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Structure and Function of the Genome of Viruses Containing Single-Stranded RNA as Genetic Material: The Concept of Transcription and Translation Helices and the Classification of these Viruses into Six Groups

  • Gerd Wengler
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 78)

Abstract

Studies on the structure of viruses have shown that the viral nucleic acid is complexed to viral protein and that these nucleoproteins can be of three different types: complex, helical, or icosahedral. No generally valid concept for the mechanism of assembly of complex nucleoproteins has been established, but the biologic and physical principles involved in the assembly of helical and icosahedral nucleoproteins have been analyzed in detail. These analyses have shown that the protein component is built up of identical subunits thus efficiently using the limited amount of viral genetic information which codes for viral structural proteins for constructing protein complexes of rather high molecular weight (Crick and Watson, 1956). It has been predicted that the organization of identical protein subunits in equivalent positions in an isometric nucleoprotein leads to the assembly of particles of cubic symmetry (Crick and Watson, 1956). Furthermore, Caspar and Klug introduced the concept of quasiequivalence into the analysis of virus structure and showed that the assembly of isometric protein complexes from identical protein subunits positioned in quasi-equivalent positions leads to particles having cubic symmetry of the icosahedral type (Caspar andKlug, 1962). Why the genetic material is organized in icosahedral nucleoproteins in some viruses and in helical nucleoproteins in others remains uncertain. Caspar and Klug have described the stability, assembly, and disassembly of these two types of nucleoproteins and have suggested that “one or the other could be selected according to the biologic function required (Caspar and Klug, 1962).”

Keywords

Tobacco Mosaic Virus Vesicular Stomatitis Virus Rous Sarcoma Virus Animal Virus Plant Rhabdovirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • Gerd Wengler
    • 1
  1. 1.Institut für VirologieJustus-Liebig-Universität GießenLahn-GießenFederal Republic of Germany

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