Abstract

As early as 1933, β-hemolytic streptococci were found to secrete into the culture medium a substance able to dissolve fibrin clots (Tillet and Garner, 1933). Since this substance, now known as streptokinase, represented a potential thrombolytic agent, the possibility of its use in human therapy attracted growing interest. In the early sixties, following extensive studies in this field, streptokinase was isolated in a highly purified form that was suitable for therapeutic use (for review see Markwardt et al., 1972; Brogden et al., 1973).

Keywords

Starch Respiration Histamine Choline Thrombin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abiondi, F.B., Hagan, J.J.: Comparison of certain properties of human plasminogen and “proactivator”. Proc. Soc. exp. Biol. (N. Y.) 95, 195 (1957)Google Scholar
  2. Ambrus, J.L., Ambrus, C.M., Back, N., Sokal, J.F., Collins, G.L.: Clinical and experimental studies on fibrinolytic enzymes. Ann. N. Y. Acad. Sci. 68, 97 (1957)PubMedCrossRefGoogle Scholar
  3. Astrup, T.: Fibrinolysis in the organism. Blood 11, 781 (1956).PubMedGoogle Scholar
  4. Back, N., Ambrus, J.L., Mink, J.B.: Distribution and fate of I131-labeled components of the fibrinolysis system. Circulat. Res. 9, 1208 (1961)PubMedGoogle Scholar
  5. Back, N., Guth, P.S., Munson, A.E.: On the relationship between plasmin and kinin. Ann. N.Y. Acad. Sci. 104, 53 (1963)PubMedCrossRefGoogle Scholar
  6. Baillie, A.J., Sim, A.K.: Activation of the fibrinolytic enzyme system in laboratory animals and in man. A comparative study. Thrombos. Diathes. haemorrh. (Stuttg.) 25, 499 (1971)Google Scholar
  7. Blix, S.: The stability of fibrinolytic inhibitors in human serum and the inhibitor content in animal sera. Scand. J. clin. Lab. Invest. 16, 614 (1964)PubMedCrossRefGoogle Scholar
  8. Broersma, R.J., Bullemer, G.D., Mammen, E.F.: Acidosis induced disseminated intravascular microthrombosis and its dissolution by streptokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 24, 55 (1970)Google Scholar
  9. Broersma, R.J., Mammen, E.F.: Streptokinase in experimental disseminated intravascular coagulation. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 47, 255 (1971)Google Scholar
  10. Brogden, R.N., Speight, T.M., Avery, G.S.: Streptokinase: A review of its clinical pharmacology, mechanism of action and therapeutic uses. Drugs 5, 353 (1973)CrossRefGoogle Scholar
  11. Buluk, K., Malofiejew, M., Czokalo, M.: Activation of fibrinolysis and of plasma-kinin system during venostasis. Thrombos. Diathes. haemorrh. (Stuttg.) 14, 500 (1965)Google Scholar
  12. Chattopadhyay, D.P., Cliffton, E.E.: Activation of rabbit plasminogen by streptokinase. Amer. J. Physiol. 208, 190 (1965)PubMedGoogle Scholar
  13. Cliffton, E.E., Cannamela, D.A.: Proteolytic and fibrinolytic activity of serum. Activation by streptokinase and staphylokinase indicating dissimilarities of enzymes. Blood 8, 554 (1953)PubMedGoogle Scholar
  14. Cliffton, E.E., Downie, G.R.: Variations in proteolytic activity of serum of animals including man. Proc. Soc. exp. Biol. (N.Y.) 73, 559 (1950)Google Scholar
  15. Cliffton, E.E., Mootse, G.: Species variations in fibrinolytic activity. Thrombos. Diathes. haemorrh. (Stuttg.) 18, 291 (1967)Google Scholar
  16. Coates, G., DeNardo, S.J., DeNardo, G.L.: Pharmacokinetics of radioiodinated streptokinase. J. nucl. Med. 14, 623 (1973)Google Scholar
  17. Coates, G., DeNardo, S.J., DeNardo, G.L., Troy, F.A.: Pharmacokinetics of radioiodinated streptokinase. J. nucl. Med. 16, 136 (1975)PubMedGoogle Scholar
  18. Doleschel, W., Auerswald, W.: Gel filtration studies of the complex forming capacity of streptokinase with human and heterologous plasminogens. Med. Pharm. exp. (Basel) 17, 248 (1967)CrossRefGoogle Scholar
  19. Dorobisz, T., Kaszubkiewicz, C., Osinski, B., Palider, S., Palider-Zaleska, H., Samplawska, B.: Frühe Streptase-Anwendung nach Transplantation von alloplastischen Aortenprothesen bei Hunden. Zbl. Chir. Suppl. 93, 167 (1969)Google Scholar
  20. Egeblad, K., Bertelsen, S.: Experimental thrombolysis by perfusion. II. Comparative study on the effect of streptokinase, urokinase and plasmin. Acta chir. scand. 135, 486 (1969)PubMedGoogle Scholar
  21. Eisen, V.: Kinin formation and fibrinolysis in human plasma. J. Physiol. (Lond.) 166, 514 (1963)Google Scholar
  22. Encke, A.: Untersuchungen zur fibrinolytischen Behandlung des Schocks. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 32, 361 (1969)Google Scholar
  23. Encke, A., Petrich, I., Schmidt, H.D., Schmier, J.: Der Einfluß einer Fibrinolysetherapie auf die Überlebensquote im normotensiven hämorrhagischen Schock. Langenbecks Arch. klin. Chir. 316, 677 (1966)CrossRefGoogle Scholar
  24. Fischer, G.: Untersuchungen über einen Antihistamin-ähnlichen Effekt der Streptokinase am isolierten Meerschweinchen-Ileum. Arzneimittel-Forsch. 19, 2017 (1969)Google Scholar
  25. Fischer, G., Udermann, H.: Kininfreisetzung aus menschlichem Plasma durch Streptokinase. Arzneimittel-Forsch. 20, 580 (1970)Google Scholar
  26. Fletcher, A.P., Alkjaersig, N., Sherry, S.: The clearance of heterologous protein from circulation in normal and immunized man. J. clin. Invest. 37, 1306 (1958)PubMedCrossRefGoogle Scholar
  27. Freimann, A.H., Bang, N.U., Cliffton, E.E.: Studies on the production of intravascular thrombi and their treatment with fibrinolysin. Circulat. Res. 8, 409 (1960)Google Scholar
  28. Geiger, W.B.: Involvement of a complement-like factor in the activation of blood protease. J. Immunol. 69, 597 (1952)PubMedGoogle Scholar
  29. Goodman, L.R., Goodman, C., Greenspan, R.H., Porter, C.D.: Failure to visualize experimentally produced emboli and thrombi using 131I-streptokinase. Investigative Radiology 8, 377 (1973)PubMedGoogle Scholar
  30. Gottlob, R., Zinner, G.: Treatment of venous thrombosis by continuous local infusions of streptokinase. Experimental investigations. J. internat. Coll. Surg. 28, 575 (1957)Google Scholar
  31. Gross, R., Hartl, W., Kloss, G., Rahn, B.: Thrombolyse durch Infusion hochgereinigter Streptokinase: Erfahrungen und Untersuchungen an den ersten 50 Kranken. Dtsch. med. Wschr. 85, 2129 (1960)PubMedCrossRefGoogle Scholar
  32. Grossi, C.E., Cliffton, E.E.: The lysis of arterial thrombi in rabbits and dogs by use of activated human plasminogen (fibrinolysin) (plasmin). Surgery 37, 794 (1955)PubMedGoogle Scholar
  33. Guest, M.M., Daly, B.M., Ware, A.G., Seegers, W.H.: A study of antifibrinolysin activity in the plasmas of various animal species. J. clin. Invest. 27, 785 (1948)CrossRefGoogle Scholar
  34. Gurevich, V., Thomas, D.P.: Streptokinase in acute pulmonary embolism. An experimental study. J. thorac. cardiovasc. Surg. 59, 655 (1970)Google Scholar
  35. Hampton, J.W., Matthews, C.: Similarities between baboon and human blood clotting. J. appl. Physiol. 21, 1713 (1966)PubMedGoogle Scholar
  36. Haustein, K.-O., Markwardt, F.: Untersuchungen über die Freisetzung gefäßwirksamer Stoffe beim Ablauf der Gerinnungs- und Fibrinolysevorgänge im menschlichen Blut. Acta biol. med. germ. 15, 386 (1965)PubMedGoogle Scholar
  37. Hawkey, C.M.: Fibrinolysis in animals. Symp. Zool. Soc. 27, 133 (1970)Google Scholar
  38. Hayashi, T., Maekawa, S.: Studies on the activating factors in fibrinolytic systems. II. Streptococcal and staphylococcal fibrinolysis. Jap. J. Exp. Med. 24, 287 (1954)Google Scholar
  39. Henry, R.L.: Methods for inducing experimental thrombosis. Angiology 13, 554 (1962)PubMedCrossRefGoogle Scholar
  40. Hiemeyer, V.: Die thrombolytische Therapie des Herzinfarktes. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 38, 249 (1970)Google Scholar
  41. Hiemeyer, V., Rasche, H.: Der Mechanismus der streptokinaseinduzierten Thrombolyse und seine Bedeutung für die Therapie akuter Gefäßverschlüsse. Klin. Wschr. 44, 539 (1966)PubMedCrossRefGoogle Scholar
  42. Hiemeyer, V., Rasche, H.: Vergleichende Untersuchungen zur Wirkung von Urokinase und Streptokinase im Tierversuch. Thrombos. Diathes. haemorrh. (Stuttg.) 17, 58 (1967)Google Scholar
  43. Hort, W., Poliwoda, H., DaCanalis, S., Knigge, J.: Untersuchungen über den Einfluß von Antikoagulantien und Fibrinolytika auf die Größe von Mikroinfarkten im Rattenherzen. Klin. Wschr. 44, 215 (1966)PubMedCrossRefGoogle Scholar
  44. Hume, M.: Thrombolysis of the experimental radioactive pulmonary embolus. Its demonstration with the use of several agents. New Engl. J. Med. 264, 471 (1961)PubMedCrossRefGoogle Scholar
  45. Hume, M.: Lysis of the experimental radioactive pulmonary embolus induced by streptokinase and streptokinase activated plasmin. Thrombos. Diathes. haemorrh. (Stuttg.) 11, 99 (1964)Google Scholar
  46. Hume, M., Glenn, W.W.L., Grillo, T.: Behavior in circulation of radioactive pulmonary embolus and its application to the study of fibrinolytic enzymes. Ann. Surg. 151, 507 (1960)PubMedCrossRefGoogle Scholar
  47. Innerfield, I., Rowley, G., Zweil, P., Siew, C.: Urinary proteolytic activity following oral streptokinase. Enzym. biol. clin. 7, 149 (1966)Google Scholar
  48. Irfan, M.: Fibrinolytic activity in animals of different species. Quart. J. exp. Physiol. 53, 374 (1968)PubMedGoogle Scholar
  49. Jestädt, R., Schlüter, G.: Tierexperimentelle Untersuchungen zur percutanen Thrombolyse mit der neuen synthetischen Heparinoid-Salbe. Med. Welt (Stuttg.) 15, 297 (1964).Google Scholar
  50. Johnson, A.J.: Recent advances in experimental thrombogenesis. Fed. Proc. 24, 827 (1965)PubMedGoogle Scholar
  51. Johnson, A.J., Tillet, W.S.: Lysis in rabbits of intravascular blood clots by the streptococcal fibrinolytic system (streptokinase). J. exp. Med. 95, 449 (1952)PubMedCrossRefGoogle Scholar
  52. Jørgensen, L., Hirsh, J., Glynn, M.F., Buhanan, M.R., Mustard, J.S.: Effect of streptokinase therapy on experimental fibrin-rich arterial thrombi. Amer. J. Path. 62, 7 (1971)PubMedGoogle Scholar
  53. Kliman, A., McKay, D.G.: The prevention of the generalized Shwartzman reaction by fibrinolytic activity. Arch. Path. 66, 715 (1958)Google Scholar
  54. Kline, D.L., Fishman, J.B.: Plasmin: The humoral protease. Ann. N.Y. Acad. Sci. 68, 25 (1957)PubMedCrossRefGoogle Scholar
  55. Kline, D.L., Fishman, J.B.: Proactivator function of human plasmin as shown by lysine esterase assay. J. biol. Chem. 236, 2907 (1964)Google Scholar
  56. Klöcking, H.-P.: Zur Pharmakologie des Streptokinasepräparates Awelysin®. Folia haemat. (Lpz.) 103, 445 (1976 a)Google Scholar
  57. Klöcking, H.-P.: Über die Aktivierung von Pferdeplasminogen durch Streptokinase. 1976 b (unpublished)Google Scholar
  58. Klöcking, H.-P., Markwardt, F.: Tierexperimentelle Verfahren zur Testung von Fibrinolytika und Antifibrinolytika. Folia haemat. (Lpz.) 92, 84 (1969)Google Scholar
  59. Klöcking, H.-P., Markwardt, F.: On toxicological examination of Streptokinase preparations. III. Symposium on toxicological testing for safety of new drugs. Prague 1976, p. 67Google Scholar
  60. Klöcking, H.-P., Senf, L., Drawert, J., Markwardt, F.: Tierexperimentelle Untersuchungen zur Pharmakokinetik von Streptokinase. Acta biol. med. germ. 34, 655 (1975)PubMedGoogle Scholar
  61. Lasch, H.G., Neuhof, H.: Die Fibrinolysebehandlung des Schocks. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 32, 355 (1969)Google Scholar
  62. Leger, L., Lande, M., Vergoz, D.: Fibrinolyse au cours de la chirurgie des cirrhoses. J. Chir. (Paris) 80, 155 (1960)Google Scholar
  63. Levis, G.P.: Formation of plasma kinins by plasmin. J. Physiol. (Lond.) 140, 285 (1958)Google Scholar
  64. Ling, C., Summaria, L., Robbins, K.C.: Isolation and characterization of bovine plasminogen activator from a human plasminogen-streptokinase mixture. J. biol. Chem. 242, 1419 (1967)PubMedGoogle Scholar
  65. Lohse, K., Krause, A.: Vergleichende Untersuchungen über die Wirkung und Nebenwirkungen von Varidase und Streptase bei der Behandlung des Hyphaemas am Kaninchenauge. Wiss. Z. Univ. Halle, Reihe M, 21, 59 (1972)Google Scholar
  66. Ludwig, H.: Experimentelle Untersuchungen zum diaplazentaren Übertritt von Streptokinase. Geburtsh. u. Frauenheilk. 26, 736 (1966)Google Scholar
  67. Ludwig, H.: Streptokinase während der Gestation. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 32, 307 (1969)Google Scholar
  68. Markwardt, F., Bernstein, K., Drawert, J., Eger, H., Klöcking, H.-P., Sedlarik, K., Vollmar, F., Wilde, J.: Thrombolytische Behandlung einer experimentellen Koronarthrombose mit Streptokinase. Exp. Path. (Jena) 14, 76 (1977)Google Scholar
  69. Markwardt, F., Klöcking, H.-P.: p-Aminomethylbenzoesäure (PAMBA), ein neues Antifibrinolytikum. Tierexperimentelle Untersuchungen. Münch. med. Wschr. 107, 2000 (1965)PubMedGoogle Scholar
  70. Markwardt, F., Klöcking, H.-P.: Tierexperimentell e Untersuchungen der Wirkung synthetischer Antifibrinolytika. Acta biol. med. germ. 17, 746 (1966)PubMedGoogle Scholar
  71. Markwardt, F., Klöcking, H.-P.: Pharmakologie des Streptokinasepräparates Awelysin®. Medicamentum 17, 197 (1976)Google Scholar
  72. Markwardt, F., Klöcking, H.-P., Sedlarik, K., Perlewitz, J., Drawert, J., Hoffmann, J.: Tierexperimentelle Untersuchungen zur thrombolytischen Wirkung von Streptokinase. Acta biol. med. germ. 35, 193 (1976)PubMedGoogle Scholar
  73. Markwardt, F., Landmann, H., Klöcking, H.-P.: Fibrinolytika und Antifibrinolytika. Jena: Fischer 1972, p. 46Google Scholar
  74. Martin, M., Hiemeyer, V., Rasche, H.: Zur intravasalen Streptokinase-induzierten Thrombolyse bei der Maus. Vitalmikroskopische und gerinnungsphysiologische Beobachtungen. Thrombos. Diathes. haemorrh. (Stuttg.) 14, 519 (1965)Google Scholar
  75. McKee, P.A., Lemmon, W.B., Hampton, J.W.: Streptokinase and urokinase activation of human, chimpanzee and baboon plasminogen. Thrombos. Diathes. haemorrh. (Stuttg.) 26, 512 (1971)Google Scholar
  76. Meyer, W.E.: Proteolytic activity of guinea pig serum activated by streptokinase-human plasminogen preparations. Amer. J. Physiol. 190, 303 (1957)Google Scholar
  77. Miller, G.A.H., Gibson, R.V., Honey, M., Sulton, G.C.: Treatment of pulmonary embolism with streptokinase. A preliminary report. Brit. med. J. 1969 I, 812Google Scholar
  78. Miller, J.M., Robinson, D.R., Jackson, D.A., Collier, C.S.: Reversal by ipsilon of lytic system in blood stream produced in rabbits by streptokinase. Arch. Surg. 78, 33 (1959)Google Scholar
  79. Mohler, S.R., Celander, D.R., Guest, M.M.: Distribution of urokinase among the common mammals. Amer. J. Physiol. 192, 186 (1958)PubMedGoogle Scholar
  80. Mootse, G., Fleming, L.B., Cliffton, E.E.: The mechanism of activation of cat plasma by streptokinase. Thrombos. Diathes. haemorrh. (Stuttg.) 14, 562 (1965)Google Scholar
  81. Müllertz, S.: Mechanism of activation and effect of plasmin in blood. Acta physiol. scand. Suppl. 38, 130 (1956)Google Scholar
  82. Niewiarowski, S., Latallo, Z.: Comparative studies of the fibrinolytic system of sera of various vertebrates. Thrombos. Diathes. haemorrh. (Stuttg.) 3, 404 (1959)Google Scholar
  83. Nowak, A., Gurewich, V.: Thrombolysis with streptokinase in rabbits. Dose response, fibrin-clot specificity and laboratory evaluation of fibrinolytic effect. Thrombos. Diathes. haemorrh. (Stuttg.) 31, 265 (1974)Google Scholar
  84. Pfeifer, G.W.: Experimentelle Untersuchungen zur Frage eines diaplacentaren Effektes von Streptokinase. Klin. Wschr. 43, 775 (1965)PubMedCrossRefGoogle Scholar
  85. Pfeifer, G.W.: Distribution and placental transfer of 131I-streptokinase. Aust. Ann. Med. 1970, Suppl., p. 17Google Scholar
  86. Pfeifer, G.W., Doerr, F., Brod, K.-H.: Zur Pharmakokinetik von 131J-Streptokinase am Menschen. Klin. Wschr. 47, 482 (1969 a)PubMedCrossRefGoogle Scholar
  87. Pfeifer, G.W., Doerr, F., Brod, K.-H., Berle, P., Dietz, M.: Verteilungsstudien zur Placentapassage von 131J-Streptokinase unter der Geburt. Arch. Gynäk. 207, 550 (1969 b)CrossRefGoogle Scholar
  88. Rasche, H., Hiemeyer, V., Heimpel, H.: Verteilungsstudien mit radioaktiv markierter Streptokinase. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 32, 133 (1969)Google Scholar
  89. Reddy, K.N.N., Kline, D.L.: Requirement of human plasmin for streptokinase activation of bovine plasminogen. Thrombos. Res. 6, 481 (1975)CrossRefGoogle Scholar
  90. Ronneberger, H.: Zur gelegentlichen Temperaturerhöhung nach Streptokinase-Infusionen. Tierexperimentelle Befunde. Arzneimittel-Forsch. 25, 641 (1975)Google Scholar
  91. Sailer, S., Eber, O.: Tierexperimentelle Thrombolyseversuche mit direkt wirkenden Fibrinolytika. Klin. Wschr. 41, 212 (1963)PubMedCrossRefGoogle Scholar
  92. Sandritter, W., Schlüter, G., Köppel, G.: Thrombolyse im Tierexperiment. Med. Welt (Stuttg.) 1964, II, 2732Google Scholar
  93. Schick, L.A., Castellino, J.: Interaction of streptokinase and rabbit plasminogen. Biochemistry 12, 4315 (1973)PubMedCrossRefGoogle Scholar
  94. Schmalisch, N.: Kollagenolytische Wirkung von Streptokinase. Verh. Dtsch. Ges. inn. Med. 74, 595 (1968)PubMedGoogle Scholar
  95. Schmidt, H.W.: Zur thrombolytischen Therapie mit Streptokinase. Dtsch. med. Wschr. 88, 1407 (1963)PubMedCrossRefGoogle Scholar
  96. Schmutzler, R., Koller, F.: Die Thrombolyse-Therapie. Erg. Inn. Med. Kinderheilk. 22, 157 (1965)Google Scholar
  97. Schwick, G.: Biochemie der Fibrinolyse. Behringwerk-Mitt. 44, 128 (1964)Google Scholar
  98. Sherry, S.: The fibrinolytic activity of streptokinase activated human plasmin. J. clin. Invest. 33, 1054 (1954)PubMedCrossRefGoogle Scholar
  99. Sherry, S., Alkjaersig, N.: Studies on the fibrinolytic enzyme of human plasma. Thrombos. Diathes. haemorrh. (Stuttg.) 1, 264 (1957)Google Scholar
  100. Sherry, S., Titchener, A., Gottesman, L., Wassermann, P., Troll, W.: The enzymatic dissolution of experimental arterial thrombi in the dog by trypsin, chymotrypsin and plasminogen activators. J. clin. Invest. 33, 1303 (1954)PubMedCrossRefGoogle Scholar
  101. Sodetz, J.M., Brockway, W.J., Castellino, F.J.: Multiplicity of rabbit plasminogen. Physical characterization. Biochemistry 11, 4451 (1972)Google Scholar
  102. Som, P., Rhodes, B.A., Bell, W.R.: Radiolabeled streptokinase and urokinase and their comparative biodistribution. Thrombos. Res. 6, 247 (1975)CrossRefGoogle Scholar
  103. Spöttl, F., Kaiser, R.: Rapid detection and quantitation of precipitating streptokinase-antibodies. Thrombos. Diathes. haemorrh. (Stuttg.) 32, 608 (1974)Google Scholar
  104. Tadokoro, S., Kurihara, Y., Shibata, K.: Pharmacological studies on streptokinase-streptodornase (Varidase), especially on its toxicity. Gunma J. med. Sci. 9, 225 (1960)Google Scholar
  105. Taylor, F.B., Jr., Singleton, J., Bickford, A.F., Jr.: In vivo activation of the fibrinolytic enzyme system of dogs. J. appl. Physiol. 18, 334 (1963)PubMedGoogle Scholar
  106. Thomas, D.P.: Treatment of pulmonary embolic disease: a clinical review of some aspects of current therapy. New Engl. J. Med. 273, 885 (1965)PubMedCrossRefGoogle Scholar
  107. Tillet, W.S., Edwards, L.B., Garner, R.L.: Fibrinolytic activity of hemolytic streptococci. The development of resistance to fibrinolysis following acute hemolytic streptococcus infection. J. clin. Invest. 13, 47(1934)Google Scholar
  108. Tillet, W.S., Garner, R.L.: The fibrinolytic activity of hemolytic streptococci. J. exp. Med. 68, 488 (1933)Google Scholar
  109. Tsapogas, M.J.: The role of fibrinolysis in the treatment of arterial thrombosis: experimental and clinical aspects. Ann. roy. Coll. Surg. 34, 293 (1964)Google Scholar
  110. Tsapogas, M.J., Flute, P.T.: Experimental thrombolysis with streptokinase and urokinase. Brit. med. Bull. 20, 223 (1964)Google Scholar
  111. Tsapogas, M.J., Flute, P.T., Cotton, L.T., Milroy, S.D.: Lysis of experimental thrombi by streptokinase. Brit. J. Surg. 50, 334 (1962)PubMedCrossRefGoogle Scholar
  112. Vogt, W.: Kinin formation by plasmin, an indirect process mediated by activation of kallikrein. J. Physiol. (Lond.) 170, 153 (1964)Google Scholar
  113. Warren, B.A.: Fibrinolytic activity of vascular endothelium. Brit. med. Bull. 20, 213 (1964)PubMedGoogle Scholar
  114. Wende, W., Stühlen, H.W., Meyer, J, Bleifeld, W., Holzhüter, H., Wenzel, E.: Die Größe des akuten tierexperimentellen Herzinfarktes unter Streptokinase-induzierter Fibrinolyse. Klin. Wschr. 53, 755 (1975)PubMedCrossRefGoogle Scholar
  115. Wulf, R.J., Mertz, E.T.: Studies on plasminogen. VIII. Species specificity of streptokinase. Canad. J. Biochem. 47, 927 (1969)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • H.-P. Klöcking

There are no affiliations available

Personalised recommendations