Skip to main content
SpringerLink
Log in

Role of the Leukocyte and Chemical Mediators of the Acute Gouty Attack

  • Chapter
Uric Acid

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 51))

  • 322 Accesses

Abstract

Experimental work in vivo (McCarty, 1970) has shown that the introduction of monosodium urate crystals into a joint cavity initiates an acute inflammatory response. Polymorphonuclear leukocytes are normally present in synovial fluid and phagocytosis of crystals by polymorphonuclear leukocytes occurs readily. Experimental work on animals has shown that the phagocytosis of crystals by polymorphonuclear leukocytes occurs independently of complement (Spilberg and Osterland, 1970). The crystals are taken into phagosomes which then merge with primary lysosomes to form phagolysosomes or secondary lysosomes. Electron microscopic studies indicate that after a crystal lies in contact with the membrane of the phagolysosome, dissolution of the membrane occurs and is followed by cell death (Schumacher and Phelps, 1968). Cell death, however, appears to be a slow process, since neutrophils which have previously ingested urate crystals in vitro have been reported to exhibit a normal phagocytic capacity for yeast (Turner et al., 1973). Weissmann and Rita (1972) have postulated that lysis of the lysosomal membrane is due to the interaction of weakly anionic urate crystals with the membrane, forming cooperative hydrogen bonds with phosphate esters of membrane phospholipids. Not only do urate crystals disrupt lysosomal membranes, they also lyse red cells (Wallingford and McCarty, 1971), the plasma membrane of polymorphonuclear leukocytes (Spilberg et al., 1975), and liposomes (Weissman and Rita, 1972), lamellar arrays of phospholipids containing cholesterol in their membranes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Austic, R.E., Cole, R.K.: Impaired renal clearance of uric acid in chickens having hyperuricemia and articular gout. Amer. J. Physiol. 223, 525–530 (1972)

    PubMed  CAS  Google Scholar 

  • Bandmann, U., Rydgren, L., Norberg, B.: The difference between random movement and Chemotaxis. Effects of antitubulins on neutrophil granulocyte locomotion. Exp. Cell Res. 88, 63–73 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Becker, E.L., Sowell, H.J., Henson, P.M., Hsu, L.S.: The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of the release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness. J. Immunol. 112, 2045–2054 (1974)

    Google Scholar 

  • Boucek, M.M., Snyderman, R.: Calcium influx requirement for human neutrophil Chemotaxis: inhibition by lanthanun chloride. Science 193, 905–907 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Bourne, H.R. et al.: Cyclic adnosine-3′, 5′-monophosphate and the regulation of human granulocyte function. J. clin. Invest. 49, 11 a Abstr. (1972)

    Google Scholar 

  • Brai, M., Oster, A.G.: Studies on the C3 shunt activation in cobra venom induced lysis of unsen-sitized erythrocytes. Proc. Soc. exp. Biol. (Med.) 140, 1116–1121 (1972)

    CAS  Google Scholar 

  • Bunch, T.W., Hunder, G.G., McDuffie, F.C., O’Brien, P.C., Markowitz, H.: Synovial fluid complement determination as a diagnostic aid in inflammatory joint diseases. Mayo Clin. Proc. 49, 715–720 (1974)

    PubMed  CAS  Google Scholar 

  • Canellakis, E.S., Tuttle, A.L., Cohen, P.P.: A comparative study of the end products of uric acid oxidation by peroxidases. J. biol. Chem. 213, 397–404 (1955)

    PubMed  CAS  Google Scholar 

  • Carter, S.B.: Principle of cell motility: the direction of cell movement and cancer invasion. Nature (Lond.) 108, 1183–1187 (1965)

    Article  Google Scholar 

  • Chang, Y.: Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation. Pharm, exp. Ther. 183, 235–244 (1972)

    CAS  Google Scholar 

  • Chang, Y., Gialla, E. J.: Suppression of urate crystalinduced canine joints inflammation by heterologous antipolymorphonuclear leukocyte serum. Arthr. and Rheum. 11, 145–150 (1968)

    Article  CAS  Google Scholar 

  • Cochrane, C. G., Revak, S. D., Aiken, B. S., Sitzer, S. S.: The structural characteristic and activation of Hageman factor in inflammation: mechanisms and control. In: Lepon, I.H., Ward, P.A. (Eds.). New York: Academic Press 1973

    Google Scholar 

  • Cohn, A.Z., Morse, S.I.: Functional and metabolic properties of polymorphonuclear leukocytes. I. Observations in the requirements and consequences of particle ingestion. J. exp. Med. 111, 667–687 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Denko, C.W.: A phlogistic function of prostaglandin E1 in urate crystal inflammation. J. Rheum. 1, 222–229 (1974)

    PubMed  CAS  Google Scholar 

  • Dipasquale, G., Rassaert, R., Welaj, P., Tripp, L.: Influence of prostaglandins (PG)E2 and F2α on the inflammatory process. Prostaglandins 3, 741–757 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Donaldson, V.H., Gluek, H.I., Fleming, T.: Rheumatoid arthritis in a patient with Hageman trait. New Engl. J. Med. 286, 528–530 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Eisen, V.: Plasma kinins in synovial exudates. Brit. J. exp. Path. 51, 322–325 (1970)

    PubMed  CAS  Google Scholar 

  • Elsbach, P.: Composition and synthesis of lipids in resting and phagocyting leukocytes. J. exp. Med. 110, 969–980 (1959)

    Article  CAS  Google Scholar 

  • Fostiropoulus, K., Austen, K.F., Bloch, K.J.: Total hemolytic complement and second component of complement activity in serum and synovial fluid. Arthr. and Rheum. 8, 219–232 (1965)

    Article  Google Scholar 

  • Gallin, J.I., Durocher, J., Kaplan, A.P.: Interaction of leukocyte chemotactic factors with the cell surface. I. Chemotactic factor induced changes in human granulocyte surface charges. J. clin. Invest. 55, 967–974 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Glatt, M., Peska, B., Brune, K.: Leukocytes and prostaglandins in acute inflammation. Experien-tia (Basel) 30, 1257–1259 (1974)

    Article  CAS  Google Scholar 

  • Glatt, M., Peska, B., Brune, K.: Leukocytes and prostaglandins in acute inflammation. Experien-tia (Basel) 30, 1257–1259 (1974)

    Article  CAS  Google Scholar 

  • Goetzl, E.J., Austen, K.F.: A method for assessing the in vitro chemotactic response of neutrophil utilizing CR 51 labeled human leukocytes. Immunol. Commun. 1, 421–430 (1972)

    PubMed  CAS  Google Scholar 

  • Goetzl, E.J., Austen, K.F.: Active site chemotactic factors and the regulation of the human neutrophil chemotactic response. Antibiot. Chemother. 19, 218–232 (1974)

    PubMed  CAS  Google Scholar 

  • Goldfinger, S.E., Howell, R.R., Seegmiller, J.E.: Suppression of metabolic accompaniments of phagocytosis by colchicine. Arthr. and Rheum. 8, 1112–1122 (1965)

    Article  CAS  Google Scholar 

  • Goldstein, I., Hoffstein, S., Gallin, J., Weissmann, G.: Mechanisms of lysosomal enzyme release from human leukocytes: Microtubule assembly and membrane fusion induced by a component of complement. Proc. nat. Acad. Sci. (Wash.) 70, 2916–2920 (1973)

    Article  CAS  Google Scholar 

  • Goldstein, I., Hoffstein, S.T., Weissmann, G.: Influence of divalent cations upon complement-mediated enzyme release from human polymorphonuclear leukocytes. J. Immunol. 115, 665–670 (1975)

    PubMed  CAS  Google Scholar 

  • Greenbaum, L.M., Kin, K.S.: The kinin forming and kinidase activities of rabbit polymorphonuclear leukocytes. Brit. J. pharm. Chemother. 29, 238–247 (1967)

    CAS  Google Scholar 

  • Hasselbacher, P., Schumacher, H. R. Jr.: Localization of immunoglobulin in gouty tophi by im-munohistology, and on the surface of monosodium urate crystals (MSU) by immune agglutination. Arthr. and Rheum. 19, 802 Abstr. (1976)

    Google Scholar 

  • Henson, P.M.: Secretion of lysosomal enzymes induced by immune complexes and complement. In: Dingle, J.T., Dean, R.T. (Eds.): Lysosomes in Biology and Pathology, Vol. 5. New York: American Elsevier Publishers 1976

    Google Scholar 

  • Hoffstein, S., Weissmann, G.: Mechanisms of lysosomal enzyme release from leukocytes. IV. Interaction of monosodium urate crystals with dogfish and human leukocytes. Arthr. and Rheum. 18, 153–165 (1975)

    Article  CAS  Google Scholar 

  • Horton, E.W.: Hypothesis on physiological roles of prostaglandins. Physiol. Rev. 49, 122–161 (1969)

    PubMed  CAS  Google Scholar 

  • Ignarro, L.J.: Regulation of lysosomal enzyme release by prostaglandins, autonomic neurohormones and cyclic nucleotides. In: Dingle, J.T., Dean, R.T. (Eds.): Lysosomes in Biology and Pathology, Vol. 4. New York: American Elsevier Publishers 1975

    Google Scholar 

  • Janoff, A., Feinstein, G., Melemud, C., Elias, J.M.: Degradation of cartilage proteoglycan by human leukocyte granule neutral protease.—A model of joint injury. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue. J. clin. Invest. 57, 615–624 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Kaley, G., Weiner, R.: Prostaglandin E1: A potential mediator of the inflammatory response. Ann. N.Y. Acad. Sci. 180, 338–350 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Kellermeyer, R.W.: Hageman factor and acute gouty arthritis. Arthr. and Rheum. 11, 452–459 (1968)

    Article  CAS  Google Scholar 

  • Klinenberg, J.R., Bluestone, R., Schlosstein, L., Waisman, J., Whitehouse, M.W.: Urate deposition disease. How it is regulated and how can it be modified? Ann. intern. Med. 78, 99–111 (1973)

    PubMed  CAS  Google Scholar 

  • Kozin, F., McCarty, D.J.: Protein adsorption to monosodium urate, calcium pyrophosphate dihydrate, and silica crystals. Arthr. and Rheum. 19, 433–438 (1976a)

    Article  CAS  Google Scholar 

  • Kozin, F., McCarty, D.J.: Adsorption of protein monosodium urate crystals: A possible mechanism of crystal-induced inflammation. Arthr. and Rheum. (Abstr.) 19, 805 (1976 b)

    Google Scholar 

  • Kozin, F., Skosey, J.L., May, J., Chow, D.C.: Modification of responses of human neutrophils to monosodium urate crystals by coating of crystals with serum proteins. Clin. Res. (Abstr.) 24, 331a (1976)

    Google Scholar 

  • Lohmander, S., Moskalewski, S., Madsen, K., Thyberg, J., Friberg, V.: Influence of colchicine on the synthesis and secretion of proteoglycans and collagen by fetal guinea-pig chondrocytes. Exp. Cell Res. 99, 333–345 (1976)

    Article  PubMed  CAS  Google Scholar 

  • McCall, E., Youlten, L.J.: Proceedings: Prostaglandin E1 synthesis by phagocytosing rabbit polymorphonuclear leukocytes: its inhibition by indomethacin and its role in Chemotaxis. J. Physiol. (Lond.) 234, 98–100 (1973)

    Google Scholar 

  • McCarty, D.J., Jr.: On the crystal deposition diseases. Dis. Month. March (1970)

    Google Scholar 

  • Malawista, S.E.: Colchicine: The common mechanism for its anti-inflammatory and anti-mytotic effects. Arthr. and Rheum. 11, 191–197 (1968)

    Article  CAS  Google Scholar 

  • Malawista, S.E., Bodel, P.T.: The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J. clin. Invest. 46, 786–796 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Mandell, B., Spilberg, I.: Role of a chemotactic factor activated serine esterase in polymorphonuclear leukocytes capping. Clin. Res. 25, (Abstr.) 363 A (1977)

    Google Scholar 

  • Mandell, B., Spilberg, I., Lichman, J.: Inhibitions of polymorphonuclear leukocyte capping by a chemotactic factor. J. Immunol. 118, 1375–1378 (1977)

    PubMed  CAS  Google Scholar 

  • Melmon, K.L., Webster, M.E., Goldfinger, S.E. et al.: The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies. Arthr. and Rheum. 10, 13–20 (1967)

    Article  CAS  Google Scholar 

  • Movat, H.Z., Habal, F.M., Macmorine, D.R.L.: Generation of a vasoactive peptide by a neutral protease of human neutrophil leukocytes. Agents Actions 6, 183–190 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Musson, R., Becker, E.L.: The inhibitory effect of chemotactic factors on erythrophagocytosis by human neutrophils. J. Immunol. 117, 433–439 (1976)

    PubMed  CAS  Google Scholar 

  • Naff, G.B., Myers, P.H.: Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals. J. Lab. clin. Med. 81, 747–760 (1960)

    Google Scholar 

  • Oliver, J.M., Zurier, R.B., Berlin, R.D.: Concanavalin-A cap formation on polymorphonuclear leukocytes of normal and beige (Chediak-Higashi) mice. Nature (Lond.) 253, 471–473 (1974)

    Article  Google Scholar 

  • Pekin, T.J., Zvaifler, N. J.: Hemolytic complement in synovial fluid. J. clin. Invest. 43, 1372–1382 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Phelps, P.: Polymorphonuclear leukocyte motility in vitro. IV. Colchicine inhibition of chemo-tactic activity formation after phagocytosis of urate-crystals. Arthr. and Rheum. 13, 1–12 (1970a)

    Article  CAS  Google Scholar 

  • Phelps, P.: Appearance of chemotactic activity following intraarticular injection of monosodium urate crystals: effect of colchicine. J. Lab. clin. Med. 76, 622–631 (1970b)

    PubMed  CAS  Google Scholar 

  • Phelps, P., McCarty, D.J., Jr.: Crystal induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes. J. exp. Med. 124, 115–127 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Phelps, P., McCarty, D.J.: Crystal induced arthritis. Postgrad, med. 45, 87–94 (1969)

    CAS  Google Scholar 

  • Phelps, P., Prockop, D.J., McCarty, D.J.: Crystal induced inflammation in canine joints. III. Evidence against bradykinin as mediator of inflammation. J. Lab. clin. Med. 68, 433–444 (1966a)

    PubMed  CAS  Google Scholar 

  • Ratnoff, O.D.: The biology and pathology of the initial stages of blood coagulation. Progr. Hematol. 5, 204–245 (1966)

    CAS  Google Scholar 

  • Rivkin, I., Rosenblat, J., Becker, E.L.: The role of cyclic AMP in the chemotactic responsiveness and expontaneous motility of rabbit peritoneal neutrophils. J. Immunol. 115, 1126–1134 (1975)

    PubMed  CAS  Google Scholar 

  • Ruddy, S., Gigli, I., Austen, F.: The complement system in man. I. New Engl. J. Med. 287, 489 – 495 (1972)

    Article  CAS  Google Scholar 

  • Rydgren, L., Simingskold, G., Bandman, V., Norberg, G.: The role of cytoplasmic microtubules in polymorphonuclear leukocyte Chemotaxis. Exp. Cell Res. 99, 207–220 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Rynes, R.I., Ruddy, S., Schur, P.H., Spragg, J., Austen, K.F.: Levels of complement components, properdin factors, and kininogen in patients with inflammatory arthritis. J. Rheum. 1, 413 – 427 (1974)

    Google Scholar 

  • Sbarra, A.J., Karnovsky, M.L.: The biochemical basis of phagocytosis. J. biol. Chem. 234, 1355 – 1362(1959)

    PubMed  CAS  Google Scholar 

  • Schliwa, M.: The role of divalent cations in the regulation of microtubule assembly. J. Cell Biol. 70, 527–540 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Schotthauer, C.V., Bollman, J.I.: Spontaneous gout in turkeys. J. Amer. Vet. med. Ass. 85, 98 – 103 (1934)

    Google Scholar 

  • Schlumberger, H.G.: Synovial gout in the parakeet. Lab. Invest. 8, 1304–1318 (1959)

    PubMed  CAS  Google Scholar 

  • Schumacher, H.R., Phelps, P.: Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopy study. Arthr. and Rheum. 11, 145–150 (1968)

    Article  Google Scholar 

  • Scott, R.E.: Effects of prostaglandins, epinephrine and NaF on human leukocyte, platelet and liver adrenyl cyclase. Blood 35, 514–516 (1970)

    PubMed  CAS  Google Scholar 

  • Skosey, J.L., Kozin, F., Chow, D.C., May, J.: Differential responses of human neutrophils to monosodium urate crystals (MSU) and MSU coated with gamma globulin. Clin. Res. 24, (Abstr.) 11a (1976)

    Google Scholar 

  • Smith, J.B., Willis, A.L.: Aspirin selectively inhibits prostaglandin production in human platelets. Nature (Lond.) New Biol. 231, 235–237 (1971)

    CAS  Google Scholar 

  • Spilberg, I.: Studies on the mechanisms of inflammation induced by calcium pyrophosphate crystals. J. Lab. clin. Med. 82, 86–91 (1973)

    PubMed  CAS  Google Scholar 

  • Spilberg, J.: Urate crystal arthritis in animals lacking Hageman factor. Arthr. and Rheum. 17, 143–148 (1974)

    Article  CAS  Google Scholar 

  • Spilberg, I.: Current concepts of the mechanisms of acute inflammation in gouty arthritis. Arthr. and Rheum. 18, 129–134 (1975)

    Article  CAS  Google Scholar 

  • Spilberg, I., Gallacher, A., Mandell, B.: Studies on crystal induced chemotactic factor. II. Role of phagocytosis. J. Lab. clin. Med. 85, 631–636 (1975)

    PubMed  CAS  Google Scholar 

  • Spilberg, J., Gallacher, A., Mandell, B.: Calcium pyrophosphate dihydrate (CPPD) crystal induced chemotactic factor. Subcellular localization, role of protein synthesis and phagocytosis. J. Lab. clin. Med. 89, 817–822 (1977b)

    PubMed  CAS  Google Scholar 

  • Spilberg, I., Gallacher, A., Mehta, J.M., Mandell, B.: Urate crystal induced chemotactic factor. Isolation and partial characterization. J. clin. Invest. 58, 815–819 (1976)

    Article  CAS  Google Scholar 

  • Spilberg, I., Mandell, B., Wochner, R.D.: Studies on crystal induced chemotactic factor. I. Role of protein synthesis and neutral protease activity. J. Lab. clin. Med. 83, 56–63 (1974)

    PubMed  CAS  Google Scholar 

  • Spilberg, I., Osterland, C.K.: Anti-inflammatory effect of the trypsin-kallikrein inhibitor in acute arthritis induced by urate crystals in rabbits. J. Lab. clin. Med. 76, 472–479 (1970)

    PubMed  CAS  Google Scholar 

  • Spilberg, I., Rosenberg, D., Mandell, B.: Induction of arthritis by purified cell derived chemotactic factor. Role of Chemotaxis and vascular permeability. J. clin. Invest. 59, 582–585 (1977 c)

    Article  PubMed  CAS  Google Scholar 

  • Spilberg, I., Rosenberg, D., Mehta, J.: Induction of cell derived chemotactic factor and of arthritis by amorphous diamond crystals. Arthr. and Rheum. (Abstr.) 20, 136 (1977d)

    Google Scholar 

  • Spilberg, I., Tanphaichitr, K., Kantor, O.: Synovial fluid pH in acute gouty arthritis. Arthr. and Rheum. 20, 142 (1977 a)

    Article  Google Scholar 

  • Tse, R.L., Phelps, P., Urban, D.: Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogs: possible role of cyclic AMP. J. Lab. clin. Med. 80, 264–274 (1972)

    PubMed  CAS  Google Scholar 

  • Turner, R.A., Schumacher, H.R., Myers, A.R.: Phagocytic function of polymorphonuclear leukocytes in rheumatic diseases. J. clin. Invest. 52, 1632–1635 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Vane, J.R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (Lond.) New Biol. 231, 232–235 (1971)

    CAS  Google Scholar 

  • Wallingford, W.R., McCarty, D.J.: Differential membranolytic effects of microcrystalline sodium urate and calcium pyrophosphate dihydrate. J. exp. Med. 133, 100–112 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Ward, P.A.: Complement derived chemotactic factors and their interaction with neutrophilic granulocytes. Ingrahm proceedings of the international symposium on the biological activities of complement, pp. 108–116. Basel: Karger AG 1971

    Google Scholar 

  • Ward, P.A., Becker, E.L.: The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase. J. exp. Med. 127, 693–709 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Ward, P.A., Becker, E.L.: Biochemical demonstration of the activatable esterase of the rabbit neutrophil involved in the chemotactic response. J. Immunol. 105, 1057–1067 (1970)

    PubMed  CAS  Google Scholar 

  • Weissmann, G.: Lysosomal mechanisms of tissue injury in arthritis. New Engl. J. Med. 286, 141 – 147 (1972)

    CAS  Google Scholar 

  • Weissmann, G., Rita, G.A.: Molecular basis of gouty inflammation: Interaction of monosodium urate crystals with lysosomes and lyposomes. Nature (Lond.) New Biol. 240, 167–172 (1972)

    Article  CAS  Google Scholar 

  • Weissmann, G., Spilberg, I., Krakauer, K.: Arthritis induced in rabbits by lysates of granulocyte lysosomes. Arthr. and Rheum. 12, 103–116 (1969)

    Article  CAS  Google Scholar 

  • Wilson, L., Banburg, J.R., Mizel, S.B. et al.: Interaction of drugs with microtubule proteins. Fed. Proc. 33, 158–166 (1974)

    PubMed  CAS  Google Scholar 

  • Zigmond, S.H.: Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes. Nature (Lond.) 249, 450–452 (1974)

    Article  CAS  Google Scholar 

  • Zigmond, S.H., Hirsch, J.G.: Leukocyte locomotion and Chemotaxis. New methods for evaluation, and demonstration of a cell-derived factor. J. exp. Med. 137, 387–410 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Zurier, R.B., Quagliata, F.: Effect of prostaglandin E1 on adjuvant arthritis. Nature (Lond.) 234, 304–305 (1971)

    Article  CAS  Google Scholar 

Download references

Authors
  1. I. Spilberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA

    William N. Kelley MD (Professor and Chairman) (Professor and Chairman)

  2. Department of Pathology, Upstate Medical Center, Syracuse, NY, 13210, USA

    Irwin M. Weiner MD (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Spilberg, I. (1978). Role of the Leukocyte and Chemical Mediators of the Acute Gouty Attack. In: Kelley, W.N., Weiner, I.M. (eds) Uric Acid. Handbook of Experimental Pharmacology, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66867-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66867-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66869-2

  • Online ISBN: 978-3-642-66867-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation