C.R., Parsons, E.M.: Definition and antagonism of histamine H2-receptors. Nature (Lond.) 236, 385–390 (1972)

    CAS  Google Scholar 

  • Black, J.W., Duncan, W.A.M., Emmett, J.C., Ganellin, C.R., Hesselbo, T, Parsons, M.E., Wyllie, J.H.: Metiamide-an orally active histamine H2 receptor antagonist. Agents Actions 3, 133–137 (1973)

    PubMed  CAS  Google Scholar 

  • Black, J.W., Owen, D.A.A., Parsons, M.E.: An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1 and H2-receptors. Brit. J. Pharmacol. 54, 319–324 (1975)

    CAS  Google Scholar 

  • Brimblecombe, R.W., Duncan, W.A.M., Durant, G.J., Emmett, J.C., Ganellin, C.R., Parsons, M.E.: Cimetidine. Nonthiourea histamine H2-receptor antagonist. J. int. med. Res. 3, 86–92 (1975)

    CAS  Google Scholar 

  • Brittain, R.T., D’Arcy, P.F., Hunt, J.H.: Resolution of chlorpheniramine and the pharmacological properties of its isomers. Nature (Lond.) 183, 734–735 (1959)

    CAS  Google Scholar 

  • Brocklehurst, W.E.: Occurrence of an unidentified substance during anaphylactic shock in cavy lung. J. Physiol. (Lond.) 120, 16 P (1953)

    Google Scholar 

  • Brocklehurst, W.E.: The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock. J. Physiol. (Lond.) 151, 416–435 (1960)

    CAS  Google Scholar 

  • Brocklehurst, W.E.: Pharmacologically active substances in hypersensitivity reactions. In: Cruickshank, R., Weir, D.M. (Eds.): Modern Trends in Immunology, Vol. 2, pp. 235–249. London: Butterworth 1967

    Google Scholar 

  • Brocklehurst, W.E., Humphrey, J H., Perry, W.L.M.: The role of histamine in cutaneous antigen-antibody reactions in the rat. J. Physiol. (Lond.) 129, 205–225 (1955)

    CAS  Google Scholar 

  • Brocklehurst, W.E., Humphrey, J.H., Perry, W.L.M.: Cutaneous antigen-antibody reactions in the rat. J. Physiol. (Lond.) 150, 489–500 (1960)

    CAS  Google Scholar 

  • Brown, P.C., Consden, R., Glynn, L.E.: Observations on the shrink temperature of collagen and its variations with age and disease. Ann. rheum. Dis. 17, 196–208 (1958)

    PubMed  CAS  Google Scholar 

  • Bushby, S.R.M., Green, A.F.: The release of histamine by polymyxin B and polymyxin E. Brit. J. Pharmacol. 10, 215–219 (1955)

    CAS  Google Scholar 

  • Cameron, J.: Anaphylactic shock in mice. Brit. J. exp. Path. 37, 470–476 (1956)

    PubMed  CAS  Google Scholar 

  • Carr, J.: The effect of anti-inflammatory drugs on increased vascular permeability induced by chemical mediators. J. Path. 108, 1–14 (1972).

    PubMed  CAS  Google Scholar 

  • Casey, F.B., Tokuda, S.: A comparative study of the mechanisms of passive cutaneous anaphylaxis induced by mouse IgG, rabbit IgG, and rabbit F (ab′)2 antibodies. Int. Arch. Allergy 44, 737–744(1973)

    PubMed  CAS  Google Scholar 

  • Casy, A.F., Ison, R.R.: Stereochemical influences upon antihistaminic activity. Further studies of isomeric 4-amino-1, 2-diarylbutenes. J. Pharm. (Lond.) 22, 270–278 (1970)

    CAS  Google Scholar 

  • Church, M. K.: Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization. Brit. J. Pharmacol. 55, 423–430 (1975)

    CAS  Google Scholar 

  • Church, M.K., Collier, H.O.J., James, G.W.L.: The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat. Brit. J. Pharmacol. 46, 56–65 (1972)

    CAS  Google Scholar 

  • Church, M.K., Miller, P.: Simple models of anaphylaxis and of histamine and 5-hydroxytryptamine induced inflammation using the mouse pinna. Brit. J. Pharmacol. 55, 315P (1975)

    CAS  Google Scholar 

  • Collier, H.O.J.: Role of kallikrein-kinin system in lung diseases. In: Proc. No. 27 of the Fogerty International Center. Washington, D.C.: U.S. Government Printing Office 1976. In press

    Google Scholar 

  • Collier, H.O.J., Holgate, J.A., Schachter, M., Shorley, P.G.: The bronchoconstrictor action of bradykinin in the guinea pig. Brit. J. Pharmacol. 15, 290–297 (1960)

    PubMed  CAS  Google Scholar 

  • Collier, H.O.J., James, G.W.L.: Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea pig in vivo. Brit. J. Pharmacol. 30, 283–301 (1967)

    PubMed  CAS  Google Scholar 

  • Collier, H.O.J., James, G.W.L., Piper, P.J.: Antagonism of fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea pig. Brit. J. Pharmacol. 34, 76–87 (1968)

    CAS  Google Scholar 

  • Collier, H.O.J., Shorley, P.G.: Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol. 15, 601–610 (1960)

    PubMed  CAS  Google Scholar 

  • Collier, H.O.J., Shorley, P.G.: Antagonism by mefenamic and flufenamic acids of the broncho-constrictor action of kinins in the guinea pig. Brit. J. Pharmacol. 20, 345–351 (1963)

    PubMed  CAS  Google Scholar 

  • Collier, H.O. J., Sweatman, W.J.F.: Antagonism by fenamates of prostaglandin F2α and of slow reacting substance on human bronchiole muscle. Nature (Lond.) 219, 864–865 (1968)

    CAS  Google Scholar 

  • Copp, F.C., Green, A.F., Hodson, H.F., Randall, A.W., Sim, M.F.: New peripheral antagonists of 5-hydroxytryptamine. Nature (Lond.) 214, 200–201 (1967)

    CAS  Google Scholar 

  • Craig, J.P., Wilhelm, D.L.: Cutaneous anaphylaxis in the guinea pig and its relative insusceptibility to an antihistamine. J. Immunol. 90, 43–51 (1963)

    PubMed  CAS  Google Scholar 

  • Craps, L., Inderbitzin, Th.: Anaphylactoid and anaphylactic cutaneous exoserosis in the rat. Int. Arch. Allergy 18, 268–285 (1961)

    PubMed  CAS  Google Scholar 

  • Day, M., Vane, J.R.: An analysis of the direct and indirect actions of drugs on the isolated guinea pig ileum. Brit. J. Pharmacol. 20, 150–170 (1963)

    PubMed  CAS  Google Scholar 

  • Di Rosa, M., Giroud J.P., Willoughby, D.A.: Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Path. 104, 15–29 (1971)

    PubMed  Google Scholar 

  • Di Rosa, M, Willoughby, D.A.: Screens for antiinflammatory drugs. J. Pharm. (Lond.) 23, 297–298(1971)

    Google Scholar 

  • Doepfner, W., Cerletti, A.: Comparison of lysergic acid derivatives and antihistamines as inhibitors of the oedema provoked in the rat’s paw by serotonin. Int. Arch. Allergy 12, 89–97 (1958)

    PubMed  CAS  Google Scholar 

  • Doherty, N.S., Robinson, B.V.: The inflammatory response to carrageenan. J. Pharm. (Lond.) 27, 701–703 (1975)

    CAS  Google Scholar 

  • Durant, G.J., Ganellin, C.R., Parsons, M.E.: Chemical differentiation of histamine H1 and H2-receptor agonists. J. med. Chem. 18, 905–909 (1975)

    PubMed  CAS  Google Scholar 

  • Dutta, N.K.: Some pharmacological properties common to antihistamine compounds. Brit. J. Pharmacol. 4, 281–289 (1949)

    CAS  Google Scholar 

  • Eakins, K.E.S., Karim, S.M.M., Miller, J.D.: Antagonism of some smooth muscle actions of prostaglandins by polyphloretin phosphate. Brit. J. Pharmacol. 39, 556–563 (1970)

    CAS  Google Scholar 

  • Eakins, K.E., SannerJ.H.: Prostaglandin antagonists. In: Karim, S.M.M. (Ed.): The Prostaglandins. Progress in Research, pp. 263–292. Oxford: Medical & Technical Publishing Co. Ltd. 1972

    Google Scholar 

  • El-Ackad, T.M., Meyer, M. J., Sturkie, P.D.: Inotropic and chronotropic actions of histamine on the avian heart. Fed. Proc. 33, Abst. 2110 (1974)

    Google Scholar 

  • Ensor, C.R., Russell, D., Chen, G.: A comparative study on some aspects of the pharmacology of diphenhydramine (Benadryl) and chemically related compounds. J. Pharmacol, exp. Ther. 112, 318–325(1954)

    CAS  Google Scholar 

  • Erspamer, V. (Ed.): 5-Hydroxytryptamine and Related Indolealkylamines. Handbook of Experimental Pharmacology, Vol. XIX. Berlin-Heidelberg-New York: Springer 1966

    Google Scholar 

  • Eyre, P.: Histamine release from calf lung in vitro by specific antigen and by compound 48/80. Arch. int. Pharmacodyn. 192, 347–352 (1971a)

    PubMed  CAS  Google Scholar 

  • Eyre, P.: Pharmacology of bovine pulmonary vein anaphylaxis in vitro. Brit. J. Pharmacol. 43, 302–311 (1971b)

    CAS  Google Scholar 

  • Eyre, P., Lewis, A.J., Wells, P.W.: Acute systemic anaphylaxis in the calf. Brit. J. Pharmacol. 47, 504–516 (1973)

    CAS  Google Scholar 

  • Eyre, P., Wells, P.W.: Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves. Brit. J. Pharmacol. 49, 364–367 (1973)

    CAS  Google Scholar 

  • Fanchamps, A., Doepfner, W., Weidmann, H., Cerletti, A.: Pharmakologische Charakterisierung von Deseril, einem Serotonin-Antagonisten. Schweiz, med. Wschr. 90, 1040–1046 (1960)

    CAS  Google Scholar 

  • Farmer, J.B., Richards, I.M., Sheard, P., Woods, A.M.: Mediators of passive lung anaphylaxis in the rat. Brit. J. Pharmacol. 55, 57–64 (1975)

    CAS  Google Scholar 

  • Fastier, F. N.: Structure activity relationships of amidine derivatives. Pharmacol. Rev. 14, 37–90 (1962)

    PubMed  CAS  Google Scholar 

  • Feinberg, S.M., Malkiel, S., Feinberg, A.R.: The Antihistamines. Their Clinical Application. Chicago-Illinois: Yearbook Publications Inc. 1950

    Google Scholar 

  • Feldberg, W., Miles, A.A.: Regional variations of increased permeability of skin capillaries induced by histamine liberator and their relation to the histamine content of the skin. J. Physiol. (Lond.) 120, 205–213 (1953)

    CAS  Google Scholar 

  • Feldberg, W., Smith, A.N.: Release of histamine by tryptamine and 5-hydroxytryptamine. Brit. J. Pharmacol. 8, 406–411 (1953)

    PubMed  CAS  Google Scholar 

  • Ferreira, S.H., Moncada, S., Vane, J. R.: Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature (New Biol.) 231, 237–239 (1971)

    CAS  Google Scholar 

  • Fink, M.A., Rothlauf, M.V.: In vitro anaphylaxis in the sensitised mouse uterus. Proc. Soc. exp. Biol. (N.Y.) 90, 477–480 (1955)

    CAS  Google Scholar 

  • Flower, R., Grygleski, R., Herbaczynska-Cedro, K., Vane, J.R.: Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature (New Biol.) 238, 104–106 (1972)

    CAS  Google Scholar 

  • Flower, R. J., Harvey, E. A., Moncada, S., Nijkamp, F., Vane, J. R.: Some properties of rabbit aorta contracting substance-releasing factor (RCS-RF). Brit. J. Pharmacol. 461P–462P (1976)

    Google Scholar 

  • Flynn, S.B., Owen, D.A.A.: Histamine receptors in peripheral vascular beds in the cat. Brit. J. Pharmacol. 55, 181–188 (1975)

    CAS  Google Scholar 

  • Fourneau, E., Bovet, D.: The “sympatholytic” action of a new derivative of dioxane. Arch. int. Pharmacodyn. 46, 178–191 (1933)

    CAS  Google Scholar 

  • Fowle, A.S.E., Hughes, D.T.D., Knight, G.J.: The evaluation of histamine antagonists in man. Europ. J. clin. Pharmacol. 3, 215–220 (1971)

    CAS  Google Scholar 

  • Gaddum J.M., Picarelli, Z.P.: Two kinds of tryptamine receptor. Brit. J. Pharmacol. 12, 323–328 (1957)

    PubMed  CAS  Google Scholar 

  • Ganellin, C.R., Port, G.N. J., Richards, W.G.: Conformation of histamine derivatives. II. Molecular orbital calculations of preferred conformations in relation to dual receptor activity. J. med. Chem. 16, 616–620 (1973)

    PubMed  CAS  Google Scholar 

  • Ganley, O.H.: Protective effect of cyproheptadine, a new antihistamine antiserotonin compound on lethal burns in the mouse. Arch. int. Pharmacodyn. 138, 125–132 (1962)

    PubMed  CAS  Google Scholar 

  • Garattini, S., Valzelli, L.: Serotonin. Amsterdam: Elsevier 1965

    Google Scholar 

  • Garcia-Arocha, H.: Liberation of 5-hydroxytryptamine and histamine in the anaphylactic reaction of the rat. Canad. J. Biochem. 39, 403–416 (1961)

    PubMed  CAS  Google Scholar 

  • Gelfand, M.D., West, G.B.: Experimental studies with the butanolamide and propanolamide of 1-methyl-lysergic acid. Int. Arch. Allergy. 18, 286–291 (1961)

    PubMed  CAS  Google Scholar 

  • Goose, J., Blair, A.M.J.N.: Passive cutaneous anaphylaxis in the rat, induced with two homolo- gous reagin-like antibodies and its specific inhibition with disodium cromoglycate. Immunology 16, 749–760 (1969)

    PubMed  CAS  Google Scholar 

  • Gramajo, R., Cervio, N.: The use in rheumatology of a synthetic antiserotonin: methysergide. Pren. méd. argent. 52, 2900–2902 (1965)

    CAS  Google Scholar 

  • Green, A.F.: The antagonism of histamine and the anaphylactic response by phenylpyridylallylamines. Brit. J. Pharmacol. 8, 171–176 (1953)

    PubMed  CAS  Google Scholar 

  • Green, A.F.: Antihypertensive drugs. In: Garattini, S., Shaw, P. A. (Eds.): Advances in Pharmacology, Vol. 1, pp. 161–225. New York: Academic Press Inc. 1962

    Google Scholar 

  • Greig, M.E., Griffin, R.L.: Antagonism of slow reacting substance in anaphylaxis (SRS-A) and other spasmogens on the guinea pig tracheal chain by hydratropic acids and their effects on anaphylaxis. J. med. Chem. 18, 112–116 (1975)

    PubMed  CAS  Google Scholar 

  • Gyermek, L.: Drugs which antagonize 5-hydroxytryptamine and related indolealkylamines. In: Erspamer, V. (Ed.): Handbook of Experimental Pharmacology, Vol. 19, pp. 471–528.Berlin-Heidelberg-New York: Springer 1966

    Google Scholar 

  • Gyermek, L., Nador, K.: The pharmacology of tropane compounds in relation to their steric structure. J. Pharm. (Lond.) 9, 209–229 (1957)

    CAS  Google Scholar 

  • Haddox, C.H., Saslaw, M.S.: Urinary 5-methoxytryptamine in patients with rheumatic fever. J. clin. Invest. 42, 435–441 (1963)

    PubMed  CAS  Google Scholar 

  • Halbert, S.P., Bircher, R., Dahle, E.: Studies on the mechanism of the lethal toxic action of streptolysin “O” and the protection by certain antiserotonin drugs. J. Lab. clin. Med. 61, 437–452 (1963)

    PubMed  CAS  Google Scholar 

  • Halpern, B.N.: Synthetic antihistamine substances. Arch. int. Pharmacodyn. 68, 339–408 (1942)

    CAS  Google Scholar 

  • Halpern, B.N., Dumas, J., Reber, H.: Rôle favorisant d’un antihistaminique de synthese dans la généralisation de l’infection locale. C.R. Soc. Biol. (Paris) 143, 1563–1565 (1949)

    CAS  Google Scholar 

  • Halpern, B.N., Liacopoulos, P., Liacopoulos-Briot, M.: Recherches sur les substances exogenes et endogenes agissant sur la permeabilite capillaire et leur antagonists. Arch. int. Pharmacodyn. 119, 56–101(1959)

    PubMed  CAS  Google Scholar 

  • Halpern, B.N., Neveu, T., Spector, S.: On the nature of the chemical mediators involved in anaphylactic reactions in mice. Brit. J. Pharmacol. 20, 389–398 (1963)

    PubMed  CAS  Google Scholar 

  • Ham, N.S.: Solution conformation of antihistamines. J. pharm. Sci. 60, 1764–1765 (1971)

    PubMed  CAS  Google Scholar 

  • Hanna, P.E., Ahmed, A.E.: Conformationally restricted analogues of histamine Hl receptor antagonists, trans and cis-1, 5-Diphenyl-3-dimethylaminopyrrolidine. J. med. Chem. 16, 963–968 (1973)

    PubMed  CAS  Google Scholar 

  • Harms, A.F., Nauta, W.T.: The effects of alkyl substitution in drugs. 1. Substituted dimethyl-aminoethyl benzhydryl ethers. J. med. Chem. 2, 57–77 (1960)

    CAS  Google Scholar 

  • Henson, P.M., Cochrane, C. G.: Immunological induction of increased vascular permeability. I.A rabbit passive cutaneous anaphylactic reaction requiring complement, platelets, and neutrophils. J. exp. Med. 129, 153–165 (1969)

    PubMed  CAS  Google Scholar 

  • Herxheimer, H.: The 5-hydroxytryptamine shock in the guinea-pig. J. Physiol. (Lond.) 128, 435–445 (1955)

    CAS  Google Scholar 

  • Herxheimer, H., Stresemann, E.: The effect of some new antihistamines on the anaphylactic microshock of the guinea pig. Brit. J. Pharmacol. 21, 414–418 (1963)

    PubMed  CAS  Google Scholar 

  • Higginbotham, R.D.: Influence of adrenalectomy and Cortisol on resistance of mice to histamine, serotonin, anaphylactic, and endotoxin shocks. J. Allergy 33, 35–44 (1962)

    PubMed  CAS  Google Scholar 

  • Highton, T.C., Garrett, M.H.: Some effects of serotonin and related compounds on human collagen. Lancet 1963, 1, 1234–1237

    PubMed  CAS  Google Scholar 

  • Ison, R.R., Casy, A.F.: Structural influences upon antihistamine activity; 3-amino-L-aryl-L-(2-pyridyl)propenes and related compounds. J. Pharm. (Lond.) 23, 848–856 (1971)

    CAS  Google Scholar 

  • Ison, R.R., Franks, F.M., Soh, K.S.: The binding of conformationally restricted antihistamines to histamine receptors. J. Pharm. (Lond.) 25, 887–894 (1973)

    CAS  Google Scholar 

  • James, M.N.G., Williams, G.J.B.: Structural studies of histamine H1 effector molecules: the crystal structure of the antihistaminic drug (+)-chlorpheniramine maleate; [(+)-S-(p-chlorophenyl)-L-(2-pyridyl)-3-N, N-dimethylamine maleate]. Canad. J. Chem. 52, 1872–1879 (1974)

    CAS  Google Scholar 

  • Jones, D.G., Kay, A.B.: Inhibition of eosinophil Chemotaxis by the antagonist of slow reacting substance of anaphylaxis-compound FPL 55712. J. Pharm. (Lond.) 26, 917–918 (1974)

    CAS  Google Scholar 

  • Julou, L., Ducrot, R., Bardone, M.C., Detaille, J.Y., Feo, C., Guyonnet, J.C., Loiseau, G., Pasquet, J.: Etude des propriétés pharmacologiques de la diméthylsulfamido-3 (diméthylamino-2 propyl)-10 phénothiazine (8, 599 R.P.). Arch. int. Pharmacodyn. 159, 70–86 (1966)

    PubMed  CAS  Google Scholar 

  • Kalz, F., Fekete, Z.: Studies on capillary permeability using Coomassie blue as indicator. J. invest. Derm. 36, 37–46 (1961)

    PubMed  CAS  Google Scholar 

  • Kellaway, C.H., Trethewie, E.R.: The liberation of a slow-reacting smooth muscle-stimulating substance in anaphylaxis. Quart. J. exp. Physiol. 30, 121–145 (1940)

    CAS  Google Scholar 

  • Kier, L.B.: Molecular orbital calculations of the preferred conformations of histamine and a theory on its dual activity. J. med. Chem. 11, 441–445 (1968 a)

    PubMed  CAS  Google Scholar 

  • Kier, L.B.: Preferred conformation of serotonin and a postulate on the nature of its receptor from molecular orbital calculations. J. pharm. Sci. 57, 1188–1191 (1968b)

    PubMed  CAS  Google Scholar 

  • Kraft, E., Zimmerman, B.G.: Influence of histamine H1 and H2-receptor blockers on sympathetic vasodilator and vasoconstrictor responses in canine paw. Brit. J. Pharmacol. 53, 51–58 (1975)

    CAS  Google Scholar 

  • Kutter, E., Hansen, C.: Steric parameters in drug design. Monoamine oxidase inhibitors and antihistamines. J. med. Chem. 12, 647–652 (1969)

    PubMed  CAS  Google Scholar 

  • Levi, R., Lee, C.-H.: Characterization of cardiac histamine receptors by means of selective H1 and H2-agonists and antagonists. Fed. Proc. 33, Abst. 2109 (1974)

    Google Scholar 

  • Lindquist, K.J.: A unique class of rabbit immuno-globulins eliciting passive cutaneous anaphylaxis in homologous skin. Immunochemistry 5, 525–542 (1968)

    Google Scholar 

  • Loew, E.R.: Pharmacology of antihistamine compounds. Physiol. Rev. 27, 542–573 (1947)

    PubMed  CAS  Google Scholar 

  • Logan, G., Wilhelm, D.L.: Vascular permeability changes in inflammation. I. The role of endogenous permeability factors in ultraviolet injury. Brit. J. exp. Path. 47, 300–314 (1966)

    PubMed  CAS  Google Scholar 

  • Maling, H.M., Webster, M.E., Williams, M.A., Wilford, S., Anderson, W.: Inflammation induced by histamine, serotonin, bradykinin and compound 48/80 in the rat: antagonists and the mechanism of action. J. Pharmacol, exp. Ther. 191, 300–310 (1974)

    CAS  Google Scholar 

  • Margolin, S., Tislow, R.: Experimental and clinical efficacy of trimeton and chlor-trimeton maleate. Ann. Allergy 8, 515–518 (1950)

    PubMed  CAS  Google Scholar 

  • Mathé, A.A., Strandberg, K.: Antagonism of slow reacting substance by polyphloretin phosphate on isolated human bronchi. Acta physiol. scand. 82, 460–465 (1971)

    PubMed  Google Scholar 

  • Mathe, A.A., Strandberg, K., Fredholm, B.: Antagonism of prostaglandin F2α induced bronchoconstriction and blood pressure changes by polyphloretin phosphate in the guinea-pig and cat. J. Pharm. (Lond.) 24, 378–382 (1972)

    CAS  Google Scholar 

  • Mawson, C., Whittington, H.: Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents. Brit. J. Pharmacol. 39, 223 P (1970)

    Google Scholar 

  • McQueen, D.S.: The effects of prostaglandin E2, prostaglandin F2α and polyphloretin phosphate on respiration and blood pressure in anaesthetized guinea pigs. Life Sci. 12, 163–172 (1973)

    CAS  Google Scholar 

  • Miles, A.A., Wilhelm, D.L.: The activation of endogenous substances inducing pathological in-creases of capillary permeability. Part I. A survey of endogenous permeability factors. In: The Biochemical Response to Injury, pp. 51–83. Oxford: Blackwell 1960

    Google Scholar 

  • Mota, I.: Mast cells and anaphylaxis. Ann. N.Y. Acad. Sci. 103, 264–277 (1963)

    PubMed  CAS  Google Scholar 

  • Mota, I.: The mechanism of anaphylaxis. I. Production and biological properties of mast cell sensitizing antibody. Immunology 7, 681–699 (1964)

    PubMed  CAS  Google Scholar 

  • Movat, H.Z., Di Lorenzo, N.L., Taichman, N.S., Berger, S., Stein, H.: Suppression by antihistamine of passive cutaneous anaphylaxis produced with anaphylactic antibody in the guinea pig. J. Immunol. 98, 230–235 (1967)

    PubMed  CAS  Google Scholar 

  • Murray, M., Smith, W.D., Waddell, A.H., Jarrett, W.F.H.: Nippostrongylus brasiliensis: histamine and 5-hydroxytryptamine inhibition and worm expulsion. Exp. Parasit. 30, 58–63 (1971)

    CAS  Google Scholar 

  • Nauta, W.T., Bultsma, T., Rekker, R.F., Timmerman, H.: Structure-activity relations in a series of compounds related to diphenhydramine. Med. Chem. Spec. Contrib. Int. Symp. 3rd., 1972, p. 125 (Pub. 1973). Ed. Pratesi, P. London: Butterworth 1973

    Google Scholar 

  • Northover, B.J., Subramanian, G.: A study of possible mediators of inflammatory reactions in the mouse foot. Brit. J. Pharmacol. 18, 346–355 (1962)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Murphy, R.C., Austen, K.F.: Inactivation of slow reacting substance of anaphylaxis (SRS-A) by arylsulfatases. J. Immunol. 113, 316–322 (1974)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Murphy, R.C., Karnovsky, M.L., Austen, K.F.: The physicochemical characteristics and purification of slow-reacting substance of anaphylaxis. J. Immunol. 110, 760–770 (1973)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Stechschulte, D.J., Austen, K.F.: Immunochemical and biologic properties of rat IgE. II. Capacity to mediate the immunologic release of histamine and slow reacting substance of anaphylaxis (SRS-A). J. Immunol. 105, 1087–1095 (1970)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Valentine, M.D., Austen, K.F.: Antigen-induced release of slow reacting substance of anaphylaxis (SRS-Arat) in rats prepared with homologous antibody. J. exp. Med. 127, 767–782(1968)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Gwilliam, J., Cox, J.S.G.: Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. Immunology 19, 469–479 (1970)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Gwilliam, J., Cox, J.S.G.: Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. II. A comparison of the rat anti-DNP 7 Sy2 and rat reagin induced cutaneous reactions. Immunology 21, 405–417 (1971)

    PubMed  CAS  Google Scholar 

  • Ovary, Z.: Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. In: Kallos, P. (Ed.): Progr. Allergy, Vol. 5, pp. 459–508. Basel-New York: S. Karger 1958

    Google Scholar 

  • Ovary, Z., Bier, O.G.: Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon. J. Immunol. 71, 6–11 (1953)

    PubMed  CAS  Google Scholar 

  • Palmer, M.A., Piper, P.J., Vane, J.R.: Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Brit. J. Pharmacol. 49, 226–242 (1973)

    CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: Release of 5-hydroxytryptamine and histamine from tissues of the rat. J. Physiol. (Lond.) 137, 179–192 (1957 a)

    CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: 5-Hydroxytryptamine and the anaphylactoid reaction in the rat. J. Physiol. (Lond.) 139, 27–41 (1957 b)

    CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: Inhibition by various substances of oedema formation in the hind-paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, egg white and compound 48/80. Brit. J. Pharmacol. 13, 65–70 (1958)

    PubMed  CAS  Google Scholar 

  • Paton, W.D.M.: Compound 48/80: a potent histamine liberator. Brit. J. Pharmacol. 6, 499–508 (1951)

    PubMed  CAS  Google Scholar 

  • Paton, W.D.M.: The release of histamine. In: Kallos, P. (Ed.): Progr. Allergy, Vol. 5, pp. 79–148. Basel-New York: S. Karger 1958

    Google Scholar 

  • Peck, A.W., Fowle, A.S.E., Bye, C.: A comparison of triprolidine and clemastine on histamine antagonism and performance tests in man: implications for the mechanism of drug induced drowsiness. Europ. J. clin. Pharmacol. 8, 455–463 (1975)

    CAS  Google Scholar 

  • Perini, A., Mota, I.: Heterogeneity of guinea-pig homocytotropic antibodies. Immunology 22, 915–923 (1972)

    PubMed  CAS  Google Scholar 

  • Petri, G., Cspiak, J., Kovacs, A., Bentzik, M.: Data on the pathology of pyogenic inflammation. I. The role of histamine in pyogenic inflammation and the effect of antihistaminics on its course. Acta med. Acad. Sci. hung 3, 347–368 (1952)

    PubMed  CAS  Google Scholar 

  • Phair, J.P., Eisenfeld, A.J., Levine, R.J., Kantor, F.S.: Effects of pharmacological inhibition of histamine synthesis upon immunological reactions in guinea-pigs. Immunology 18, 611–619 (1970)

    PubMed  CAS  Google Scholar 

  • Piper, P.J., Vane, J.R.: Release of additional factors in anaphylaxis and its antagonism by antiin-flammatory drugs. Nature (Lond.) 223, 29–35 (1969)

    CAS  Google Scholar 

  • Pletscher, A., Shore, P.A., Brodie, B.B.: Serotonin release as a possible mechanism of reserpine action. Science 122, 374–375 (1955)

    PubMed  CAS  Google Scholar 

  • Pletscher, A., Shore, P.A., Brodie, B.B.: Serotonin as a mediator of reserpine action in brain. J. Pharmacol, exp. Ther. 116, 84–89 (1956)

    CAS  Google Scholar 

  • Radwan, A.C., West, G.B.: Alterations in histidine decarboxylase activity during anaphylactic shock in the rat. Brit. J. Pharmacol. 30, 392–399 (1967)

    PubMed  CAS  Google Scholar 

  • Rekker, R.F., Nauta, W.T., Bultsma, T., Waringa, C.G.: Integrated QSAR of Hreceptor antagonists. Europ. J. med. Chem. 10, 557–562 (1975)

    Google Scholar 

  • Reuse, J.J.: Antihistamine drugs and histamine release, especially in anaphylaxis. In: Wolstenholme, G.E.W., O’Connor, C.M. (Eds.): Histamine. Ciba Foundation Symposium 1955, pp. 150–154. London: Churchill 1956

    Google Scholar 

  • Rieveschl, G.R.: Dialkylaminoalkyl benzhydryl ethers. U.S. Patent 2, 421, 714 (1947)

    Google Scholar 

  • Rochae Silva, M.: Chemical mediators of the acute inflammatory reaction. Ann. N.Y. Acad. Sci. 116, 899–911(1964)

    CAS  Google Scholar 

  • Rochae Silva, M. Ed.: Handbook of Experimental Pharmacology. Histamine and Antihistaminics. Part 1. Histamine. Its chemistry, metabolism, and physiological and pharmacological actions, Vol. XVIII. Berlin-Heidelberg-New York: Springer 1966

    Google Scholar 

  • Rochae Silva, M. (Eds.): Handbook of Experimental Pharmacology, Part 2. Histaminen and Antihistaminics, Vol. XVIII. Berlin-Heidelberg-New York: Springer 1977

    Google Scholar 

  • Rowley, D.A., Benditt, E. P.: 5-Hydroxytryptamine and histamine as mediators of the vascular injury produced by agents which damage mast cells in rats. J. exp. Med. 103, 399–411 (1956)

    PubMed  CAS  Google Scholar 

  • Sanyal, R.K., West, G.B.: Anaphylactic shock in the albino rat. J. Physiol. (Lond.) 142, 571–584 (1958 a)

    CAS  Google Scholar 

  • Sanyal, R.K., West, G.B.: The relationship of histamine and 5-hydroxytryptamine to anaphylactic shock in different species. J. Physiol. (Lond.) 144, 525–531 (1958 b)

    CAS  Google Scholar 

  • Schachter, M.: Histamine and Antihistamines, Vol. I. International Encyclopedia of Pharmacology and Therapeutics, Section 74. Oxford-New York-Toronto-Sydney-Braunschweig: Pergamon Press 1973

    Google Scholar 

  • Scherbel, A.L., Harrison, J.W.: Exaggerated reactivity to serotonin in patients with rheumatoid arthritis and related diseases. Circulation 18, 777 (1958)

    Google Scholar 

  • Scherbel, A.L., McKittrick, R.L., Hawk, W. A.: Lesions in rats caused by serotonin and histamine before and after amine oxidase inactivation and serotonin inhibition. J. clin. Invest. 39, 1025–1026 (1960)

    Google Scholar 

  • Scherbel, A.L., Schmid, E.A.: Effect of serotonin inhibitors on connective tissue disease. Cleveland Clin. Quart. 29, 1–15 (1962)

    PubMed  CAS  Google Scholar 

  • Schneider, J.A.: Pharmacology of Rauwolfia. In: Rauwolfia. Pharmacology of Rauwolfia, pp. 109–143. Boston, Mass.: Little, Brown 1957

    Google Scholar 

  • Sevitt, S.: Early and delayed oedema and increase in capillary permeability after burns of the skin. J. Path. Bact. 75, 27–37 (1958)

    PubMed  CAS  Google Scholar 

  • Sevitt, S., Bull, J.P., Cruickshank, C.N.D., Jackson, D.M., Lowbury, E.J.L.: Failure of an antihistamine drug to influence the course of experimental human burns. Brit. med. J. 1952II, 57–62

    Google Scholar 

  • Sicuteri, R, Michelacci, S., Franchi, G.: Antagonism between an antiserotonin-the butanolamide of 1-methyl-lysergic-acid-and the effects of a histamine-liberating substance 48/80 B.W. in man. Int. Arch. Allergy 15, 291–299 (1959)

    PubMed  CAS  Google Scholar 

  • Shafi’ee, A., Hite, G.: The absolute configurations of the pheniramines, methyl phenidates, and pipradols. J. med. Chem. 12, 266–270 (1969)

    PubMed  Google Scholar 

  • Smith, J.B., Willis, A.L.: Aspirin selectively inhibits prostaglandin production in human platelets. Nature (New Biol.) 231, 235–237 (1971)

    CAS  Google Scholar 

  • Sparrow, E.M., Wilhelm, D.L.: Species differences in susceptibility to capillary permeability factors: histamine, 5-hydroxytryptamine, and compound 48/80. J. Physiol. (Lond.) 137, 51–65 (1957)

    CAS  Google Scholar 

  • Spector, W.G., Willoughby, D.A.: Histamine and 5-hydroxytryptamine in acute experimental pleurisy. J. Path. Bact. 74, 57–65 (1957)

    CAS  Google Scholar 

  • Spector, W.G., Willoughby, D.A.: Experimental suppression of the early inflammatory phenomena of turpentine pleurisy in rats. Nature (Lond.) 181, 708–709 (1958)

    CAS  Google Scholar 

  • Spector, W.G., Willoughby, D.A.: Experimental suppression of the acute inflammatory changes of thermal injury. J. Path. Bact. 78, 121–132 (1959a)

    PubMed  CAS  Google Scholar 

  • Spector, W.G., Willoughby, D.A.: The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes. J. Path. Bact. 77, 1–17 (1959 b)

    PubMed  CAS  Google Scholar 

  • Spector, W.G., Willoughby, D.A.: The inflammatory response. Bact. Rev. 27, 117–154 (1963)

    PubMed  CAS  Google Scholar 

  • Stacey, R.S.: Clinical aspects of cerebral and extracerebral 5-hydroxytryptamine. In: Handbook of Experimental Pharmacology. 5-Hydroxytryptamine and related indolealkylamines. Berlin-Heidelberg-New York: Springer-Verlag 1965, Vol. XIX

    Google Scholar 

  • Starr, M.S., West, G.B.: Bradykinin and oedema formation in heated paws of rats. Brit. J. Pharmacol. 31, 178–187 (1967)

    PubMed  CAS  Google Scholar 

  • Stechschulte, D.J., Austen, K.F.: Anaphylaxis. In: Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.): The Inflammatory Process, 2nd Ed., Vol. III, Ch. 5. New York-London: Academic Press 1974

    Google Scholar 

  • Stechschulte, D.J., Austen, K.F., Bloch, K.J.: Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat. J. exp. Med. 125, 127–147 (1967)

    PubMed  CAS  Google Scholar 

  • Stewart, P.B., Bliss, J.Q.: The permeability-increasing factor in diluted human plasma. Brit. J. exp. Path. 38, 462–466 (1957)

    PubMed  CAS  Google Scholar 

  • Stone, C.A., Wenger, H.C., Ludden, C.T., Stavorski, J.M., Ross, C.A.: Antiserotonin-antihistaminic properties of cyproheptadine. J. Pharmacol, exp. Ther. 131, 73–84 (1961)

    CAS  Google Scholar 

  • Strandberg, K., Uvnas, B.: Purification and properties of the slow reacting substance formed in the cat paw perfused with compound 48/80. Acta physiol. scand. 82, 358–374 (1971)

    PubMed  CAS  Google Scholar 

  • Stringer, H.C.W., Highton, T.C.: The shrinkage temperature of skin collagen. Aust. J. Derm. 5, 230–234(1960)

    Google Scholar 

  • Takagi, K., Tukao, T.: Effects of some drugs on capillary permeability in the anaphylaxis of the mouse. Jap. J. Pharmacol. 21, 455–465 (1971)

    PubMed  CAS  Google Scholar 

  • Tokuda, S., Weiser, R.S.: Studies on the role of serotonin and mast cells in anaphylaxis of the mouse produced with soluble antigen-antibody complexes. J. Immunol. 86, 292–301 (1961)

    PubMed  CAS  Google Scholar 

  • Toldy, L., Vargha, L., Toth, L, Borsy, J.: Promethazine 1. Acta chim. Acad. Sci. hung. 19, 273–275 (1959)

    CAS  Google Scholar 

  • Trendelenberg, U.: The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J. Pharmacol, exp. Ther. 130, 450–460 (1960)

    Google Scholar 

  • Uda, T.: The mode of inhibitory actions of guaiazulene and some other antiinflammatory agents on the anaphylactoid edemas. Nippon Yakurigaku Zasshi 56, 1151–1163 (1960)

    CAS  Google Scholar 

  • Van Arman, C.G., Begany, A.J., Miller, L.M., Pless, H.H.: Some details of the inflammations caused by yeast and carrageenin. J. Pharmacol, exp. Ther. 150, 328–334 (1965)

    Google Scholar 

  • Vane, J.R.: Inhibition of prostaglandin synthesis as a mechanism for aspirinlike drugs. Nature (New Biol.) 231, 232–235 (1971)

    CAS  Google Scholar 

  • Vane, J.R., Ferreira, S.H.: Interactions between bradykinin and prostaglandins. Life Sci. 16, 804–805 (1975)

    Google Scholar 

  • Vane, J.R., Ferreira, S.H.: Interactions between bradykinin and prostaglandins. In: Proc. No. 27 of the Fogerty International Center. Washington, D.C.: U.S. Government Printing Office 1976. In press

    Google Scholar 

  • Vaz, N.M., Prouvost-Danon, A.: Behaviour of mouse mast cells during anaphylaxis in vitro. In: Kallos, P., Waksman, B.H. (Eds.): Progr. Allergy, Vol. XIII, pp. 111–173. Basel-New York: S. Karger 1969

    Google Scholar 

  • Villaneuva, R., Hinds, L., Katz, R.L., Eakins, KE.: The effect of polyphloretin phosphate on some smooth muscle actions of prostaglandins in the cat. J. Pharmacol, exp. Ther. 180, 78–85 (1972)

    Google Scholar 

  • Vinegar, R., Schreiber, W., Hugo, R.: Biphasic development of carrageenin edema in rats. J. Pharmacol, exp. Ther. 166, 96–103 (1969)

    CAS  Google Scholar 

  • Vinegar, R., Truax, J.F., Selph, J.L.: Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proc. Soc. exp. Biol. (N.Y.) 143, 711–714 (1973)

    CAS  Google Scholar 

  • Vogel, G., Marek, M.L.: Über die Hemmung verschiedener Rattenpfoten-Ödeme durch Serotonin-Antagonisten. Arzneimittel-Forsch. 11, 1051–1054 (1961)

    CAS  Google Scholar 

  • Warner, R.R.P.: Current status and implications of serotonin in clinical medicine. In: Dock, W., Snapper, I. (Eds.): Advances in Internal Medicine, Vol. XIII, pp. 241–282. Chicago: New Book Medical Publ. Inc. 1967

    Google Scholar 

  • Weeks, R.E., Gunnar, R.M.: Effect of tripelennamine hydrochloride on acute inflammation. Arch. Path. (Chicago) 48, 178–182 (1949)

    CAS  Google Scholar 

  • Weis, J.: Investigations on some experimental inflammations in mouse paws. Med. exp. (Basel) 8, 1–11(1963)

    CAS  Google Scholar 

  • Wells, P.W., Eyre, P.: The pharmacology of passive cutaneous anaphylaxis in the calf. Canad. J. Physiol. Pharmacol. 50, 255–262 (1972)

    CAS  Google Scholar 

  • West, G.B.: 5-Hydroxytryptamine, tissue mast cells and skin oedema. Int. Arch. Allergy 10, 257–275 (1957)

    PubMed  CAS  Google Scholar 

  • Wilhelm, D.L.: The mediation of increased vascular permeability in inflammation. Pharmacol. Rev. 14, 251–280(1962)

    PubMed  CAS  Google Scholar 

  • Wilhelm, D.L.: Chemical mediators. In: Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.): The Inflammatory Process, 2nd Ed., Vol. II, pp. 251–301. New York-London: Academic Press 1973

    Google Scholar 

  • Wilhelm, D.L., Mason, B.: Rationale of antihistaminic therapy in thermal injury. An experimental evaluation in the guinea pig. Brit. med. J. 1958II, 1141–1143

    Google Scholar 

  • Wilhelm, D.L., Mason, B.: Vascular permeability changes in inflammation: the role of endogenous permeability factors in mild thermal injury. Brit. J. exp. Path. 41, 487–506 (1960)

    PubMed  CAS  Google Scholar 

  • Willis, A.L.: Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion. J. Pharm. (Lond.) 21, 126–128 (1969 a)

    CAS  Google Scholar 

  • Willis, A.L.: Release of histamine, kinin, and prostaglandins during carrageenin-induced inflammation in the rat. In: Mantegazza, P., Horton, E.W. (Eds.): Prostaglandins, Peptides, and Amines, pp. 31–38. London-New York: Academic Press 1969b

    Google Scholar 

  • Willoughby, D.A.: Pharmacological suppression of increased capillary permeability following irradiation of the intestine of rats. Nature (Lond.) 184, 1156 (1959)

    Google Scholar 

  • Willoughby, D.A.: Pharmacological aspects of the vascular permeability changes in the rat’s intestine following abdominal radiation. Brit. J. Radiol. 33, 515–519 (1960)

    PubMed  CAS  Google Scholar 

  • Willoughby, D.A.: Mediation of increased vascular permeability of inflammation. In: Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.): The Inflammatory Process, 2nd Ed., Vol. II, pp. 303–331. New York-London: Academic Press 1973

    Google Scholar 

  • Winter, C.A., Risley, E.A., Nuss, G.W.: Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. exp. Biol. (N.Y.) 111, 544–547 (1962)

    CAS  Google Scholar 

  • Winter, C.A., Risley, E.A., Nuss, G.W.: Antiinflammatory and antipyretic activities of indome-thacin, l-(p-chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid. J. Pharmacol, exp. Ther. 141, 369–376 (1963)

    CAS  Google Scholar 

  • Witiak, D.T.: Antiallergenic agents. In: Burger, A. (Ed.): Medicinal Chemistry, Vol. 2, 3rd Ed., Ch. 65, pp. 1643–1668. New York: Wiley 1970

    Google Scholar 

  • Wood, D.R.: The effect on gastric secretion of different rates of histamine infusion and of “Neoantergan”. Brit. J. Pharmacol. 3, 231–236 (1948)

    PubMed  CAS  Google Scholar 

  • Woolley, D.W., Shaw, E.: Differentiation between receptors for serotonin and tryptamine by means of the exquisite specificity of antimetabolites. J. Pharmacol, exp. Ther. 121, 13–17 (1957)

    CAS  Google Scholar 

  • Wyllie, J.H., Hesselbo, T., Black, J.W.: Effects in man of histamine H2-receptor blockade by burimamide. Lancet 1972II, (7787), 1117–1120

    Google Scholar 

  • Zileli, T., Chapman, L., Wolff, H.G.: Antiinflammatory action of UML-491 (1-methyl-D-lysergic acid butanolamide dimaleate) demonstrated by the granuloma pouch technique in rats. Arch. int. Pharmacodyn. 136, 463–464 (1962)

    CAS  Google Scholar 

  • Zvaifler, N.J., Bauer, H., Robinson, J.O.: IgE immunoglobulin in the rabbit. In: Austen, K.F., Becker, E.L. (Eds.): Biochemistry of the Acute Allergic Reactions, Vol. 2, pp. 33–44. Oxford: Blackwell 1971

    Google Scholar 

Download references

Authors
  1. A. F. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. G. Garland
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. F. Hodson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Green, A.F., Garland, L.G., Hodson, H.F. (1979). Antagonists of Histamine, 5-Hydroxytryptamine and SRS-A. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66891-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66893-7

  • Online ISBN: 978-3-642-66891-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation