Abstract
A precise description of the initial events of an episode of acute gouty arthritis as it spontaneously occurs is not possible, as there have been no sequential studies in humans beginning before the onset of acute inflammation. Part of the picture, however, can be constructed from experimental human and dog studies and from observations during spontaneous arthritis. Crystals of monosodium urate seem to be essential for induction of gouty joint inflammation. There are several possible ways in which they may do this.
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References
Agudelo, C.A., Schumacher, H.R.: The synovitis of acute gouty arthritis. A light and electron microscopic study. Hum. Pathol. 2, 265–279 (1973)
Brandt, K.D.: The effect of synovial fluid hyaluronate on the ingestion of monosodium urate crystals by leucocytes. Clin. chim. Acta 55, 207–315 (1974)
Capstick, R.B., Lewis, D.A., Cosh, J.A.: Naturally occuring anti-inflammatory factors in the synovial fluids of patients with rheumatic disease and their possible modes of action. Ann. rheum. Dis. 24, 213–218 (1975)
Dieppe, P.A., Crocker, P., Huskisson, E.C., Willoughby, D.A.: Apatite deposition disease. A new arthropathy. Lancet 1976I, 266–269
Di Sabatino, C.A., Breitenstein, M.G., Malawista, S.E.: Crystal induced membrane permeability in liposomes: Dissolved urate reverses the protective effect of albumin. (Abst.) Arthr. and Rheum. 20, 113 (1977)
Hasselbacher, P., Schumacher, H.R.: Localization of immunoglobulin in gouty tophi by immu-nohistology and on the surface of monosodium urate crystals by immune agglutination. (Abst.) Arthr. and Rheum. 19, 802 (1976)
Howell, R.R., Seegmiller, J.E.: Uricolysis by human leukocytes. Nature (Lond.) 196, 482–483 (1962)
Katz, W., Ligot, P.: Deposition of urate crystals in gout. (Abstr.) Clin. Res. 20, 511 (1972)
Kippen, I., Klinenberg, J.R., Weinberger, A., Wilcox, W.R.: Factors affecting urate solubility in vitro. Ann. Rheum. Dis. 33, 313–317 (1974)
Kozin, F., McCarty, D.J.: Absorption of protein to monosodium urate (MSU) crystals: A possible mechanism of crystal-induced inflammation. (Abst.) Arthr. and Rheum. 19, 805–806 (1976)
McCarty, D.J.: Mechanisms of crystal deposition diseases. Gout and pseudogout (Editorial). Ann. intern. Med. 78, 767–771 (1973)
Naff, G.B., Byers, P.H.: Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals. J. Lab. clin. Med. 81, 747–760 (1973)
Oertel, R.W., Newcombe, D.S.: Acute gouty arthritis and response to colchicine in the virtual absence of synovial fluid leucocytes. New Engl. J. Med. 290, 1363–1364 (1974)
Phelps, P.: Polymorphonuclear leucocyte motility in vitro. IV. Colchicine inhibition of chemotac-tic activity formation after phagocytosis of urate crystals. Arthr. and Rheum. 13, 1–9 (1970)
Phelps, P., McCarty, D.J.: Crystal induced inflammation in canine joints. II. Importance of polymorphonuclear leucocytes. J. exp. Med. 124, 115–125 (1966)
Schumacher, H.R.: Morphologic studies of the unresolved problems in crystal-induced arthritis. Inflo. 7, 3 (1974)
Schumacher, H.R.: Pathology of the synovial membrane in gout. Light and electron microscopic studies. Arthr. and Rheum. 18, 771–782 (1975)
Schumacher, H.R.: Pathogenesis of crystal induced arthritis. Clin. rheum. Dis. 3, 105–131 (1977a)
Schumacher, H.R.: Bullous tophi in gout. Ann. Rheum. Dis. 36, 91–93 (1977b)
Schumacher, H.R., Agudelo, C.A.: Intravascular degranulation of neutrophils: An important factor in inflammation. Science 175, 1139–1140 (1972)
Schumacher, H.R., Fishbein, P., Phelps, P., Tse, R., Krauser, R.: Comparison of sodium urate and calcium pyrophosphate crystal phagocytosis by polymorphonuclear leucocytes. Effects of crystal size and other factors. Arthr. and Rheum. 18, 783–792 (1975)
Schumacher, H.R., Phelps, P.: Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopic study. Arthr. and Rheum. 14, 513–526 (1971)
Schumacher, H.R., Phelps, P., Agudelo, C.A.: Urate crystal induced inflammation in dog joints: Sequence of synovial changes. J. Rheum. 1, 102–113 (1974)
Seegmiller, J.E., Howell, R.R., Malawista, S. E.: The inflammatory reaction to sodium urate. J. Amer. med. Ass. 180, 469–475 (1962)
Simkin, P.A.: Local concentration of urate in the pathogenesis of gout. Lancet 1973II, 1295 – 1298
Sokoloff, L.: The pathology of gout. Metabolism 6, 230–241 (1957)
Wallingford, W.R., McCarty, D.J.: Differential membranolytic effects of microcrystalline sodium urate and calcium pyrophosphate dihydrate. J. exp. Med. 133, 100–112 (1971)
Ward, P.A., Zvaifler, N.J.: Complement derived chemotactic factors in inflammatory synovial fluids of humans. J. clin. Invest. 50, 606–616 (1971)
Weissman, G.: The molecular basis of gout. Hosp. Pract. 6, 43–52 (1971)
Wilcox, W.R., Khalaf, A., Weinberger, A., Kippen, I., Klinenberg, J.R.: Solubility of uric acid and monosodium urate. Med. Biol. Eng. 10, 522–531 (1972)
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Schumacher, H.R. (1978). Initial Events in the Development of an Acute Attack of Gouty Arthritis. In: Kelley, W.N., Weiner, I.M. (eds) Uric Acid. Handbook of Experimental Pharmacology, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66867-8_13
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DOI: https://doi.org/10.1007/978-3-642-66867-8_13
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