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Pain and Inflammatory Mediators

  • Chapter
Inflammation

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 1))

Abstract

Pain and hyperalgesia are common features of the inflammatory process. Some pain arises as an immediate sensation after tissue injury, due to direct stimulation of sensory nerve endings. Another component arises with the inflammation which ensues after injury; the pain which then develops is a combination of mechanical and chemical stimulation due to the vascular changes inherent to the inflammatory process and due to direct chemical stimulation by the pain producing substances released.

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  1. S. Moncada
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  2. S. H. Ferreira
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  3. J. R. Vane
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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Moncada, S., Ferreira, S.H., Vane, J.R. (1978). Pain and Inflammatory Mediators. In: Vane, J.R., Ferreira, S.H. (eds) Inflammation. Handbook of Experimental Pharmacology, vol 50 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66888-3_18

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