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DNA Replication—Bacteriophage Lambda

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 78))

Abstract

The last thorough review of λ DNA replication was written by Dale Kaiser for the “Lambda Book” in 1971. At this time most of the phage functions (e.g., N, O and P) and some of the bacterial functions (e.g., dnaR) essential for λ replication had been identified. Many structural details concerning circle replication had been elucidated and its origin and bidirectional nature determined electron microscopically. The reader is referred to that article for details and references to the earlier studies on which this knowledge was based. The ensuing years have provided a fuller understanding of many aspects of replication first alluded to in that review, some of them summarized in a general context by Yarmolinsky (1975). This chapter summarizes the basic findings since that time, with particular emphasis on the relationship between early (circle) and late (rolling circle) λ replication, a topic that has been central to the interest of our laboratory for the past several years.

“…To understand a phenomenon is to understand a category of phenomena or it is nothing. Understanding is reached through creative acts.

The universe presents an infinite number of phenomena. The faith of the scientist, if he has faith, is that these can be reduced to a finite number of categories. Even so, he tends to consider the path toward his goal as endless…”

(A.D. Hershey, 1967)

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Authors and Affiliations

  1. Roche Institute of Molecular Biology, 07110, Nutley, NJ, USA

    Anna Marie Skalka

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  1. Basle, Switzerland

    W. Arber

  2. Philadelphia, USA

    W. Henle

  3. Martinsried, Germany

    P. H. Hofschneider

  4. London, UK

    J. H. Humphrey

  5. Dallas, USA

    J. Klein

  6. Philadelphia, USA

    P. Koldovský

  7. Philadelphia, USA

    H. Koprowski

  8. Copenhagen, Denmark

    O. Maaløe

  9. Basle, Switzerland

    F. Melchers

  10. Gießen, Germany

    R. Rott

  11. Wilhelmshaven, Germany

    H. G. Schweiger

  12. Prague, Czech Republic

    L. Syruček

  13. Los Angeles, USA

    P. K. Vogt

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© 1977 Springer-Verlag Berlin Heidelberg

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Skalka, A.M. (1977). DNA Replication—Bacteriophage Lambda. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66800-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-66800-5_7

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