Abstract
During the inflammatory response, cells elaborate many biologically active chemicals and the tenor of pharmacological research at any time is, not unnaturally, set by the current state of knowledge concerning these inflammatory mediators; thus, in the past, this field has been dominated by the discovery of histamine, bradykinin and 5-hydroxytryptamine (5-HT), with the subsequent invention of antihistamine and anti-5-HT drugs.
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References
Aas, K. A., Gardner, F.H.: Survival of blood platelets with chromium51. J. clin. Invest. 37, 1232–1257 (1958)
Ahern, D.G., Downing, D.T.: Inhibition of prostaglandin biosynthesis by eicosa-5, 8,11,14-tetraynoic acid. Biochim. biophys. Acta 210, 456–461 (1970)
Anderson, F.L., Jubiz, W., Kralios, A.C., Tsagaris, T.G.: Plasma prostaglandin E levels during endotoxin shock in dogs. Clin. Res. 21, 194 (1973)
Anderson, M.W., Eling, T.E.: Prostaglandin removal and metabolism by isolated perfused rat lung. Prostaglandins 11, 645–677 (1976)
Änggård, E.: The biological activities of three metabolites of prostaglandin E1. Acta physiol. scand. 66, 509–510 (1966)
Änggård, E., Larsson, C., Samuelsson, B.: The distribution of 15-hydroxyprostaglandin dehydrogenase and prostaglandin Δ13 reductase in tissues of the swine. Acta Physiol. Scand. 81, 396–404 (1971)
Änggård, E., Samuelsson, B.: Prostaglandins and related factors. 28. Metabolism of prostaglandin E1 in guinea pig lung: the structures of two metabolites. J. biol. Chem. 239, 4087–4102 (1964)
Änggård, E., Samuelsson, B.: Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors 38. J. biol. Chem. 240, 3518–3521 (1965)
Änggård, E., Samuelsson, B.: Purification and properties of a 15-hydroxy prostaglandin dehydrogenase from swine lung. Prostaglandins and related factors 55. Ark. kemi 25, 293–300 (1966)
Änggård, E., Samuelsson, B.: The metabolism of prostaglandins in lung tissue. In: Nobel Symposium 2, Prostaglandins, pp. 97–105. New York: Interscience 1967
Audet, A., Nantel, G., Proulx, P.: Phospholipase A activity in growing Escherichia coli cells. Biochim. biophys. Acta 348, 334–343 (1974)
Bartels, J., Kunze, H., Vogt, W., Wille, G.: Prostaglandin: liberation from and formation in perfused frog intestine. Naunyn-Schmiedebergs Arch. Pharmacol. 266, 199–207 (1970)
Bedwani, J.R., Marley, P.B.: Increased inactivation of prostaglandin E2 by the rabbit lung during pregnancy. Brit. J. Pharmacol. 50, 459P (1974)
Bennet, A.: Prostaglandin antagonists. Advanc. Drug Res. London: Academic Press (1975)
Bennett, A., Friedman, C.A., Vane, J.R.: Release of Prostaglandin E1 from the rat stomach. Nature (Lond.) 216, 873–876 (1967)
Bennett, J., Glavenovich, J., Liskay, R., Wullf, D.L., Cronan Jr., J.E.: Phospholipid hydrolysis in Escherichia coli infected with rapid lysis mutants of phage T4. Virology 43, 516–518 (1971)
Bergström, S., Danielsson, H., Kienberg, D., Samuelsson, B.: The enzymatic conversion of essential fatty acids into prostaglandins. J. biol. Chem. 239, PC 4006 (1964 a)
Bergström, S., Danielsson, H., Samuelsson, B.: The enzymatic formation of prostaglandin E2 from arachidonic acid. Prostaglandins and related factors. 32. Biochim. biophys. Acta 90, 207–210 (1964 b)
Blackwell, G.J., Duncombe, W.G., Flower, R.J., Parsons, M. F., Vane, J.R.: The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs (1976). Brit. J. Pharmacol. 59, 353–366 (1977)
Blackwell, G.J., Flower, R.J.: Effects of steroid hormones on tissue levels of prostaglandin 15-hydroxydehydrogenase in the rat. Brit. J. Pharmacol. 56, 343P (1976 a)
Blackwell, G.J., Flower, R.J.: A rapid method for the estimation of prostaglandin 15-hydroxyde-hydrogenase activity and its application to pharmacology. Brit. J. Pharmacol. 57, 589–598 (1976 b)
Blackwell, G.J., Flower, R.J., Parsons, M.F., Vane, J.R.: Factors influencing the metabolic turnover of prostaglandin synthetase. Brit. J. Pharmacol. 53, 467P (1975 a)
Blackwell, G.J., Flower, R.J., Vane, J.R.: Rapid reduction of prostaglandin 15-hydroxy dehydrogenase activity in rat tissues after treatment with protein synthesis inhibitors. Brit. J. Pharmacol. 55, 233–238 (1975b)
Blackwell, G.J., Flower, R.J., Vane, J.R.: Some characteristics of the prostaglandin synthesizing system in rabbit kidney microsomes. Biochim. biophys. Acta 398, 178–190 (1975 c)
Bohman, S.O., Larsson, C.A.: Prostaglandin synthesis in membrane fractions from the rabbit renal medulla. Acta physiol. scand. 94, 244–258 (1975)
Boyd, D.H. J., Adams, G.A.: An assay method for lipoxidase in animal tissue. Canad.J. Biochem. 33, 191–198 (1955)
Chan J. A., Nagasawa, N., Takeguchi, C., Sih, C.J.: On agents favouring prostaglandin F formation during biosynthesis. Biochemistry 14, 2987–2991 (1975)
Chasalow, F.I., Phariss, B. B.: Luteinizing hormone stimulation of ovarian prostaglandin biosynthesis. Prostaglandins 1, 107–117 (1972)
Christ, E. J., Dorp, D.A. van: Comparative aspects of prostaglandin biosynthesis in animal tissues. Biochim. biophys. Acta 270, 537–545 (1972)
Christ, E. J., Dorp, D.A. van: Comparative aspects of prostaglandin biosynthesis in animal tissue. In: Supplementum to Advances in the Biosciences. International Conference on Prostaglandins, Vienna, pp. 35–38. Braunschweig: Vieweg-Pergamon Press 1973
Coceani, F., Pace-Asciak, C., Volta, F., Wolfe, L.S.: Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Amer. J. Physiol. 213, 1056–1064 (1967)
Cook, H.W., Lands, W.E.M.: Evidence for an activating factor formed during prostaglandin biosynthesis. Biochem. biophys. Res. Commun. 65, 464–471 (1975)
Crutchley, D.J., Piper, P.J.: Prostaglandin inactivation in guinea pig lung and its inhibition. Brit. J. Pharmacol. 52, 197–203 (1974)
Crutchley, D.J., Piper, P.J.: Inhibition of the pulmonary inactivation of prostaglandins in rabbit in vivo. Brit. J. Pharmacol. 53, 467 P (1975)
Dahle, I.K., Hill, E.G., Holman, R.T.: The thiobarbituric acid reaction and the auto-oxidation of polyunsaturated fatty acid methyl esters. Arch. Biochem. 98, 253–261 (1962)
Daniels, E.G., Krueger, W.C., Kupiecki, F.P., Pike J.E., Schneider, W. P.: Isolation and characterization of a new prostaglandin isomeR.J. Amer. chem. Soc. 90, 5894–5895 (1968)
Danon, A., Heimberg, M., Oates, J.A.: Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors. Biochim. biophys. Acta 388, 318–330 (1975)
Dawson, W., Lewis, R.L., Macmahon, R.E., Sweatman, W. J.F.: Potent bronchconstrictor activity of 15-keto prostaglandin F2α. Nature (Lond.) 250, 331–332 (1974)
Dawson, W., Ramwell, P.W., Shaw J.: Metabolism of prostaglandins by rat isolated liver. Brit. J. Pharmacol. 34, 668–669 (1968)
Dorp, D.A. van: Aspects of the biosynthesis of prostaglandins. Progr. biochem. Pharmacol. 3, 71–82 (1967)
Dorp, D.A. van, Beerthuis, R.K., Nugteren, D.H., Vonkeman, H.: Enzymatic conversion of all-cis-polyunsaturated fatty acids into prostaglandins. Nature (Lond.) 203, 839–843 (1964a)
Dorp, D.A. van, Beerthuis, R.K., Nugteren, D.H., Vonkeman, H.: The biosynthesis of prostaglandins. Biochim. biophys. Acta 90, 204–207 1964b
Downing, D.T., Barve, J.A., Gunstone, F.D., Jacobsberg, M., Lie, K.J.: Structural requirements of acetylenic fatty acids for inhibition of soyabean lipoxygenase and prostaglandin synthetase. Biochim. biophys. Acta 280, 343–347 (1972)
Dray, F., Charbonnel, B.: Letter to the editor. Radioimmunoassay of PGF α in human plasma: very low levels. Prostaglandins 5, 173–174 (1974)
Ferreira, S.H., Vane, J.R.: Prostaglandins: their disappearance from and release into the circulation. Nature (Lond.) 216, 868–873 (1967)
Ferreira, S.H., Vane, J.R.: Aspirin and prostaglandins. In: The Prostaglandins, Vol.11, pp. 1–34. New York: Plenum Press 1974
Flower, R.J.: Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev. 26, 33–67 (1974a)
Flower, R.J.: Prostaglandin synthetase and its inhibition by aspirin-like drugs. Ph.D. Thesis, London University (1974b)
Flower, R.J., Blackwell, G.J.: The importance of phospholipase A2 in prostaglandin biosynthesis. Biochem. Pharmacol. 25, 285–291 (1976)
Flower, R.J., Cheung, H.S., Cushman, D.W.: Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase system of bovine seminal vesicles. Prostaglandins 4, 325–341 (1973)
Flower, R.J., Harvey, E.A., Kingston, W.P.: Inflammatory effects of prostaglandin D2 in rat and human skin. Brit. J. Pharmacol. 56, 229–233 (1976)
Flower, R.J., Vane, J.R.: Some pharmacologic and biochemical aspects of prostaglandin biosynthesis and its inhibition. In: Prostaglandin Synthetase Inhibitors, pp.9–18. New York: Raven Press 1974
Fried, J., Mehr er, M. M., Gaede, B.J.: Novel selective inhibitors of human placental PG-15-dehy-drogenase. In: Supplementum to Advances in the Biosciences, International Conference on Prostaglandins, Vienna. Braunschweig: Vieweg-Pergamon Press 1973
Friedman, Y., Lang, M., Burke, G.: Further characterization of bovine thyroid prostaglandin synthetase. Biochim. biophys. Acta 397, 331–341 (1975)
Granström, E. (1968): Quoted in: Biosynthesis of Prostaglandins by B. Samuelsson. Prog. biochem. Pharmacol. 5, 109–128 (1969)
Gréen, K., Bygdeman, M., Toppozada, M., Wiqvist, N.: The role of prostaglandin F 2α in human parturition. Endogenous plasma levels of 15-keto-13, 14-dihydro-prostaglandin F 2α during labour. Amer. J. Obstet. Gynec. 120, 25–31 (1974)
Gréen, K., Samuelsson, B.: Quantitative studies on the synthesis in vivo of prostaglandins in the rat. Cold stress induced stimulation of synthesis. Europ. J. Biochem. 22, 391–395 (1971)
Gryglewski, R., Vane, J.R.: The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Brit. J. Pharmacol. 45, 37–47 (1972a)
Gryglewski, R., Vane, J.R.: The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins. Brit. J. Pharmacol. 46, 449–457 (1972b)
Hamberg, M.: Inhibition of prostaglandin synthesis in man. Biochem. biophys. Res. Commun. 49, 720–726 (1972)
Hamberg, M.: A note on nomenclature. In: Advances in the Biosciences, pp.847–850. Braunschweig: Vieweg-Pergamon Press 1973a
Hamberg, M.: Quantitative studies of prostaglandin synthesis in man. II. Determination of the major urinary metabolite of prostaglandins F1α and F2α . Analyt. Biochem. 55, 368–378 (1973b)
Hamberg, M.: Quantitative studies on prostaglandin synthesis in man. III. Excretion of the major urinary metabolite of prostaglandins F1α and F2α during pregnancy. Life Sci. 14, 247–252 (1974)
Hamberg, M., Jonsson, C.E.: Increased synthesis of prostaglandins in the guinea pig following scalding injury. Acta physiol. scand. 87, 240–245 (1973)
Hamberg, M., Samuelsson, B.: Novel biological transformations of 8,11,14-eicosatrienoic acid. J. Amer. chem. Soc. 88, 2349–2350 (1966)
Hamberg, M., Samuelsson, B.: On the mechanism of the biosynthesis of prostaglandins E1 and F1α . J. biol. Chem. 242, 5336–5343 (1967a)
Hamberg, M., Samuelsson, B.: Oxygenation of unsaturated fatty acids by vesicular gland of sheep. J. biol. Chem. 242, 5344–5354 (1976b)
Hamberg, M., Samuelsson, B.: On the specificity of the oxygenation of unsaturated fatty acids catalysed by the soybean lipoxidase. J. biol. Chem. 242, 5329–5335 (1967c)
Hamberg, M., Samuelsson, B.: On the metabolism of prostaglandins E1 and E2 in man. J. biol. Chem. 246, 6713–6721 (1971)
Hamberg, M., Samuelsson, B.: On the metabolism of prostaglandins E1 and E2 in the guinea pig. J. biol. Chem. 247, 3495–3502 (1972)
Hamberg, M., Samuelsson, B.: Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc. nat. Acad. Sci. (Wash.) 70, 899–903 (1973)
Hamberg, M., Samuelsson, B.: Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. nat. Acad. Sci. (Wash.) 71, 3400–3404 (1974a)
Hamberg, M., Samuelsson, B.: Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung. Biochem. biophys. Res. Commun. 61, 942–949 (1974b)
Hamberg, M., Samuelsson, B., Björkhem, I., Danielsson, H.: Molecular mechanisms of oxygen activation. New York: Academic Press 1974a
Hamberg, M., Svensson, J., Wakabayashi, T., Samuelsson, B.: Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. nat. Acad. Sci. (Wash.) 71, 345–349 (1974b)
Hamberg, M., Svensson, J., Samuelsson, B.: Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc. nat. Acad. Sci. (Wash.) 71, 3824–3828 (1974 c)
Hamberg, M., Svensson, J., Samuelsson, B.: Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. nat. Acad. Sci. (Wash.) 72, 2994–2998 (1975)
Hammarstrom, S., Hamberg, M., Samuelsson, B., Duell, E.A., Stawiski, M., Voorhees, J.J.: Increased concentrations of non-esterified arachidonic acid, 12L-hydroxy 5,8,10,14,-eicosa-tetraenoic acid, prostaglandin E2 and prostaglandin F2α in epidermis of psoriasis. Proc. nat. Acad. Sci. (Wash.) 72, 5130–5134 (1975)
Hansen, H.S.: Inhibition by indomethacin and aspirin of 15-hydroxy prostaglandin dehydrogenase in vitro. Prostaglandins 8, 95–105 (1974)
Haye, B., Champion, S., Jacquemin, C.: Control of TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid. FEBS Lett. 30, 253–260 (1973)
Hong, S.-C.L., Levine, L.: Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc. nat. Acad. Sci. (Wash.) 73, 1730–1734 (1976)
Horton, E.W.: Hypothesis on physiological roles of prostaglandins. Physiol. Rev. 49, 122–161 (1969)
Horton, E.W., Jones, R.L.: Prostaglandins A1 A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. Brit. J. Pharmacol. 37, 705–722 (1969)
Horton, E.W., Jones, R.L., Marr, G.G.: Effects of aspirin on prostaglandin and fructose levels in human semen. J. Reprod. Fertil. 33, 385–392 (1973)
Jones, R.L.: Actions of prostaglandins on the arterial system of the sheep: some structure-activity relationships. Brit. J. Pharmacol. 53, 464 P (1975)
Kessler, E., Hughes, R.C., Bennett, E. N., Nadella, S. M.: Evidence for the presence of prostaglandin-like material in the plasma of dogs with endotoxin shock. J. Lab. clin. Med. 81, 85–94 (1973)
Kloeze, J.: Relationship between chemical structures and platelet-aggregation activity of prostaglandins. Biochem. biophys. Acta 187, 285–292 (1969)
Kocsis, J.J., Hernandovich, J., Silver, M.J., Smith, J.B., Ingerman, C.: Duration of inhibition of platelet prostaglandin formation and aggregation by ingested aspirin or indomethacin. Prostaglandins 3, 141–145 (1973)
Kunze, H., Bohn, E., Vogt, W.: The effects of local anaesthetics on prostaglandin biosynthesis in vitro. Biochim. biophys. Acta 360, 260–269 (1974)
Kunze, H., Vogt, W.: Significance of phospholipase A for prostaglandin formation. Ann. N. Y. Acad. Sci. 180, 123–125 (1971)
Lands, W.E.M., LeTellier, P. R., Rome, L. H., Vanderhoek J. Y.: Modes of inhibiting the prostaglandin synthetic capacity of sheep vesicular gland preparations. Fed. Proc. 31, 476 A (1972)
Lands, W.E.M., LeTellier, P.R., Rome, L.H., Vanderhoek, J.Y.: Inhibition of prostaglandin biosynthesis. In: Advances in the Biosciences. Bergstrom, S., Bernhard, S. (Eds.). Oxford: Pergamon Press 1973, Vol. IX, pp. 15–28
Lands, W.E.M., Samuelsson, B.: Phospholipid precursors of prostaglandins. Biochim. biophys. Acta 164, 426–429 (1968)
Lee, R.E., Lands, W.E.M.: Cofactors in the biosynthesis of prostaglandins Flα and F2α . Biochim. biophys. Acta 260, 203–211 (1972)
Leslie, C.A., Levine, L.: Evidence for the presence of a prostaglandin E2–9-keto reductase in rat organs. Biochem. biophys. Res. Commun. 52, 717–724 (1973)
Light, R.J., Samuelsson, B.: Identification of prostaglandins in the Gorgonian plexaura homomalla. Europ. J. Biochem. 28, 232–240 (1972)
Limas, C.J., Conn, J. N.: Isolation and properties of myocardial prostaglandin synthetase. Cardiovasc. Res. 7, 623–628 (1973)
Luckner, G., Rene, P.: On the phospholipase activity in bovine seminal vesicles and its possible role in the regulation of the prostaglandin biosynthesis. Z. Naturforsch. 30, 429–433 (1975)
McGiff, J.C., Terragno, N.A., Strand, J.C., Lee, J.B., Lonigro, A.J., Ng, K.K.F.: Selective passage of prostaglandins across the lung. Nature (Lond.) 223, 742–745 (1967)
Maddox, I.S.: Copper in PG synthesis. Biochim. biophys. Acta (Amst.) 306, 74–81 (1973)
Malmsten, C., Hamberg, M., Svensson, J., Samuelsson, B.: Physiological role of an endoperoxide in human platelets: haemostatic defect due to a platelet cyclo-oxygenase deficiency. Proc. nat. Acad. Sci. (Wash.) 72, 1446–1450 (1975)
Marcel, Y.L., Christiansen, K., Holman, R.T.: The preferred metabolic pathway from linolenic acid to arachidonic acid in vitro. Biochim. biophys. Acta 164, 25–34 (1968)
Marnett, L.J., Wlodawer, P., Samuelsson, B.: Light emission during the action of prostaglandin synthetase. Biochem. biophys. Res. Commun. 60, 1286–1294 (1974)
Marnett, L.J., Wlodawer, P., Samuelsson, B.: Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland. J. biol. Chem. 250, 8510–8517 (1975)
Marrazzi, M.A., Matschinsky, M.: Properties of 15-hydroxy prostaglandin dehydrogenase. Structural requirements for binding. Prostaglandins 1, 373–388 (1972)
Milton, A.S., Wendlandt, S.: Effects on body temperature of prostaglandins of the A, E, and F series on injection into the third ventricle of unanaesthetised cats and rabbits. J. Physiol. (Lond.) 218, 325–336 (1971)
Miyamoto, T., Yamamoto, S., Hayaishi, O.: Prostaglandin synthetase system-resolution into oxygenase and isomerase components. Proc. nat. Acad. Sci. (Wash.) 71, 3645–3648 (1974)
Miyares-Cao, C.M., Menendez-Cepero, E.: Identification of prostaglandin-like substances in plants. In: Advances in Prostaglandin and Thromboxane Research. New York: Raven Press 1976, p. 877
Nakano, J.: Metabolism of prostaglandin E1 in dog kidneys. Brit. J. Pharmacol. 40, 317–325 (1970a)
Nakano, J.: Metabolism of Prostaglandin E1 (PGE1) in kidney and lung. Fed. Proc. 29, 746 (1970 b)
Nakano, J.: Effects of the metabolites of prostaglandin E1 of the systemic and peripheral circulation in dogs. Proc. Soc. exp. Biol. (N.Y.) 136, 1265–1268 (1971)
Nakano, J., Änggård, E., Samuelsson, B.: 15-hydroxy prostanoate dehydrogenase. Prostaglandins as substrates and inhibitors. Europ. J. Biochem. 11, 386–389 (1969)
Nakano, J., Montague, B., Darrow, B.: Metabolism of prostaglandin E1 in human plasma, uterus and placenta in swine ovary and in rat testicle. Biochem. Pharmacol. 20, 2512–2514 (1971).
Nakano, J., Morsy, N.H.: Beta-oxidation of prostaglandins E1 and E2 in rat lung and kidney homogenates. Clin. Res. 19, 142 (1971)
Nakano, J., Prancan, A.V.: Metabolic degradation of prostaglandin E1 in the rat plasma and in the rat brain, heart, lung, kidney, and testicle homogenates. J. Pharm. (Lond.) 23, 231–232 (1971)
Nakano, J., Prancan, A.V.: Metabolic degradation of prostaglandin E1 in the lung and kidney of rats in endotoxin shock. Proc. Soc. exp. Biol. (N.Y.) 144, 506–508 (1973)
Nelson, N.A.: Prostaglandin nomenclature. J. med. Chem. 17, 911–918 (1974)
Niehaus, W.G., Samuelsson, B.: Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Europ. J. Biochem. 6, 126–130 (1968)
Nijkamp, F.P., Flower, R.J., Moncada, S., Vane, J.R.: Partial purification of RCS-RF (rabbit aorta conctracting substance releasing factor) and inhibition of its action by anti-inflammatory steroids. Nature. (1976) (in press)
Nissen, H.M., Andersen, H.: On the localization of a prostaglandin-dehydrogenase activity in the kidney. Histochemie 14, 189–200 (1968)
Nissen, H.M., Andersen, H.: On the activity of prostaglandin dehydrogenase system in the kidney. A histo-chemical study during hydration-dehydration and salt-repletion-depletion. Histochemie 17, 241–247 (1969)
Nugteren, D.H.: Inhibition of prostaglandin biosynthesis by 8 cis, 12 trans, 14 cis-eicosatetra-enoic acid. Biochim. biophys. Acta 210, 171–176 (1970)
Nugteren, D.H.: Arachidonate lipoxygenase in blood platelets. Biochim. biophys. Acta 380, 299–307 (1975 a)
Nugteren, D.H.: The determination of prostaglandin metabolites in human urine. J. biol. Chem. 250, 2808–2812 (1975 b)
Nugteren, D.H., Beerthuis, R.K., van Dorp, D.A.: The enzymic conversion of all-cis 8, 14 eicosa-trienoic acid into prostaglandin E1 Rec. Trav. chim. Pays-Bas 85, 405–419 (1966)
Nugteren, D.H., Hazelhof, E.: Isolation and properties of intermediates in prostaglandin biosynthesis. Biochim. biophys. Acta 326, 448–461 (1973)
Pace-Asciak, C.: Polyhydroxy cyclic ethers formed from tritiated arachidonic acid by acetone powders of sheep seminal vesicles. Biochemistry 10, 3664–3669 (1971)
Pace-Asciak, C.: Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norephinephrine and related compounds. Biochim. biophys. Acta 280, 161–171 (1972)
Pace-Asciak, C., Cole, S.: Inhibitors of prostaglandin catabolism. I. Differential sensitivity of 9-PGDH, 13-PGR and 15-PGDH to low concentrations of indomethacin. Experientia (Basel) 31, 143–145 (1975)
Pace-Asciak, C., Miller, D.: Prostaglandins during development I. Age dependent activity profiles of prostaglandin 15-hydroxy dehydrogenase and 13, 14—reductase in lung tissue of late prenatal, early postnatal and adult rats. Prostaglandins 4, 351–362 (1973)
Pace-Asciak, C., Wolfe, L.S.: A novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates. Biochemistry 10, 3657–3664 (1971)
Palmer, M.A., Piper, P.J., Vane, J.R.: Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Brit. J. Pharmacol. 49, 226–242 (1973)
Parkes, D.G., Eling, T.E.: Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid. Biochemistry 13, 2598–2604 (1974)
Parkinson, T.M., Schneider, J.C.: Absorption and metabolism of Prostaglandin El by perfused rat jejunum in vitro. Biochim. biophys. Acta 176, 78 (1969)
Parratt, J.R., Sturgess, R.M.: Evidence that prostaglandin release mediates pulmonary vascular constriction induced by endotoxin. J. Physiol. (Lond.) 84, 41 (1974)
Patriarca, P., Beckerdite, S., Elsbach, P.: Phospholipases and phospholipid turnover in Escherichia coli spheroplasts. Biochim. biophys. Acta 260, 593–600 (1972)
Paulsrud, J.R., Miller, O.N., Schlegel, W.: Inhibition of 15-OH-prostaglandin dehydrogenase by several diuretic drugs. Fed. Proc. 33, 590 (1974)
Pike, J.E., Kupiecki, F. P., Weeks, J.R.: Biological activity of the prostaglandins and related analogies, In: Prostaglandins, Nobel Symposium, Vol.11, pp.161–171. New York: Interscience 1967
Piper, P.J., Vane, J.R.: Release of additional factors in anaphylaxis and its antagonism by antiinflammatory drugs. Nature (Lond.) 233, 29–35 (1969)
Piper, P.J., Vane, J.R.: The release of prostaglandins from lung and other tissues. Ann. N.Y. Acad. Sci. 180, 363–385 (1971)
Piper, P.J., Vane, J.R., Wyllie, J.H.: Inactivation of prostaglandins by the lungs. Nature (Lond.) 225, 600–604 (1970)
Pollard, J., Flower, R.J.: (1973) Unpublished observations
Portoghese, P.S., Svanborg, K., Samuelsson, B.: Oxidation of oxyphenbutazone by sheep vesicular gland microsomes and lipoxygenase. Biochem. biophys. Res. Commun. 63, 748–755 (1975)
Ramwell, P.W., Shaw, J.E.: Biological significance of the prostaglandins. Recent Progr. Hormone Res. 26, 139–187 (1970)
Raz, A., Schwartzman, M., Gafni, Y., Kenig-Wakshal, R.: Properties of solubilized prostaglandin synthetase from sheep vesicular glands and from rabbit and rat kidney. In: Advances in Prostaglandin and Thrombosane Research, pp. 859–860. New York: Raven Press 1976
Rose, A. J., Collins, A. J.: The effect of pH on the production of prostaglandins E2 and F2α , and a possible pH dependent inhibitor. Prostaglandins 8, 271–283 (1974)
Roth, G.J., Stanford, N., Majerus, P.W.: Acetylation of prostaglandin synthetase by aspirin. Proc. nat. Acad. Sci. (Wash.) 72, 3073–3076 (1975)
Ruthven, C.R.J., Sandler, M.: An improved method for the estimation of homovanillic acid in human urine. Clin. chim. Acta 14, 511–518 (1966)
Samuelsson, B.: On the incorporation of oxygen in the conversion of 8, 11, 14-eicosatrienoic acid to prostaglandin E1 J. Amer. chem. Soc. 87, 3011–3013 (1965)
Samuelsson, B.: Biosynthesis of prostaglandins. Progr. biochem. Pharmacol. 5, 109–128 (1969)
Samuelsson, B.: Structures, biosynthesis and metabolism of prostaglandins. In: Lipid Metabolism, pp. 107–153. New York-London: Academic Press 1970
Samuelsson, B.: Biosynthesis of prostaglandins. Fed. Proc. 31, 1442–1450 (1972)
Samuelsson, B., Granström, E., Green, K., Hamberg, M.: Metabolism of prostaglandins. Ann. N.Y. Acad. Sci. 180, 138–163 (1971)
Samuelsson, B., Granström, E., Hamberg, M.: On the mechanisms of the biosynthesis of prostaglandins. In: Prostaglandins, Nobel Symposium, Vol. II, pp. 31–44. Stockholm: Almqvist and Wicksell 1967
Samuelsson, B., Gréen, K.: Endogenous levels of 15-keto-dihydro prostaglandins in human plasma. Parameters for monitoring prostaglandin synthesis. Biochem. Med. 11, 298–303 (1974)
Samuelsson, B., Hamberg, M.: Role of endoperoxides in the biosynthesis and action of Prostaglandins. In: Prostaglandin Synthetase Inhibitors, pp. 107–119. New York: Raven Press 1974
Scandella, J., Kornberg, A.: A membrane bound phospholipase A1 purified from Escherichia coli. Biochemistry 10, 4447–4456 (1971)
Scarnes, R.C., Harper, M.J. K.: Relationship between endotoxin induced abortion and synthesis of prostaglandin F. Prostaglandins 1, 191–203 (1972)
Scherphof, G.L., Scarpa, A., Van Toorenenbergen, A.: The effect of local anesthetics on the hydrolysis of free and bound membrane phospholipids catalysed by various phospholipases. Biochim. biophys. Acta 270, 226–240 (1972)
Schultz, H.W.: Symposium on foods: lipids and their oxidation. Westport: AVI Publ. Co. 1962
Sih, C.J., Takeguchi, C.A.: Biosynthesis. In: The Prostaglandins, pp. 83–100. New York-London: Plenum Press 1973
Smith, M.J.H., Dawkins, P.D.: Salicylate and enzymes. J. Pharm. (Lond.) 23, 729–744 (1971)
Smith, W.L., Lands, W.E.M.: Stimulation and blockade of prostaglandin biosynthesis. J. biol. Chem. 246, 6700–6704 (1971)
Smith, W.L., Lands, W.E.M.: Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep seminal vesicular glands. Biochemistry 11, 3276–3285 (1972)
Smith, J.B., MacFarlane, D.E.: Platelets. In: The Prostaglandins, pp. 293–335. New York-London: Plenum Press 1974
Sprecher, H., Lee, C.J.: The absence of an 8-desaturase in rat liver: a re-evaluation of optional pathways for the metabolism of linoleic and linolenic acids. Biochem. biophys. Acta 388, 113–125 (1975)
Steiner, M.: Platelet protein synthesis studied in a cell-free system. Experientia (Basel) 26, 786–789 (1970)
Strandberg, K., Hamberg, M.: Increased excretion of 5α 7α dihydroxy-11-keto tetranor prostanoic acid on anaphylaxis in the guinea-pig. Prostaglandins 6, 159–170 (1974)
Sun, F.F., Armour, S.R.: Prostaglandin 15-hydroxy dehydrogenase and 13 reductase levels in the lungs of maternal fetal and neonatal rabbits. Prostaglandins 7, 327–338 (1974)
Takeguchi, C., Kohno, E., Sih, C.J.: Mechanism of prostaglandin biosynthesiS.I. Characterization and assay of bovine prostaglandin synthetase. Biochemistry 10, 2372–2376 (1971)
Takeguchi, C., Sih, C.J.: A rapid spectrophotometric assay for prostaglandin synthetase: application of the study of non-steroidal, anti-inflammatory agents. Prostaglandins 2, 169–184 (1972)
Tan, L., Wang, H.M., Lehoux, J.-G.: Binding of prostaglandins and cytochrome P-450. Prostaglandins 4, 9–17 (1973)
Tappel, A.L.: Oxidative fat rancidity in food product: lin oleate oxidation catalyzed by hemin, hemoglobin, cytochrome. Food Res. 18, 560–573 (1953)
Tappel, A.L.: Lipoxidase. In: The Enzymes. New York: Academic Press 1963, pp. 275–283
Tomlinson, R.V., Ringold, H.J., Qureshi, M.C., Forchielli, E.: Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs. Biochem. biophys. Res. Commun. 46, 552–559 (1972)
Turner, S.R., Trainer, J.A., Lynn, W.S.: Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Nature (Lond.) 257, 680–681 (1975)
Vane, J.R.: Inhibition of prostaglandin synthetase as a mechanism of action for aspirin-like drugs. Nature (New Biol.) 231, 232–235 (1971)
Vane, J.R.: Prostaglandins as mediators of inflammation. In: Advances in Prostaglandin and Thromboxane Research, pp. 791–801. New York: Raven Press 1976
Vargaftig, B.B.; Dao Hai, N.: Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin. J. Pharm. (Lond.) 24, 159–161 (1972)
Varley, H.: Practical clinical biochemistry, 4th. ed. London: Medical Books Ltd. 1967
Vogt, W., Meyer, U., Kunze, H., Lufft, E., Babilli, S.: Entstehung von SRS-C in der durchströmten Meerschweinchenlunge durch Phospholipase A. Identifizierung mit Prostaglandin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 262, 124–134 (1969)
Vonkeman, H., van Dorp, D.A.: The action of prostaglandin synthetase on 2-arachidonyl-lecithin. Biochim. biophys. Acta 164, 430–432 (1968)
Wallach, D.P.: Enzymatic conversion of arachidonic acid to prostaglandin E2 with acetone powder preparations of bovine seminal vesicles. Life Sci. 4, 361–364 (1965)
Wallach, D. P., Daniels, E.G.: Properties of a novel preparation of prostaglandin synthetase from sheep seminal vesicles. Biochim. biophys. Acta 231, 445–457 (1971)
Willis, A.L., Cornai, K., Kuhn, D.C., Paulsrud, J.: Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivo. Prostaglandins 8, 509–519 (1974 a)
Willis, A.L., Vane, F.M., Kuhn, D.C., Scott, S.G., Petrin, M.: An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli. Prostaglandins 8, 453–507 (1974b)
Wlodawer, P., Samuelsson, B.: On the organization and mechanism of prostaglandin synthetase. J. biol. Chem. 248, 5673–5678 (1973)
Yoshimoto, A., Ito, H., Tomita, K.: Cofactor requirements of the enzyme synthesising prostaglandin in bovine seminal vesicles. J. Biochem. (Tokyo) 68, 487–499 (1970)
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Flower, R.J. (1978). Prostaglandins and Related Compounds. In: Vane, J.R., Ferreira, S.H. (eds) Inflammation. Handbook of Experimental Pharmacology, vol 50 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66888-3_13
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