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Lymphokines

  • Chapter
Inflammation

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 1))

Abstract

Allergic responses can be broadly divided into antibody-mediated and cell-mediated responses. This division was first appreciated by Zinsser (1925) who noted the delay in onset of skin reactions evoked in animals sensitized by intracellular parasites as compared with the relatively rapid response to antigen in animals sensitized by intradermal administration of protein antigen. An experimental basis for this distinction was provided by Landsteinder and Chase (1942), who demonstrated that delayed type hypersensitivity could be transferred to unsensitized guinea pigs by injection of live lymphoid cells from sensitized donor animals, but not by serum, dead cells or cell extracts. This contrasted with the immediate type of response which could be transferred to unsensitized animals by injection of serum and which was known to be attributable to immunoglobulins present in the serum. Subsequently, similar experimental evidence was obtained for other allergic responses of delayed onset, so that by the mid-1960s, there was general agreement as to the validity of grouping responses such as contact sensitivity, bacterial allergy and homograft rejection under the common heading of delayed hypersensitivity (Turk, 1967).

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Authors
  1. J. Morley
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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© 1978 Springer-Verlag Berlin Heidelberg

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Morley, J. (1978). Lymphokines. In: Vane, J.R., Ferreira, S.H. (eds) Inflammation. Handbook of Experimental Pharmacology, vol 50 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66888-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-66888-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66890-6

  • Online ISBN: 978-3-642-66888-3

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