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Role of Proteoglycans in the Development of Gouty Arthritis

  • Chapter
Uric Acid

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 51))

Abstract

Gout is defined as the deposition of urate crystals, clinically expressed by acute arthritis or tophi. It is well accepted that hyperuricemia, or at least an abnormally high total uric acid pool, is a critical precursor to the deposition phenomenon and that urate crystals, once precipitated in the joint, give rise to an intense phlogistic reaction. The mechanism of urate deposition remains enigmatic and controversial. Garrod (1876) was one of the first to recognize that gouty arthritis was caused by the precipitation of sodium urate crystals in the joints or neighboring tissues:

“Gouty inflammation is invariably attended with the deposition of urate of soda... This fact I wish to impress forcibly upon my readers because in the constancy of such deposition lies the clue that has long been wanting; the occurrence of the deposit is at once pathognomonic and separates gout from every other disease which at first sight might appear allied to it.”

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Authors
  1. W. A. Katz
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Editors and Affiliations

  1. Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA

    William N. Kelley MD (Professor and Chairman) (Professor and Chairman)

  2. Department of Pathology, Upstate Medical Center, Syracuse, NY, 13210, USA

    Irwin M. Weiner MD (Professor and Chairman) (Professor and Chairman)

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© 1978 Springer-Verlag Berlin Heidelberg

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Katz, W.A. (1978). Role of Proteoglycans in the Development of Gouty Arthritis. In: Kelley, W.N., Weiner, I.M. (eds) Uric Acid. Handbook of Experimental Pharmacology, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66867-8_14

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  • DOI: https://doi.org/10.1007/978-3-642-66867-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66869-2

  • Online ISBN: 978-3-642-66867-8

  • eBook Packages: Springer Book Archive

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