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Antigen-Receptor Interactions in the Induction of B-Lymphocyte Unresponsiveness

  • Gerhard G. B. Klaus
  • Abul K. Abbas
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 78)

Abstract

In the past decade it has been established that antigen-reactive cells are lymphocytes and can be divided into two distinct functional classes. Thymus-processed (T-) lymphocytes are the effectors of cell-mediated immunity (e.g., delayed-type hypersensitivity and graft rejection), and also exert important regulatory (helper or suppressor) influences on thymus-independent (bone marrow-derived) B-lymphocytes, which are the direct precursors of antibody-forming cells (AFC).

Keywords

Antigen Receptor Tolerance Induction Cell Tolerance Immunological Tolerance Clonal Selection Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ABC

Antigen-binding cell(s)

A-CHO

Group A streptococcal carbohydrate

AFC

Antibody-forming cell(s)

Anti-id

Anti-idiotypic antibodies

BGG

Bovine γ-globulin

DNP

2, 4 dinitrophenyl

DGL

Copolymer of D-glutamic acid and D-lysine

HGG

Human γ-globulin

Ig

Immunoglobulin

KLH

Keyhole limpet hemocyanin

LGL

Copolymer of L-glutamic acid and L-lysine

LPS

Bacterial lipopolysaccharide

MGG

mouse γ-globulin

NIP

4-hydroxy 3-iodo 5-nitrophenacetyl

PBL

Peripheral blood lymphocyte(s)

POL

Polymerized Salmonella flagellin

S3

type III pneumococcal polysaccharide

S-Ig

Surface Ig

SRBC

Sheep red blood cells

TI

T-cell independent

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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • Gerhard G. B. Klaus
    • 1
  • Abul K. Abbas
    • 2
  1. 1.Division of ImmunologyNational Institute for Medical ResearchLondonUK
  2. 2.Dept. PathologyPeter Bent Brigham HospitalBostonUSA

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