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Antigen-Receptor Interactions in the Induction of B-Lymphocyte Unresponsiveness

  • Chapter
Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 78))

Abstract

In the past decade it has been established that antigen-reactive cells are lymphocytes and can be divided into two distinct functional classes. Thymus-processed (T-) lymphocytes are the effectors of cell-mediated immunity (e.g., delayed-type hypersensitivity and graft rejection), and also exert important regulatory (helper or suppressor) influences on thymus-independent (bone marrow-derived) B-lymphocytes, which are the direct precursors of antibody-forming cells (AFC).

Truth is rarely pure, and never simple

Oscar Wilde

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Abbreviations

ABC:

Antigen-binding cell(s)

A-CHO:

Group A streptococcal carbohydrate

AFC:

Antibody-forming cell(s)

Anti-id:

Anti-idiotypic antibodies

BGG:

Bovine γ-globulin

DNP:

2, 4 dinitrophenyl

DGL:

Copolymer of D-glutamic acid and D-lysine

HGG:

Human γ-globulin

Ig:

Immunoglobulin

KLH:

Keyhole limpet hemocyanin

LGL:

Copolymer of L-glutamic acid and L-lysine

LPS:

Bacterial lipopolysaccharide

MGG:

mouse γ-globulin

NIP:

4-hydroxy 3-iodo 5-nitrophenacetyl

PBL:

Peripheral blood lymphocyte(s)

POL:

Polymerized Salmonella flagellin

S3:

type III pneumococcal polysaccharide

S-Ig:

Surface Ig

SRBC:

Sheep red blood cells

TI:

T-cell independent

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  1. Abul K. Abbas

    Present address: Dept. Pathology, Peter Bent Brigham Hospital, Boston, Mass, USA

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  1. Division of Immunology, National Institute for Medical Research, NW7, 1AA, Mill Hill, London, UK

    Gerhard G. B. Klaus

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    W. Arber

  2. Philadelphia, USA

    W. Henle

  3. Martinsried, Germany

    P. H. Hofschneider

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  5. Dallas, USA

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Klaus, G.G.B., Abbas, A.K. (1977). Antigen-Receptor Interactions in the Induction of B-Lymphocyte Unresponsiveness. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66800-5_2

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