Antigen-Receptor Interactions in the Induction of B-Lymphocyte Unresponsiveness

  • Gerhard G. B. Klaus
  • Abul K. Abbas
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 78)


In the past decade it has been established that antigen-reactive cells are lymphocytes and can be divided into two distinct functional classes. Thymus-processed (T-) lymphocytes are the effectors of cell-mediated immunity (e.g., delayed-type hypersensitivity and graft rejection), and also exert important regulatory (helper or suppressor) influences on thymus-independent (bone marrow-derived) B-lymphocytes, which are the direct precursors of antibody-forming cells (AFC).


Antigen Receptor Tolerance Induction Cell Tolerance Immunological Tolerance Clonal Selection Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Antigen-binding cell(s)


Group A streptococcal carbohydrate


Antibody-forming cell(s)


Anti-idiotypic antibodies


Bovine γ-globulin


2, 4 dinitrophenyl


Copolymer of D-glutamic acid and D-lysine


Human γ-globulin




Keyhole limpet hemocyanin


Copolymer of L-glutamic acid and L-lysine


Bacterial lipopolysaccharide


mouse γ-globulin


4-hydroxy 3-iodo 5-nitrophenacetyl


Peripheral blood lymphocyte(s)


Polymerized Salmonella flagellin


type III pneumococcal polysaccharide


Surface Ig


Sheep red blood cells


T-cell independent


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  1. Abbas, A.K., Klaus, G.G.B.: Inhibition of antibody production in plasmacytoma cells by antigens. Eur. J. Immunol., 1977 (in press)Google Scholar
  2. Abbas, A.K, Unanue, E.R.: Interrelationship of surface immunoglobulin and Fc receptors on mouse B lymphocytes. J. Immunol. 115, 1665–1671 (1975)PubMedGoogle Scholar
  3. Abbas, A.K, Klaus, G.G.B., McElroy, P.J.: Mechanisms of B cell tolerance. I. Dynamic nature of the induction of hapten-specific unresponsiveness by hapten-conjugated pneumococcal polysaccharide. Eur. J. Immunol. 7, 382–387 (1977)PubMedCrossRefGoogle Scholar
  4. Abbas, A.K., Unanue, E.R., Karnovsky, M.J.: Current techniques for the detection of surface immunoglobulin on lymphocytes. In: Techniques of Biochemical and Biophysical Morphology. New York: John Wiley 1977 (in press)Google Scholar
  5. Abney, E.R., Parkhouse, R.M.E.: Candidate for IgD present on murine B lymphocytes. Nature (Lond.) 252, 600–602 (1974)CrossRefGoogle Scholar
  6. Ada, G.L.: Antigen-binding cells in tolerance and immunity. Transplant. Rev. 5, 105–129 (1970)PubMedGoogle Scholar
  7. Aldo-Benson, M., Borel, Y.: The tolerant cell: direct evidence for receptor blockade by tolerogen. J. Immunol. 112, 1793–1803 (1974)PubMedGoogle Scholar
  8. Aldo-Benson, M., Borel, Y.: Loss of carrier-determined tolerance in vitro with loss of receptor blockade. J. Immunol. 116, 223–226 (1976)PubMedGoogle Scholar
  9. Allison, A.C.: Unresponsiveness to self antigens. Lancet 1971/II, 1401–1403CrossRefGoogle Scholar
  10. Allison, A.C., Denman, A.M.: Self-tolerance and autoimmunity. Br. Med. Bull. 32, 124–129 (1976)PubMedGoogle Scholar
  11. Anderson, C.L., Grey, H.M.: Receptors for aggregated IgG on mouse lymphocytes. Their presence on thymocytes, thymus-derived, and bone-marrow derived lymphocytes. J. Exp. Med. 139, 1175–1188 (1974)PubMedCrossRefGoogle Scholar
  12. Andersson, J., Sjoberg, O., Moller, G.: Mitogens as probes for immunocyte activation and cellular cooperation. Transplant. Rev. 11, 131–177 (1972)PubMedGoogle Scholar
  13. Andersson, J., Bullock, W.W., Moller, G.: Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies. Eur. J. Immunol. 4, 715–722 (1974)PubMedCrossRefGoogle Scholar
  14. Andersson, J., Buxbaum, J., Citronbaum, R., Douglas, S., Forni, L., Melchers, F., Pernis, B., Stott, D.: IgM-producing tumors in the Balb/c mouse: a model for B-cell maturation. J. Exp. Med. 140, 742–763 (1974)PubMedCrossRefGoogle Scholar
  15. Andre, C., Heremans, J.F., Vaerman, J.P., Cambiaso, C.L.: A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes. J. Exp. Med. 142, 1509–1519 (1975)PubMedCrossRefGoogle Scholar
  16. Ashman, R.F., Raff, M.C.: Direct demonstration of theta-positive antigen-binding cells, with antigen-induced movement of thymus-dependent cell receptors. J. Exp. Med. 137, 69–78 (1973)PubMedCrossRefGoogle Scholar
  17. Askonas, BA., Schimpl, A., Wecker, E.: The differentiation function of TRF in nu/nu spleen cell cultures. Eur. J. Immunol. 4, 164–169 (1974)PubMedCrossRefGoogle Scholar
  18. Ault, K.A., Unanue, E.R.: Events following the binding of antigen to lymphocytes. J. Exp. Med. 139, 1110–1124 (1974)PubMedCrossRefGoogle Scholar
  19. Ault, K.A., Unanue, E.R., Katz, D.H., Benacerraf, B.: Failure of lymphocytes to re-express antigen receptors after brief interaction with a tolerogenic D-amino acid copolymer. Proc. Natl. Acad. Sci. U.S.A. 71, 3111–3114 (1974)PubMedCrossRefGoogle Scholar
  20. Baker, P.J.: Homeostatic control of antibody responses: a model based on the recognition of cell-associated antibody by regulatory T cells. Transplant. Rev. 26, 3–20 (1975)PubMedGoogle Scholar
  21. Bankhurst, A.D., Torrigiani, G., Allison, A.C.: Lymphocytes binding human thyroglobulin in healthy people and its relevance to tolerance to autoantigens. Lancet 1973/1, 226–230PubMedCrossRefGoogle Scholar
  22. Basten, A., Howard, J.G.: Thymus independence. Contemp. Top. Immunobiol. 2, 265–291 (1973)Google Scholar
  23. Basten, A., Miller, J.F.A.P., Sprent, J., Pye, J.: A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J. Exp. Med. 135, 610–626 (1972)PubMedCrossRefGoogle Scholar
  24. Becker, K.E., Ishizaka, T., Metzger, H., Ishizaka, K., Grimley, P.M.: Surface IgE on human basophils during histamine release. J. Exp. Med. 138, 394–409 (1973)PubMedCrossRefGoogle Scholar
  25. Benacerraf, B., Katz, D.H.: The histocompatibility linked immune response genes. Adv. Cancer Res. 21, 121–174 (1975)PubMedCrossRefGoogle Scholar
  26. Benjamin, D.C.: Evidence for specific suppression in the maintenance of immunologic tolerance. J. Exp. Med. 141, 635–646 (1975)PubMedCrossRefGoogle Scholar
  27. Berke, G., Levey, R.H.: Cellular immunoabsorbents in transplantation immunity. Specific in vitro depletion and recovery of mouse lymphoid cells sensitized against allogeneic tumors. J. Exp. Med. 135, 972–984 (1972)PubMedCrossRefGoogle Scholar
  28. Billingham, R.E., Brent, L., Medawar, P.B.: Actively acquired tolerance of foreign cells. Nature (Lond.) 172, 603–606 (1953)CrossRefGoogle Scholar
  29. Binz, H., Wigzell, H.: Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. i. Demonstration of similar or identical idio- types on IgG molecules and T-cell receptors for the same alloantigens. J Exp. Med. 142, 197–211 (1975)PubMedCrossRefGoogle Scholar
  30. Binz, H., Wigzell, H.: Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinant. V. Biochemical and serological characteristics of naturally occurring antigen-binding T-lymphocyte-derived molecules. Scand. J. Immunol. 5, 559–572 (1976)PubMedCrossRefGoogle Scholar
  31. Black, S.J., Hämmer ling, G.J., Berek, C., Rajewsky, K., Eichmann, K.: Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody. J. Exp. Med. 143, 846–860 (1976)PubMedCrossRefGoogle Scholar
  32. Borel, Y.: Isologous IgG induced immunologic tolerance to haptens: a model of self versus non-self recognition. Transplant. Rev. 31, 1–22 (1976)Google Scholar
  33. Borel, Y, Reinish, C.L., Schlossman, S.F.: T and B cell in hapten-specific carrier-determined tolerance. J. Exp. Med. 142, 1254–1262 (1975)PubMedCrossRefGoogle Scholar
  34. Borel, Y., Golan, D.T., Kilham, L., Borel, H.: Carrier determined tolerance with various subclasses of murine myeloma IgG. J. Immunol. 116, 854–858 (1976)PubMedGoogle Scholar
  35. Bretscher, P.A., Cohn, M.: A theory of self-nonself discrimination. Science. 169, 1042–1049 (1970)PubMedCrossRefGoogle Scholar
  36. Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Nashville: Vanderbilt University Press 1959Google Scholar
  37. Burnet, F.M., Fenner, F.: The Production of Antibodies, 2nd. ed. London: Macmillan 1949Google Scholar
  38. Byrt, P., Ada, G.L.: An in vitro reaction between labelled flagellin or haemocyanin and lymphocyte-like cells from normal animals. Immunology 17, 503–516 (1969)PubMedGoogle Scholar
  39. Cambier, J.C., Vitetta, E.S., Uhr, J.W., Kettman, J.R.: B-cell tolerance. II. TNP17 HGG- induced tolerance in adult and neonatal murine B cells responsive to thymus dependent and independent forms of the same hapten. J. Exp. Med. 145, 778–783 (1971)CrossRefGoogle Scholar
  40. Chiller, J.M., Habicht, G.S., Weigle, W.O.: Cellular sites of immunologic unresponsiveness. Proc. Natl Acad. Sci. U.S.A. 65, 551–556 (1970)PubMedCrossRefGoogle Scholar
  41. Chiorazzi, N., Esshar, Z., Katz, D.H.: Induction of immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy. Proc. Natl. Acad. Sci. U.S.A. 73, 2091–2095 (1976)PubMedCrossRefGoogle Scholar
  42. Claman, H.N., Hosier, D.E.: Cell-cell interactions in antibody production. Prog. Allergy 16, 40–80 (1972)PubMedCrossRefGoogle Scholar
  43. Coutinho, A., Moller, G.: Immune activation of B cells: evidence for ‘one non-specific triggering signal’ not delivered by the Ig receptors. Scand. J. Immunol. 3, 133–146 (1974)PubMedCrossRefGoogle Scholar
  44. Cunningham, A.J.: Self-tolerance maintained by active suppressor mechanisms. Transplant. Rev. 31, 23–13 (1976)PubMedGoogle Scholar
  45. Cunningham, B.A., Wang, J.L., Gunther, G.R., Reeke, G.N., Becker, J.W.: Molecular analysis of the initial events in mitogenesis. In: Cellular Selection and Regulation in the Immune Response. New York: Raven 1974Google Scholar
  46. Davie, J.M., Paul, W.E.: Antigen-binding receptors on lymphocytes. Contemp. Top. Immu- nobiol. 3, 171–192 (1974)Google Scholar
  47. Diener, E., Armstrong, W.D.: Immunological tolerance in vitro: kinetic studies at the cellular level. J. Exp. Med. 129, 591–603 (1969)PubMedCrossRefGoogle Scholar
  48. Diener, E., Feldmann, M.: Relationship between antigen and antibody-induced suppression of immunity. Transplant. Rev. 8, 76–103 (1972)PubMedGoogle Scholar
  49. Diener, E., Feldmann, M.: Mechanisms at the cellular level during induction of high zone tolerance in vitro. Cell. Immunol. 5, 130–136 (1972 a)PubMedCrossRefGoogle Scholar
  50. Diener, E., Paetkau, V.H.: Antigen recognition: early surface-receptor phenomena induced by binding of a tritium-labeled antigen. Proc. Natl. Acad. Sci. U.S.A. 69, 2364–2368 (1972)PubMedCrossRefGoogle Scholar
  51. Diener, E., Kraft, N., Armstrong, W.D.: Antigen recognition. I. Immunological significance of antigen binding cells. Cell. Immunol. 6, 80–86 (1973)PubMedCrossRefGoogle Scholar
  52. Diener, E., Kraft, N., Lee, K.C., Shiozawa, C.: Antigen recognition. IV. Discrimination by antigen-binding immunocompetent B cells between immunity and tolerance is determined by adherent cells. J. Exp. Med. 143, 805–821 (1976)PubMedCrossRefGoogle Scholar
  53. Dresser, D. W.: Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology 5, 378–388 (1962)PubMedGoogle Scholar
  54. Dresser, D.W.: Tolerance induction as a model for cell differentiation. Br. Med. Bull. 32, 147–151 (1976)PubMedGoogle Scholar
  55. Dresser, D. W., Mitchison, N.A.: The mechanism of immunological paralysis. Adv. Immunol. 8, 129–181 (1968)PubMedCrossRefGoogle Scholar
  56. Ehrlich, P., Morgenroth, J.: Über Hemolysine. Berl. Klin. Wochenschr. 37, 453–458 (1900)Google Scholar
  57. Eichmann, K: Idiotype suppression. II. Amplification of a suppressor T cell with anti-idiotype activity. Eur. J. Immunol. 5, 511–517 (1975)PubMedCrossRefGoogle Scholar
  58. Eichmann, K, Rajewsky, K.: Induction of T and B cell immunity by anti-idiotypic antibody. Eur. J. Immunol. 5, 661–666 (1975)PubMedCrossRefGoogle Scholar
  59. Elliott, B.E., Haskill, J.S.: Characterization of thymus-derived and bone marrow-derived rosette-forming lymphocytes. Eur. J. Immunol. 3, 68–74 (1973)PubMedCrossRefGoogle Scholar
  60. Eshhar, Z., Benacerraf, B., Katz, D.H.: Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL). J. Immunol. 114, 872–876 (1975)PubMedGoogle Scholar
  61. Fanger, M.W., Hart, D.A., Wells, J.V., Nisonoff A.: Requirement for crosslinkage in the stimulation of transformation of rabbit peripheral lymphocytes by antiglobulin reagents. J. Immunol. 105, 1484–1492 (1970)PubMedGoogle Scholar
  62. Feldmann, M.: Induction of immunity and tolerance in vitro by hapten-protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin. J. Exp. Med. 135, 735–753 (1972)PubMedCrossRefGoogle Scholar
  63. Feldmann, M., Diener, E.: Antibody mediated suppression of the immune response in vitro. I. Evidence for a central effect. J. Exp. Med. 131, 247–274 (1970)PubMedCrossRefGoogle Scholar
  64. Feldmann, M., Diener, E.: Antibody mediated suppression of the immune response in vitro. III. Low zone tolerance in vitro. Immunology 21, 387–404 (1971)PubMedGoogle Scholar
  65. Feldmann, M., Diener, E.: Antibody-mediated suppression of the immune response in vitro. IV. The effects of antibody fragments. J. Immunol. 108, 93–101 (1972)PubMedGoogle Scholar
  66. Fitch, F.W.: Selective suppression of immune responses. Prog. Allergy 19, 195–244 (1975)PubMedGoogle Scholar
  67. Froland, S., Natvig, J.: Identification of three different human lymphocyte populations by surface markers. Transplant. Rev. 16, 114–162 (1973)PubMedGoogle Scholar
  68. Fu, S.M., Winchester, R.J., Feizi, T., Walzer, P.D., Kunkel, E.G.: Idiotypic specificity of surface Ig and the maturation of leukemic bone-marrow-derived lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 71, 4487–4490 (1974)PubMedCrossRefGoogle Scholar
  69. Galanaud, P., Crevon, M.-C., Erard, D., Dormont, J.: Hapten-IgG-induced suppression of the in vitro antibody response. Cell. Immunol. 29, 72–85 (1977)PubMedCrossRefGoogle Scholar
  70. Gelfand, M.C., Elfenbein, G.J., Frank, M.M., Paul, W.E.: Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface Ig and complement receptors. J. Exp. Med. 139, 1125–1141 (1974)PubMedCrossRefGoogle Scholar
  71. Goding, J.W., Layton, J.E.: Antigen induced capping of IgM and IgD-like receptors on murine B cells. J. Exp. Med. 144, 852–856 (1976)PubMedCrossRefGoogle Scholar
  72. Greaves, M.F.: Cell surface receptors: a biological perspective. In: Receptors and Recognition. Series A, Vol. I. London: Chapman and Hall 1975Google Scholar
  73. Greeley, E.A., Scott, D.W.: Receptors for antigen on lymphoid cells. II. The nature of the molecule responsible for plaque forming cell adherence. J. Immunol. 115, 409–13 (1975)PubMedGoogle Scholar
  74. Gronowicz, E., Coutinho, A.: Hapten-induced B cell paralysis. II. Evidence for trivial mechanisms of tolerance. Eur. J. Immunol. 5, 413–420 (1975)CrossRefGoogle Scholar
  75. Hamaoka, T., Katz, D.H.: Immunological tolerance in bone marrow-derived lymphocytes. II. Effects of allogeneic cell interactions and enzymatic digestion with trypsin on inactivated hapten-specific precursor cells. J. Exp. Med. 139, 1446–1463 (1974)PubMedCrossRefGoogle Scholar
  76. Hamilton, J.A., Miller, J.F.A.P.: Induction of a primary antihapten response in vivo by a graft-versus-host reaction. J. Exp. Med. 138, 1009–1014 (1973)PubMedCrossRefGoogle Scholar
  77. Hämmer ling, G.J., McDevitt, H.O.: Comparative analysis of antigen-binding T cells in genetic high and low responder mice. J. Exp. Med. 140, 1180–1188 (1974)PubMedCrossRefGoogle Scholar
  78. Hämmer ling, G.J., Black, S.J., Berek, C., Rajewsky, K., Eichmann, K.: Idiotypic analysis of lymphocytes in vitro. II. Genetic analysis of T helper cell responsiveness to anti-idiotype antibody. J. Exp. Med. 143, 861–869 (1976)PubMedCrossRefGoogle Scholar
  79. Hellstrom, K.E., Hellstrom, I.: Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv. Immunol. 18, 209–277 (1974)PubMedCrossRefGoogle Scholar
  80. Howard, J.G., Courtenay, B.M.: Induction of B cell tolerance to polysaccharides by exhaustive immunization and during immunosuppression with cyclophosphamide. Eur. J. Immunol. 4, 603–608 (1974)PubMedCrossRefGoogle Scholar
  81. Howard, J.G., Courtenay, B.M.: Influence of molecular structure on the tolerogenicity of bacterial dextrans. II. The al-3-linked epitope of dextran B1355. Immunology 29, 599–610 (1975)PubMedGoogle Scholar
  82. Howard, J.G., Hale, C.: Lack of neonatal susceptibility to induction of tolerogen by polysaccharide antigens. Eur. J. Immunol. 6, 486–492 (1976)PubMedCrossRefGoogle Scholar
  83. Howard, J.G., Mitchison, N.A.: Immunological tolerance. Prog. Allergy. 18, 43–96 (1975)PubMedGoogle Scholar
  84. Howard, J.G., Elson, J., Christie, R.G., Kinsky, R.G.: Studies on immunological paralysis. II. The detection and significance of antibody-forming cells in the spleen during immunological paralysis with type III pneumococcal polysaccharide. Clin. Exp. Immunol. 4, 41–53 (1969)PubMedGoogle Scholar
  85. Howard, J.G., Christie, G.H., Courtenay, B.M.: Studies on immunological paralysis. VII. Rapid reversal of Felton’s paralysis as evidence for tolerant cells. Proc. R. Soc. B. 180, 347–362 (1972)CrossRefGoogle Scholar
  86. Hudson, L., Sprent, J., Miller, J.F.A.P., Playfair, J.H.L.: B cell-derived immunoglobulin on activated mouse T lymphocytes. Nature (Lond.) 25, 60–62 (1974)CrossRefGoogle Scholar
  87. Iverson, G.M.: Ability of CBA mice to produce anti-idiotypic sera to 5563 myeloma protein. Nature (Lond.) 227, 273 (1970)CrossRefGoogle Scholar
  88. Iverson, G.M., Lindenmann, J.: The role of a carrier determinant and T cells in the induction of liver-specific autoantibodies in the mouse. Eur. J. Immunol. 2, 195–197 (1972)PubMedCrossRefGoogle Scholar
  89. Janossy, G., Greaves, M.F.: Functional analysis of murine and human B lymphocyte subsets. Transplant. Rev. 24, 177–210 (1975)PubMedGoogle Scholar
  90. Jerne, N.K.: Towards a network theory of the immune system. Ann. Immunol. (Paris) 125 C, 373–389 (1974)Google Scholar
  91. Jones, P.P., Cebra, J.J., Herzenberg, L.A.: Immunoglobulin allotype markers on rabbit lymphocytes: separation of cells bearing different allotypes and demonstration of the binding of Ig to lymphoid cell membranes. J. Immunol. 111, 1334–1348 (1973)PubMedGoogle Scholar
  92. Julius, M.H., Herzenberg, L.A.: Isolation of antigen-binding cells from unprimed mice. Demonstration of AFC precursor activity and correlation between precursor and secreted antibody avidity. J. Exp. Med. 140, 904–920 (1974)PubMedCrossRefGoogle Scholar
  93. Kahn, C.R.: Membrane receptors for hormones and neurotransmitters. J. Cell. Biol. 70, 261–286 (1976)PubMedCrossRefGoogle Scholar
  94. Katz, D.H.: The allogeneic effect on immune responses: model for regulatory influences of T lymphocytes on the immune system. Transplant. Rev. 12, 141–179 (1972)PubMedGoogle Scholar
  95. Katz, D.H., Benacerraf, B.: The regulatory influence of activated T cells on B cell responses to antigen. Adv. Immunol. 15, 1–94 (1972)PubMedCrossRefGoogle Scholar
  96. Katz, D.H., Osborne, D.P.: The allogeneic effect in inbred mice. II. Establishment of the cellular interactions required for enhancement of antibody production by the graft- versus-host reaction. J. Exp. Med. 136, 455–465 (1972)PubMedCrossRefGoogle Scholar
  97. Katz, D.H., Davie, J.M., Paul, W.E., Benacerraf, B.: Carrier function in antihapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by ‘non-immunogenic ‘hapten-polypeptide conjugates. J. Exp. Med. 134, 201–223 (1971)PubMedCrossRefGoogle Scholar
  98. Katz, D.H., Hamaoka, T., Benacerraf, B.: Immunological tolerance in bone marrow derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten- specific precursors of antibody-forming cells. J. Exp. Med. 136, 1404–1429 (1972)PubMedCrossRefGoogle Scholar
  99. Katz, D.H., Hamaoka, T., Benacerraf, B.: Induction of immunological tolerance in bone- marrow-derived lymphocytes of the IgE antibody class. Proc. Natl. Acad. Sci. U.S.A. 70, 2776–2780 (1973)PubMedCrossRefGoogle Scholar
  100. Kearney, J.F., Cooper, M.D., Lawton, A.R.: B lymphocyte differentiation induced by lipo- polysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies. J. Immunol. 116, 1664–1668 (1976)PubMedGoogle Scholar
  101. Kishimoto, T., Ishizaka, K: Regulation of antibody response in vitro. IV. Heavy chain antigenic determinants of hapten-specific memory cells. J. Immunol. 109, 1163–1173 (1972)PubMedGoogle Scholar
  102. Klaus, G.G.B.: B cell tolerance induced by polymeric antigens. II. Effects of tolerance on hapten-binding lymphocyte levels in primary and secondary antibody responses. Eur. J. Immunol. 5, 366–372 (1975)CrossRefGoogle Scholar
  103. Klaus, G.G.B.: B cell tolerance induced by polymeric antigens. IV. Antigen-mediated inhibition of antibody forming cells. Eur. J. Immunol. 6, 200–207 (1976)PubMedCrossRefGoogle Scholar
  104. Klaus, G.G.B.: B cell tolerance induced by polymeric antigens. VI. Kinetics and reversibility of the inhibition of antibody-forming cells by antigen. Eur. J. Immunol. 6, 389–393 (1976 a)PubMedCrossRefGoogle Scholar
  105. Klaus, G.G.B.: B cell maturation: its relationship to immune induction and tolerance. In: B and T cells in Immune Recognition. Chichester: John Wiley 1977Google Scholar
  106. Klaus, G.G.B., Humphrey, J.H.: The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyl-lysine-substituted pneumococcal polysaccharide (SIII) and levan. Eur. J. Immunol. 4, 370–377 (1974)Google Scholar
  107. Klaus, G.G.B., Janossy, G., Humphrey, J.H.: The immunological properties of haptens coupled to thymus-independent carrier molecules. III. The role of the immunogenicity and mitogenicity of the carrier in the induction of primary IgM anti-hapten responses. Eur. J. Immunol. 5, 105–111 (1975)PubMedCrossRefGoogle Scholar
  108. Klaus, G.G.B., Howard, J.G., Feldmann, M.: Mechanisms of B cell tolerance. Br. Med. Bull. 32, 141–146 (1976)PubMedGoogle Scholar
  109. Klaus, G.G.B., Abbas, A.K, McElroy, P.J.: Mechanisms of B cell tolerance. II. Evidence for inhibition of antigen receptor expression as a mechanism of unresponsiveness. Eur. J. Immunol. 7, 387–393 (1977)PubMedCrossRefGoogle Scholar
  110. Klinman, N.R., Press, J.L.: The B cell specificity repertoire: its relationship to definable subpopulations. Transplant. Rev. 24, 41–83 (1975)PubMedGoogle Scholar
  111. Kohler, H.: The response to phosphorylcholine: dissecting an immune response. Transplant. Rev. 27, 24–56 (1975)PubMedGoogle Scholar
  112. Kotlarski, I., Courteney, B.M., Howard, J.G.: Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide. Eur. J. Immunol. 3, 496–502 (1973)PubMedCrossRefGoogle Scholar
  113. Krawinkel, U., Rajewsky, K.: Specific enrichment of antigen-binding receptors from sensitized murine lymphocytes. Eur. J. Immunol. 6 529–536 (1976)PubMedCrossRefGoogle Scholar
  114. Lawson, D., Fewtrell, C., Gomperts, B., Raff, M.C.: Anti-immunoglobulin induced histamine secretion by rat peritoneal mast cells studied by immunoferritin electron microscopy. J. Exp. Med. 142, 391–402 (1975)PubMedCrossRefGoogle Scholar
  115. Lawton, A.R., Cooper, M.D.: Modification of B lymphocyte differentiation by anti-immunoglobulin antibodies. Contemp. Top. Immunobiol. 3, 193–225 (1973)Google Scholar
  116. Lee, W.Y., Sehon, A.H.: Suppression of reaginic antibody formation. III. Relationship between immunogenicity and tolerogenicity of hapten-carrier conjugates. J. Immunol. 116, 1711–1718 (1976)PubMedGoogle Scholar
  117. Lerman, S.P., Romano, T.J., Mond, J.J., Heidelberger, M., Thorbecke, G.J.: Induction of primary and inhibition of secondary antibody response to hapten by hapten conjugates of type III pneumococcal polysaccharide. Cell. Immunol. 15, 321–335 (1975)PubMedCrossRefGoogle Scholar
  118. Lipsky, P.E., Rosenthal, A.S.: Macrophage-lymphocyte interaction. II. Antigen-mediated physical interaction between immune guinea pig lymph node lymphocytes and syngeneic macrophages. J. Exp. Med. 141, 138–154 (1975)PubMedCrossRefGoogle Scholar
  119. Lobo, P.I., Westervelt, F.B., Horwitz, D.A.: Identification of two populations of immunoglobulin-bearing lymphocytes in man. J. Immunol. 114, 116–119 (1975)PubMedGoogle Scholar
  120. Lord, E.M., Button, R.W.: Antigen suppression of the in vitro development of plaque forming cells to autologous erythrocyte antigens. J. Immunol. 115, 1631–1635 (1975)PubMedGoogle Scholar
  121. Louis, J.A., Chiller, J.M., Weigle, W.O.: The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. J. Exp. Med. 138, 1481–1495 (1973)PubMedCrossRefGoogle Scholar
  122. Mason, D.W.: The class of surface immunoglobulin on cells carrying IgG memory in rat thoracic duct lymph: the size of the subpopulation mediating IgG memory. J. Exp. Med. 143, 1122–1130 (1976)PubMedCrossRefGoogle Scholar
  123. McConnell, I.: Antigen receptors on the surface of antibody forming cells. Nature [New Biol.] 233, 177–179 (1971)Google Scholar
  124. McConnell, I., Hurd, C.M.: Lymphocyte receptors. I. Receptors for Fc of IgG and complement (C3b) on immunoglobulin-bearing, antigen-binding and antibody-forming cells. Immunology 30, 825–834 (1976)PubMedGoogle Scholar
  125. Melcher, M., Vitetta, E.S., McWilliams, M., Lamm, M.E., Phillips-Quagliata, J., Uhr, J.W.: Cell surface immunoglobulin. X. The identification of an IgD-like molecule on the surface of murine splenocytes. J. Exp. Med. 140, 1427–1431 (1974)Google Scholar
  126. Metcalf, E.S., Klinman, N.R.: In vitro tolerance induction of neonatal murine B cells. J. Exp. Med. 143, 1327–1340 (1976)PubMedCrossRefGoogle Scholar
  127. Mosier, D.E., Johnson, B.M.: Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes. J. Exp. Med. 141, 226 (1975)CrossRefGoogle Scholar
  128. Nossal, G.J.V., Lay ton, J.E.: Antigen-induced aggregation and modulation of receptors on hapten-specific B lymphocytes. J. Exp. Med. 143, 511–528 (1976)PubMedCrossRefGoogle Scholar
  129. Nossal, G.J.V., Lewis, H.: Variations in accessible cell surface immunoglobulin among antibody-forming cells. J. Exp. Med. 135, 1416–1422 (1972)PubMedCrossRefGoogle Scholar
  130. Nossal, G.J. V., Pike, B.L.: Evidence for the clonal abortion theory of B-lymphocyte tolerance. J. Exp. Med. 141, 904–917 (1975)PubMedGoogle Scholar
  131. Nossal, G.J. V., Pike, B.L., Katz, D.H.: Induction of B cell tolerance in vitro to 2, 4-dini- trophenyl coupled to a copolymer of D-glutamic acid and D-lysine (DNP-D-GL). J. Exp. Med. 138, 312–317 (1973)PubMedCrossRefGoogle Scholar
  132. Nussenzweig, V.: Receptors for immune complexes on lymphocytes. Adv. Immunol. 19, 258 (1974)Google Scholar
  133. Okumura, K, Julius, M.H., Tsu, T., Herzenberg, L.A., Herzenberg, L.A.: Demonstration that IgG memory is carried by IgG bearing cells. Eur. J. Immunol. 6, 467–472 (1976)PubMedCrossRefGoogle Scholar
  134. Oppenheim, J.J., Rosenstreich, D.L.: Signals regulating the in vitro activation of lymphocytes. Prog. Allergy 20, 65–194 (1976)PubMedCrossRefGoogle Scholar
  135. Ordal, J., Smith, S., Ness, D., Gershon, R.K., Grumet, F.C.: IgM-mediated T cell independent suppression of immunity. J. Immunol. 116, 1182–1187 (1976)PubMedGoogle Scholar
  136. Ortiz-Ortiz, L., Weigle, W.O.: Cellular events in the induction of experimental allergic encephalo-myelitis in rats. J. Exp. Med. 144, 604–616 (1976)PubMedCrossRefGoogle Scholar
  137. Osborne, D.P., Katz, D.H.: The allogeneic effect in inbred mice. III. Unique antigenic structural requirements in the expression of the phenomenon in unprimed cell populations in vivo. J. Exp. Med. 137, 991–1008 (1973)PubMedCrossRefGoogle Scholar
  138. Parker, D.C.: Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin Nature (Lond.) 258, 361–363 (1975) Pepys, M.B.: Role of complement in the induction of immunological responses. Transplant. Rev. 32, 93–120 (1976)Google Scholar
  139. Perelson, A.S.: Models of the events responsible for antibody production by B lymphocytes. In: Theoretical Immunology. New York: Marcel Dekker 1977 (in press)Google Scholar
  140. Pernis, B., Forni, L., Amante, L.: Immunoglobulins as cell receptors. Ann. N.Y. Acad. Sci. 190, 420–431 (1971)Google Scholar
  141. Pierce, C.W., Asofsky, R., Solliday, S.: Immunoglobulin receptors on B lymphocytes: shifts in immunoglobulin class during immune responses. Fed. Proc. 32, 41–43 (1973)PubMedGoogle Scholar
  142. Pike, B.L., Nossal, G.J.V.: Requirement for persistent extracellular antigen in cultures of antigen-binding B lymphocytes. J. Exp. Med. 144, 568–572 (1976)PubMedCrossRefGoogle Scholar
  143. Raff, M.C., Megson, M., Owen, J.J.T., Cooper, M.D.: Early production of intracellular IgM by B lymphocyte precursors in mouse. Nature (Lond.) 259, 224–226 (1976)CrossRefGoogle Scholar
  144. Raff, M.C., Owen, J.J.T., Cooper, M.D., Lawton, A.R., Megson, M., Gathings, W.E.: Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin induced immunoglobulin suppression in vitro. J. Exp. Med. 142, 1052–1064 (1975)PubMedCrossRefGoogle Scholar
  145. Reichlin, M.: Localizing antigenic determinants in human hemoglobin with mutants: molecular correlations in immunological tolerance. J. Mol. Biol. 64, 485–196 (1972)PubMedCrossRefGoogle Scholar
  146. Roelants, G.E., Askonas, B.A.: Cell cooperation in antibody induction. The susceptibility of helper cells to specific lethal radioactive antigen. Eur. J. Immunol. 1, 151–157 (1971)PubMedCrossRefGoogle Scholar
  147. Romano, T.J., Lerman, S.P., Thorbecke, G.J.: Mechanisms by which hapten conjugates of pneumococcal polysaccharide interfere with the challenge of anti-hapten memory cells. Eur. J. Immunol. 6, 434–442 (1976)PubMedCrossRefGoogle Scholar
  148. Rowe, D.S., Hug, K., Forni, L., Pernis, B.: Immunoglobulin D as a lymphocyte receptor. J. Exp. Med. 138, 965–972 (1973)PubMedCrossRefGoogle Scholar
  149. Rowley, D.A., Fitch, F.W., Stuart, F.P., Köhler, H., Cosenza, H.: Specific suppression of immune responses. Science 131, 1133–1141 (1973)CrossRefGoogle Scholar
  150. Ryan, J.L., Henkart, P.A.: Fc receptor mediated inhibition of B lymphocyte activation. J. Exp. Med. 144, 768–775 (1976)PubMedCrossRefGoogle Scholar
  151. Ryan, J.L., Arbeit, R.D., Dickler, H.B., Henkart, P.A.: Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes. J. Exp. Med. 142, 814–826 (1975)PubMedCrossRefGoogle Scholar
  152. Scher, I., Sharrow, S.O., Wis tar, R., Asofsky, R., Paul, W.E.: B lymphocyte heterogeneity: ontogenetic development and organ distribution of B lymphocyte populations defined by their density of surface immunoglobulin. J. Exp. Med. 144, 494–506 (1976)PubMedCrossRefGoogle Scholar
  153. Schimpl, A., Wecker, E.: A third signal in B cell activation given by TRF. Transplant. Rev. 23, 176–188 (1975)PubMedGoogle Scholar
  154. Schräder, J.W.: Mechanism of activation of bone-marrow-derived lymphocytes. III. A distinction between a macrophage produced triggering signal and the amplifying effect on triggered B lymphocytes of allogeneic interactions. J. Exp. Med. 138, 1466–1480 (1973)PubMedCrossRefGoogle Scholar
  155. Schräder, J. W.: Induction of immunological tolerance to a thymus-dependent antigen in the absence of thymus-derived cells. J. Exp. Med. 139, 1303–1316 (1974)PubMedCrossRefGoogle Scholar
  156. Schrader, J.W.: Mechanism of activation of bone marrow derived lymphocytes. ii. A “second signal” for antigen-specific activation provided by flagellin and LPS. Eur. J. Immunol. 4, 20–25 (1974a)PubMedCrossRefGoogle Scholar
  157. Schrader, J.W.: Antagonism of B lymphocyte mitogenesis by anti-immunoglobulin antibody. J. Immunol. 115, 323–326 (1975)PubMedGoogle Scholar
  158. Schrader, J.W.: The in vitro induction of immunological tolerance in the B lymphocyte by oligovalent thymus-dependent antigens. J. Exp. Med. 141, 962–973 (1975 a)PubMedCrossRefGoogle Scholar
  159. Schrader, J.W., Nossal, G.J.V.: Effector cell blockade: a new mechanism of immune hypo reactivity induced by multivalent antigens. J. Exp. Med. 139, 1582–1598 (1974)PubMedCrossRefGoogle Scholar
  160. Schreiner, G.F., Unanue, E.R.: Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interaction. Adv. Immunol. 24, 37–165 (1976)PubMedCrossRefGoogle Scholar
  161. Scott, D.W.: Cellular events in tolerance. V. Detection, isolation and fate of lymphoid cells which bind fluoresceinated antigen in vivo. Cell Immunol. 22, 311–322 (1976)PubMedCrossRefGoogle Scholar
  162. Scott, D.W., Diener, E.: Effect of lipopolysaccharide on the induction of tolerance to POL. J. Immunol. 116, 1220–1223 (1976)PubMedGoogle Scholar
  163. Sell, S., Gell, P.G.H.: Studies on rabbit lymphocytes in vitro. I. Stimulation of blast transformation with an antiallotype serum. J. Exp. Med. 122, 423–439 (1965)Google Scholar
  164. Sidman, C.L., Unanue, E.R.: Receptor-mediated inactivation of early B lymphocytes. Nature (Lond.) 257, 149–151 (1975)CrossRefGoogle Scholar
  165. Sidman, C.L., Unanue, E.R.: Control of B lymphocyte function. I. Inactivation of mitogenesis by interactions with surface immunoglobulin and Fc receptor molecules. J. Exp. Med. 144, 882–896 (1976)Google Scholar
  166. Sinclair, N.R.St.C., Lees, R.K., Abrahams, S., Chan, P.L., Fagan, G., Stiller, C.R.: Regulation of the immune response. XI. Antigen-antibody complex inactivation of cells involved in adoptive transfer. J. Immunol. 113, 1493–1500 (1974)Google Scholar
  167. Sirisinha, S., Eisen, H.E.: Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins. Proc. Natl. Acad. Sci. U.S.A. 68, 3130–3135 (1971)PubMedCrossRefGoogle Scholar
  168. Sjoberg, O.: Antigen binding cells in mice immune or tolerant to Escherichia coli polysaccharide. J. Exp. Med. 133, 1015–1025 (1971)PubMedCrossRefGoogle Scholar
  169. Sjoberg, O.: Rapid breaking of tolerance against Escherichia coli polysaccharide in vivo and in vitro. J. Exp. Med. 135, 850–859 (1972)PubMedCrossRefGoogle Scholar
  170. Sterzl, J.: Immunological tolerance as the result of terminal differentiation of immunologically competent cells. Nature (Lond.) 209, 416–416 (1966)CrossRefGoogle Scholar
  171. Strayer, D.S., Cosenza, H., Lee, W.M.F., Rowley, D.A., Kohler, H.: Neonatal tolerance induced by antibody against antigen-specific receptor. Science 186, 640–643 (1974)PubMedCrossRefGoogle Scholar
  172. Takahashi, T., Old, L.J., Mclntire, K.R., Boyse, E.A.: Immunoglobulins and other surface antigens of cells of the immune system. J. Exp. Med. 134, 815–832 (1971)PubMedCrossRefGoogle Scholar
  173. Talal, N.: Disordered immunologic regulation and autoimmunity. Transplant. Rev. 31, 240–263 (1976)PubMedGoogle Scholar
  174. Taylor, R.B., Basten, A.: Suppressor cells in humoral immunity and tolerance. Br. Med. Bull. 32, 152–157 (1976)PubMedGoogle Scholar
  175. Taylor, R.B., Duffus, W.P.H., Raff, M.C., De Petris, S.: Redistribution and pinocytosis of lymphocyte surface Ig molecules induced by anti-Ig antibody. Nature [New Biol.] 233, 225–229 (1971)Google Scholar
  176. Terres, G., Aldo-Benson, M., Borel, Y.: Effect of anti-carrier antibody on carrier-determined tolerance. Eur. J. Immunol. 6, 492–497 (1976)PubMedCrossRefGoogle Scholar
  177. Trenkner, E., Riblet, R.: Induction of anti-phosphorylcholine antibody formation by anti- idiotypic antibodies. J. Exp. Med. 142, 1121–1132 (1975)PubMedCrossRefGoogle Scholar
  178. Uhr, J. W, Moller, G.: Regulatory effect of antibody on the immune response. Adv. Immunol. 8, 81–127 (1968)PubMedCrossRefGoogle Scholar
  179. Unanue, E.R.: Antigen binding cells. I. Their identification and role in the immune response. J. Immunol. 107, 1168–1174 (1971) Vitetta, E.S., Uhr, J.W.: Immunoblobulin receptors revisited. Science 189, 964–968 (1975)Google Scholar
  180. Warner, N.L.: Membrane immunoglobulin and antigen receptors on B and T lymphocytes. Adv. Immunol. 19, 67–226 (1974)PubMedCrossRefGoogle Scholar
  181. Wason, W.M., Fitch, F.W.: Suppression of the antibody response to SRBC with F(ab’)2 and IgG in vitro. J. Immunol. 110, 1427–1429 (1973)PubMedGoogle Scholar
  182. Wedner, H.J., Parker, C.W.: Lymphocyte activation. Prog. Allergy. 20, 195–300 (1976)PubMedCrossRefGoogle Scholar
  183. Weigle, W.O.: The induction of autoimmunity in rabbits following injection of heterologous or altered thyroglobulin. J. Exp. Med. 121, 289–308 (1965)PubMedCrossRefGoogle Scholar
  184. Weigle, W.O.: Recent observations and concepts in immunological unresponsiveness and auto-immunity. Clin. Exp. Immunol. 9, 437–447 (1971)PubMedGoogle Scholar
  185. Weigle, W.O.: Immunological unresponsiveness. Adv. Immunol. 16, 61–122 (1973)PubMedCrossRefGoogle Scholar
  186. Weiner, H.L., Moorhead, J.W., Claman, H.N.: Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response. J. Immunol. 116, 1656–1661 (1976)PubMedGoogle Scholar
  187. Wigzell, H.: On the relationship between cellular and humoral antibodies. Con temp. Top. ImmunobioL. 3, 77–96 (1974)Google Scholar
  188. Williams, A.F., Gowans, J.L.: The presence of IgA on the surface of rat thoracic duct lymphocytes which contain internal IgA. J. Exp. Med. 141, 335–345 (1975)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • Gerhard G. B. Klaus
    • 1
  • Abul K. Abbas
    • 2
  1. 1.Division of ImmunologyNational Institute for Medical ResearchLondonUK
  2. 2.Dept. PathologyPeter Bent Brigham HospitalBostonUSA

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