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Reaction of Rat Hypothalamic, Supraoptic, and Arcuate Nuclei Neurons in Experiment

  • S. L. Kuznetsov
Conference paper

Abstract

Studies on 65 male rats were made by comparing the activity of supraoptic- (SON) and arcuate (AN)-nuclei neurons after dehydration, unilateral adrenalectomy, and nonspecific-factor effect, i.e., growth of Jensen’s-sarcoma conditions. The neuronal activity was assessed by the neuronal-nucleolar optical density (OD) after staining with gallocyanin chromalum (EINARSON, 1951). After 2 days of dry feeding, considerable activation of SON neurons was observed (with OD increasing to 112%, P < 0.01). This activation remained until the 5th day, when the level fell. After unilateral adrenalectomy, neuronal activity increased by 109% compared with that of sham-operated rats. In Jensen’s-sarcoma growth conditions, the SON neuronal activation was observed on the 21st day of the experiment, and was somewhat lower on the 35th day. AN neuronal activity after 2 days of dehydration was strikingly increased (118.5%, P < 0.001) with a negligible decrease on the 5th day. After unilateral adrenalectomy the activity was practically unchanged on the 5th day, but it decreased on the 15th day (94% of control, P < 0.05). The AN neurons’ response to Jensen’s-sarcoma growth was the same as that of the SON neurons, but it was less marked. The data enable us to conclude that the system of magno- and parvocellular hypothalamic nuclei is involved in stress-reaction formation and in aqueoussaline- equilibrium regulation. The increase of SON neuronal activity on the 15th day after adrenalectomy, when there is some decrease of AN neuronal activity, suggests that the SON has a predominant role in compensatory hypertrophy of the adrenal gland.

Keywords

Optical Density Adrenal Gland Neuronal Activity Medical Institute Predominant Role 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • S. L. Kuznetsov
    • 1
  1. 1.The First Moscow Medical InstituteMoscowUSSR

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