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Regression of Early Lesions in Monkeys

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Atherosclerosis — is it reversible?

Abstract

This paper presents electron microscopic observations on the mechanism whereby early atherosclerotic plaques are resolved after the serum cholesterol level is lowered. In particular, it shows how cells that proliferate during the hypercholesterolemic period are removed and suggests mechanisms by which intracellular lipid inclusions are removed from arterial smooth muscle cells.

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References

  1. Novtkoff, A.B.: Lysosomes: A personal account. In: Lysosomes and storage diseases. Hers, H.G., Van Hoof, F. (Eds.). New York: Academic Press 1973, pp. 1–41.

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  2. Stary, H.C.: Progression and regression of experimental atherosclerosis in rhesus monkeys. In: Medical Primatology, Part III. Basel: Karger 1972, pp. 356–367.

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  3. Stary, H.C., Strong, J.P.: Coronary artery fine structure in rhesus monkeys: Nonatherosclerotic intimal thickening. Primates in Med. 9, 321–358 (1976a).

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  4. Stary, H.C., Strong, J.P.: The fine structure of nonatherosclerotic intimal thickening, of developing, and of regressing atherosclerotic lesions at the bifurcation of the left coronary artery. Adv. Exp. Med. Biol. 67, 89–108 (1976b).

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  5. Zahn, F.W.: Untersuchung über die Vernarbung von Querrissen der Arterienintima und Media nach vorheriger Umschnürung. Virchows Arch. path. Anat. 96, 1–15 (1884).

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Authors
  1. H. C. Stary
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Klinikum der Universität Heidelberg, Bergheimerstraße 58, D-6900, Heidelberg, Germany

    Gotthard Schettler

  2. Department Innere Medizin, Universität Ulm, Steinhövelstraße 9, D-7900, Ulm, Germany

    Eduard Friedrich Stange

  3. The Division of the Biological Sciences and the Pritzker School of Medicine, The University of Chicago, 950 East 59th Street, Chicago, IL, 60637, USA

    Robert W. Wissler

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© 1978 Springer-Verlag Berlin · Heidelberg

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Stary, H.C. (1978). Regression of Early Lesions in Monkeys. In: Schettler, G., Stange, E.F., Wissler, R.W. (eds) Atherosclerosis — is it reversible?. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66850-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-66850-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08582-9

  • Online ISBN: 978-3-642-66850-0

  • eBook Packages: Springer Book Archive

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