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Urokinase

  • Chapter
Fibrinolytics and Antifibrinolytics

Abstract

The wide distribution in human body fluids and tissues of fibrinolysis activators most probably reflects their outstanding physiologic importance. The proteolytic activity of urine was discovered in 1861 by von Brücke, its ability to dissolve fibrin clots by Sahli in 1885. The existence of several proteolytic enzymes, some with pH optimum in the weak alkaline range, was soon recognized (Gehrig, 1886; Grützner, 1891).

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References

  • Åstedt, B.: Release of plasminogen activators from isolated human glomeruli. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 339 (1975)

    Google Scholar 

  • Åstedt, B., Pandolfi, M., Nilsson, I. M.: Inhibitory effect of placenta on plasminogen activation in human organ culture. Proc. Soc. exp. Biol. (N.Y.) 139, 1421–1424 (1972)

    Google Scholar 

  • Albrechtsen, O. K.: The fibrinolytic activity of animal tissues. Acta physiol. scand. 39, 284–290 (1957 a)

    Article  PubMed  CAS  Google Scholar 

  • Albrechtsen, O. K.: The fibrinolytic activity of human tissues. Brit. J. Haemat. 3, 284–291 (1957b)

    Article  PubMed  CAS  Google Scholar 

  • Ali S. Y., Evans, L.: Purification of rabbit kidney cytokinase and a comparison of its properties with human urokinase. Biochem. J. 107, 293–303 (1968)

    PubMed  CAS  Google Scholar 

  • Alkjaersig, N., Fletcher, A. P.: Metabolism of urokinase. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 129–141 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Alkjaersig, N., Fletcher, A. P., Sherry, S.: The activation of human plasminogen II. A kinetic study of activation with trypsin, urokinase and streptokinase. J. biol. Chem. 233, 86–90 (1958)

    PubMed  CAS  Google Scholar 

  • Alkjaersig, N., Fletcher, A. P., Sherry, S.: ε-Aminocaproic acid: an inhibitor of plasminogen activation. J. biol. Chem. 234, 832–837 (1959)

    PubMed  CAS  Google Scholar 

  • Alkjaersig, N., Fletcher, A. P., Sherry, S.: The assay of urokinase preparations for contamination with thromboplastic moieties. J. Lab. clin. Med. 65, 732–738 (1965)

    PubMed  CAS  Google Scholar 

  • Ambrus, C. M., Ambrus, J. L., Roholt, B. K., Shields, R. R.: Insolubilized activators of the fibrinolytic system: in vitro studies. J. Med. exp. clin. 3, 270–281 (1972b)

    CAS  Google Scholar 

  • Ambrus, C. M., Roholt, O.A., Meyer, B. K.: Enzymatic activity of insolubilized streptokinase (I-SK) and urokinase (I-UK). Fed. Proc. 31, 267 (1972 a)

    Google Scholar 

  • Andrassy, K., Ritz, E., Bleyl, U., Egbring, R.: Purification of human urokinase and its topographical localisation in renal parenchyma. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 338 (1975)

    CAS  Google Scholar 

  • Aoki, N., Kaulla, K. N. von: Dissimilarity of human vascular plasminogen activator and human urokinase. J. Lab. clin. Med. 78, 354–362 (1971)

    PubMed  CAS  Google Scholar 

  • Arnesen, H., Fagerhol, M. K.: α 2-Macroglobulin, α 1-antitrypsin and antithrombin III in plasma and serum during fibrinolytic therapy with urokinase Scand. J. clin. Lab. Invest. 29, 259–263 (1972)

    Article  CAS  Google Scholar 

  • Astrup, T., Stage, A.: Isolation of a soluble fibrinolytic activator from animal tissue. Nature (Lond.) 170, 929 (1952)

    Article  CAS  Google Scholar 

  • Astrup, T., Sterndorff, I.: An activator of plasminogen in normal urine. Proc. Soc. exp. Biol. (N.Y.) 81 675–678 (1952)

    CAS  Google Scholar 

  • Astrup, T., Sterndorff, I.: Fibrinolysokinase activity in animal and human tissue. Acta physiol. scand. 37, 40–47 (1956)

    Article  PubMed  CAS  Google Scholar 

  • Bachmann, F.: The role of the human liver in the regulation of thrombolytic activity. J. Lab. clin. Med. 68, 854–855 (1966)

    Google Scholar 

  • Back, N., Ambrus, J. L., Muik, I. B.: Distribution and fate of I131-labeled compounds of the fibrinolysin system. Circulat. Res. 9, 1208–1216 (1961)

    PubMed  CAS  Google Scholar 

  • Ball, A. P., Day, E. D.: Urokinase-induced fibrinolysis of 125I-fibrin. Thrombos. Diathes. haemorrh. (Stuttg.) 24, 463–474 (1970)

    CAS  Google Scholar 

  • Barlow, G. H., Lazer, L.: Characterization of the plasminogen activator isolated from human embryo kidney cells. comparison with urokinase. Thrombos. Res. 1, 201–208 (1972)

    Article  CAS  Google Scholar 

  • Barlow, G. H., Lazer, L., Rueter, A., Tribby, I.: Production of plasminogen activator by tissue culture techniques. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 75–81 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Barlow, G. H., Rueter, A., Tribby, I.: Production of plasminogen activator by tissue culture technique. In: Proteases and Biological Control, pp. 325–331. Cold Spring Habor Laboratory 1975

    Google Scholar 

  • Barnett, E. V., Baron, S.: Cell culture produced activator for serum proteolytic proenzyme and its presence in poliomyelitis vaccine. Fed. Proc. 17, 503 (1958)

    Google Scholar 

  • Barnett, E. V., Baron, S.: An activator of plasminogen produced by cell cultures. Proc. Soc. exp. Biol. (N.Y.) 102, 308–311 (1959)

    CAS  Google Scholar 

  • Berg, W.: Activation of plasminogen and spontaneous inactivation of the plasmin formed. A kinetic study. Thrombos. Diathes. haemorrh. (Stuttg.) 19, 145–160 (1968 a)

    CAS  Google Scholar 

  • Berg, W.: A method to correct for the continuing activation during the second stage in a two-stage assay. Thrombos. Diathes. haemorrh. (Stuttg.) 19, 161–168 (1968 b)

    CAS  Google Scholar 

  • Berg, W., Korsan-Bengsten, K., Ygge, J.: Theoretical basis and standardization of the one-stage lysis time method for determination of urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 19, 169–177 (1968)

    CAS  Google Scholar 

  • Bergstein, J. M., Michael, Jr., A. F.: Cortical fibrinolytic activity in normal and diseased human kidneys. J. Lab. clin. Med. 709, 701 (1972)

    Google Scholar 

  • Bergstein, J. M., Michael, Jr. A. F.: Glomerular plasminogen activator activity in renal homograft rejection. Transplantation 17, 443–446 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Bergström, K.: A preparative method for the partial purification of human urokinase. Ark. Kemi 21, 535–546 (1963)

    Google Scholar 

  • Bergström, K.: Purified bovine plasminogen preparation. N-terminal amino acid sequence, isoelectric point, and activation with urokinase. Ark. Kemi 21, 547–554 (1963)

    Google Scholar 

  • Bernik, M. B.: Increased plasminogen activator (urokinase) in tissue cultures after fibrin deposition. J. clin. Invest. 52, 823–834 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Bernik, M. B., Kwaan, H. C.: Origin of fibrinolytic activity in cultures of the human kidney. J. Lab. clin. Med. 70, 650–661 (1967)

    PubMed  CAS  Google Scholar 

  • Bernik, M. B., Kwaan, H. C: Plasminogen activator activity in cultures from human tissues. An immunological and histochemical study. J. clin. Invest. 48, 1740–1753 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Bernik, M. B., White, W. F., Oller, E. P., Kwaan, H. C.: Immunologic identity of plasminogen activator in human urine, heart, blood vessels and tissue culture. J. Lab. clin. Med. 84, 546–558 (1974)

    PubMed  CAS  Google Scholar 

  • Bjerrehuus, I.: Fibrinolytic activity in urine. Scand. J. clin. Invest. 4, 179–182 (1952)

    Article  PubMed  CAS  Google Scholar 

  • Blix, S.: The effectiveness of activators in clot lysis with special reference to fibrinolytic therapy. Acta med. scand. Suppl. 386, 1–24 (1962)

    PubMed  CAS  Google Scholar 

  • Boomgard, J., Vreeken, J., Bleyenberg, A., Deggeller, K.: Studies on urokinase. Some physiological considerations concerning normal urokinase excretion. Clin. chim. Acta 13, 484–490 (1966)

    Article  Google Scholar 

  • Boucher, B. J., Connolly, E. M., Farrow, S. C.: The use of intraarterial urokinase in a case of recurrent arterial occlusion. Postgrad. med. J. 49, 365–367 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Brakman, P., Astrup, T.: Selective inhibition in human pregnancy blood of urokinase induced fibrinolysis. Scand. J. clin. Lab. Invest. 15, 603–609 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Brochier, M., Griguer, P.: L’emploi de l’urokinase à doses modérées dans le traitement des embolies pulmonaires de haute gravité. Journées angéiologiques de langue française. Expansion scientifique. 82–86 (1974)

    Google Scholar 

  • Brochier, M., Raynaud, R., Griguer, P., Fauchier, J.-P., Morand, Ph., Archamband, D., Ginies, G., Bienvenu, P.: Traitement thrombolytique par urokinase des embolies pulmonaires de haute gravité. Sem. Hôp. (Paris) 49, 1825–1836 (1973)

    CAS  Google Scholar 

  • Brochier, M., Raynaud, R., Planiel, T., Fauchier, J. P., Griguer, P., Archamband, D., Pellois, A., Clisson, M.: Le traitment par l’urokinase des infarctus du myocarde et des syndromes de menace. Arch. Mal. Coeur 68, 563–569 (1975)

    PubMed  CAS  Google Scholar 

  • Brodrick, J. D., Hall, R. D.: Management and prognosis of secondary hyphaema. Proc. roy. Soc. Med. 64, 931–934 (1971)

    PubMed  CAS  Google Scholar 

  • Brooks, J., Davis, D., Devivo, G.: Blood hypercoagulability in acute cerebrovascular syndroms: its control with urokinase therapy. J. Lab. clin. Med. 76, 879–880 (1970)

    Google Scholar 

  • Brücke, E. von: Die verdauende Substanz im Urin. S-B Akad. Wiss. (Wien) math.-nat. Kl. 43, 601 (1861)

    Google Scholar 

  • Buluk, K., Furman, M.: On the controlling function of kidneys in fibrinolysis. Experientia (Basel) 18, 146–147 (1962)

    Article  CAS  Google Scholar 

  • Burges, R. A., Brammer, K. W., Coombes, J. D.: Molecular weight of urokinase. Nature (Lond.) 208, 894 (1965)

    Article  CAS  Google Scholar 

  • Camiolo, S. M., Thorsen, S., Astrup, T.: Fibrinogenolysis and fibrinolysis with tissue plasminogen activator, urokinase, streptokinase-activated human globulin and plasmin. Proc. Soc. exp. Biol. (N.Y.) 138, 277–280 (1971)

    CAS  Google Scholar 

  • Capet-Antonini, F. C., Grimard, M., Tamenasse, J.: Properties of two types of solid-phase urokinase preparations.Thrombos. Res. 2, 479–486 (1973)

    Article  CAS  Google Scholar 

  • Celander, D. R., Guest, M. M.: Purification and properties of a urinary activation of plasma Profibrinolysin. Fed. Proc. 14, 27 (1955)

    Google Scholar 

  • Celander, D. R., Langlinais, P., Guest, M. M.: The application of foam technique to the partial purification of urine activator of plasma Profibrinolysin. Arch. Biochem. 55, 286–287 (1955)

    Article  PubMed  CAS  Google Scholar 

  • Celander, D. R., Schlagenhauf, G. K. Jr., Guest, M. M.: Purification of urokinase and some characteristics of the product. Thrombos. Diathes. haemorrh. (Stuttg.) 3, 359 (1959)

    Google Scholar 

  • Cooley, R. N., Howard, M. D., De Groot, W. J., Dickie, K. J., Guest, M. M.: Angiographic observations on the treatment of pulmonary thromboembolism with urokinase. Amer. J. Roentgenol. 106, 576–590 (1969)

    PubMed  CAS  Google Scholar 

  • Crawford, G. P. M., Ogston, D.: The influence of α-1-antitrypsin on plasmin, urokinase and Hageman factor cofactor. Biochim. biophys. Acta (Amst.) 354, 107–113 (1974)

    CAS  Google Scholar 

  • Day, E. D., Ball, A. P., Jeffords, D., Woodard, W. T., Jr., Silver, D.: The immunoassay of human urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 21, 273–286 (1969)

    CAS  Google Scholar 

  • Deutsch, D. G., Mertz, E. T.: Activation of plasminogen with insoluble derivation of urokinase. J. Med. exp. clin. 3, 224–230 (1972)

    CAS  Google Scholar 

  • Dickie, K. J., DeGroot, W. J., Cooley, R. N., Bond, T. P., Guest, M. M.: Hemodynamic effect of bolus infusion of urokinase in pulmonary embolism. Amer. Rev. resp. Dis. 109, 48–56 (1974)

    PubMed  CAS  Google Scholar 

  • Dickie, K. J., DeGroot, W. J., Cooley, R. N., Guest, M. M., Bond, T.: Urokinase in pulmonary thromboembolic disease: preliminary report. Tex. Rep. Biol. Med. 25, 613–624 (1967)

    PubMed  CAS  Google Scholar 

  • Doleschel, W., Auerswald, W.: Physiko-chemische Untersuchungen an humaner Urokinase mit besonderer Berücksichtigung ihres Verhaltens gegen Adsorbentien. Wien. Z. inn. Med. 41, 49–58 (1960)

    PubMed  CAS  Google Scholar 

  • Doleschel, W., Auerswald, W.: Determination of the molecular weights of uroprotein fractions with urokinase activity by means of molecular sieving. Med. Pharm. Exp. 16, 225–231 (1967)

    CAS  Google Scholar 

  • Dubber, A. H. C., McNicol, G. P., Wilson, P. A., Douglas, A. S.: Studies with a preparation of urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 18, 133–149 (1967)

    CAS  Google Scholar 

  • Duckert, F.: Lack of antigenicity of human urokinase. Unpublished data (1967)

    Google Scholar 

  • Duckert, F., Bruhn, H. D.: Urokinase and plasmin assay. Unpublished data (1967)

    Google Scholar 

  • Duckert, F., Gurland, H. J., Bounameaux, Y.: Urokinase in shunts. Unpublished data (1970)

    Google Scholar 

  • Duckert, F., McNicol, G. P., Godal, H. C., Herold, R.: Influence of various initial doses of urokinase on coagulation parameters. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 45, 23–36 (1971)

    Google Scholar 

  • Duckert, F. Müller, G.: Thrombolysis and pulmonary embolism. Unpublished observations (1970)

    Google Scholar 

  • DudokdeWit, C.: Investigations on the inhibition of the fibrinolytic system. Thrombos. Diathes. haemorrh. (Stuttg.) 12, 105–118 (1964)

    Google Scholar 

  • DudokdeWit, C., Den Ottolander, G. J. H., Krijnen, H. W.: The measurement of fibrinolytic activity with I131-labeled clots. II. Application. Thrombos. Diathes. haemorrh. (Stuttg.) 8, 322–332 (1962)

    CAS  Google Scholar 

  • Dugan, M. A., Kozar, J. J., Ganse, G., Charkes, N. D.: Localization of deep vein thrombosis using radioactive streptokinase. J. nucl. Med. 14, 233–234 (1973)

    PubMed  CAS  Google Scholar 

  • Dugmore, W. N., Raichand, M.: Intravitreal urokinase in treatment of vitreous haemorrhage. Lancet 1972/II, 660

    Google Scholar 

  • Editorial Committee: The urokinase pulmonary embolism trial. A national cooperative study. Circulation 47, Suppl. 2, 1–108 (1973)

    Google Scholar 

  • Editorial Committee: Urokinase-streptokinase embolism trial. A cooperative study. J. Amer. med. Ass. 229, 1606–1613 (1974)

    Article  Google Scholar 

  • Edwards, I. R., MacLean, K. S., Dow, J. D.: Low-dose urokinase in major pulmonary embolism. Lancet 1973/II, 409–413

    Google Scholar 

  • European Collaborative Study: Controlled trial of urokinase in myocardial infarction. Lancet 1975/II, 624–626

    Google Scholar 

  • Fischer, M., Pilgerstorfer, H. W.: Urokinase “Green Cross”, eine neue Urokinasepräparation. II In-vivo Untersuchungen. Int. J. clin. Pharmacol. 2, 142–149 (1969)

    CAS  Google Scholar 

  • Fletcher, A. P., Alkjaersig, N.: Blood hypercoagulability, intravascular coagulation and thrombosis. New diagnostic concepts. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 45, 389–394 (1971)

    Google Scholar 

  • Fletcher, A. P., Alkjaersig, N.: Use of urokinase therapy in cerebrovascular disease. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 203–215 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Fletcher, A. P., Alkjaersig, N., Sherry, S., Genton, E., Hirsh, J., Bachmann, F.: The development of urokinase as a thrombolytic agent. Maintenance of a sustained thrombolytic state in man by its intravenous infusion. J. Lab. clin. Med. 65, 713–731 (1965)

    PubMed  CAS  Google Scholar 

  • Forbes, C. D., Turpie, A.G., McNicol, G. P.: Enhancement of the activity of optimum concentration of urokinase by the venom of Echis cannata. Nature (Lond.) 211, 989–990 (1966)

    Article  CAS  Google Scholar 

  • Forrester, J. V., Williamson, J.: Resolution of intravitreal clots by urokinase Lancet 1973II, 179–181

    Google Scholar 

  • Gehrig, F.: Über Fermente im Harn. Pflügers Arch. ges. Physiol. 38, 35–93 (1886)

    Article  Google Scholar 

  • Genton, E., Claman, H. N.: Urokinase: Antigenic studies in patients following thrombolytic therapy. J. Lab. clin. Med. 75, 619–621 (1970)

    Google Scholar 

  • Genton, E., Wolf, P. S.: Experimental pulmonary embolism: effects of urokinase therapy on organizing thrombi. J. Lab. clin. Med. 70, 311–325 (1967)

    PubMed  CAS  Google Scholar 

  • Genton, E., Wolf, P. S.: Urokinase therapy in pulmonary thromboembolism. Amer. Heart. J. 76, 628–637 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Geratz, J. D., Cheng, M. C.-F.: The inhibition of urokinase by aromatic diamidines. Thrombos. Diathes. haemorrh. (Stuttg.) 33, 230–243 (1975)

    CAS  Google Scholar 

  • Gormsen, J., Tidstrøm, B., Feddersen, C., Ploug, J.: Biochemical evaluation of low dose of urokinase in acute myocardial infarction. Acta med. scand. 194, 191–198 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Greul, W., Tilsner, V.: Thrombolysis with urokinase in arterial and venous thrombosis. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 235–242 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Griguer, P.: L’augmentation de l’agréagation plaquettaire. Effet inattendu de la thérapeutique fibrinolytique. Ann. Cardiol. Angéiol. 22, 223–230 (1973)

    CAS  Google Scholar 

  • Grützner, P.: Über Fermente im Harn. Dtsch. med. Wschr. 17, 10–13 (1891)

    Article  Google Scholar 

  • Guest, M. M., Celander, D. R.: Urokinase. Physiologic activator of Profibrinolysin. Tex. Rep. Biol. Med. 19, 89–105 (1961)

    PubMed  CAS  Google Scholar 

  • Hansen, P. F., Jørgensen, M., Kjeldgaard, N. O., Ploug, J.: Urokinase an activator of plasminogen from human urine. Eperiences with intravenous application on twenty-two patients. Angiology 12, 367–371 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Hashida, E., Maekawa, F., Mori, Y., Rin, K., Yamada, T.: Feasibility of urokinase in the treatment of acute myocardial infarction. Jap. Circulat. J. 36, 941–944 (1972)

    Article  CAS  Google Scholar 

  • Hedner, U., Nilsson, I. M.: Urokinase inhibitors in serum in a clinical series. Acta med. scand. 189, 185–189 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Hiemeyer, V., Rasche, H.: Vergleichende Untersuchungen zur Wirkung von Urokinase und Streptokinase im Tierversuch. Thrombos. Diathes. haemorrh. (Stuttg.) 17, 58–64 (1967)

    CAS  Google Scholar 

  • Hilgard, O.: Comparative studies of the fibrinolytic system in rats and humans. Haemostasis 1, 101–107(1972)

    CAS  Google Scholar 

  • Hisazumi, H., Naito, K., Misaki, T.: Fibrinolytic activity in normal and cancerous tissues of the bladder. Invest. Urol. 11, 28–34 (1973)

    PubMed  CAS  Google Scholar 

  • Holemans, R., Johnston, J. G., Reddick, R. L.: Release of plasminogen activator by the isolated perfused dog kidney. Nature (Lond.) 208, 291–292 (1965)

    Article  CAS  Google Scholar 

  • Holemans, R., McConnell, D., Johnston, J. G.: Urokinase levels in urine after nicotinic acid injection. Thrombos. Diathes. haemorrh. (Stuttg.) 15, 192–204 (1966)

    CAS  Google Scholar 

  • Januszko, T., Furman, M., Buluk, K.: The kidneys and the liver as the organs regulating the fibrinolytic system of the circulating blood. Thrombos. Diathes. haemorrh. (Stuttg.) 15, 554–560 (1966)

    CAS  Google Scholar 

  • Johnson, A. J., Kline, D. L., Alkjaersig, N.: Assay methods and standard preparations for plasmin, plasminogen and urokinase in purified systems, 1967–1968. Thrombos. Diathes. haemorrh. (Stuttg.) 21, 259–272 (1969)

    CAS  Google Scholar 

  • Johnson, A. J., McCarty, W. R., Newman, J.: Thrombolysis in man with urokinase (UK). Proc. IXth Congr. Europ. Soc. Haemat. (Lissabon) p. 1389. Basel: Karger 1963b

    Google Scholar 

  • Johnson, A. J., McCarty, W. R., Newman, J., Lackner, H.: Thrombolysis in man with urokinase. Blood 22, 829 (1963 a)

    Google Scholar 

  • Johnson, A. J., Soberano, M. E., Ong, E. B., Levy, M., Schoellmann, G.: Urinary urokinase, two molecules or one? In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 59–67 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Kaulla, K. N. von: Urin adsorbate with fibrinolytic and thromboplastic properties. J. Lab. clin. Med. 44, 944 (1954)

    Google Scholar 

  • Kaulla, K. N. von: Methods for preparation of purified human thromboplastin and fibrinolysokinase from urine. Acta haemat. (Basel) 16, 315–321 (1956)

    Article  CAS  Google Scholar 

  • Kaulla, K. N. von: Components of the human fibrinolytic system in blood and urine and their relationship to therapeutic and spontaneous fibrinolysis. In: Page, I. H. (Ed.): Connective Tissue, Thrombosis and Atherosclerosis, pp. 259–279. New York: Academic Press 1959a

    Google Scholar 

  • Kaulla, K. N. von: Urokinase studies. Thrombos. Diathes. haemorrh. (Stuttg.) 3, 358–359 (1959b)

    Google Scholar 

  • Kaulla, K. N. von, Riggenbach, N.: Urokinase excretion in man: A method of determination and consideration of its significance. Thrombos. Diathes. haemorrh. (Stuttg.) 5, 162–178 (1960)

    Google Scholar 

  • Kaulla, K. N. von, Schneeberger, E., Curry, M.: Quantitative determination of urokinase. Fed. Proc. 17, 167 (1958)

    Google Scholar 

  • Kawano, T., Morimoto, K., Uemura, Y.: Urokinase inhibitor in human placenta. Nature (Lond.) 217, 253–254 (1968)

    Article  CAS  Google Scholar 

  • Kawano, T., Uemura, Y.: Inhibition of tissue activator by urokinase inhibitor. Thrombos. Diathes. haemorrh. (Stuttg.) 25, 129–133 (1971)

    CAS  Google Scholar 

  • Kickhöfen, B., Struwe, F. E., Bramesfeld, B., Westphal, O.: Über einige Beobachtungen am Uropepsinogen und Plasminogen-Aktivator des menschlichen Urins. Biochem. Z. 330, 467–482 (1958)

    PubMed  Google Scholar 

  • Kjeldgaard, N. O., Ploug, J.: Urokinase. An activator of plasminogen from human urine. I. Mechanism of plasminogen activation. Biochim. biophys. Acta. (Amst.) 24, 283–289 (1957)

    Article  CAS  Google Scholar 

  • Koch, M., Binder, B., Auerswald, W.: Release of fibrinolytically active compounds during platelet-UK interactions. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 318 (1975)

    CAS  Google Scholar 

  • Kok, P., Astrup, T.: Isolation and purification of a tissue plasminogen activator and its comparison with urokinase. Biochemistry 8, 79–86 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Kucinski, C., Fletcher, A. P.: Immunologic distinction between human plasma plasminogen activator and human urokinase. Fed. Proc. 25, 194 (1966)

    Google Scholar 

  • Kucinski, C., Fletcher, A. P.: Immunological studies with urokinase. Fed. Proc. 26, 647 (1967)

    Google Scholar 

  • Kucinski, C., Fletcher, A. P., Sherry, S.: Effect of urokinase antiserum on plasminogen activators: Demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase. J. clin. Invest. 47, 1238–1253 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Kusserow, B. K., Larrow, R.: Use of surface bonded, covaiently crosslinked urokinase as an approach to the creation of a thromboresistant synthetic surface with fibrinolytic capability. Circulation 46, Suppl. 2, 11–54 (1972)

    Google Scholar 

  • Kwaan, H. C.: Inhibitors of fibrinolysis. Thrombos. Res. 2, 31–40 (1973)

    Article  CAS  Google Scholar 

  • Kwaan, H. C., Dobbie, J. G., Fetkenhour, C. L.: The use of anticoagulants and thrombolytic agents in occlusive retinal vascular disease. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 191–198 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Kwaan, H. C., Fischer, S.: Localization of fibrinolytic activity in kidney tissues. Fed. Proc. 24, 387 (1965)

    Google Scholar 

  • Ladehoff, A. A.: The content of plasminogen activator in the human urinary tract. Scand. J. clin. Invest. 12, 136–139 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Landmann, H.: Studies on the mechanism of action of synthetic antifibrinolytics. Thrombos. Diathes. haemorrh. (Stuttg.) 29, 253–275 (1973)

    CAS  Google Scholar 

  • Landmann, H., Markwardt, F.: Irreversible synthetische Inhibitoren der Urokinase. Experientia (Basel) 26, 145–147(1970)

    Article  CAS  Google Scholar 

  • Laragh, J. H., Bär, L., Brunner, H. R., Bühler, F. R., Sealey, J. E., Darracott Vaughan, Jr., E.: Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Amer. J. Med. 52, 633–652 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Lesuk, A., Terminiello, L., Traver, J. H.: Crystalline human urokinase: some properties. Science 147, 880–882 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Lesuk, A., Terminiello, L., Traver, J. H.: Sephadex gel-filtration of human urokinase preparations. Fed. Proc. 25, 194 (1966)

    Google Scholar 

  • Lesuk, A., Terminiello, L., Traver, J. H., LeGroff, J. L.: Proteolytic degradation of urokinase to active fragments. Fed. Proc. 26, 647 (1967)

    Google Scholar 

  • Lesuk, A., Terminiello, L., Traver, J. H., LeGroff, J. L.: Biochemical and biophysical studies of human urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 18, 293–294 (1968)

    Google Scholar 

  • Lipinski, B., Gurewich, V., Hyde, E.: Fibrinolysis versus fibrinogenolysis: the specificity of human vascular activator (VA) as compared to urokinase (UK) and streptokinase (SK). Thrombos. Diathes. haemorrh. (Stuttg.) 34, 351 (1975)

    CAS  Google Scholar 

  • Litman, G. I., Smiley, R. B., Wenger, N. K.: The feasibility of urokinase therapy in acute myocardial infarction. Amer. J. Cardiol. 27, 636–640 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Lorand, L., Condit, E. V.: Ester hydrolysis by urokinase. Biochemistry 4, 265–270 (1965)

    Article  CAS  Google Scholar 

  • Lorand, L., Mozen, M. M.: Ester hydrolyzing activity of urokinase preparations. Nature (Lond.) 201, 392–393 (1964)

    Article  CAS  Google Scholar 

  • MacFarlane, R. G., Pilling, J.: Fibrinolytic activity of normal urine. Nature (Lond.) 159, 779 (1947)

    Article  CAS  Google Scholar 

  • Maciag, T., Mochan, B., Pye, E. K., Iyengar, M. R.: Plasminogen activator stimulation by plasma components in tissue culture. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase, pp.103–118. London: Academic Press. Proceedings of the Serono Symposia, vol.9, 1977

    Google Scholar 

  • McConnell, D., Johnston, D. G., Holemans, R., Cohen, L. A.: Blood plasminogen activator: mechanism of its release and lack of identity with urokinase. Fed. Proc. 25, 194 (1966a)

    Google Scholar 

  • McConnell, D., Johnston, J. G., Young, I., Holemans, R.: Localization of plasminogen activator in kidney tissue. Lab. Invest. 15, 980–986 (1966b)

    PubMed  CAS  Google Scholar 

  • McKee, P. A., Lemmon, W. B., Hampton, J. W.: Streptokinase and urokinase activation of human, chimpanzee and baboon plasminogen. Thrombos. Diathes. haemorrh. (Stuttg.) 26, 512–522 (1971)

    CAS  Google Scholar 

  • McNicol, G. P., Gale, S. B., Douglas, A. S.: In vitro and in vivo studies of a preparation of urokinase. Brit. med. J. 1963I, 909–915

    Google Scholar 

  • Millar, W. T., Smith, J. F. B.: Localization of deep venous thrombosis using technetium-99m-labelled urokinase. Lancet 1974II, 695–696

    Google Scholar 

  • Mohler, S. R., Celander, D. R., Guest, M. M.: Distribution of urokinase among mammals. Amer. J. Physiol. 192, 186–190 (1958)

    PubMed  CAS  Google Scholar 

  • Mootse, G., Marley, C., Cliffton, E. E.: Species-specific activation of plasminogen: comparison of human urokinase and cat urine. Amer. J. Physiol. 212, 657–661 (1967)

    PubMed  CAS  Google Scholar 

  • Müllertz, S.: Different molecular forms of plasminogen and plasmin produced by urokinase in human plasma and their relation to protease inhibitors and lysis of fibrinogen and fibrin. Biochem. J. 143, 273–283 (1974)

    PubMed  Google Scholar 

  • Murray, J., Crawford, G. P. M., Ogston, D., Douglas, A. S.: Studies on an inhibitor of plasminogen activators in human platelets. Brit. J. Haemat. 26 661–668 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Nanninga, L. B., Guest, M. M.: Antiactivation (antikinase) activity of human plasma and its blocking by parachloromercuribenzoate and salicylate. Thrombos. Diathes. haemorrh. (Stuttg.) 26, 541–556 (1971)

    CAS  Google Scholar 

  • Neidhart, P., Hofer, B., Duckert, F., Fridrich, R.: Die diagnostische Verwendung von 131I-Urokinase. Schweiz. med. Wschr. 104, 141–142 (1974)

    PubMed  CAS  Google Scholar 

  • Niewiarowski, S., Prokopowicz, J., Poplavski, A., Worowski, K.: Inhibition of dog fibrinolytic system in experimental tubular necrosis of kidney. Experientia (Basel) 20, 101–103 (1964)

    Article  CAS  Google Scholar 

  • Nishi, N., Tokura, S., Noguchi, J.: The synthesis of benzoyl-l arginine p-nitroanilide. Bull. chem. Soc. Jap. 43, 2900 (1970)

    Article  CAS  Google Scholar 

  • Ogawa, N., Yamamoto, H., Katamine, T., Tajima, H.: Purification and some properties of urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 194–209 (1975)

    CAS  Google Scholar 

  • Ogston, C. M., Ogston, D., Fullerton, H. W.: Observations on the lysis of artificial thrombi by urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 19, 107–116 (1968)

    CAS  Google Scholar 

  • Ottolander, G. J. H., den, Leijnse, B., Cremer-Elfrink, H. M. J.: Plasmatic and platelet antiplasmins and anti-activators. Thrombos. Diathes. haemorrh. (Stuttg.) 18, 404–415 (1967)

    Google Scholar 

  • Ottolander, G. J. H., den, Leijnse, B., Cremer-Elfrink, H. M. J.: Plasmatic and thrombotic antiplasmins and anti-activators II. Thrombos. Diathes. haemorrh. (Stuttg.) 21, 26–34 (1969 a)

    Google Scholar 

  • Ottolander, G. J. H., den, Leijnse, B., Cremer-Elfrink, H. M. J.: Plasmatic and platelet anti-plasmins and anti-activators III. Thrombos. Diathes. haemorrh. (Stuttg.) 21, 35–41 (1969 b)

    Google Scholar 

  • Painter, R. H., Charles, A. F.: Characterization of a soluble plasminogen activator from kidney cell cultures. Amer. J. Physiol. 202, 1125–1130 (1962)

    PubMed  CAS  Google Scholar 

  • Petkov, D., Christova, E., Karadjova, M.: Amidase activity of urokinase I. Hydrolysis of α-N-acetyl-L-lysine p-nitroanilide. Thrombos. Diathes. haemorrh. (Stuttg.) 29, 276–285 (1973)

    CAS  Google Scholar 

  • Pierse, D., Legrice, H.: Urokinase in ophtalmology. Lancet 1963II, 1143–1144

    Google Scholar 

  • Pierse, D., Legrice, H.: The use of urokinase in the anterior chamber of the eye. J. clin. Path. 17, 362 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Ploug, J., Kjeldgaard, N. O.: Isolation of a plasminogen activator (urokinase) from urine. Arch. Biochem. 62, 500 (1956)

    Article  PubMed  CAS  Google Scholar 

  • Ploug, J., Kjeldgaard, N. O.: Urokinase. An activator of plasminogen from human urine. 1. Isolation and properties. Biochem. biophys. Acta (Amst.) 24, 278–282 (1957)

    Article  CAS  Google Scholar 

  • Prentice, C. R. M., Turpie, A. G. G., McNicol, G. P., Douglas, A.S.: Urokinase therapy: Dosage schedules and coagulant side effects. Brit. J. Haemat. 22, 567–577 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Pye, E. K., Maciag, T., Kelly, P., Iyengar, M. R.: Purification of urokinase by affinity chromatography. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 43–58 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Raab, W.: Die Urokinase des Meerschweinchens. Experientia (Basel) 20, 546–547 (1964)

    Article  CAS  Google Scholar 

  • Rakusin, W.: Urokinase in the management of traumatic hyphaema. Brit. J. Ophthal. 55, 826–832 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Rhodes, B. A., Turhisi, K. S., Bell, W. R., Wagner, H. N., Jr.: Radioactive urokinase for blood clot scanning. J. Nucl. Med. 13, 646–648 (1972)

    PubMed  CAS  Google Scholar 

  • Rickli, E. E., Otavsky, W. I.: Release of an N-terminal peptide from human plasminogen during activation with urokinase. Biochim. biophys. Acta. (Amst.) 295, 381–384 (1973)

    CAS  Google Scholar 

  • Robbins, K. C., Summaria, L., Hsieh, B., Shak, R. J.: The peptide chains of human plasmin mechanism of activation of human plasminogen to plasmin. J. biol. Chem. 242, 2333–2342 (1967)

    PubMed  CAS  Google Scholar 

  • Roberts, H. R., Astrup, T.: Content of tissue activator of plasminogen in monkey tissues. Thrombos. Diathes. haemorrh. (Stuttg.) 1, 376–379 (1957)

    CAS  Google Scholar 

  • Robinson, B. J., Glanville, J. N., Smith, P. H., Rosen, S. M.: Management of clotting in arteriovenous cannulae in patients on regular dialysis therapy. Brit. J. Urol. 42, 590–597 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Sahli, W.: Über das Vorkommen von Pepsin und Trypsin im normalen menschlichen Harn. Pflügers Arch. ges. Physiol. 36, 209–229 (1885)

    Article  Google Scholar 

  • Sasahara, A. A., Cannula, J. E., Belko, J. S., Morse, R. L., Criss, A. J.: Urokinase therapy in clinical pulmonary embolism. New Engl. J. Med. 277, 1168–1173 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Sautter, R. D., Emanuel, D. A., Fletcher, F. W., Wenzel, F. J., Matson, J. L: Urokinase for the treatment of acute pulmonary thromboembolism. J. Amer. med. Ass. 202, 215–218 (1967)

    Article  CAS  Google Scholar 

  • Sawyer, W. D., Alkjaersig, N., Fletcher, A. P., Sherry, S.: A comparison of the fibrinolytic and fibrinogenolytic effects of plasminogen activators and proteolytic enzymes in plasma. Thrombos. Diathes. haemorrh. (Stuttg.) 5, 149–161 (1961)

    Google Scholar 

  • Sgouris, J. T., Inman, J. K., McCall, K. B.: The preparation of human urokinase. Amer. J. Cardiol. 6,406–408 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Sgouris, J. T., Storey, M. W., McCall, K. B., Anderson, H. D.: The purification, assay, sterilization and removal of pyrogenicity of human urokinase. Vox Sang. (Basel) 7, 739–749 (1962)

    Article  CAS  Google Scholar 

  • Sgouris, J. T., Taylor, H. L., McCall, K. B.: Urokinase activation of human plasminogen. National Meet. Amer. chem. Soc. 129, Abstr. 13 (1956)

    Google Scholar 

  • Shaper, A. G., Macintosh, D. M., Kyobe, J.: Fibrinolytic activity in pregnancy during parturition and in the Puerperium. Lancet 1966II, 874–876

    Google Scholar 

  • Sherry, S., Alkjaersig, N.: Studies on the activation of plasminogen (Profibrinolysin). J. clin. Invest. 35, 735 (1956)

    Google Scholar 

  • Siegel, M. E., Malmud, L. S., Rhodes, B. A., Bell, W. S., Wagner, H. N., Jr.: Scanning of thromboemboli with 131I-streptokinase. Radiology 103, 695–696 (1972)

    PubMed  CAS  Google Scholar 

  • Silver, D.: Urokinase in the management of acute arterial and venous thrombosis. Arch. Surg. (Chic.) 97, 910–916 (1968)

    CAS  Google Scholar 

  • Smyrniotis, F. E., Fletcher, A. P., Alkjaersig, N., Sherry, S.: Urokinase excretion in health and its alteration in certain disease states. Thrombos. Diathes. haemorrh. (Stuttg.) 3, 257–270 (1959)

    CAS  Google Scholar 

  • Sobel, G. W., Mohler, S. R., Jones, N. W., Dowdy, A. B. C., Guest, M. M.: Urokinase: an activator of plasma Profibrinolysin extracted from urine. Amer. J. Physiol. 171, 768–769 (1952)

    Google Scholar 

  • Sodetz, J., M., Castellino, F. J.: Mechanism of activation of rabbit plasminogen by urokinase. J. biol. Chem. 250, 3041 (1975)

    PubMed  CAS  Google Scholar 

  • Som, P., Rhodes, B. A., Bell, W. R.: Radiolabeled streptokinase and urokinase and their comparative biodistribution. Thrombos. Res. 6, 247–253 (1975)

    Article  CAS  Google Scholar 

  • Soong, B. C. F., Miller, S. P.: Coagulation disorders in cancer. III. Fibrinolysis and inhibitors. Cancer (Philad.) 25, 867–874 (1970)

    Article  CAS  Google Scholar 

  • Studer, R. O., Roncari, G., Lergier, W.: Characterization of urokinase from human urine. In: Paoletti, R., Sherry, S. (Eds.): Thrombosis and Urokinase pp. 89–90 London: Academic Press. Proceedings of the Serono Symposia vol. 9, 1977

    Google Scholar 

  • Sturrock, R. D., Watkin, C., Williamson, T., Dick, W.C.: Intra-articular urokinase in rheumatical arthritis. Ann. rheum. Dis. 33, 124–125 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Svendsen, L., Senn, H. P., Amundsen, E.: Determination of urokinase and urinkallikrein by means of new chromogenic amide substrates, chromozym UK and chromozym GK. Int. Symp. on Vasopeptides (Fiesole) (1975)

    Google Scholar 

  • Tajima, H., Ishiguro, J., Nonaka, R., Kurita, M., Tanaka, S., Ogawa, N.: Metabolic fate of urokinase. Chem. pharm. Bull. 22, 727–735 (1974)

    PubMed  CAS  Google Scholar 

  • Theiss, W., Gräff, H., Bleyl, U., Immich, H., Kuhn, W.: Reversible Stadien intravaskulärer Gerinnung und ihre Auswirkungen auf Nierenfunktion und Urokinaseausscheidung. Thrombos. Diathes. haemorrh. (Stuttg.) 23, 369–385 (1970)

    CAS  Google Scholar 

  • Thorsen, S.: The inhibition of tissue plasminogen activator and urokinase induced fibrinolysis by some natural proteinase inhibitors and by plasma and serum from normal and pregnant subjects. Scand. J. clin. Lab. Invest. 31, 51–59 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Thorsen, S., Astrup, T.: Biphasic inhibition of urokinase-induced fibrinolysis by ε-aminocaproic acid; distinction from plasminogen tissue activator. Proc. Soc. exp. Biol. (N.Y.) 130, 811–814 (1969)

    CAS  Google Scholar 

  • Thorsen, S., Astrup, T.: Substrate composition and the effect of ε-aminocaproic acid on tissue plasminogen activator and urokinase induced fibrinolysis. Thrombos. Diathes. haemorrh. (Stuttg.) 32, 306–324 (1974)

    CAS  Google Scholar 

  • Thorsen, S., Glas-Greenwalt, P., Astrup, T.: Differences in the binding to fibrin of urokinase and tissue plasminogen activator. Thrombos. Diathes. haemorrh. (Stuttg.) 28, 65–74 (1972)

    CAS  Google Scholar 

  • Todd, A. S.: Fibrinolysis autographs. Nature (Lond.) 181, 495–496 (1958)

    Article  CAS  Google Scholar 

  • Todd, A. S.: Localization of fibrinolytic activity in tissues. Brit. med. Bull. 20, 210–212 (1964)

    PubMed  CAS  Google Scholar 

  • Tow, D. E., Wagner, H. N., Holmes, R. A.: Urokinase in pulmonary embolism. New Engl. J. Med. 277, 1161–1167 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Tsapogas, M. J., Flute, P. T.: Experimental thrombolysis with streptokinase and urokinase. Brit. med. Bull. 20, 223–227 (1964)

    CAS  Google Scholar 

  • Vreeken, J., Boomgard, J., Deggeler, K.: Urokinase excretion in patients with renal diseases. Acta med. scand. 180, 153–157 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Vukovich, T., Binder, B., Auerswald, W.: “Different” forms of urokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 338 (1975)

    CAS  Google Scholar 

  • Walther, P. J., Steinman, H. M., Hill, R. L., McKee, P. A.: Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide. J. biol. Chem. 249, 1173–1181 (1974)

    PubMed  CAS  Google Scholar 

  • Walton, P. L.: The hydrolysis of N-acetyl-glycyl-l-lysine methyl ester by urokinase. Biochim. biophys. Acta (Amst.) 132, 104–114 (1967)

    CAS  Google Scholar 

  • White, W. F., Barlow, G. H., Mozen, M. M.: The isolation and characterization of plasminogen activators (urokinase) from human urine. Biochemistry 5, 2160–2169 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Williams, J. R. B.: The fibrinolytic activity of urine. Brit. J. exp. Path. 32, 530–537 (1951)

    PubMed  CAS  Google Scholar 

  • Williamson, J., Forrester, J. V.: Urokinase in the treatment of vitreous haemorrhage. Lancet 1972II, 488

    Google Scholar 

  • Williamson, J., Forrester, J. V.: Treatment of vitreous haemorrhage with urokinase. Lancet 1973 II, 888

    Google Scholar 

  • Wiman, B.: Primary structure of peptides released during activation of human plasminogen by urokinase. Europ. J. Biochem. 39, 1–9 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Wiman, B., Wallén, P.: Activation of human plasminogen by an insoluble derivative of urokinase. Europ. J. Biochem. 36, 25–31 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Witteween, S. A. G. J., Hemker, H. C., Hollaar, L., Hermens, W. T.: Quantitation of infarct size in man by means of plasma enzyme levels. Brit. Heart J. 37, 795–805 (1975)

    Article  Google Scholar 

  • Worowski, K., Niewiarowski, S., Prokopowicz, J.: Fibrinolysis and fibrinogen breakdown products (antithrombin VI) in renal venous blood (RVB) in dogs. Thrombos. Diathes. haemorrh. (Stuttg.) 12, 87–104 (1964)

    CAS  Google Scholar 

  • Zubairov, D. M., Asadullin, M. G., Zinkevich, O. D., Chenborisova, G. S., Timerbaev, V. N.: Tshe isolation and some properties of human urokinase. Biokhimiya 39, 378–383 (1974)

    Google Scholar 

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    F. Markwardt

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Duckert, F. (1978). Urokinase. In: Markwardt, F. (eds) Fibrinolytics and Antifibrinolytics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66863-0_8

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