Skip to main content

Abstract

This chapter intends to portray the present knowledge on site and mechanism of action of the ergot alkaloids. The presentation is based chietly on selected work performed in defined isolated systems in which the interference with specific substrates usually called receptors has been sufficiently proven. We hope that this presentation will contribute to the understanding of the complexity of ergot pharmacology as presented in the following chapters.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aberg, G., Andersson, R., Welin-Fogelberg, I.: Inhibition of tone in the taenia of the guinea pig caecum. Europ. J. Pharmacol. 7, 296–299 (1969)

    Article  CAS  Google Scholar 

  • Abrahams, S.L.: Effect of serotonin, LSD, and other indoleamines on adenyl cyclase in the liver fluke. Fed. Proc. 33, 1249 (1974)

    Google Scholar 

  • Abrahams, S.L., Northup, J.K., Mansour, T.E.: Adenosine cyclic 3′, 5′-monophosphate in the liver fluke, Fasciola hepatica. I. Activation of adenylate cyclase by 5-hydroxyptamine. Molec. Pharmacol. 12, 49–58 (1976)

    CAS  Google Scholar 

  • Acheson, G.H.: The responses of the nictitating membrane of the cat to certain stimulants after ergotoxine. Amer. J. Physiol. 128, 695–702 (1940)

    CAS  Google Scholar 

  • Aellig, W.H.: Periphere Kreislaufwirkungen von Ergotamin, Dihydroergotamin und 1-Methylergotamin an der innervierten, perfundierten Hinterextremitat des Hundes. Helv. physiol. Pharmacol. Acta 25, 374–396 (1967)

    PubMed  CAS  Google Scholar 

  • Aellig, W.H.: Venoconstrictor effect of dihydroergotamine in superficial hand veins. Europ. J. clin. Pharmacol. 7, 137–139 (1974)

    Article  CAS  Google Scholar 

  • Aellig, W.H., Berde, B.: Studies of the effect of natural and synthetic polypeptide type ergot compounds on a peripheral vascular bed. Brit. J. Pharmacol. 36, 561–570 (1969)

    CAS  Google Scholar 

  • Aghajanian, G.K.: Influence of drugs on the firing of serotonin-containing neurons in brain. Fed. Proc. 31, 91–96 (1972a)

    PubMed  CAS  Google Scholar 

  • Aghajanian, G.K.: Chemical feedback regulation of serotonin-containing neurons in brain. Ann. N.Y. Acad. Sci. 193, 86–94 (1972b)

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Haigler, H.J.: Mode of action of LSD on serotonergic neurons. Adv. Biochem. Psychopharmacol. 10, 167–177 (1974)

    PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Weiss, B.L.: Block by LSD of the increase in brain serotonin turnover induced by elevated ambient temperature. Nature (Lond.) 220, 795–796 (1968)

    Article  CAS  Google Scholar 

  • Aghajanian, G.K., Rosecrans, J.A., Sheard, M.H.: Serotonin: release in the forebrain by stimulation of midbrain raphe. Science 156, 402–403 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Foote, W.E., Sheard, M.H.: Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe. Science 161, 706–708 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Foote, W.E., Sheard, M.H.: Action of psychotogenic drugs on single midbrain raphe neurons. J. Pharmacol. exp. Ther. 171, 178–187 (1970a)

    PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Graham, A.W., Sheard, M.H.: Serotonin-containing neurons in brain: depression of firing by monoamine oxidase inhibitors. Science 169, 1100–1102 (1970b)

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G.K., Haigler, H.J., Bloom, F.E.: Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. Life Sci. 11(I), 615–622 (1972)

    Article  CAS  Google Scholar 

  • Aghajanian, G.K., Kuhar, M.J., Roth, R.H.: Serotonin-containing neuronal perikarya and terminals: differential effects of p-chlorophenylalanine. Brain Res. 54, 85–101 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Ahlquist, R.P.: A study of the adrenotropic receptors. Amer. J. Physiol. 153, 586–600 (1948)

    PubMed  CAS  Google Scholar 

  • Ahlquist, R.P., Levy, B.: Adrenergic receptive mechanism of canine ileum. J. Pharmacol. exp. Ther. 127, 146–149 (1959)

    PubMed  CAS  Google Scholar 

  • Aiello, E., Guideri, G.: Nervous control of ciliary activity. Science 146, 1692–1693 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Aiello, E., Guideri, G.: Relationship between 5-hydroxy tryptamine and nerve stimulation of ciliary activity. J. Pharmacol. exp. Ther. 154, 517–523 (1966)

    PubMed  CAS  Google Scholar 

  • Aiello, E., Paparo, A.: A role for acetylcholine in the regulation of ciliary activity. Comp. gen. Pharmacol. 5, 285–297 (1974)

    Article  Google Scholar 

  • Alabaster, V.A., Bakhle, Y.S.: Release of smooth muscle-contracting substances from isolated perfused lungs. Europ. J. Pharmacol. 35, 349–360 (1976)

    Article  CAS  Google Scholar 

  • Allen, G.S., Henderson, L.M., Chou, S.N., French, L.A.: Cerebral arterial spasm. Part 2: In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery, and its blockage by methylsergide and phenoxybenzamine. J. Neurosurg. 40, 442–450 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Altura, B.M., Malaviya, D., Reich, C.F., Orkin, L.R.: Effects of vasoactive agents on isolated human umbilical arteries and veins. Amer. J. Physiol. 222, 345–355 (1972)

    PubMed  CAS  Google Scholar 

  • Ambache, N., Zar, M.A.: Evidence against adrenergic motor transmission in the guinea-pig vas deferens. J. Physiol. (Lond.) 216, 359–389 (1971)

    CAS  Google Scholar 

  • Ambache, N., Dunk, L.P., Miall, P., Zar, M.A.: Unexplained inhibitory action of D-lysergic acid diethylamide (LSD) on postganglionic motor transmission in the guinea-pig vas deferens. Brit. J. Pharmacol. 42, 659P–660P (1971)

    CAS  Google Scholar 

  • Ambache, N., Dunk, L.P., Verney, J., Zar, M.A.: An inhibition of post-ganglionic motor transmission in the mammalian vas deferens by D-lysergic acid diethylamide. J. Physiol. (Lond.) 231, 251–270 (1973a)

    CAS  Google Scholar 

  • Ambache, N., Killick, S.W., Srinivasan, V., Zar, M.A.: Presynaptic inhibition of adrenergic motor transmission in rat anococcygeus muscle by D-lysergic acid diethylamide (LSD). J. Physiol. (Lond.) 233, 35P–37P (1973b)

    CAS  Google Scholar 

  • Ambache, N., Killick, S.W., Srinivasan, V., Zar, M.A.: Effects of lysergic acid diethylamide on autonomic postganglionic transmission. J. Physiol. (Lond.) 246, 571–593 (1975)

    CAS  Google Scholar 

  • Ames, A. III, Pollen, D.A.: Neurotransmission in central nervous tissue: A study of isolated rabbit retina. J. Neurophysiol. 32, 424–442 (1969)

    PubMed  Google Scholar 

  • Ammon, R.: Die Cholinesterase. Ergebn. Enzymforsch. 4, 102–110 (1935)

    CAS  Google Scholar 

  • Andén, N.-E.: Changes in the impulse flow of central monoamine nerves by drugs affecting monoamine receptors. Acta pharmacol. (Kbh.) 25, 5–6 (1968)

    Article  Google Scholar 

  • Andén, N.-E., Dahlström, A., Fuxe, K., Larsson, K., Olson, L., Ungerstedt, U.: Ascending monoamine neurons to the telencephalon and diencephalon. Acta physiol. scand. 67, 313–326 (1966)

    Article  Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K., Hökfelt, T.: Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide. Brit. J. Pharmacol. 34, 1–7 (1968)

    Google Scholar 

  • Andén, N.-E., Carlsson, A., Haggendal, J.: Adrenergic mechanisms. Annu. Rev. Pharmacol. 9, 119–134 (1969)

    Article  PubMed  Google Scholar 

  • Anderson, E.G.: Bulbospinal serotonin-containing neurons and motor control. Fed. Proc. 31, 107–112 (1972)

    PubMed  CAS  Google Scholar 

  • Anderson, E.G., Baker, R.G., Banna, N.R.: The effects of monoamine oxidase inhibitors on spinal synaptic activity. J. Pharmacol. exp. Ther. 158, 405–415 (1967)

    PubMed  CAS  Google Scholar 

  • Ansell, G.B., Beeson, M.F., Bradley, P.B.: The effects of stressful stimuli and drugs on the concentrations and turnover rates of monoamines in rat brain. In: The Present Status of Psychotropic Drugs. Cerletti, A., Bové, F.J. (eds.), pp. 299–301. Amsterdam: Exerpta Medica Foundation 1969

    Google Scholar 

  • Apperley, E., Humphrey, P.P.A., Levy, G.P.: Receptors for 5-hydroxytryptamine and noradrenaline in rabbit aorta and central ear artery. Brit. J. Pharmacol. 52, 131P–132P (1974)

    CAS  Google Scholar 

  • Apperley, E., Humphrey, P.P.A., Levy, G.P.: Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. Brit. J. Pharmacol. 58, 211–221 (1976)

    CAS  Google Scholar 

  • Arcari, G., Dorigotti, L., Fregnan, G.B., Glasser, A.H.: Vasodilating and alpha-receptor blocking activity of a new ergoline derivative. Brit. J. Pharmacol. 34, 700P (1968)

    CAS  Google Scholar 

  • Arcari, G., Bernardi, L., Bosisio, G., Coda, S., Fregnan, G.B., Glässer, A.H.: 10-Methoxyergoline derivatives as α-adrenergic blocking agents. Experientia (Basel) 28, 819–820 (1972)

    Article  CAS  Google Scholar 

  • Arefolov, V.A., Pidevich, I.N., Panasyuk, L.V., Firsov, V.K.: Pharmacological analysis of some adrenomimetic effects of serotonin. Byul. eksp. Biol. Med. 80, 45–48 (1975)

    CAS  Google Scholar 

  • Ariens, E.J.: Affinity and intrinsic activity in the theory of competitive inhibition. Part I: Problems and theory. Arch. int. Pharmacodyn. 99, 32–49 (1954)

    PubMed  CAS  Google Scholar 

  • Ariens, E.J., Van Rossum, J.M., Simonis, A.M.: A theoretical basis of molecular pharmacology. Part II: Interactions of one or two compounds with two interdependent receptor systems. Arzneimittel-Forsch. 6, 611–621 (1956)

    CAS  Google Scholar 

  • Arunlakshana, O., Schild, H.O.: Some quantitative uses of drug antagonists. Brit. J. Pharmacol. 14, 48–58 (1959)

    PubMed  CAS  Google Scholar 

  • Ascher, P.: Inhibitory and excitatory effects of dopamine on Aplysia neurones. J. Physiol. (Lond.) 225, 173–209 (1972)

    CAS  Google Scholar 

  • Åström, A., Samelius, U.: The action of 5-hydroxytryptamine and some of its antagonists on the umbilical vessels of the human placenta. Brit. J. Pharmacol. 12, 410–414 (1957)

    PubMed  Google Scholar 

  • Bach, N.J., Hall, D.A., Kornfeld, E.C.: Descarboxylysergic acid (9,10-didehydro-6-methylergoline). J. med. Chem. 17, 312–314 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Bacq, Z.M.: The action of ergotamine on the chromatophores of the catfish (Ameiurus nebulosus). Biol. Bull. 65, 387–388 (1933)

    Article  Google Scholar 

  • Bacq, Z.M.: La pharmacologic du système nerveux autonome, et particulièrement du sympathique, d’après la théorie neurohumorale. Ann. Physiol. 10, 468–528 (1934a)

    Google Scholar 

  • Bacq, Z.M.: Action de l’ergotamine et de l’ergotaminine sur la membrane nictitante. C.R. Soc. Biol. (Paris) 116, 341–342 (1934b)

    CAS  Google Scholar 

  • Bacq, Z.M.: Recherches sur la physiologie du système nerveux autonome. IV. Réactions de la vésicule séminale et du canal déférent du cobaye à l’adrénaline, à l’acétylcholine et aux ions Ca et K. Arch. int. Pharmacodyn. 47, 123–129 (1934c)

    CAS  Google Scholar 

  • Bakhle, Y.S., Smith, T.W.: Release of spasmogenic substances induced by vasoactive amines from isolated lungs. Brit. J. Pharmacol. 46, 543P–544P (1972)

    CAS  Google Scholar 

  • Bakhle, Y.S., Smith, T.W.: The nature of the tryptamine receptor mediating spasmogen release from rat isolated lungs. Brit. J. Pharmacol. 50, 463P (1974a)

    CAS  Google Scholar 

  • Bakhle, Y.S., Smith, T.W.: Tryptamine receptors in rat pulmonary artery. Brit. J. Pharmacol. 51, 459–461 (1974b)

    CAS  Google Scholar 

  • Baldratti, G., Arcari, G., Suchowsky, G.K.: Studies on a compound antagonistic to 5-hydroxytryptamine. Experientia (Basel) 21, 396–397 (1965)

    Article  CAS  Google Scholar 

  • Banna, N.R., Anderson, E.G.: The effects of 5-hydroxytryptamine antagonists on spinal neuronal activity. J. Pharmacol. exp. Ther. 162, 319–325 (1968)

    PubMed  CAS  Google Scholar 

  • Barabe, J., Park, W.K., Regoli, D.: Application of drug receptor theories to the analysis of the myotropic effects of bradykinin. Canad. J. Physiol. Pharmacol. 53, 345–353 (1975)

    Article  CAS  Google Scholar 

  • Barasi, S., Roberts, M.H.T.: The action of 5-hydroxytryptamine antagonists and precursors on bulbospinal facilitation of spinal reflexes. Brain Res. 52, 385–388 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Barasi, S., Roberts, M.H.T.: The modification of lumbar motoneurone excitability by stimulation of a putative 5-hydroxy-tryptamine pathway. Brit. J. Pharmacol. 52, 339–348 (1974)

    CAS  Google Scholar 

  • Barfknecht, C.F., Nichols, D.E., Rusterholz, D.B., Long, J.P., Engelbrecht, J.A., Beaton, J.M., Bradley, R.J., Dyer, D.C.: Potential psychotomimetics. 2-amino-1,2,3,4-tetrahydronaphthalene analogs. J. med. Chem. 16, 804–808 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Barlow, R.B.: Effects on amine oxydase of substances which antagonize 5-hydroxytryptamine more than tryptamine on the rat fundus strip preparation. Brit. J. Pharmacol. 16, 153–162 (1961)

    PubMed  CAS  Google Scholar 

  • Barlow, R.B., Khan, I.: Actions of some analogues of tryptamine on the rat uterus and on the isolated rat fundus strip preparation. Brit. J. Pharmacol. 14, 99–107 (1959a)

    PubMed  CAS  Google Scholar 

  • Barlow, R.B., Khan, I.: Actions of some analogues of 5-hydroxy-tryptamine on the isolated rat uterus and the rat fundus strip preparations. Brit. J. Pharmacol. 14, 265–272 (1959b)

    PubMed  CAS  Google Scholar 

  • Barthel, W., Markwardt, F.: Aggregation of blood platelets by biogenic amines and its inhibition by antiadrenergic and antiserotoninergic agents. Biochem. Pharmacol. 23, 37–45 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Barthel, W., Markwardt, F.: Aggregation of blood platelets by adrenaline and its uptake. Biochem. Pharmacol. 24, 1903–1904 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Bartlet, A.L.: Actions of putative transmitters in the chicken vagus nerve/oesophagus and Remak nerve/rectum preparations. Brit. J. Pharmacol. 51, 549–558 (1974)

    CAS  Google Scholar 

  • Bartlet, A.L., Hassan, T.: Some actions of histamine and 5-hydroxytryptamine on isolated chicken oesophagus. Brit. J. Pharmacol. 32, 156–163 (1968)

    PubMed  CAS  Google Scholar 

  • Barzaghi, F., Baumgartner, H.R., Carruba, M., Mantegazza, P., Pletscher, A.: The 5-hydroxytryptamine-like actions of 5,6-dihydroxytryptamine. Brit. J. Pharmacol. 48, 245–254 (1973)

    CAS  Google Scholar 

  • Beernink, K.D., Nelson, S.D., Mansour, T.E.: Effect of lysergic acid derivatives on the liver fluke Fasciola hepatica. Int. J. Neuropharmacol. 2, 105–112 (1963)

    Article  Google Scholar 

  • Belamarich, F.A., Simoneit, L.W.: Aggregation of duck thrombocytes by 5-hydroxytryptamine. Micro vasc. Res. 6, 229–234 (1973)

    Article  CAS  Google Scholar 

  • Beleslin, D., Varagić, V.: The effect of cooling and of 5-hydroxytryptamine on the peristaltic reflex of the isolated guinea-pig ileum. Brit. J. Pharmacol. 13, 266–270 (1958)

    PubMed  CAS  Google Scholar 

  • Belisle, S., Gagnon, D.J.: Stimulating action of catecholamines on isolated preparations of the rat colon and human and rabbit taeniae coli. Brit. J. Pharmacol. 41, 361–366 (1971)

    CAS  Google Scholar 

  • Bell, J.A., Martin, W.R.: Studies of tryptamine and lysergic acid diethylamide (LSD) on cutaneous C-fiber and polysynaptic reflexes in the cat. J. Pharmacol. exp. Ther. 190, 492–500 (1974)

    PubMed  CAS  Google Scholar 

  • Benfey, B.G., Cohen, J., Kunos, G, Vermes-Kunos, I.: Dissociation of 5-hydroxytryptamine effects on myocardial contractility and cyclic AMP accumulation. Brit. J. Pharmacol. 50, 581–585 (1974)

    CAS  Google Scholar 

  • Bennett, A., Stockley, H.L.: The intrinsic innervation of the human alimentary tract and its relation to function. Gut 16, 443–453 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Bennett, J.L., Aghajanian, G.K.: D-LSD binding to brain homogenates: Possible relationship to serotonin receptors. Life Sci. 15, 1935–1944 (1974)

    Article  CAS  Google Scholar 

  • Bennett, J.L., Aghajanian, G.K.: Response of single raphe neurons to (+)-LSD: Correlation with (+)-LSD binding in brain. J. Pharm. Pharmacol. 28, 516–518 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Bennett, J.L., Bueding, E.: Uptake of 5-hydroxytryptamine by Schistosoma mansoni. Molec. Pharmacol. 9, 311–319 (1973)

    CAS  Google Scholar 

  • Bennett, J.P., Snyder, S.H.: Stereospecific binding of D-lysergic acid diethylamide (LSD) to brain membranes: relationship to serotonin receptors. Brain Res. 94, 523–544 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Bennett, J.P., Snyder, S.H.: Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors. Molec. Pharmacol. 12, 373–389 (1976)

    CAS  Google Scholar 

  • Bennett, M.R., Middleton, J.: An electrophysiological analysis of the effects of amine-uptake blockers and α-adrenoceptor blockers on adrenergic neuromuscular transmission. Brit. J. Pharmacol. 55, 87–95 (1975)

    CAS  Google Scholar 

  • Berde, B.: New studies on the circulatory effects of ergot compounds with implications to migraine. In: Background to Migraine. Cumings, J.N. (ed.), pp. 66–75. London: William Heinemann Medical Books 1971

    Google Scholar 

  • Berde, B.: Some new vascular and biochemical aspects of the mechanism of action of ergot compounds. Headache 11, 139–147 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Berde, B., Cerletti, A.: Über den Melanophoreneffekt von D-Lysergsäure-diäthylamid und verwandten Verbindungen. Helv. physiol. pharmacol. Acta 14, 325–333 (1956)

    PubMed  CAS  Google Scholar 

  • Berde, B., Cerletti, A.: Über den Angriffspunkt von D-Lysergsäure-diäthylamid und 5-Hydroxytryptamin im Melanophorentest. Z. ges. exp. Med. 129, 149–153 (1957)

    Article  PubMed  CAS  Google Scholar 

  • Berde, B., Doepfner, W., Cerletti, A.: Über die Wirkungsdauer einiger Serotoninantagonisten. Helv. physiol. pharmacol. Acta 18, 537–544 (1960)

    CAS  Google Scholar 

  • Beretta, C., Locatelli, A.: Inhibitory activity of 8β-carbobenzyloxyaminomethyl-1,6-dimethyl-10α-ergoline towards stimulant effects by 5-hydroxytryptamine and amphetamine on liver fluke, Fasciola hepatica, in vitro. J. Pharm. Pharmacol. 20, 744–748 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Beretta, C., Ferrini, R., Glässer, A.H.: 1-Methyl-8β-carbobenzyloxy-aminomethyl-10α-ergoline, a potent and long-lasting 5-hydroxytryptamine antagonist. Nature (Lond.) 207, 421–422 (1965a)

    Article  CAS  Google Scholar 

  • Beretta, C., Glässer, A.H., Nobili, M.B., Silvestri, R.: Antagonism of 5-hydroxytryptamine-induced bronchospasm in guinea-pigs by 8β-carbobenzyloxyaminomethyl-1,6-dimethyl-10α-ergoline. J. Pharm. Pharmacol. 17, 423–428 (1965b)

    Article  PubMed  CAS  Google Scholar 

  • Bernardi, L., Bosisio, G., Elli, C., Patelli, B., Temperilli, A., Arcari, G., Glässer, H.A.: Ergoline derivatives. Note XIII. α-adrenergic blocking drugs. Farmaco [Sci.] 30, 789–801 (1975)

    CAS  Google Scholar 

  • Berridge, M.J., Prince, W.T.: Mode of action of hallucinogenic molecules. Nature (Lond.) New Biol. 243, 283–284 (1973)

    Article  CAS  Google Scholar 

  • Berridge, M.J., Prince, W.T.: The nature of the binding between LSD and a 5-HT receptor: A possible explanation for hallucinogenic activity. Brit. J. Pharmacol. 51, 269–278 (1974)

    CAS  Google Scholar 

  • Berry, P.A., Collier, H.O.J.: Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig isolated lung. Brit. J. Pharmacol. 23, 201–216 (1964)

    PubMed  CAS  Google Scholar 

  • Berry, M.S., Cottrell, G.A.: Excitatory, inhibitory and biphasic synaptic potentials mediated by an identified dopamine-containing neurone. J. Physiol. (Lond.) 244, 589–612 (1975)

    CAS  Google Scholar 

  • Bevan, P., Bradshaw, C.M., Roberts, M.H.T., Szabadi, E.: The effect of microelectrophoretically applied mescaline on cortical neurones. Neuropharmacology 13, 1033–1045 (1974a)

    Article  PubMed  CAS  Google Scholar 

  • Bevan, P., Bradshaw, C.M., Szabadi, E.: Potentiation and antagonism of neuronal responses to monoamines by methysergide and sotalol. Brit. J. Pharmacol. 50, 445 P (1974b)

    CAS  Google Scholar 

  • Bhattacharya, B.K.: A pharmacological study on the effect of 5-hydroxytryptamine and its antagonists on the bronchial musculature. Arch. int. Pharmacodyn. 103, 357–367 (1955)

    PubMed  CAS  Google Scholar 

  • Biber, B., Fara, J., Lundgren, O.: A pharmacological study of intestinal vasodilator mechanisms in the cat. Acta physiol. scand. 90, 673–683 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Bickerton, R.K., Rockhold, W.T., Micalizzi, E.R.: Use of isolated strips of cat spleen for the assay of a-adrenergic blocking compounds. J. Pharm. Sci. 51, 837–840 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Bindler, E.H., Gyermek, L.: Influence of 5-HT antagonists on the ganglionic stimulant action of 5-HT and DMPP. Fed. Proc. 20, 319 (1961)

    Google Scholar 

  • Bircher, R., Schalch, W.R.: Über die Wirkung von Mutterkornalkaloiden bei histaminergischen Reaktionen. Helv. physiol. pharmacol. Acta 6, 813–820 (1948)

    PubMed  CAS  Google Scholar 

  • Birmingham, A.T., Szolcsányi, J.: Competitive blockade of adrenergic α-receptors and histamine receptors by thymoxamine. J. Pharm. Pharmacol. 17, 449–458 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Birmingham, A.T., Wilson, A.B.: Preganglionic and postganglionic stimulation of the guineapig isolated vas deferens preparation. Brit. J. Pharmacol. 21, 569–580 (1963)

    PubMed  CAS  Google Scholar 

  • Birnbaumer, L., Pohl, S.L., Kaumann, A.J.: Receptors and acceptors: A necessary distinction in hormone binding studies. Adv. Cyclic Nucleotide Res. 4, 239–281 (1974)

    PubMed  CAS  Google Scholar 

  • Blakeley, A.G.H., Brown, G.L., Ferry, C.B.: Pharmacological experiments on the release of the sympathetic transmitter. J. Physiol. (Lond.) 167, 505–514 (1963)

    CAS  Google Scholar 

  • Bloom, F.E., Costa, E., Salmoiraghi, G.C.: Analysis of individual rabbit olfactory bulb neuron responses to the microelectrophoresis of acetylcholine, norepinephrine and serotonin synergists and antagonists. J. Pharmacol. exp. Ther. 146, 16–23 (1964)

    PubMed  CAS  Google Scholar 

  • Bloom, F.E., Hoffer, B.J., Siggins, G.R., Barker, J.L., Nicoll, R.A.: Effects of serotonin on central neurons: Microiontophoretic administration. Fed. Proc. 31, 97–106 (1972)

    PubMed  CAS  Google Scholar 

  • Bloom, F.E., Hoffer, B.J., Nelson, C., Sheu, Y., Siggins, G.R.: The physiology and pharmacology of serotonin mediated synapses. In: Serotonin and Behavior. Barchas, J., Usdin, E. (eds.), pp. 249–261. New York: Academic Press 1973

    Google Scholar 

  • Boakes, R.J., Bradley, P.B., Briggs, I., Dray, A.: Antagonism by LSD to effects of 5-HT on single neurones. Brain Res. 15, 529–531 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Boakes, R.J., Bradley, P.B., Briggs, I., Dray, A.: Effects of lysergic acid derivatives on 5-hydroxytryptamine excitation of brain stem neurones. Brit. J. Pharmacol. 38, 453P–454P (1970a)

    CAS  Google Scholar 

  • Boakes, R.J., Bradley, P.B., Briggs, I., Dray, A.: Antagonism of 5-hydroxytryptamine by LSD-25 in the central nervous system: A possible neuronal basis for the actions of LSD-25. Brit. J. Pharmacol. 40, 202–218 (1970b)

    CAS  Google Scholar 

  • Boggan, W.O., Freedman, D.X.: LSD tolerance and brain serotonin metabolism. Fed. Proc. 32, 694 (1973)

    Google Scholar 

  • Bond, H.W., Guth, P.S.: Interaction of 5-hydroxytryptamine and lysergic acid diethylamide in the central nervous system. Pharmacologist 6, 171 (1964)

    Google Scholar 

  • Born, G.V.R.: The uptake of adrenaline by human blood platelets. Naunyn-Schmiedebergs Arch. Pharmacol. 259, 155–156 (1967)

    Google Scholar 

  • Born, G.V.R., Smith, J.B.: Uptake, metabolism and release of [3H]-adrenaline by human platelets. Brit. J. Pharmacol. 39, 765–778 (1970)

    CAS  Google Scholar 

  • Born, G.V.R., Mills, D.C.B., Roberts, G.C.K.: Potentiation of platelet aggregation by adrenaline. J. Physiol. (Lond.) 191, 43P–44P (1967a)

    CAS  Google Scholar 

  • Born, G.V.R., Day, M., Stockbridge, A.: The uptake of amines by human erythrocytes in vitro. J. Physiol. (Lond.) 193, 405–418 (1967b)

    CAS  Google Scholar 

  • Born, G.V.R., Juengjaroen, K., Michal, F.: Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues. Brit. J. Pharmacol. 44, 117–139 (1972)

    CAS  Google Scholar 

  • Borsy, J., Magó-Karacsony, E., Balogh, T., Pik, K.: Preparation new semi-synthetic lysergic acid derivatives: Investigation into the correlation of molecular structure and antiserotonin activity II. Acta pharm. hung. 43, 207–217 (1973)

    PubMed  CAS  Google Scholar 

  • Boullin, D.J., Green, A.R.: Effect of brain 5-HT agonists and antagonists on platelet aggregation. Sixth Internat. Congr. Pharmacol., Helsinki, 1975. Abstract 695

    Google Scholar 

  • Boullin, D.J., Green, A.R., Grimes, R.P.J.: Human blood platelet aggregation induced by dopamine, 5-hydroxytryptamine and analogues. J. Physiol. (Lond.) 252, 46P–47P (1975a)

    CAS  Google Scholar 

  • Boullin, D.J., Grimes, R.P.J., Orr, M.W.: The actions of flupethixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets. Brit. J. Pharmacol. 55, 555–557 (1975b)

    CAS  Google Scholar 

  • Boyd, H., Chang, V., Rand, M.J.: The anticholinesterase activity of some antiadrenaline agents. Brit. J. Pharmacol. 15, 525–531 (1960)

    PubMed  CAS  Google Scholar 

  • Bradley, P.B.: The effects of 5-hydroxytryptamine on the electrical activity of the brain and on behaviour in the conscious cat. In: 5-Hydroxytryptamine. Lewis, G.P. (ed.), pp. 214–220. London: Pergamon Press 1958

    Google Scholar 

  • Bradley, P.B., Hance, A.J.: The effects of intraventricular injections of D-lysergic acid diethylamide (LSD 25) and 5-hydroxytryptamine (serotonin) on the electrical activity of the brain of the conscious cat. J. Physiol. (Lond.) 132, 50P–51P (1956a)

    Google Scholar 

  • Bradley, P.B., Hance, A.J.: The effects of intraventricular injections of drugs on the electrical activity of the brain of the conscious cat. Electroenceph. clin. Neurophysiol. 8, 699–700 (1956b)

    Article  Google Scholar 

  • Bradley, P.B., Wolstencroft, J.H.: The action of drugs on single neurones in the brain stem. In: Neuro-Psychopharmacology. Bradley, P.B., Fluegel, F., Hoch, P.H. (eds.), pp. 237–240. Amsterdam: Elsevier 1964

    Google Scholar 

  • Bradley, P.B., Wolstencroft, J.H.: Actions of drugs on single neurones in the brain stem. Brit. med. Bull. 21, 15–18 (1965)

    PubMed  CAS  Google Scholar 

  • Bradshaw, C.M., Roberts, M.H.T., Szabadi, E.: Effect of mescaline on single cortical neurones. Brit. J. Pharmacol. 43, 871–873 (1971)

    CAS  Google Scholar 

  • Bramwell, G.J., Gonye, T.: Responses of midbrain neurones to iontophoretically applied 5-hydroxytryptamine. Brit. J. Pharmacol. 48, 357P–358P (1973)

    CAS  Google Scholar 

  • Briggs, I.: Excitatory responses to raphe stimulation in the rat bulbar reticular formation. J. Physiol. (Lond.) 256, 111P (1976)

    Google Scholar 

  • Brodie, B.B.: Storage and release of 5-hydroxytryptamine (HT). Possible significance in chemical mediation in brain. In: Ciba Symposium on Hypertension, pp. 64–83. London: Churchill 1954

    Google Scholar 

  • Brodie, B., Shore, P.A., Pletscher, A.: Serotonin-releasing activity limited to Rauwolfia alkaloids with tranquilizing action. Science 123, 992–993 (1956)

    Article  PubMed  CAS  Google Scholar 

  • Broom, W.A., Clark, A.J.: The standardisation of ergot preparations. J. Pharmacol. exp. Ther. 22, 59–74 (1923)

    CAS  Google Scholar 

  • Brown, B.E.: Proctolin: A peptide transmitter candidate in insects. Life Sci. 17, 1241–1252 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Brown, L.: The release and fate of the transmitter liberated by adrenergic nerves. Proc. roy. Soc. B 162, 1–19 (1965)

    Article  Google Scholar 

  • Brown, G.L., Dale, H.: The pharmacology of ergometrine. Proc. roy. Soc. B 118, 446–477 (1935)

    Article  CAS  Google Scholar 

  • Brown, G.L., Gillespie, J.S.: The output of sympathetic transmitter from the spleen of the cat. J. Physiol. (Lond.) 138, 81–102 (1957)

    CAS  Google Scholar 

  • Brown, G.L., Davies, B.N., Ferry, C.B.: The effect of neuronal rest on the output of sympathetic transmitter from the spleen. J. Physiol. (Lond.) 159, 365–380 (1961)

    CAS  Google Scholar 

  • Brownlee, G., Johnson, E.S.: The site of the 5-hydroxytryptamine receptor on the intramural nervous plexus of the guinea-pig isolated ileum. Brit. J. Pharmacol. 21, 306–322 (1963)

    PubMed  CAS  Google Scholar 

  • Brügger, I.: Experimenteller Beitrag zur Wirkungsweise vegetativer Pharmaka. Arch. int. Pharmacodyn. 59, 43–60 (1938)

    Google Scholar 

  • Brügger, J.: Die isolierte Samenblase des Meerschweinchens als biologisches Testobjekt zur quantitativen Differenzierung der sympathikolytischen Wirkung der genuinen Mutterkornalkaloide und ihrer Dihydroderivate. Helv. physiol. pharmacol. Acta 3, 117–134 (1945)

    Google Scholar 

  • Brundin, J.: The effect of prostaglandin E on the response of the rabbit oviduct to hypogastric nerve stimulation. Acta physiol. scand.73, 54–57 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Buchan, P., Lewis, A.J., Sugrue, M.F.: A comparison of the accumulation of noradrenaline and 5-hydroxytryptamine into arterial smooth muscle. Brit. J. Pharmacol. 52, 132P–133P (1974)

    CAS  Google Scholar 

  • Bucknell, A., Whitney, B.: A preliminary investigation of the pharmacology of the human isolated taenia coli preparation. Brit. J. Pharmacol. 23, 164–175 (1964)

    PubMed  CAS  Google Scholar 

  • Bullard, B.: The nervous control of the anterior byssus retractor muscle of Mytilus edulis. Comp. Biochem. Physiol. 23, 749–759 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Burgers, A.C.J., Imai, K.: The melanophore-stimulating potency of single pituitary glands of normal and of D-lysergic acid diethylamide (D-LSD)-treated Xenopus laevis. Gen. comp. Endocr. 2, 603–604 (1962)

    Google Scholar 

  • Burgers, A.C.J., Leemreis, W., Dominiczak, T., Van Oordt, G.J.: Inhibition of the secretion of intermedine by D-lysergic acid diethylamide (LSD-25) in the toad, Xenopus laevis. Acta endocr. (Kbh.) 29, 191–200 (1958)

    CAS  Google Scholar 

  • Burgers, A.C.J., Zandee, D.I., Van Bakel, J.M.M., Hillemans, G.M.L., Van Oordt, G.J.: The effect of LSD-derivatives and serotonin on the melanophores of the toad, Xenopus laevis. Acta physiol. pharmacol. need. 11, 341–342 (1962)

    Google Scholar 

  • Burn, J.H., Ng, K.K.F.: The action of Hydergine at postganglionic sympathetic terminations. J. Physiol. (Lond.) 175, 66P (1964)

    Google Scholar 

  • Burnstein, S., Levin, E., Varanelli, C.: Prostaglandins and cannabis — II. Inhibition of biosynthesis by the naturally occurring cannabinoids. Biochem. Pharmacol. 22, 2908–2910 (1973)

    Google Scholar 

  • Burt, D.R., Creese, I., Snyder, S.H.: Binding interaction of lysergic acid diethylamide and related agents with dopamine receptors in the brain. Molec. Pharmacol. 12, 631–638 (1976a)

    CAS  Google Scholar 

  • Burt, D.R., Creese, I., Snyder, S.H.: Properties of [3H] haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes. Molec. Pharmacol. 12, 800–812 (1976b)

    CAS  Google Scholar 

  • Cambridge, G.W., Holgate, J.A.: Superfusion as a method for the study of drug antagonism. Brit. J. Pharmacol. 10, 326–334 (1955)

    PubMed  CAS  Google Scholar 

  • Cannon, W.B., Rosenblueth, A.: Autonomic neuro-effector systems. Experimental Biology Monographs. New York: MacMillan 1937

    Google Scholar 

  • Carlsson, A., Lindqvist, M: The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo. J. Neural Transm. 33, 23–43 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Carlsson, A., Shore, P.A., Brodie, B.B.: Release of serotonin from blood platelets by reserpine in vitro. J. Pharmacol. exp. Ther. 120, 334–339 (1957)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Bedard, P., Lindqvist, M., Magnusson, T.: The influence of nerve-impulse flow on the synthesis and metabolism of 5-hydroxytryptamine. Biochem. J. 128, 70P–71P (1972a)

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Bedard, P., Lindqvist, M., Magnusson, T.: The influence of nerve-impulse flow on the synthesis and metabolism of 5-hydroxytryptamine in the central nervous system. In: Neurotransmitters and Metabolic Regulation. Smellie, R.M.S. (ed.), pp. 17–32. London: The Biochemical Society 1972b

    Google Scholar 

  • Carpi, A., Virno, M.: The action of ergotamine on the intracranial venous pressure and on the cerebral venous outflow of the dog. Brit. J. Pharmacol. 12, 232–239 (1957)

    PubMed  CAS  Google Scholar 

  • Carroll, P.R., Glover, W.E.: Independence of the vasoconstrictor and the potentiating effects of 5-hydroxytryptamine and some ergot derivatives. Proc. Aust. physiol. pharmacol. Soc. 4, 40 (1973)

    Google Scholar 

  • Carroll, P.R., Ebeling, P.W., Glover, W.E.: Vascular responses to some drugs used in the treatment of migraine. Abstracts, Australasian Society for Clinical and Experimental Pharmacologists, November 1972

    Google Scholar 

  • Carroll, P.R., Ebeling, P.W., Glover, W.E.: The responses of the human temporal and rabbit ear artery to 5-hydroxytryptamine and some of its antagonists. Ajebak 52, 813–823 (1974)

    PubMed  CAS  Google Scholar 

  • Casentini, S., Galli, G.: Serotonina, antiserotoninici e motilita gastrica. Boll. Soc. ital. Biol. sper. 32, 1640–1642 (1956)

    PubMed  CAS  Google Scholar 

  • Cerletti, A.: Lysergic acid diethylamide (LSD) and related compounds. In: Neuropharmacology. Abramson, H.A. (ed.), pp. 9–84. Trans. Second Conf. Princeton: Josiah Macy, Jr., Foundation 1955

    Google Scholar 

  • Cerletti, A.: Ergostin — Neue Perspektiven der Chemie und Pharmakologie des Mutterkorns. Med. exp. (Basel) 8, 278–286 (1963)

    Article  CAS  Google Scholar 

  • Cerletti, A., Berde, B.: Die Wirkung von D-Lysergsäure-diäthylamid (LSD 25) und 5-Oxytryptamin auf die Chromatophoren von Poecilia reticulatus. Experientia (Basel) 11, 312–313 (1955)

    Article  CAS  Google Scholar 

  • Cerletti, A., Berde, B.: New approaches in the development of compounds from ergot with potential therapeutic use in migraine. In: Background to Migraine. Smith, R. (ed.), pp. 53–64. London: William Heinemann Medical Books 1967

    Google Scholar 

  • Cerletti, A., Doepfner, W.: Über die 5-Oxytryptamin-hemmende Wirkung von LSD-Derivaten und andern Lysergsäureamiden am isolierten Rattenuterus. 20th Intern. Physiol. Congress Bruxelles, 1956, Abstr. Comm., pp. 165–166

    Google Scholar 

  • Cerletti, A., Doepfner, W.: Spezifische Steigerung der serotonin-antagonistischen Wirkung von Lysergsäurederivaten durch Methylierung des Indolstickstoffes der Lysergsäure. Helv. physiol. pharmacol. Acta 16, C55–C57 (1958a)

    Google Scholar 

  • Cerletti, A., Doepfner, W.: Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids. J. Pharmacol. exp. Ther. 122, 124–136 (1958b)

    PubMed  CAS  Google Scholar 

  • Cerletti, A., Konzett, H.: Spezifische Hemmung von 5-Oxytryptamin-Effekten durch Lysergsäurediäthylamid und ähnliche Körper. Naunyn-Schmiedebergs Arch. Pharmacol. 228, 146–148 (1956)

    Article  CAS  Google Scholar 

  • Cerletti, A., Rothlin, E.: Role of 5-hydroxytryptamine in mental diseases and its antagonism to lysergic acid derivatives. Nature (Lond.) 176, 785–786 (1955)

    Article  CAS  Google Scholar 

  • Chahl, L.A., Ladd, R.J.: The effects of prostaglandins E1, E2 and F on the cutaneous vasculature of the rat. Brit. J. Pharmacol. 56, 317–322 (1976)

    CAS  Google Scholar 

  • Chahl, L.A., O’Donnell, S.R.: The effects on some receptors of guinea-pig trachea of a series of sympathomimetic amines. Europ. J. Pharmacol. 16, 201–208 (1971)

    Article  CAS  Google Scholar 

  • Chambers, P.N., Marshall, P.B.: Similar pharmacological properties of ergometrine and methysergide. J. Pharm. Pharmacol. 19, 65 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Chan, P.S., Ellenbogen, L.: New evidence for the β-adrenergic receptor blocking activity of dihydroergotamine. Arch. int. Pharmacodyn. 209, 204–213 (1974)

    PubMed  CAS  Google Scholar 

  • Chase, T.N., Breese, G.R., Kopin, I.J.: Serotonin release from brain slices by electrical stimulation: Regional differences and effect of LSD. Science 157, 1461–1463 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Chase, T.N., Katz, R.I., Kopin, I.J.: Release of [3H] serotonin from brain slices. J. Neurochem. 16, 607–615 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Chodera, A.: Blockade of 5-hydroxytryptamine antidiuresis in rats by 2-bromlysergic acid diethylamide tartrate and 1-methyl-lysergic acid butanolamide. J. Pharm. Pharmacol. 15, 386–389 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Chong, G.C., Phillis, J.W.: Pharmacological studies on the heart of Tapes watlingi: A mollusc of the family Veneridae. Brit. J. Pharmacol. 25, 481–496 (1965)

    PubMed  CAS  Google Scholar 

  • Christ, D.D., Nishi, S.: Site of adrenaline blockade in the superior cervical ganglion of the rabbit. J. Physiol. (Lond.) 213, 107–117 (1971)

    CAS  Google Scholar 

  • Christian, S.T., McClain, L.D., Morin, R.D., Benington, F.: Blockage of LSD binding at its high affinity site on synaptosomal membranes by 1-methyl-1,2,5,6-tetrahydropyridine-N,N-diethyl-carboxamide. Experientia (Basel) 31, 910–911 (1975)

    Article  CAS  Google Scholar 

  • Chu, D., Sturmer, E.: Studies on the mechanism of action of dihydroergotamine (DHE) on the vascular bed of cat skeletal muscle. Brit. J. Pharmacol. 48, 331P–332P (1973)

    CAS  Google Scholar 

  • Chu, D., Owen, D.A.A., Stürmer, E.: Effects of ergotamine and dihydroergotamine on the resistance and capacitance vessels of skin and skeletal muscle in the cat. Postgrad. med. J. 52 (Suppl. 1), 32–36 (1976)

    CAS  Google Scholar 

  • Church, M.K.: Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization. Brit. J. Pharmacol. 55, 423–430 (1975)

    CAS  Google Scholar 

  • Church, M.K., Miller, P.: Simple models of anaphylaxis and of histamine and 5-hydroxytryptamine induced inflammation using the mouse pinna. Brit. J. Pharmacol. 55, 315P (1975)

    CAS  Google Scholar 

  • Cima, G., Freschi, C.: Attivitá della serotonina e dei suoi antagonisti sull’uretere isolato. Boll. Soc. ital. Biol. sper. 33, 867–869 (1957)

    PubMed  CAS  Google Scholar 

  • Cleugh, J., Gaddum, J.H., Holton, P., Leach, E.: Assay of substance P on the fowl rectal caecum. Brit. J. Pharmacol. 17, 144–158 (1961)

    PubMed  CAS  Google Scholar 

  • Clineschmidt, B.V., Anderson, E.G.: Lysergic acid diethylamide: antagonism of supraspinal inhibiton of spinal reflexes. Brain Res. 16, 296–300 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Clineschmidt, B.V., Anderson, E.G.: The blockade of bulbospinal inhibition by 5-hydroxytryptamine antagonists. Exp. Brain Res. 11, 175–186 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Clineschmidt, B.V., Lotti, V.J.: Indoleamine antagonists: relative potencies as inhibitors of tryptamine-and 5-hydroxytryptophan-evoked responses. Brit. J. Pharmacol. 50, 311–313 (1974)

    CAS  Google Scholar 

  • Closse, A., Hauser, D.: Dihydroergotamine binding to rat brain membranes. Life Sci. 19, 1851–1864 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Cohen, M.L., Berkowitz, B.A.: Differences between the effects of dopamine and apomorphine on rat aortic strips. Europ. J. Pharmacol. 34, 49–58 (1975)

    Article  CAS  Google Scholar 

  • Collier, J.G., Nachev, C., Robinson, B.F.: Effect of catecholamines and other vasoactive substances on superficial hand veins in man. Clin. Sci. 43, 455–467 (1972)

    PubMed  CAS  Google Scholar 

  • Constantine, J.W., Knott, C.: Benzquinamide and the 5-hydroxytryptamine receptors in guinea pig trachea. J. Pharmacol. exp. Ther. 146, 400–403 (1964)

    PubMed  CAS  Google Scholar 

  • Cools, A.R.: Two topographically, functionally and pharmacologically distinct dopamine-sensitive sites within the cat brain. Sixth Internat. Congr. Pharmacol., Helsinki, 1975, Abstract 1149

    Google Scholar 

  • Cools, A.R., Van Rossum, J.M.: Excitation-mediating and inhibition-mediating dopaminereceptors: A new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data. Psychopharmacologia 45, 243–254 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Cools, A.R., Struyker Boudier, H.A.J., Van Rossum, J.M.: Depamine receptors: Selective agonists and antagonists of functionally distinct types within the feline brain. Europ. J. Pharmacol. 37, 283–293 (1976)

    Article  CAS  Google Scholar 

  • Corrodi, H., Fuxe, K., Hökfelt, T., Lidbrink, P., Ungerstedt, U.: Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons. J. Pharm. Pharmacol. 25, 409–412 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Corrodi, H., Farnebo, L.O., Fuxe, K., Hamberger, B.: Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. Europ. J. Pharmacol. 30, 172–181 (1975)

    Article  CAS  Google Scholar 

  • Costa, E.: Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions. Proc. Soc. exp. Biol. (N.Y.) 91, 39–41 (1956)

    CAS  Google Scholar 

  • Costa, E., Zetler, G.: Interactions between epinephrine and some psychotomimetic drugs. J. Pharmacol. exp. Ther. 125, 230–236 (1959)

    PubMed  CAS  Google Scholar 

  • Costall, B., Naylor, R.J.: Apomorphine as an antagonist of the dopamine response from the nucleus accumbens. J. Pharm. Pharmacol. 28, 592–595 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Cottrell, G.A.: Direct post-synaptic responses to stimulation of serotonin-containing neurons. Nature (Lond.) 225, 1060–1062 (1970a)

    Article  CAS  Google Scholar 

  • Cottrell, G.A.: Actions of LSD-25 and reserpine on a serotonergic synapse. J. Physiol. (Lond.) 208, 28P–29P (1970b)

    CAS  Google Scholar 

  • Cottrell, G.A., Macon, J.B.: Synaptic connexions of two symmetrically placed giant serotonin-containing neurones. J. Physiol. (Lond.) 236, 435–464 (1974)

    CAS  Google Scholar 

  • Cottrell, G.A., Berry, M.S., Macon, J.B.: Synapses of a giant serotonin neurone and a giant dopamine neurone: studies using antagonists. Neuropharmacology 13, 431–439 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Couch, J.R.: Blockade of excitatory 5-HT synapse by LSD. Pharmacologist 16, 244 (1974)

    Google Scholar 

  • Creese, I., Burt, D.R., Snyder, S.H.: The dopamine receptor: differential binding of D-LSD and related agents to agonist and antagonist states. Life Sci. 17, 1715–1720 (1976)

    Article  Google Scholar 

  • Cripps, H., Dearnaley, D.P.: Evidence suggesting uptake of noradrenaline at adrenergic receptors in the isolated blood-perfused cat spleen. J. Physiol. (Lond.) 216, 55P–56P (1971)

    CAS  Google Scholar 

  • Cripps, H., Dearnaley, D.P.: Vascular responses and noradrenaline overflow in the isolated blood-perfused cat spleen: some effects of cocaine, normetanephrine and α-blocking agents. J. Physiol. (Lond.) 227, 647–664 (1972)

    CAS  Google Scholar 

  • Crossman, A.R., ElKhawad, A.O.A., Walker, R.J., Woodruff, G.N.: Effects of ergometrine on dopamine receptors. J. Physiol. (Lond.) 232, 59P (1973)

    CAS  Google Scholar 

  • Crunkhorn, P., Meacock, S.C.R.: Mediators of the inflammation induced in the rat paw by carrageenin. Brit. J. Pharmacol. 42, 392–402 (1971)

    CAS  Google Scholar 

  • Crunkhorn, P., Willis, A.L.: Cutaneous reactions to intradermal prostaglandins. Brit. J. Pharmacol. 41, 49–56 (1971)

    CAS  Google Scholar 

  • Cuatrecasas, P., Greaves, M.F.: Receptors and recognition. Series A, Vol. I. London: Chapman and Hall; New York: Wiley 1976

    Google Scholar 

  • Cuatrecasas, P., Hollenberg, M.D., Chang, K.-J., Bennett, V.: Hormone receptor complexes and their modulation of membrane function. Recent Progr. Hormone Res. 31, 37–94 (1975)

    PubMed  CAS  Google Scholar 

  • Cumings, J.N.: The relationship of serotonin and platelets in migraine. Arch. Neurobiol. 37 (Suppl.), 67–75, 77–84 (1974)

    Google Scholar 

  • Cumings, J.N., Hilton, B.P.: Effects of methysergide on platelets incubated with reserpine. Brit. J. Pharmacol. 42, 611–619 (1971)

    CAS  Google Scholar 

  • Curtis, D.R., Davis, R.: A central action of 5-hydroxytryptamine and noradrenaline. Nature (Lond.) 192, 1083–1084 (1961)

    Article  CAS  Google Scholar 

  • Curtis, D.R., Davis, R.: Pharmacological studies upon neurons of the lateral geniculate nucleus of the cat. Brit. J. Pharmacol. 18, 217–246 (1962)

    PubMed  CAS  Google Scholar 

  • Curzon, G., Marsden, C.A.: Effect of LSD on rat brain 5-hydroxytryptamine metabolism at elevated environmental temperature. Brit. J. Pharmacol. 56, 368P–369P (1976)

    CAS  Google Scholar 

  • Dahlström, A., Fuxe, K.: Evidence for the existence of mono-amine neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta physiol. scand. 62 (Suppl. 232), 5–55 (1964)

    Google Scholar 

  • Dahlström, A., Fuxe, K.: Evidence for the existence of mono-amine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems. Acta physiol. scand. 64 (Suppl. 247), 7–36 (1965)

    Google Scholar 

  • Daicoff, G.R., Chavez, F.R., Anton, A.H., Swenson, E.W.: Serotonin-induced pulmonary venous hypertension in pulmonary embolism. Thorac. cardiovasc. Surg. 56, 810–815 (1968)

    CAS  Google Scholar 

  • Dale, H.H.: On some physiological actions of ergot. J. Physiol. (Lond.) 34, 163–206 (1906)

    Google Scholar 

  • Dalessio, D.J., Camp, W.A., Goodell, H., Chapman, L.F., Zileli, T., Ramos, A.O., Ehrlich, R., Fortuin, F., McCattell, K., Wolff, H.C.: Studies on headache: the relevance of the prophylactic action of UML-491 in vascular headache of the migraine type to the pathophysiology of this syndrome. Wld Neurol. 3, 66–72 (1962)

    Google Scholar 

  • Da Graca-Fernandez, M., Osswald, W.: Einfluss von Ergotamin und Pentobarbital auf die Blutdruck-und Nickhautwirkungen von Noradrenalin und Tyramin. Med. Pharmacol. exp. 17, 65–71 (1967)

    Google Scholar 

  • D’Amico, D.J., Patel, B.C., Klawans, H.L.: The effect of methysergide on 5-hydroxytryptamine turnover in whole brain. J. Pharm. Pharmacol. 28, 454–456 (1976)

    Article  PubMed  Google Scholar 

  • Da Prada, M., Saner, A., Burkhard, W.P., Bartholini, G., Pletscher, A.: Evidence for stimulation of cerebral dopamine receptors by LSD. Sixth Internat. Congr. Pharmacol., Helsinki, 1975a, Abstract 187

    Google Scholar 

  • Da Prada, M., Saner, A., Burkard, W.P., Bartholini, G., Pletscher, A.: Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors. Brain Res. 94, 67–73 (1975b)

    Article  PubMed  CAS  Google Scholar 

  • Davis, M.E., Adair, F.L., Chen, K.K., Swanson, E.E.: The pharmacologic action of ergotocin, a new ergot principle. J. Pharmacol. exp. Ther. 54, 398–407 (1935)

    CAS  Google Scholar 

  • Davis, W.G: A dual action of 5-hydroxytryptamine on the ovarian suspensory ligament of the rat. J. Pharm. Pharmacol. 28, 502–504 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Day, M., Vane, J.R.: An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum. Brit. J. Pharmacol. 20, 150–170 (1963)

    PubMed  CAS  Google Scholar 

  • Deffenu, G., Mantegazzini, P.: Effects of 5-hydroxytryptamine on spinal reflexes of the cat. Psychopharmacologia 10, 96–102 (1966)

    Article  PubMed  CAS  Google Scholar 

  • De La Lande, I.S., Cannel, V.A., Waterson, J.G: The interaction of serotonin and noradrenaline on the perfused artery. Brit. J. Pharmacol. 28, 255–272 (1966)

    Google Scholar 

  • De La Lande, I.S., Rand, M.J.: A simple isolated nerve-blood vessel preparation. Aust. J. exp. Biol. med. Sci. 43, 639–656 (1965)

    Article  PubMed  Google Scholar 

  • Delay, J., Thuillier, J.: Dualité d’action du diethylamide de l’acide lysergique sur la contraction uterine provoquée par la 5-hydroxytryptamine (sérotonine). C.R. Soc. Biol. (Paris) 150, 1335–1336 (1956)

    CAS  Google Scholar 

  • Del Bianco, P.L., Fanciullacci, M., Franchi, G., Sicuteri, F.: Human 5-hydroxytryptamine venomotor receptors. Pharmacol. Res. Commun. 7, 395–408 (1975)

    Article  Google Scholar 

  • Del Bianco, P.L., Franchi, G., Fanciullacci, M., Sicuteri, F.: Clinical pharmacology of 5-hydroxytryptamine and catecholamines venomotor receptors. Arch. int. Pharmacodyn. 196 (Suppl.), 113–116 (1972)

    PubMed  Google Scholar 

  • Del Greco, F., Masson, G.M.C., Corcoran, A.C.: Renal and arterial effects of serotonin in the anesthetized rat. Amer. J. Physiol. 187, 509–514 (1956)

    Google Scholar 

  • Dengler, H.J., Spiegel, H.E., Titus, E.O.: Effects of drugs on uptake of isotopic norepinephrine by cat tissues. Nature (Lond.) 191, 816–817 (1961)

    Article  CAS  Google Scholar 

  • Dette, G.A., Wesemann, W.: Studies on serotonin binding proteins of nerve ending membranes. J. Neural Transm. 37, 281–295 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Diab, I.M., Freedman, D.X., Roth, L.J.: [3H] Lysergic acid diethylamide: cellular autoradiographic localization in rat brain. Science 173, 1022–1024 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Diaz, J.-L., Huttunen, M.O.: Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat. Science 174, 62–64 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Diaz, P., Ngai, S.H., Costa, E.: The effect of LSD on the metabolism of rat brain serotonin (5-HT). Pharmacologist 9, 251 (1967)

    Google Scholar 

  • Diaz, P.M., Ngai, S.H., Costa, E.: Factors modulating brain serotonin turnover. Adv. Pharmacol. Chemother. 6B, 75–92 (1968)

    Article  Google Scholar 

  • Dingledine, R., Goldstein, A., Kendig, J.: Effects of narcotic opiates and serotonin on the electrical behaviour of neurons in the guinea-pig myenteric plexus. Life Sci. 14, 2299–2309 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Doepfner, W., Cerletti, A.: Über den Serotonin-Antagonismus einiger Antihistaminika unter Berücksichtigung ihrer chemischen Struktur. Int. Arch. Allergy 10, 348–354 (1957)

    Article  PubMed  CAS  Google Scholar 

  • Doepfner, W., Cerletti, A.: Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat’s paw by serotonin. Int. Arch. Allergy 12, 89–97 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Dougan, D.F.H., McLean, J.R.: Evidence for the presence of dopaminergic nerves and receptors in the intestine of a mollusc, Tapes watlingi. Comp. gen. Pharmacol. 1, 33–46 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Drakontides, A.B., Gershon, M.D.: 5-Hydroxytryptamine receptors in the mouse duodenum. Brit. J. Pharmacol. 33, 480–492 (1968)

    PubMed  CAS  Google Scholar 

  • Dretchen, K., Ghoneim, M.M., Long, J.P.: Interactions of serotonin with neuromuscular blocking agents. Europ. J. Pharmacol. 18, 121–127 (1972)

    Article  CAS  Google Scholar 

  • Drew, G.M.: Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors. Europ. J. Pharmacol. 36, 313–320 (1976)

    Article  CAS  Google Scholar 

  • Drummond, A.H., Gordon, J.L.: Platelet release reaction induced by 5-hydroxytryptamine. J. Physiol. (Lond.) 240, 39P–40P (1974)

    CAS  Google Scholar 

  • Drummond, A.H., Gordon, J.L.: Inhibition of 5-hydroxy-[3H]-tryptamine binding to rat blood platelets by 5-HT antagonists and uptake inhibitors. Brit. J. Pharmacol. 55, 257–258 (1975a)

    Google Scholar 

  • Drummond, A.H., Gordon, J.L.: Specific binding sites for 5-hydroxytryptamine on rat blood platelets. Biochem. J. 150, 129–132 (1975b)

    PubMed  CAS  Google Scholar 

  • Drummond, A.H., Whigham, K.A.E., Prentice, C.R.M.: Effects of chlorprothixene isomers on platelet 5-hydroxytryptamine receptors: evidence for different 5-hydroxytryptamine conformations at uptake and stimulatory sites. Europ. J. Pharmacol. 37, 385–388 (1976)

    Article  CAS  Google Scholar 

  • Dyer, D.C.: The pharmacology of spirally-cut sheep umbilical blood vessels. Pharmacologist 11, 230 (1969)

    Google Scholar 

  • Dyer, D.C.: The pharmacology of isolated sheep umbilical blood vessels. J. Pharmacol. exp. Ther. 175, 565–570 (1970)

    PubMed  CAS  Google Scholar 

  • Dyer, D.C.: Evidence for the action of D-lysergic acid diethylamide, mescaline and bufotenine on 5-hydroxytryptamine receptors in umbilical vasculature. J. Pharmacol. exp. Ther. 188, 336–341 (1974)

    PubMed  CAS  Google Scholar 

  • Dyer, D.C., Gant, D.W.: Vasoconstriction produced by hallucinogens on isolated human and sheep umbilical vasculature. J. Pharmacol. exp. Ther. 184, 366–375 (1973)

    PubMed  CAS  Google Scholar 

  • Dyer, D.C., Ueland, K., Eng, M.: Responses of isolated monkey umbilical veins to biogenic amines and polypeptides. Arch. int. Pharmacodyn. 200, 213–221 (1972)

    PubMed  CAS  Google Scholar 

  • Dykstra, S.L., Berdahl, J.M., Campbell, K.N., Combs, C.M., Lankin, D.G: Phenylindenes and phenylindans with antireserpine activity. J. med. Chem. 10, 418–428 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Dykstra, S.J., Minielli, J.L., Lawson, J.E., Ferguson, H.C., Dungan, K.W.: Lysergic acid and quinidine analogs. 2-(O-acylamino-phenethyl) piperidines. J. med. Chem. 16, 1015–1020 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Ehrenpreis, S., Fleisch, J.H., Mittag, T.W.: Approaches to the molecular nature of pharmacological receptors. Pharmacol. Rev. 21, 131–181 (1969)

    PubMed  CAS  Google Scholar 

  • Eliasson, R., Åström, A.: Pharmacological studies on the perfused human placenta. Acta Pharmacol. (Kbh.) 11, 254–264 (1955)

    Article  CAS  Google Scholar 

  • ElKhawad, A.O., Woodruff, G.N.: Evidence for direct stimulation of dopamine receptors by ergometrine in mice and rats. Sixth Internat. Congr. Pharmacol., Helsinki, 1975, Abstract 1147

    Google Scholar 

  • ElKhawad, A.O., Munday, K.A., Poat, J.A., Woodruff, G.N.: The effect of dopamine receptor stimulants on locomotor activity and cyclic AMP levels in the rat striatum. Brit. J. Pharmacol. 53, 456P–457P (1975)

    CAS  Google Scholar 

  • Engberg, I., Lundberg, A., Ryall, R.W.: The effect of reserpine on transmission from the flexor reflex afferents. Acta physiol. scand. 68 (Suppl. 277), 45 (1966)

    Google Scholar 

  • Engberg, I., Lundberg, A., Ryall, R.W.: The effect of reserpine on transmission in the spinal cord. Acta physiol. scand. 72, 115–122 (1968a)

    Article  PubMed  CAS  Google Scholar 

  • Engberg, I., Lundberg, A., Ryall, R.W.: Is the tonic decerebrate inhibition of reflex paths mediated by monoaminergic pathways? Acta physiol. scand. 72, 123–133 (1968b)

    Article  PubMed  CAS  Google Scholar 

  • Engelhardt, G.: Zur Pharmakologie des 9,10-Dihydro-10-(1-methyl-4-piperidyliden)-9-anthrol (WA 335), eines Histamin-und Serotoninantagonisten. Arzneimittel-Forsch. 25, 1723–1737 (1975)

    CAS  Google Scholar 

  • Erspamer, V.: Modificazioni delle azioni dell enteramina ad opera di farmaci simpaticomimetici e di farmaci simpaticolitici. Ricerca Sci. 22, 1568–1577 (1952)

    CAS  Google Scholar 

  • Erspamer, V.: Pharmacological studies on enteramine (5-Hydroxytryptamine). Arch. int. Pharmacodyn. 93, 293–316 (1953)

    PubMed  CAS  Google Scholar 

  • Euler, U.S.v.: Effect of some metabolic factors and drugs on uptake and release of catecholamines in vitro and in vivo. In: New Aspects of Storage and Release Mechanisms of Catecholamines. Schumann, H.J., Kroneberg, G. (eds.), pp. 144–158. Berlin-Heidelberg-New York: Springer 1970

    Google Scholar 

  • Euler, U.S.v.: Adrenergic nerve particles in relation to uptake and release of neurotransmitter. J. Endocr. 55, 2–9 (1972)

    Google Scholar 

  • Euler, U.S.v., Hedqvist, P.: Inhibitory action of prostaglandins E1 and E2 on the neuromuscular transmission in the guinea-pig vas deferens. Acta physiol. scand. 77, 510–512 (1969)

    Article  Google Scholar 

  • Euler, U.S.v., Lishajko, F.: Inhibitory action of adrenergic blocking agents on catecholamine release and uptake in isolated nerve granules. Acta physiol. scand. 68, 257–262 (1966)

    Article  Google Scholar 

  • Euler, U.S.v., Lishajko, F.: Inhibitory action of adrenergic blocking agents on reuptake and net uptake of noradrenaline in nerve granules. Acta physiol. scand. 74, 501–506 (1968)

    Article  Google Scholar 

  • Evans, D.H.L., Schild, H.O., Thesleff, S.: Effects of drugs on depolarized plain muscle. J. Physiol. (Lond.) 143, 474–485 (1958)

    CAS  Google Scholar 

  • Eyre, P.: Pharmacology of bovine pulmonary vein anaphylaxis in vitro. Brit. J. Pharmacol. 43, 302–311 (1971)

    CAS  Google Scholar 

  • Eyre, P.: Atypical tryptamine receptors in sheep pulmonary vein. Brit. J. Pharmacol. 55, 329–333 (1975)

    CAS  Google Scholar 

  • Fanchamps, A., Doepfner, W., Weidmann, H., Cerletti, A.: Pharmakologische Charakterisierung von Deseril, einem Serotonin-Antagonisten. Schweiz. med. Wschr. 90, 1040–1046 (1960)

    PubMed  CAS  Google Scholar 

  • Fanciullacci, M., Franchi, G., Sicuteri, F.: Facilitazione dell’ azione venocostrittrice della 5-idrossitriptamina da ergotamina, metisergide e LSD-25 nell’uomo. Boll. Soc. ital. Biol. sper. 51, 517–522 (1975)

    PubMed  CAS  Google Scholar 

  • Fara, J.: Mesenteric vasodilator responses to 5-hydroxytryptamine. Gastroenterology 66, 689 (1974)

    Google Scholar 

  • Farnebo, L.-O., Hamberger, B.: Drug-induced changes in the release of [3H]-noradrenaline from field stimulated rat iris. Brit. J. Pharmacol. 43, 97–106 (1971a)

    CAS  Google Scholar 

  • Farnebo, L.-O., Hamberger, B.: Drug-induced changes in the release of 3H-monoamines from field stimulated rat brain slices. Acta physiol. scand. (Suppl.) 371, 35–44 (1971b)

    Article  CAS  Google Scholar 

  • Farnebo, L.-O., Hamberger, B.: Regulation of [3H] 5-hydroxytryptamine release from rat brain slices. J. Pharm. Pharmacol. 26, 642–644 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Farrow, J.T., Van Vunakis, H.: Binding of D-lysergic acid diethylamide to subcellular fractions from rat brain. Nature (Lond.) 237, 164–165 (1972)

    Article  CAS  Google Scholar 

  • Farrow, J.T., Van Vunakis, H.: Characteristics of D-lysergic acid diethylamide binding to subcellular fractions derived from rat brain. Biochem. Pharmacol. 22, 1103–1113 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Feldman, J.M., Lebovitz, H.E.: Specificity of serotonin inhibition of insulin release from golden hamster pancreas. Diabetes 19, 475–479 (1970a)

    PubMed  CAS  Google Scholar 

  • Feldman, J.M., Lebovitz, H.E.: Mechanism of epinephrine and serotonin inhibition of insulin release in the golden hamster in vitro. Diabetes 19, 480–486 (1970b)

    PubMed  CAS  Google Scholar 

  • Ferrini, R., Glässer, A.: Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1,6-dimethyl-8β-carbo-benzyloxyaminomethyl-10α-ergoline). Psychopharmacologia 8, 271–276 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Fillion, G., Fillion, M.-P., Spirakis, Ch., Bahers, J.-M., Jacob, J.: 5-Hydroxytryptamine binding to synaptic membranes from rat brain. Life Sci. 18, 65–74 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Fingerman, M., Rao, K.R.: Action of biogenic amines on crustacean chromatophores. Comp. gen. Pharmacol. 1, 341–348 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Fingl, E., Gaddum, J.H.: Hydroxytryptamine blockade by dihydroergotamine in vitro. Fed. Proc. 12, 320 (1953)

    Google Scholar 

  • Fishlock, D.J.: The action of 5-hydroxytryptamine on the circular muscle of the human ileum and colon in vitro. J. Physiol. (Lond.) 170, 11P–12P (1964)

    CAS  Google Scholar 

  • Fishlock, D.J., Parks, A.G., Dewell, J.V.: Action of 5-hydroxytryptamine on the human stomach, duodenum and jejunum in vitro. Gut 6, 338–342 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein, A.: A quantitative study of antagonists of adrenaline on the vessels of the rabbit’s ear. Brit. J. Pharmacol. 7, 553–562 (1952)

    PubMed  CAS  Google Scholar 

  • Fleisch, J.H., Maling, H.M., Brodie, B.B.: Evidence for existence of alpha-adrenergic receptors in the mammalian trachea. Amer. J. Physiol. 218, 596–599 (1970)

    PubMed  CAS  Google Scholar 

  • Flückiger, E., Balthasar, H.U.: Dihydroergocristin: Unterschiedliche Wirkungen an venösem und arteriellem Gewebe. Arzneimittel-Forsch. 17, 6–9 (1967)

    Google Scholar 

  • Flückiger, E., Salzmann, R.: Serotoninantagonismus an der Placenta. Experientia (Basel) 17, 131 (1961)

    Article  Google Scholar 

  • Foote, W.E., Sheard, M.H., Aghajanian, G.K.: Comparison of effects of LSD and amphetamine on midbrain raphe units. Nature (Lond.) 222, 567–569 (1969)

    Article  CAS  Google Scholar 

  • Fozard, J.R.: Clonidine and methysergide: effects on an isolated artery. Naunyn-Schmiedebergs Arch. Pharmacol. 279 (Suppl.), R21 (1973a)

    Google Scholar 

  • Fozard, J.R.: Drug interactions on an isolated artery. In: Background to Migraine. Cumings, J.N. (ed.), pp. 150–169. London: William Heinemann Medical Books 1973b

    Google Scholar 

  • Fozard, J.R.: The mechanisms by which migraine prophylactic drugs modify vascular reactivity in vitro. “Headache ‘76”, Joint Meeting of the Italian Headache and the Scandinavian Migraine Societies, Florence, 1976a, Abstract, pp. 7–8

    Google Scholar 

  • Fozard, J.R.: Comparative effects of four migraine prophylactic drugs on an isolated extracranial artery. Europ. J. Pharmacol. 36, 127–139 (1976b)

    Article  CAS  Google Scholar 

  • Fozard, J.R., Berry, J.L.: Interactions between antimigraine drugs and a high affinity uptake and storage machanism for 5-hydroxytryptamine. Pharmacology 14, 357–361 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Fozard, J.R., Leach, G.D.H.: The hypotensive action of 5-hydroxytryptamine (5-HT) in anaesthetised and pithed rats. Europ. J. Pharmacol. 2, 239–249 (1968)

    Article  CAS  Google Scholar 

  • Fozard, J.R., Wright, J.L.: Interaction between antimigraine drugs and a high affinity uptake and storage mechanism for 5-hydroxytryptamine. Sixth Migraine Symposium, London, 1974, Abstract, pp. 9–10

    Google Scholar 

  • Frankhuijzen, A.L.: Analysis of ergotamine-5-HT interaction on the isolated rat stomach preparation. Europ. J. Pharmacol. 30, 205–212 (1975)

    Article  CAS  Google Scholar 

  • Frankhuijzen, A.L., Bonta, I.L.: Effect of mianserin, a potent anti-serotonin agent, on the isolated rat stomach fundus preparation. Europ. J. Pharmacol. 25, 40–50 (1974a)

    Article  Google Scholar 

  • Frankhuijzen, A.L., Bonta, I.L.: Receptors involved in the action of 5-HT and tryptamine on the isolated rat stomach fundus preparation. Europ. J. Pharmacol. 26, 220–230 (1974b)

    Article  CAS  Google Scholar 

  • Fredholm, B.B., Rosell, S.: Fate of 3H-noradrenaline in canine subcutaneous adipose tissue. Acta physiol. scand. 80, 404–411 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Freedman, D.X.: LSD-25 and brain serotonin in reserpinized rat. Fed. Proc. 19, 266 (1960)

    Google Scholar 

  • Freedman, D.X.: Effects of LSD-25 on brain serotonin. J. Pharmacol. exp. Ther. 134, 160–166 (1961)

    PubMed  CAS  Google Scholar 

  • Freedman, D.X.: Psychotomimetic drugs and brain biogenic amines. Amer. J. Psychiat. 119, 843–850 (1963)

    PubMed  CAS  Google Scholar 

  • Freedman, D.X.: Aspects of the biochemical pharmacology of psychotropic drugs. In: Psychiatric Drugs. Solomon, P. (ed.), pp. 32–57. New York: Grune and Stratton 1966

    Google Scholar 

  • Freedman, D.X.: LSD, psychotogenic procedures and brain neuro-humors. Psychopharmacol. Bull. 11, 42–43 (1975)

    PubMed  CAS  Google Scholar 

  • Freedman, D.X., Aghajanian, G.K.: Approaches to the pharmacology of LSD-25. Lloydia 29, 309–314 (1967)

    Google Scholar 

  • Freedman, D.X., Boggan, W.O.: Brain serotonin metabolism after tolerance dosage of LSD. Adv. Biochem. Psychopharmacol. 10, 151–157 (1974)

    PubMed  CAS  Google Scholar 

  • Freedman, D.X., Coquet, C.A.: Regional and subcellular distribution of LSD and effects on 5-HT levels. Pharmacologist 7, 183 (1965)

    Google Scholar 

  • Freedman, D.X., Giarman, N.J.: LSD-25 and the status and level of brain serotonin. Ann. N.Y. Acad. Sci. 96, 98–106 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Freedman, D.X., Gottlieb, R., Lovell, R.A.: Psychotomimetic drugs and brain 5-hydroxytryptamine metabolism. Biochem. Pharmacol. 19, 1181–1188 (1970)

    Article  CAS  Google Scholar 

  • Fregnan, G.B., Glässer, A.H.: Activity of eledoisin, other polypeptides and ergometrine on the uterus in situ of rabbit and other animal species. J. Pharm. Pharmacol. 16, 744–750 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Fregnan, G.B., Glasser, A.H.: Structure-activity relationship of various acyl derivatives of 6-methyl-8β-aminomethyl-10α-ergoline (dihydrolysergamine). Experientia (Basel) 24, 150–151 (1968)

    Article  CAS  Google Scholar 

  • Froment, J.L., Eskazan, E., Jouvet, M.: Effets du LSD et du méthysergide sur les pointes ponto géniculo occipitales. C.R. Soc. Biol. (Paris) 165, 2153–2157 (1971)

    CAS  Google Scholar 

  • Furchgott, R.F.: Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors. J. Pharmacol. exp. Ther. 111, 265–284 (1954)

    PubMed  CAS  Google Scholar 

  • Furchgott, R.F.: The pharmacology of vascular smooth muscle. Pharmacol. Rev. 7, 183–265 (1955)

    PubMed  CAS  Google Scholar 

  • Furchgott, R.F.: Receptors for sympathomimetic amines. In: Ciba Foundation Symposium on Adrenergic Mechanisms. Wolstenholme, G.E.W., O’Connor, M. (eds.), pp. 246–252. London: J. and A. Churchill 1960

    Google Scholar 

  • Furchgott, R.F.: The pharmacological differentiation of adrenergic receptors. Ann. N.Y. Acad. Sci. 139, 553–570 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Furchgott, R.F.: The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Handbook of Experimental Pharmacology. Catecholamines. Blaschko, H., Muscholl, E. (eds.), Vol. XXXIII, pp. 283–335. Berlin-Heidelberg-New York: Springer 1972

    Google Scholar 

  • Furukawa, K., Nomoto, T.: 5-Hydroxytryptamine receptors in isolated rat ileum. Jap. J. Pharmacol. 24 (Suppl.), 95 (1974)

    Article  PubMed  Google Scholar 

  • Furukawa, K., Nomoto, T.: Changes in the response to ACh, nicotine and 5-hydroxytryptamine in chemical sympathectomized rat ileum. Jap. J. Pharmacol. 25 (Suppl.), 29P (1975)

    Article  Google Scholar 

  • Fuxe, K.: Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine terminals in the central nervous system. Acta physiol. scand. 64 (Suppl. 247), 37–85 (1965)

    Google Scholar 

  • Fuxe, K., Corrodi, H., Hökfelt, T., Lidbrink, P., Ungerstedt, U.: Ergocornine and 2-Br-α-ergocryptine. Evidence for prolonged dopamine receptor stimulation. Med. Biol. 52, 121–132 (1974)

    PubMed  CAS  Google Scholar 

  • Fuxe, K., Agnati, L., Everitt, B.: Effects of methergoline on central monoamine neurones. Evidence for a selective blockade of central 5-HT receptors. Neurosci. Lett. 1, 283–290 (1975a)

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., Agnati, L.F., Hökfelt, T., Jonsson, G., Lidbrink, P., Ljungdahl, A., Lofstrom, A., Ungerstedt, U.: The effect of dopamine receptor stimulating and blocking agents on the activity of supersensitive dopamine receptors and on the amine turnover in various dopamine nerve terminal systems in the rat brain. J. Pharmacol. (Paris) 6, 117–129 (1975b)

    CAS  Google Scholar 

  • Gaddum, J.H.: The action of adrenalin and ergotamine on the uterus of the rabbit. J. Physiol. (Lond.) 61, 141–150 (1926)

    CAS  Google Scholar 

  • Gaddum, J.H.: Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine. J. Physiol. (Lond.) 121, 15P (1953)

    CAS  Google Scholar 

  • Gaddum, J.H.: Drugs antagonistic to 5-hydroxytryptamine. In: Ciba Symposium on Hypertension. Wolstenholme, G.E.W., Cameron, M.P. (eds.), pp. 75–77. London: J. and A. Churchill 1954

    Google Scholar 

  • Gaddum, J.H.: Drugs which antagonize the actions of 5-hydroxytryptamine on peripheral tissues. In: 5-Hydroxytryptamine. Lewis, G.P. (ed.), pp. 195–205. New York: Pergamon Press 1957

    Google Scholar 

  • Gaddum, J.H., Hameed, K.A.: Drugs which antagonize 5-hydroxytryptamine. Brit. J. Pharmacol. 9, 240–248 (1954)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Paasonen, M.K.: The use of some molluscan hearts for the estimation of 5-hydroxytryptamine. Brit. J. Pharmacol. 10, 474–483 (1955)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Picarelli, Z.P.: Two kinds of tryptamine receptor. Brit. J. Pharmacol. 12, 323–328 (1957)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Szerb, J.C.: Assay of substance P on goldfish intestine in a microbath. Brit. J. Pharmacol. 17, 451–463 (1961)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Vogt, M.: Some central actions of 5-hydroxytryptamine and various antagonists. Brit. J. Pharmacol. 11, 175–179 (1956)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Hebb, C.O., Silver, A., Swan, A.A.B.: 5-Hydroxytryptamine. Pharmacological action and destruction in perfused lungs. Quart. J. exp. Physiol. 38, 255–262 (1953)

    PubMed  CAS  Google Scholar 

  • Gaddum, J.H., Hameed, K.A., Hathway, D.E., Stephens, F.F.: Quantitative studies of antagonists for 5-hydroxytryptamine. Quart. J. exp. Physiol. 40, 49–74 (1955)

    PubMed  CAS  Google Scholar 

  • Gagnon, D.J.: Contraction of the rat colon by sympathomimetic amines: effect of methysergide and 5-HT desensitization. Europ. J. Pharmacol. 17, 319–324 (1972)

    Article  CAS  Google Scholar 

  • Gallager, D.W., Aghajanian, G.K.: Chlorimipramine and LSD: differential effects on the in vivo release of 3H-5HT. Pharmacologist 16, 244 (1974)

    Google Scholar 

  • Gallager, D.W., Aghajanian, G.K.: Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3H-serotonin: correlations with serotonergic impulse flow. J. Pharmacol. exp. Ther. 193, 785–795 (1975)

    PubMed  CAS  Google Scholar 

  • Gallager, D.W., Aghajanian, G.K.: Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602. Neuropharmacology 15, 149–156 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Gant, D.W., Dyer, D.C.: D-Lysergic acid diethylamide (LSD-25): a constrictor of human umbilical vein. Life Sci. 10, 235–240 (1971)

    Article  CAS  Google Scholar 

  • Garrett, R.L., Brown, J.H.: Bradykinin-potentiated contractions induced by serotonin (5-HT), norepinephrine (NE) and potassium (K+) in rabbit aortic strips. Pharmacologist 12, 263 (1970)

    Google Scholar 

  • Garrett, R.L., Brown, J.H.: Bradykinin interaction with 5-hydroxytryptamine, norepinephrine and potassium chloride in rabbit aorta. Proc. Soc. exp. Biol. (N.Y.) 139, 1344–1348 (1972)

    CAS  Google Scholar 

  • Garrett, W.J.: The effects of adrenaline, noradrenaline and dihydroergotamine on excised human myometrium. Brit. J. Pharmacol. 10, 39–44 (1955)

    PubMed  CAS  Google Scholar 

  • Gautrelet, J., Scheiner, H.: Détermination du pouvoir anticholinesterasique de différentes substances par la méthode de la décontraction du muscle droit de l’abdomen de la grenouille contracté par l’acétylcholine. C.R. Soc. Biol. (Paris) 131, 738–740 (1939)

    CAS  Google Scholar 

  • Gelfand, M.D., West, G.B.: Experimental studies with the butanolamide and propanolamide of 1-methyl-lysergic acid. Int. Arch. Allergy 18, 286–291 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Gerschenfeld, H.M.: Serotonin: Two different inhibitory actions on snail neurons. Science 171, 1252–1254 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Gerschenfeld, H.M., Paupardin, D.: Actions of 5-hydroxytryptamine on mulluscan neuronal membranes. In: Drug Receptors. Rang, H.P. (ed.), pp. 45–61. London: Macmillan 1972

    Google Scholar 

  • Gerschenfeld, H.M., Paupardin-Tritsch, D.: Ionic mechanisms and receptor properties underlying the responses of molluscan neurones to 5-hydroxytryptamine. J. Physiol. (Lond.) 243, 427–456 (1974a)

    CAS  Google Scholar 

  • Gerschenfeld, H.M., Paupardin-Tritsch, D.: On the transmitter function of 5-hydroxytryptamine at excitatory and inhibitory monosynaptic junctions. J. Physiol. (Lond.) 243, 457–481 (1974b)

    CAS  Google Scholar 

  • Gerschenfeld, H.M., Paupardin-Tritsch, D.: Excitatory and inhibitory monosynaptic actions mediated by a serotonin ccntaining neuron in Aplysia californica. J. Physiol. (Lond.) 243, 28P–29P (1974c)

    Google Scholar 

  • Gerschenfeld, H.M., Stefani, E.: 5-Hydroxytryptamine receptors and synaptic transmission in molluscan neurones. Nature (Lond.) 205, 1216–1218 (1965)

    Article  Google Scholar 

  • Gerschenfeld, H.M., Stefani, E.: An electrophysiological study of 5-hydroxytryptamine receptors of neurones in the molluscan nervous system. J. Physiol. (Lond.) 185, 684–700 (1966)

    CAS  Google Scholar 

  • Gerschenfeld, H.M., Stefani, E.: Acetylcholine and 5-hydroxytryptamine receptors in neurones of the land-snail Cryptomphallus aspersa. J. Physiol. (Lond.) 191, 14P–15P (1967)

    CAS  Google Scholar 

  • Gerschenfeld, H.M., Stefani, E.: Evidence for an excitatory transmitter role of serotonin in molluscan central synapses. In: Advances in Pharmacology. Garattini, S., Shore, P.A. (eds.), pp. 369–392. New York-London: Academic Press 1968

    Google Scholar 

  • Gerschenfeld, H.M., Tauc, L.: Différents aspects de la pharmacologic des synapses dans le système nerveux central des mollusques. J. Physiol. (Paris) 56, 360–361 (1964)

    CAS  Google Scholar 

  • Gilbert, J.-C., Goldberg, L.I.: Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries. J. Pharmacol. exp. Ther. 193, 435–442 (1975)

    PubMed  CAS  Google Scholar 

  • Gillespie, J.S., Kirpekar, S.M.: Uptake and release of H3-noradrenaline by the splenic nerves. J. Physiol. (Lond.) 178, 44P–45P (1965a)

    CAS  Google Scholar 

  • Gillespie, J.S., Kirpekar, S.M.: The inactivation of infused noradrenaline by the cat spleen. J. Physiol. (Lond.) 176, 205–227 (1965b)

    CAS  Google Scholar 

  • Gillespie, J.S., McGrath, J.C.: The effect of lysergic acid diethylamide (LSD) on the vas deferens and anococcygeus muscle. Brit. J. Pharmacol. 52, 128P (1974)

    CAS  Google Scholar 

  • Gillespie, J.S., McGrath, J.C: The effects of lysergic acid diethylamide on the response to field stimulation of the rat vas deferens and the rat and cat anococcygeus muscles. Brit. J. Pharmacol. 54, 481–488 (1975)

    CAS  Google Scholar 

  • Gillespie, J.S., Muir, T.C.: A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat. Brit. J. Pharmacol. 30, 78–87 (1967)

    PubMed  CAS  Google Scholar 

  • Gillespie, J.S., Hamilton, D.N.H., Hosie, R.J.A.: The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation. J. Physiol. (Lond.) 206, 563–590 (1970)

    CAS  Google Scholar 

  • Ginzel, K.H.: The action of lysergic acid diethylamide (LSD 25), its 2-brom derivative (BOL 148) and of 5-hydroxytryptamine (5-HT) on the peristaltic reflex of the guinea-pig ileum. J. Physiol. (Lond.) 137, 62P–63P (1957)

    CAS  Google Scholar 

  • Ginzel, K.H., Kottegoda, S.R.: A study of the vascular actions of 5-hydroxytryptamine, tryptamine, adrenaline and nor-adrenaline. Quart. J. exp. Physiol. 38, 225–231 (1953)

    PubMed  CAS  Google Scholar 

  • Glegg, A.M., Turner, P.: Cholinergic interactions of methysergide and cinanserin on isolated human smooth muscle. Arch. int. Pharmacodyn. 191, 301–309 (1971)

    PubMed  CAS  Google Scholar 

  • Glover, W.E., Marshall, R.J., Whelan, R.F.: The antagonism of the vascular effects of 5-hydroxytryptamine by BOL 148 and sodium salicylate in the human subject. Brit. J. Pharmacol. 12, 498–503 (1957)

    PubMed  CAS  Google Scholar 

  • Glowinski, J., Hamon, M., Hery, F.: Regulation of 5-HT synthesis in central serotoninergic neurons. In: New Concepts in Neurotransmitter Regulation. Mandell, A.J. (ed.), pp. 239–257. New York: Plenum Press 1973

    Chapter  Google Scholar 

  • Görlitz, B.D., Frey, H.H.: Comparison of the blocking effects of antagonists of adrenaline and 5-hydroxytryptamine on their mutual receptors. J. Pharm. Pharmacol. 25, 651–653 (1973)

    Article  PubMed  Google Scholar 

  • Goetz, C.G., Klawans, H.L.: Myoclonus, methysergide, and serotonin. Lancet 1974/I, 1284–1285

    Article  Google Scholar 

  • Gogerty, J.H., Dille, J.M.: Pharmacology of D-lysergic acid morpholide (LSM). J. Pharmacol. exp. Ther. 120, 340–348 (1957)

    PubMed  CAS  Google Scholar 

  • Gokhale, S.D., Gulati, O.D., Kelkar, L.V., Kelkar, V.V.: Effect of some drugs on human umbilical artery in vitro. Brit. J. Pharmacol. 27, 332–346 (1966)

    PubMed  CAS  Google Scholar 

  • Goldberg, L.I.: Comparison of putative dopamine receptors in blood vessels and the central nervous system. Adv. Neurol. 9, 53–56 (1975)

    PubMed  CAS  Google Scholar 

  • Goldberg, L.I., Toda, N.: Dopamine induced relaxation of isolated canine renal, mesenteric and femoral arteries contracted with prostaglandin F. Circulat. Res. 36 (Suppl. I), 97–102 (1975)

    PubMed  CAS  Google Scholar 

  • Goldberg, L.I., Tjandramaga, T.B., Anton, A.H., Toda, N.: New investigations of the cardiovascular actions of dopamine. In: Frontiers in Catecholamine Research. Usdin, E., Snyder, S. (eds.), pp. 513–521. New York: Pergamon Press 1973

    Google Scholar 

  • Goldman, J.M., Hadley, M.E.: In vitro demonstration of adrenergic receptors controlling melanophore responses of the lizard, Anolis carolinensis. J. Pharmacol. exp. Ther. 166, 1–7 (1969)

    PubMed  CAS  Google Scholar 

  • Goldman, J.M., Hadley, M.E.: Direct agonistic and antagonistic effects of ergotamine on vertebrate melanophores. Arch. int. Pharmacodyn. 183, 239–246 (1970a)

    PubMed  CAS  Google Scholar 

  • Goldman, J.M., Hadley, M.E.: Cyclic AMP and adrenergic receptors in melanophore responses to methylxanthines. Europ. J. Pharmacol. 12, 365–370 (1970b)

    Article  CAS  Google Scholar 

  • Goldman, J.M., Hadley, M.E.: Sulfhydryl requirement for alpha adrenergic receptor activity and melanophore stimulating hormone (MSH) action on melanophores. J. Pharmacol. exp. Ther. 182, 93–100 (1972)

    PubMed  CAS  Google Scholar 

  • Gonzáles, R., Garcia, M., Rojas, R.: The mode of action of serotonin on the isolated atrium of hamsters. Sixth Internat. Congr. Pharmacol., Helsinki, 1975, Abstract 1433

    Google Scholar 

  • Gordon, J.L., Drummond, A.H.: Irreversible aggregation of pig platelets and release of intracellular constituents induced by 5-hydroxytryptamine. Biochem. Pharmacol. 24, 33–36 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Greeff, K., Holtz, P.: Über die Uteruswirkung des Adrenalins und Arterenols. Ein Beitrag zum Problem der Uterusinnervation Arch. int. Pharmacodyn. 88, 228–252 (1951)

    PubMed  CAS  Google Scholar 

  • Greeff, K., Benfey, B.G., Bokelmann, A.: Anaphylaktische Reaktionen am isolierten Herzvorhofpräparat des Meerschweinchens und ihre Beeinflussung durch Antihistaminica, BOL, Dihydroergotamin und Reserpin. Naunyn-Schmiedebergs Arch. Pharmacol. 236, 421–434 (1959)

    CAS  Google Scholar 

  • Greenberg, D.A., U’Prichard, D.C., Snyder, S.H.: Alpha-noradrenergic receptor binding in mammalian brain: differential labeling of agonist and antagonist states. Life Sci. 19, 69–76 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Greenberg, M.J.: The responses of the venus heart to catecholamines and high concentrations of 5-hydroxytryptamine. Brit. J. Pharmacol. 15, 365–374 (1960a)

    PubMed  CAS  Google Scholar 

  • Greenberg, M.J.: Structure-activity relationship of tryptamine analogues on the heart of Venus mercenaria. Brit. J. Pharmacol. 15, 375–388 (1960b)

    CAS  Google Scholar 

  • Grove, D.J., O’Neill, J.G., Spillett, P.B.: The action of 5-hydroxytryptamine on longitudinal gastric smooth muscle of the plaice, Pleuronectes platessa. Comp. gen. Pharmacol. 5, 229–238 (1974)

    Article  Google Scholar 

  • Guimarães, S.: Reversal by pronethalol of dibenamine blockade: A study on the seminal vesicle of the guinea-pig. Brit. J. Pharmacol. 36, 594–601 (1969a)

    Google Scholar 

  • Guimarães, S.: Alpha excitatory, alpha inhibitory and beta inhibitory adrenergic receptors in the guinea-pig stomach. Arch. int. Pharmacodyn. 179, 188–201 (1969b)

    PubMed  Google Scholar 

  • Guimarães, S., Osswald, W.: Adrenergic receptors in the veins of the dog. Europ. J. Pharmacol. 5, 133–140 (1969)

    Article  Google Scholar 

  • Gulati, O.D., Kelkar, V.V.: Effect of tyramine on human umbilical artery in vitro. Brit. J. Pharmacol. 42, 155–158 (1971)

    CAS  Google Scholar 

  • Guth, P.S., Spirtes, M.A.: Interaction in the central nervous system between serotonin and lysergic acid derivatives. In: Neuropsychopharmacology. Proc. 1st. Intern. Congr. Neuropharmacol., Rome, Bradley, P.B., Deniker, P., Radouco-Thomas, C. (eds.), pp. 319–323. London: Elsevier 1958

    Google Scholar 

  • Gyermek, L.: The action of 5-hydroxytryptamine on the urinary bladder of the dog. Pharmacologist 2, 89 (1960)

    Google Scholar 

  • Gyermek, L.: Action of 5-hydroxytryptamine on the urinary bladder of the dog. Arch. int. Pharmacodyn. 137, 137–144 (1962)

    PubMed  CAS  Google Scholar 

  • Gyermek, L.: Drugs which antagonize 5-hydroxytryptamine and related indolealkylamines. In: 5-Hydroxytryptamine and Related Indolealkylamines. Handbook of Experimental Pharmacology. Eichler, O., Farah, A. (eds.), Vol. XIX, pp. 471–528. Berlin-Heidelberg-New York: Springer 1966

    Google Scholar 

  • Gyermek, L., Bindler, E.: Blockade of the ganglionic stimulant action of 5-hydroxytryptamine. J. Pharmacol. exp. Ther. 135, 344–348 (1962)

    PubMed  CAS  Google Scholar 

  • Gyermek, L., Sumi, T.: Potentiating actions of indolealkylamines and lysergic acid diethylamide on reflexes elicited by 5-hydroxytryptamine. Proc. Soc. exp. Biol. (N.Y.) 114, 436–439 (1963)

    CAS  Google Scholar 

  • Gyires, K., Knoll, J.: Inflammation and writhing syndrome inducing effect of PGE1, PGE2 and the inhibition of these actions. Pol. J. Pharmacol. Pharm. 27, 257–264 (1975)

    PubMed  CAS  Google Scholar 

  • György, L., Borbely, L., Kelemen, B., Somkúti, T.: Über die adrenerg-erregenden Eigenschaften des Ergotoxins. Acta physiol. Acad. Sci. hung. 14, 391–398 (1958a)

    Google Scholar 

  • György, L., Somkuti, T., Kelemen, B., Borbély, L.: The problem of ergotoxin-adrenaline synergism and antagonism: the effect of general anaesthesia. Acta physiol. Acad. Sci. hung. 14, 287–300 (1958b)

    Google Scholar 

  • Haefely, W.: Effects of serotonin (5-HT) and some related indole compounds in a mammalian sympathetic ganglion. Experientia (Basel) 27, 1112 (1971)

    Google Scholar 

  • Haefely, W.: The effects of 5-hydroxytryptamine and some related compounds on the cat superior cervical ganglion in situ. Naunyn-Schmiedebergs Arch. Pharmacol. 281, 145–165 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Haefely, W., Ruch-Monachon, M.A., Jalfre, M.: Interaction of psychotropic agents with central neurotransmitters as revealed by their effects on PGO waves in the cat. Arzneimittel-Forsch. 26, 1036–1039 (1976)

    CAS  Google Scholar 

  • Haeusler, G., Finch, L.: Vascular reactivity to 5-hydroxytryptamine and hypertension in the rat. Naunyn-Schmiedebergs Arch. Pharmacol. 272, 101–116 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Haigler, H.J., Aghajanian, G.K.: Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain. Europ. J. Pharmacol. 21, 53–60 (1973a)

    Article  CAS  Google Scholar 

  • Haigler, H.J., Aghajanian, G.K.: A comparison of effects of D-lysergic acid diethylamide (LSD) and serotonin on pre-and postsynaptic cells in the serotonin system. Fed. Proc. 32, 303 (1973b)

    Google Scholar 

  • Haigler, H.J., Aghajanian, G.K.: Peripheral serotonin antagonists: failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. J. Neural Transm. 35, 257–273 (1974a)

    Article  CAS  Google Scholar 

  • Haigler, H.J., Aghajanian, G.K.: Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving serotonergic input. J. Pharmacol. exp. Ther. 188, 688–699 (1974b)

    PubMed  CAS  Google Scholar 

  • Halaris, A.E., Lovell, R.A.: On the nature of the serotonin binding after LSD. Fed. Proc. 32, 694 (1973)

    Google Scholar 

  • Halaris, A.E., Freedman, D.X., Fang, V.S.: Plasma corticoids and brain tryptophan after acute and tolerance dosage of LSD. Life Sci. 17, 1467–1472 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Hall, W.J., O’Connor, P.C.: The action of vasoactive drugs on longitudinal and circular muscle of dog mesenteric vein. J. Pharm. Pharmacol. 25, 109–118 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Halmagyi, D.F.J., Colebatch, H.J.H.: Serotonin-like cardiorespiratory effects of a serotonin antagonist. J. Pharmacol. exp. Ther. 134, 47–52 (1961)

    PubMed  CAS  Google Scholar 

  • Hamon, M., Glowinski, J.: Regulation of serotonin synthesis. Life Sci. 15, 1533–1548 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hamon, M., Bourgoin, S., Jagger, J., Glowinski, J.: Effects of LSD on synthesis and release of 5-HT in rat brain slices. Brain Res. 69, 265–280 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hamon, M., Bourgoin, S., Enjalbert, A., Bockaert, J., Hery, F., Ternaux, J.P., Glowinski, J.: The effect of quipazine on 5-HT metabolism in the rat brain. Naunyn-Schmiedebergs Arch. Pharmacol. 294, 99–108 (1976a)

    Article  PubMed  CAS  Google Scholar 

  • Hamon, M., Bourgoin, S., Hery, F., Ternaux, J.P.: In vivo and in vitro activation of soluble tryptophan hydroxylase from rat brainstem. Nature (Lond.) 260, 61–63 (1976b)

    Article  CAS  Google Scholar 

  • Handforth, A., Sourkes, T.L.: Inhibition by dopamine agonists of dopamine accumulation following γ-hydroxybutyrate treatment. Europ. J. Pharmacol. 34, 311–319 (1975)

    Article  CAS  Google Scholar 

  • Handschumacher, R.E., Vane, J.R.: Studies relating constrictions to entrance of 5-hydroxytryptamine (5-HT) and tryptamine (T) in smooth muscle. Fed. Proc. 22, 167 (1963)

    Google Scholar 

  • Handschumacher, R.E., Vane, J.R.: The relationship between the penetration of tryptamine and 5-hydroxytryptamine into smooth muscle and the associated contractions. Brit. J. Pharmacol. 29, 105–118 (1967)

    PubMed  CAS  Google Scholar 

  • Hardebo, J.E., Edvinsson, L.: Mechanical actions of serotonin and the effect of related inhibitors in intracranial and extracranial vessels. “Headache ‘76”, Joint Meeting of the Italian Headache and the Scandinavian Migraine Societies, Florence, 1976, Abstract, pp. 11–13

    Google Scholar 

  • Hariri, M.: Uptake of 5-hydroxytryptamine by Mesocestoides corti (Cestoda). J. Parasit. 61, 440–448 (1975)

    Article  CAS  Google Scholar 

  • Harper, M.J.K., Skarnes, R.C.: Inhibition of abortion and fetal death produced by endotoxin or prostaglandin F. Prostaglandins 2, 295–309 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Hauge, A., Lunde, P.K.M., Waaler, B.A.: The effect of bradykinin, kallidin and eledoisin upon the pulmonary vascular bed of an isolated blood-perfused rabbit lung preparation. Acta physiol. scand. 66, 269–277 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Hayashi, A.: Receptors for phenylephrine and 5-hydroxytryptamine in the rat jejunum. Fukushima J. med. Sci. 21, 59–68 (1975)

    PubMed  CAS  Google Scholar 

  • Hedqvist, P.: Modulating effect of prostaglandin E2 on noradrenaline release from the isolated cat spleen. Acta physiol. scand. 75, 511–512 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P.: Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. Acta physiol. scand. (Suppl.) 345, 1–40 (1970a)

    CAS  Google Scholar 

  • Hedqvist, P.: Control by prostaglandin E2 of sympathetic neurotransmission in the spleen. Life Sci. 9, 269–278 (1970b)

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P.: Dissociation of prostaglandin and a-receptor mediated control of adrenergic transmitter release. Acta physiol. scand. 87, 42A–43A (1973)

    Google Scholar 

  • Hedqvist, P.: Role of the a-receptor in the control of noradrenaline release from sympathetic nerves. Acta physiol. scand. 90, 158–165 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P., Brundin, J.: Inhibition by prostaglandin Ex of noradrenaline release and of effector response to nerve stimulation in the cat spleen. Life Sci. 8, 389–395 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P., von Euler, U.S.: Prostaglandin-induced neurotransmission failure in the fieldstimulated, isolated vas deferens. Neuropharmacology 11, 177–187 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P., Stjärne, L., Wennmalm, Å.: Inhibition by prostaglandin E2 of sympathetic neurotransmission in the rabbit heart. Acta physiol. scand. 79, 139–141 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Henderson, G., North, R.A.: Presynaptic action of 5-hydroxytryptamine in the myenteric plexus of the guinea-pig ileum. Brit. J. Pharmacol. 54, 265 (1975)

    Google Scholar 

  • Hertzler, E.C.: 5-Hydroxytryptamine and transmission in sympathetic ganglia. Brit. J. Pharmacol. 17, 406–413 (1961)

    PubMed  CAS  Google Scholar 

  • Herxheimer, H.: Further observations on the influence of 5-hydroxytryptamine on bronchial function. J. Physiol. (Lond.) 122, 49P–50P (1953)

    Google Scholar 

  • Herxheimer, H.: The 5-hydroxytryptamine shock in the guinea-pig. J. Physiol. (Lond.) 128, 435–445 (1955)

    CAS  Google Scholar 

  • Herxheimer, H.: Bronchoconstrictor agents and their antagonists in the intact guinea-pig. Arch. int. Pharmacodyn. 106, 371–380 (1956)

    PubMed  CAS  Google Scholar 

  • Higgins, W.J.: Intracellular actions of 5-hydroxytryptamine on the bivalve myocardium. J. exp. Zool. 190, 99–109 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hillman, G.R., Olsen, N.J., Senft, A.W.: Effect of methysergide and dihydroergotamine on Schistosoma mansoni. J. Pharmacol. exp. Ther. 188, 529–535 (1974)

    PubMed  CAS  Google Scholar 

  • Hill-Samli, M., MacLeod, R.M.: Thyrotropin-releasing hormone blockade of the ergocryptine and apomorphine inhibition of prolactin release in vitro. Proc. Soc. exp. Biol. (N.Y.) 149, 511–514 (1975)

    CAS  Google Scholar 

  • Hilton, B.P., Cumings, J.N.: An assessment of platelet aggregation induced by 5-hydroxytryptamine. J. clin. Path. 24, 250–258 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Hirst, G.D.S., McKirdy, H.C.: Synaptic potentials recorded from neurones of the submucous plexus of guinea-pig intestine. J. Physiol. (Lond.) 249, 369–385 (1975)

    CAS  Google Scholar 

  • Hirst, G.D.S., Silinsky, E.M.: Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine. J. Physiol. (Lond.) 251, 817–832 (1975)

    CAS  Google Scholar 

  • Hitner, H., Di Gregorio, G.J.: Preliminary investigation of the peripheral sympathomimetic effects of phencyclidine. Arch. int. Pharmacodyn. 212, 36–42 (1974)

    PubMed  CAS  Google Scholar 

  • Hökfelt, T., Fuxe, K.: On the morphology and the neuroendocrine role of the hypothalamic catecholamine neurons. In: Brain-Endocrine Interaction. Median Eminence: Structure and Function, Knigge, K.M., Scott, D.F., Weindt, A. (eds.), pp. 181–223. Basle: Karger 1972

    Google Scholar 

  • Holgate, J.A., Warner, B.T.: Evaluation of antagonists of histamine, 5-hydroxytryptamine and acetylcholine in the guinea-pig. Brit. J. Pharmacol. 15, 561–566 (1960)

    PubMed  CAS  Google Scholar 

  • Hollenberg, M.D., Cuatrecasas, P.: Studies on the interaction of hormones with plasma membrane receptors. Biochem. Actions Horm. 3, 41–85 (1975)

    CAS  Google Scholar 

  • Holroyde, M.C., Eyre, P.: Reactivity of isolated bovine mesenteric and hepatic veins to vasoactive agents and specific antigen. Europ. J. Pharmacol. 30, 36–42 (1975)

    Article  CAS  Google Scholar 

  • Holzbauer, M., Vogt, M.: Modification by drugs of the response of the rat’s uterus to adrenaline. Brit. J. Pharmacol. 10, 186–190 (1955)

    PubMed  CAS  Google Scholar 

  • Hughes, J.: Inhibition of noradrenaline release by lysergic acid diethylamide. Brit. J. Pharmacol. 49, 706–708 (1973)

    CAS  Google Scholar 

  • Hughes, J., Vane, J.R.: An analysis of the responses of the isolated portal vein of the rabbit to electrical stimulation and to drugs. Brit. J. Pharmacol. 30, 46–66 (1967)

    PubMed  CAS  Google Scholar 

  • Hughes, J., Vane, J.R.: Relaxations of the isolated portal vein of the rabbit induced by nicotine and electrical stimulation. Brit. J. Pharmacol. 39, 476–489 (1970)

    CAS  Google Scholar 

  • Hughes, J., Kosterlitz, H.W., Leslie, F.M.: Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antagonist potencies of narcotic analgesics. Brit. J. Pharmacol. 53, 371–381 (1975)

    CAS  Google Scholar 

  • Ichimasa, S., Kushiku, K., Furukawa, T.: Pharmacological studies on ganglionic transmission: Influence of antagonists on the catecholamine-induced ganglionic inhibition in the cardiac sympathetic ganglia. Jap. J. Pharmacol. 25 (Suppl.), 20 (1975)

    Google Scholar 

  • Innes, I.R.: Identification of the smooth muscle excitatory receptors for ergot alkaloids. Brit. J. Pharmacol. 19, 120–128 (1962a)

    PubMed  CAS  Google Scholar 

  • Innes, I.R.: An action of 5-hydroxytryptamine on adrenaline receptors. Brit. J. Pharmacol. 19, 427–441 (1962b)

    PubMed  CAS  Google Scholar 

  • Innes, I.R., Kohli, J.D.: Excitatory action of sympathomimetic amines on 5-hydroxytryptamine receptors of gut. Brit. J. Pharmacol. 35, 383–393 (1969)

    CAS  Google Scholar 

  • Iturriza, F.C.: The effect of D-lysergic acid diethylamide on the melanophores of the toad Bufo arenarum under different experimental conditions. Acta endocr. (Kbh.) 48, 322–328 (1965)

    CAS  Google Scholar 

  • Iturriza, F.C., Koch, O.R.: Effect of administration of lysergic acid diethylamide (LSD) on the colloid vesicles of the pars intermedia of the toad pituitary. Endocrinology 75, 615–616 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Iversen, L.L.: The inhibition of noradrenaline uptake by drugs. In: Advances in Drug Research. Harper, N.J., Simmonds, A.B. (eds.), pp. 1–46. London-New York: Academic Press 1965

    Google Scholar 

  • Iversen, L.L.: The uptake and storage of noradrenaline in sympathetic nerves. Cambridge: University Press 1967

    Google Scholar 

  • Iversen, L.L.: Catecholamine uptake processes. Brit. med. Bull. 29, 130–135 (1973)

    PubMed  CAS  Google Scholar 

  • Jacoby, J.H., Shabshelowitz, H., Fernstrom, J.D., Wurtman, R.J.: The mechanism by which methiothepin, a putative serotonin receptor antagonist, increases brain 5-hydroxyindole levels. J. Pharmacol. exp. Ther. 195, 257–264 (1975)

    PubMed  CAS  Google Scholar 

  • Jafferji, S.S., Michell, R.H.: Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea-pig ileum. Biochem. Pharmacol. 25, 1429–1430 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Jalfre, M., Monachon, M.-A., Haefely, W.: Pharmacological modifications of benzoquinolizine-induced geniculate spikes. Experientia (Basel) 26, 691 (1970)

    Google Scholar 

  • Jalfre, M., Monachon, M.A., Haefely, W.: Drugs and PGO waves in the cat. In: First Can. Int. Symposium of Sleep. McClure, D.J. (ed.), pp. 155–185. Montreal: Roche Scientific Service 1972

    Google Scholar 

  • Jalfre, M., Ruch-Monachon, M.-A., Haefely, W.: Methods for assessing the interaction of agents with 5-hydroxytryptamine neurons and receptors in the brain. Adv. Biochem. Psychopharmacol. 10, 121–134 (1974)

    PubMed  CAS  Google Scholar 

  • Jang, C.S.: The potentiation and paralysis of adrenergic effects by ergotoxine and other substances. J. Pharmacol. exp. Ther. 71, 87–94 (1941)

    CAS  Google Scholar 

  • Jaques, R., Bein, H.J., Meier, R.: 5-Hydroxytryptamine antagonists, with special reference to the importance of sympathomimetic amines and isopropyl-noradrenaline. Helv. physiol. Pharmacol. Acta 14, 269–278 (1956)

    PubMed  CAS  Google Scholar 

  • Jasmin, G., Bois, P.: Effect of various agents on the development of kidney infarcts in rats treated with serotonin. Lab. Invest. 9, 503–513 (1960)

    PubMed  CAS  Google Scholar 

  • Jenkinson, D.H., Morton, I.K.M.: Adrenergic blocking drugs as tools in the study of the actions of catecholamines on the smooth muscle membrane. Ann. N.Y. Acad. Sci. 139, 762–771 (1967a)

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson, D.H., Morton, I.K.M.: The effect of noradrenaline on the permeability of depolarized intestinal smooth muscle to inorganic ions. J. Physiol. (Lond.) 188, 373–386 (1967b)

    CAS  Google Scholar 

  • Jenkinson, D.H., Morton, I.K.M.: The role of α-and β-adrenergic receptors in some actions of catecholamines on intestinal smooth muscle. J. Physiol. (Lond.) 188, 387–402 (1967c)

    CAS  Google Scholar 

  • Joiner, P.D., Kadowitz, P.J., Davis, L.B., Hyman, A.L.: Contractile responses of canine isolated intrapulmonary arteries (IPA) and veins (IPV) to norepinephrine (NE), serotonin (5-HT) and tyramine (TYR). Pharmacologist 16, 299 (1974)

    Google Scholar 

  • Joiner, P.D., Kadowitz, P.J., Davis, L.B., Hyman, A.L.: Contractile responses of canine isolated pulmonary lobar arteries and veins to norepinephrine, serotonin and tyramine. Canad. J. Physiol. Pharmacol. 53, 830–838 (1975)

    Article  CAS  Google Scholar 

  • Kahn, C.R.: Membrane receptors for hormones and neurotransmitters. J. Cell Biol. 70, 261–286 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Kahr, H., Fischer, W.: Die Wirkung des 5-Oxtryptamins auf das Pigmentsystem der Haut. Klin. Wschr. 35, 41–44 (1957)

    Article  PubMed  CAS  Google Scholar 

  • Kalbermatten, J.P. de: Effet de la sérotonine sur l’hypersensibilité de dénervation du ganglion sympathique cervical isolé du rat. Helv. physiol. pharmacol. Acta 20, 294–315 (1962)

    CAS  Google Scholar 

  • Karlsberg, P., Adams, J.E., Elliott, H.W.: Inhibition and reversal of serotonin-induced cerebral vasospasm. Surg. Forum 13, 425–427 (1962)

    Google Scholar 

  • Karlsberg, P., Elliott, H.W., Adams, J.E.: Effects of various pharmacologic agents on cerebral arteries. Neurology (Minneap.) 13, 772–778 (1963)

    CAS  Google Scholar 

  • Katsuragi, T., Suzuki, T.: Methysergide-induced potentiation of the cholinergic response of the guinea-pig vas deferens. Jap. J. Pharmacol. 24 (Suppl.), 145 (1974)

    PubMed  Google Scholar 

  • Katz, R.I., Kopin, I.J.: Effect of D-LSD and related compounds on release of norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation. Pharmacol. Res. Commun. 1, 54–62 (1969)

    Article  CAS  Google Scholar 

  • Kawai, N.: Release of 5-hydroxytryptamine from slices of superior colliculus by optic tract stimulation. Neuropharmacology 9, 395–397 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Kawai, N., Yamamoto, C.: Antagonism between serotonin and LSD studied in vitro in thin sections from the superior colliculus of guinea-pig. Brain Res. 7, 325–328 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Kawai, N., Yamamoto, C.: Effects of 5-hydroxytryptamine, LSD and related compounds on electrical activities evoked in vitro in thin sections from the superior colliculus. Int. J. Neuropharmacol. 8, 437–449 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Kelly, M.J.: Receptors for dopamine in some isolated vascular tissues of the dog. Brit. J. Pharmacol. 46, 575P–577P (1972)

    CAS  Google Scholar 

  • Kerkut, G.A., Laverack, M.S.: A cardio-accelerator present in tissue extracts of the snail Helix aspersa. Comp. Biochem. Physiol. 1, 62–71 (1960)

    Article  CAS  Google Scholar 

  • Khairallah, P.A., Page, I.H., Türker, R.K.: Some properties of prostaglandin E1 action on muscle. Arch. int. Pharmacodyn. 169, 328–341 (1967)

    PubMed  CAS  Google Scholar 

  • Kimura, M., Waki, I., Tamura, H.: Actions of dibenamine on adrenergic β-receptors in cat’s papillary muscle (Molecular pharmacological studies on drug-receptor interaction systems in drug action IX). Jap. J. Pharmacol. 20, 16–22 (1970)

    Article  PubMed  CAS  Google Scholar 

  • King, T.O.: Hydroxytryptamine. The antagonism of its broncho-constrictor action. Int. Physiologenkongress, Brüssel, August 1956, p. 499

    Google Scholar 

  • King, T.O.: The antagonism of 5-hydroxytryptamine pneumoconstriction. Arch. int. Pharmacodyn. 110, 71–76 (1957)

    PubMed  CAS  Google Scholar 

  • King, A.R., Martin, I.L., Melville, K.A.: Reversal learning enhanced by lysergic acid diethylamide (LSD): concomitant rise in brain 5-hydroxytryptamine levels. Brit. J. Pharmacol. 52, 419–425 (1974)

    CAS  Google Scholar 

  • Kirpekar, S.M., Cervoni, P.: Effect of cocaine, phenoxybenzamine and phentolamine on the catecholamine output from spleen and adrenal medulla. J. Pharmacol. exp. Ther. 142, 59–70 (1963)

    PubMed  CAS  Google Scholar 

  • Kirpekar, S.M., Puig, M.: Effect of flow-stop on noradrenaline release from normal spleens and spleens treated with cocain, phentolamine or phenoxybenzamine. Brit. J. Pharmacol. 43, 359–369 (1971)

    CAS  Google Scholar 

  • Klawans, Jr., H.L., Goetz, C., Weiner, W.J.: 5-Hydroxytryptophan-induced myoclonus in guinea-pigs and the possible role of serotonin in infantile myoclonus. Neurology (Minneap.) 23, 1234–1240 (1973)

    CAS  Google Scholar 

  • Klawans, H.L., D’Amico, D.J., Patel, B.C.: Behavioral supersensitivity to 5-hydroxytryptophan induced by chronic methysergide pretreatment. Psychopharmacologia 44, 297–300 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Klinge, E., Sjöstrand, N.O.: Contraction and relaxation of the retractor penis muscle and the penile artery of the bull. Acta physiol. scand. (Suppl.) 420, 1–88 (1974)

    CAS  Google Scholar 

  • Kohli, J.D.: Receptors for sympathomimetic amines in the rabbit aorta: Differentiation by specific antagonists. Brit. J. Pharmacol. 32, 273–279 (1968)

    PubMed  CAS  Google Scholar 

  • Kohli, J.D.: A comparative study of dopamine and noradrenaline on the rabbit aorta. Canad. J. Physiol. Pharmacol. 47, 171–174 (1969)

    Article  CAS  Google Scholar 

  • Kohli, J.D., Innes, I.R.: Differentiation between norepinephrine (NE) and 5-hydroxytryptamine (5-HT) receptors in vascular smooth muscle with 2-bromo-lysergic acid diethylamide (BOL). Pharmacologist 6, 207 (1964)

    Google Scholar 

  • Komiskey, H.L., Rudy, T.A.: The involvement of methysergide-sensitive receptors and prostaglandins in the hyperthermia evoked by 5-HT in the cat. Res. Commun. Chem. Path. Pharmacol. 11, 195–208 (1975)

    CAS  Google Scholar 

  • Konzett, H.: The effects of 5-hydroxytryptamine and its antagonists on tidal air. Brit. J. Pharmacol. 11, 289–294 (1956)

    PubMed  CAS  Google Scholar 

  • Konzett, H.: Specific antagonism of dibenamine to ergometrine. In: Ciba Foundation Symposium on Adrenergic Mechanisms. Wolstenholme, G.E.W., O’Connor, M. (eds.), pp. 463–465. London: J. and A. Churchill 1960

    Google Scholar 

  • Kopin, I.J.: V. Interaction between the drugs and brain amines. Neurosci. Res. Prog. Bull. 8, 27–32 (1970)

    Google Scholar 

  • Kostowski, W., Giacalone, E.: Effect of psychotropic drugs on the release of serotonin induced by electrical stimulation of midbrain raphe in rats. In: The Present Status of Psychotropic Drugs. Cerletti, A., Bove, F.J. (eds.), pp. 289–291. Amsterdam: Excerpta Medica Foundation 1969

    Google Scholar 

  • Kostowski, W., Gumulka, W., Jerlicz, M.: The effects of serotonin injections into the locus coeruleus on ponto geniculo occipital (PGO) waves and cortical EEG pattern in cats. Pol. J. Pharmacol. Pharm. 27, 127–137 (1975)

    PubMed  CAS  Google Scholar 

  • Krishnamurty, V.S.R.: Receptors for sympathomimetic amines and 5-hydroxytryptamine in the rat aorta. Arch. int. Pharmacodyn. 189, 90–99 (1971)

    PubMed  CAS  Google Scholar 

  • Krivoy, W. A.: The preservation of substance P by lysergic acid diethylamide. Brit. J. Pharmacol. 12, 361–364 (1957)

    PubMed  CAS  Google Scholar 

  • Krnjević, K., Phillis, J.W.: Actions of certain amines on cerebral cortical neurones. Brit. J. Pharmacol. 20, 471–490 (1963a)

    PubMed  Google Scholar 

  • Krnjević, K., Phillis, J.W.: Iontophoretic studies of neurones in the mammalian cerebral cortex. J. Physiol. (Lond.) 165, 274–304 (1963b)

    Google Scholar 

  • Kuhar, M.J., Roth, R.H., Aghajanian, G.K.: Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Res. 35, 167–176 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Kuhar, M.J., Aghajanian, G.K., Roth, R.H.: Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain lesions: correlations with serotonin levels and histochemical fluorescence. Brain Res. 44, 165–176 (1972a)

    Article  PubMed  CAS  Google Scholar 

  • Kuhar, M.J., Roth, R.H., Aghajanian, G.K.: Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reductions of serotonin uptake. J. Pharmacol. exp. Ther. 181, 36–45 (1972b)

    PubMed  CAS  Google Scholar 

  • Langer, S.Z., Enero, M.A., Adler-Graschinsky, E., Dubocovich, M.L., Celuchi, S.M.: Presynaptic regulatory mechanisms for noradrenaline release by nerve stimulation. In: Central Action of Drugs in Blood Pressure Regulation. Davies, D.S., Reid, J.L. (eds.), pp. 133–150. Kent: Pitman Medical Publishing 1975

    Google Scholar 

  • Lecomte, J.: Sensibilisation à l’adrénaline par la 5-hydroxytryptamine. Arch. int. Physiol. Biochim. 61, 84–85 (1953)

    Article  CAS  Google Scholar 

  • Legge, K.F., Randic, M., Straughan, D.W.: The pharmacology of neurones in the pyriform cortex. Brit. J. Pharmacol. 26, 87–107 (1966)

    PubMed  CAS  Google Scholar 

  • Leitch, J.L., Liebig, C.S., Haley, T.J.: The use of the rat’s isolated seminal vesicle for the assay of sympatholytic drugs. Brit. J. Pharmacol. 9, 236–239 (1954)

    PubMed  CAS  Google Scholar 

  • Leonard, B.E., Liska, K.J.: Effects of morpholino-, pyrrolidino-, piperizino-, and cyclooctylderivatives of beta-alanine on brain amines and amino acids. Life Sci. 10, 93–104 (1971)

    Article  CAS  Google Scholar 

  • Levy, B., Ahlquist, R.P.: An analysis of adrenergic blocking activity. J. Pharmacol. exp. Ther. 133, 202–210 (1961)

    PubMed  CAS  Google Scholar 

  • Levy, B., Tozzi, S.: The adrenergic receptive mechanism of the rat uterus. J. Pharmacol. exp. Ther. 142, 178–184 (1963)

    PubMed  CAS  Google Scholar 

  • Levy, B., Wilkenfeld, E.: The actions of selective β-receptor antagonists on the guinea-pig trachea. Europ. J. Pharmacol. 11, 67–74 (1970)

    Article  CAS  Google Scholar 

  • Levy, J., Michel-Ber, E.: Contribution à l’action pharmacologique exercée par la sérotonine sur quelques organes isolés (intestine et oreillette). J. Physiol. (Paris) 48, 1051–1084 (1956)

    CAS  Google Scholar 

  • Liao, S.: Cellular receptors and mechanisms of action of steroid hormones. Int. Rev. Cytol. 41, 87–172 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Liebeswar, G., Goldman, J.E., Koester, J., Mayeri, E.: Neural control of circulation in Aplysia. III. Neurotransmitters. J. Neurophysiol. 38, 767–779 (1975)

    PubMed  CAS  Google Scholar 

  • Lin, R.C., Ngai, S.H., Costa, E.: Lysergic acid diethylamide: role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine). Science 166, 237–239 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Lingjaerde, O. Jr.: Effects of ergotamine and dihydroergotamine on uptake of 5-hydroxytryptamine in blood platelets. Europ. J. Pharmacol. 13, 76–82 (1970)

    Article  CAS  Google Scholar 

  • Little, K.D., DiStefano, V., Leary, D.E.: LSD and serotonin effects on spinal reflexes in the cat. J. Pharm. exp. Ther. 119, 161 (1957)

    Google Scholar 

  • Loew, D.M., Depoortere, H., Buerki, H.R.: Effects of dihydrogenated ergot alkaloids on the sleep-wakefulness cycle and on brain biogenic amines in the rat. Arzneimittel-Forsch. 26, 1080–1083 (1976)

    CAS  Google Scholar 

  • Loew, E.R., Kaiser, M.E., Moore, V.: Effect of various drugs on experimental asthma produced in guinea-pig by exposure to atomized histamine. J. Pharm. exp. Ther. 86, 1–6 (1946)

    CAS  Google Scholar 

  • Loewi, O., Navratil, E.: Über humorale Übertragbarkeit der Herznervenwirkung. XI. Über den Mechanismus der Vaguswirkung von Physostigmin und Ergotamin. Pflügers Arch. 214, 689–696 (1926)

    Article  CAS  Google Scholar 

  • Lovell, R.A., Freedman, D.X.: Stereospecific receptor sites for D-lysergic acid diethylamide in rat brain: Effects of neurotransmitters, amine antagonists, and other psychotropic drugs. Molec. Pharmacol. 12, 620–630 (1976)

    CAS  Google Scholar 

  • Lovell, R.A., Rosecrans, J.A., Freedman, D.X.: Effects of LSD on rat brain serotonin metabolism. Fed. Proc. 26, 708 (1967)

    Google Scholar 

  • Ludány, G., Gáti, T., Szabó, St., Hideg, J.: 5-Hydroxytryptamin (Enteramin, Serotonin) und die Darmzottenbewegung. Arch. int. Pharmacodyn. 118, 62–69 (1959)

    PubMed  Google Scholar 

  • Lum, B.K.B., Kermani, M.H., Heilman, R.D.: Intestinal relaxation produced by sympathomimetic amines in the isolated rabbit jejunum: selective inhibition by adrenergic blocking agents and by cold storage. J. Pharmacol. exp. Ther. 154, 463–471 (1966)

    PubMed  CAS  Google Scholar 

  • McCulloch, M.W., Rand, M.J., Story, D.F.: Inhibition of 3H-noradrenaline release from sympathetic nerves of guinea-pig atria by a presynaptic α-adrenoceptor mechanism. Brit. J. Pharmacol. 46, 523P–524P (1972)

    CAS  Google Scholar 

  • MacLeod, R.M., Lehmeyer, J.E.: Regulation of the synthesis and release of prolactin. In: Lactogenic Hormones. Wolstenholme, G.E.W., Knight, J. (eds.). A Ciba Foundation Symposium, pp. 53–76. Edinburgh-London: Churchill Livingstone 1972

    Google Scholar 

  • MacLeod, R.M., Lehmeyer, J.E.: Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion. Endocrinology 94, 1077–1085 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Magistretti, M., Valzelli, L.: Ricerche sulla attività inotropa della serotonina sull’orecchietta e sul cuore isolati. Boll. Soc. ital. Biol. sper. 31, 1035–1037 (1955)

    PubMed  CAS  Google Scholar 

  • Malanga, C.J.: Dopaminergic responses by gill cilia of bivalve molluscs. Fed. Proc. 32, 691 (1973)

    Google Scholar 

  • Malanga, C.J.: Dopaminergic stimulation of ciliary activity in the gill of the bivalve mollusc, Mytilus edulis. Fed. Proc. 33, 551 (1974)

    Google Scholar 

  • Maling, H.M., Webster, M.E., Williams, M.A., Saul, W., Anderson, W., Jr.: Inflammation induced by histamine, serotonin, bradykinin and compound 48/80 in the rat: antagonists and mechanisms of action. J. Pharmacol. exp. Ther. 191, 300–310 (1974)

    PubMed  CAS  Google Scholar 

  • Malorny, G., Orzechowski, G.: Untersuchungen liber die Wirkungsweise der Sympathicomimetica. III. Über die ephedrinahnliche Wirkung der Secalealkaloide Ergotamin und Ergometrin. Naunyn-Schmiedebergs Arch. Pharmacol. 196, 253–259 (1940)

    Article  CAS  Google Scholar 

  • Mansour, T.E.: Effect of lysergic acid diethylamide, serotonin and related compounds on a parasitic trematode, Fasciola hepatica. Fed. Proc. 15, 454–455 (1956)

    Google Scholar 

  • Mansour, T.E.: The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica. Brit. J. Pharmacol. 12, 406–409 (1957)

    PubMed  CAS  Google Scholar 

  • Mansour, T.E., Lago, A.D., Hawkins, J.L.: Occurrence and possible role of serotonin in Fasciola hepatica. Fed. Proc. 16, 319 (1957)

    Google Scholar 

  • Mansour, T.E., Sutherland, E.W., Rail, T.W., Bueding, E.: The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3′,5′-phosphate by tissue particles from the liver fluke, Fasciola hepatica. J. biol. Chem. 235, 466–470 (1960)

    PubMed  CAS  Google Scholar 

  • Marchbanks, R.M.: Serotonin binding to nerve ending particles and other preparations from rat brain. J. Neurochem. 13, 1481–1493 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Marchbanks, R.M.: Inhibitory effects of lysergic acid derivatives and reserpine on 5-HT binding to nerve ending particles. Biochem. Pharmacol. 16, 1971–1979 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Marchbanks, R.M., Rosenblatt, F., O’Brien, R.D.: Serotonin binding to nerve-ending particles of the rat brain and its inhibition by lysergic acid diethylamide. Science 144, 1135–1137 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Markstein, R., Wagner, H.: The effect of dihydroergotoxin, phentolamine and pindolol on catecholamine-stimulated adenylcyclase in rat cerebral cortex. F.E.B.S. Lett. 55, 275–277 (1975)

    Article  CAS  Google Scholar 

  • Markstein, R., Wagner, H.: Effect of dihydroergotoxine on cyclic AMP generating systems in rat cerebral cortex slices. Gerontology 24 (Suppl. I), 94–105 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Markstein, R. et al.: unpublished results 1976

    Google Scholar 

  • Marley, E., Vane, J.R.: Tryptamines and spinal cord reflexes in cats. Brit. J. Pharmacol. 31, 447–465 (1967)

    PubMed  CAS  Google Scholar 

  • Marley, E., Whelan, J.E.: Some unexpected pharmacological effects of p-chlorophenylalanine methyl ester (PCPA methyl ester). Brit. J. Pharmacol. 52, 133P–134P (1974)

    CAS  Google Scholar 

  • Marley, E., Whelan, J.E.: Some pharmacological effects of p-chlorphenylalanine unrelated to tryptophan hydroxylase inhibition. Brit. J. Pharmacol. 56, 133–144 (1976)

    CAS  Google Scholar 

  • Marrazzi, A.S.: The effects of certain drugs on cerebral synapses. Ann. N.Y. Acad. Sci. 66, 496–507 (1957)

    Article  PubMed  CAS  Google Scholar 

  • Marrazzi, A.S., Hart, E.R.: Evoked cortical responses under the influence of hallucinogens and related drugs. Electroencephalogr. Clin. Neurophysiol. 7, 146 (1955a)

    Google Scholar 

  • Marrazzi, A.S., Hart, E.R.: Relationship of hallucinogens to adrenergic cerebral neurohumors. Science 121, 365–367 (1955b)

    Article  PubMed  CAS  Google Scholar 

  • Martin, W.R., Eades, C.G.: The action of tryptamine on the dog spinal cord and its relationship to the agonistic actions of LSD-like psychotogens. Psychopharmacologia 17, 242–257 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Matin, M.A., Vijayvargiya, R.: Chlorpromazine-lysergic acid diethylamide antagonism. J. Pharm. Pharmacol. 19, 192–193 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Matthes, K.: The action of blood on acetylcholine. J. Physiol. (Lond.) 70, 338–348 (1930)

    CAS  Google Scholar 

  • Maurer, R., Grieder, A.: Effects of dihydroergotamine on cAMP content in cultured glial cells. Experientia (Basel) 31, 730–731 (1975)

    Google Scholar 

  • Mawson, C., Whittington, H.: Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents. Brit. J. Pharmacol. 39, 223P (1970)

    CAS  Google Scholar 

  • Mchedlishvili, G.I., Ormotsadze, L.G.: Experimental models of spasm of the internal carotid artery. Pat. Fiziol. eksp. Ter. 5, 79–81 (1974)

    PubMed  Google Scholar 

  • Mena, M.A., Vidrio, H.: On the mechanism of the coronary dilator effect of serotonin in the dog. Europ. J. Pharmacol. 36, 1–5 (1976)

    Article  CAS  Google Scholar 

  • Mendez, R.: Antagonism of adrenaline by ergotamine. J. Pharmacol. 32, 451–464 (1928)

    CAS  Google Scholar 

  • Metcalfe, H.L., Turner, P.: Pharmacological studies of cinanserin in human isolated smooth muscle. Brit. J. Pharmacol. 37, 519P (1969)

    CAS  Google Scholar 

  • Metcalfe, H.L., Turner, P.: A comparison of the effects of cinanserin and methysergide on responses of isolated smooth muscle to acetylcholine. Arch. int. Pharmacodyn. 183, 148–158 (1970)

    PubMed  CAS  Google Scholar 

  • Meyer, D.K., Abele, M., Hertting, G.: Influence of serotonin on water intake and the reninangiotensin system in the rat. Arch. int. Pharmacodyn. 212, 130–140 (1974)

    PubMed  CAS  Google Scholar 

  • Michal, F.: D-receptor for serotonin on blood platelets. Nature (Lond.) 221, 1253–1254 (1969)

    Article  CAS  Google Scholar 

  • Michal, F., Motamed, M.: Time-dependent potentiation and inhibition by 5-hydroxytryptamine of platelet aggregation induced by ADP. Brit. J. Pharmacol. 54, 221–222 (1975)

    Google Scholar 

  • Michal, F., Motamed, M.: Shape change and aggregation of blood platelets: interaction between the effects of adenosine diphosphate, 5-hydroxytryptamine and adrenaline. Brit. J. Pharmacol. 56, 209–218 (1976)

    CAS  Google Scholar 

  • Mielke, H., Seiler, K.-U., Stumpf, U., Wassermann, O.: Über eine Beziehung zwischen dem Serotoninstoffwechsel und der pulmonalen Hypertonic bei Ratten nach Gabe verschiedener Anorektika. Z. Kardiol. 62, 1090–1098 (1973)

    PubMed  CAS  Google Scholar 

  • Mills, D.C.B., Roberts, G.C.K.: Effects of adrenaline on human blood platelets. J. Physiol. (Lond.) 193, 443–453 (1967)

    CAS  Google Scholar 

  • Mitchell, J.R.A., Sharp, A.A.: Platelet clumping in vitro. Brit. J. Haematol. 10, 78–93 (1964)

    Article  CAS  Google Scholar 

  • Mörsdorf, K., Bode, H.H.: Zur Beeinflussung der Permeabilitatssteigernden Wirkung des Serotonins durch verschiedenartige Pharmaka. Arch. int. Pharmacodyn. 118, 292–297 (1959)

    PubMed  Google Scholar 

  • Monachon, M.-A., Burkhard, W.P., Jalfre, M., Haefely, W.: Blockade of central 5-hydroxytryptamine receptors by methiothepin. Naunyn-Schmiedebergs Arch. Pharmacol. 274, 192–197 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Mosko, S., Jacobs, B.L.: Effect of peripherally administered serotonin on the neuronal activity of midbrain raphe neurons. Brain Res. 79, 315–320 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Mouton, Y., Demaille, A.: La barriere capillaire du mesentere de rat ayant recu une injection intravasculaire d’hepatome ascitique de Zajdela. III. Influence de la sérotonine et de l’histamine sur l’extravasation tumorale. C. R. Soc. Biol. (Paris) 169, 974–978 (1975)

    CAS  Google Scholar 

  • Müller-Schweinitzer, E.: Investigations on the mode of action of dihydroergotamine in human saphenous and dog saphenous and femoral veins. Naunyn-Schmiedebergs Arch. Pharmacol. 279 (Suppl.), R44 (1973)

    Google Scholar 

  • Müller-Schweinitzer, E.: Further studies on the mode of action of ergotamine on canine vein strips. Naunyn-Schmiedebergs Arch. Pharmacol. 282 (Suppl.), R68 (1974a)

    PubMed  Google Scholar 

  • Müller-Schweinitzer, E.: Enhanced synthesis of prostaglandin-like substance(s) contributes to the mode of action of dihydroergotamine. Naunyn-Schmiedebergs Arch. Pharmacol. 285 (Suppl.), R57 (1974b)

    Google Scholar 

  • Müller-Schweinitzer, E.: Studies on the peripheral mode of action of dihydroergotamine in human and canine veins. Europ. J. Pharmacol. 27, 231–237 (1974c)

    Article  Google Scholar 

  • Müller-Schweinitzer, E.: Differentiation between serotonin-and alpha-adrenoceptor blocking agents in isolated canine saphenous arteries. Naunyn-Schmiedebergs Arch. Pharmacol. 287 (Suppl.), R21 (1975a)

    PubMed  Google Scholar 

  • Müller-Schweinitzer, E.: unpublished results 1975 b

    Google Scholar 

  • Müller-Schweinitzer, E.: Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine. Naunyn-Schmiedebergs Arch. Pharmacol. 292, 113–118 (1976a)

    Article  PubMed  Google Scholar 

  • Müller-Schweinitzer, E.: Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine. Naunyn-Schmiedebergs Arch. Pharmacol. 295, 41–44 (1976b)

    Article  PubMed  Google Scholar 

  • Müller-Schweinitzer, E.: Comparative studies on the mode of action of ergotamine in canine and human arteries. “Headache ‘76”, Joint Meeting of the Italian Headache and the Scandinavian Migraine Societies, Florence, 1976c, Abstract, pp. 22–23

    Google Scholar 

  • Müller-Schweinitzer, E.: Comparative studies on the mode of action of ergotamine in canine and human arteries. In: Proceedings of “Headache ‘76”. Torino: C.G. Edizioni Medico-Scientifico 1976d (in press)

    Google Scholar 

  • Müller-Schweinitzer, E., Brundell, J.: Enhanced prostaglandin synthesis contributes to the venoconstrictor activity of ergotamine. Blood Vessels 12, 193–205 (1975a)

    PubMed  Google Scholar 

  • Müller-Schweinitzer, E., Brundell, J.: Modification of canine vascular smooth muscle responses to dihydroergotamine by endogenous prostaglandin synthesis. Europ. J. Pharmacol. 34, 197–206 (1975b)

    Article  Google Scholar 

  • Müller-Schweinitzer, E., Stürmer, E.: Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog. Experientia (Basel) 28, 743 (1972)

    Google Scholar 

  • Müller-Schweinitzer, E., Stürmer, E.: Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog. Brit. J. Pharmacol. 51, 441–446 (1974a)

    Google Scholar 

  • Müller-Schweinitzer, E., Stürmer, E.: Studies on the mechanism of the venoconstrictor activity of ergotamine on isolated canine saphenous veins. Blood Vessels 11, 183–190 (1974b)

    PubMed  Google Scholar 

  • Müller-Schweinitzer, E., Stürmer, E.: Effects of ergotamine on the responses of isolated saphenous and external carotid arteries of the dog to noradrenaline and serotonin: Sixth Internat. Congress Pharmacol., Helsinki, 1975, Abstract 1555

    Google Scholar 

  • Mulder, A.H., Stoof, J.C., Tilders, F.J.H.: Depolarization-induced release of central neurotransmitters from rat brain synaptosomes embedded in sephadex G-15 in a superfusion system. Sixth Internat. Congress Pharmacol., Helsinki, 1975, Abstract 1118

    Google Scholar 

  • Munday, K.A., Poat, J.A., Woodruff, G.N.: Structure activity studies on dopamine receptors, a comparison between rat striatal adenylate cyclase and Helix aspersa neurones. Brit. J. Pharmacol. 57, 452P–453P (1976)

    CAS  Google Scholar 

  • Nair, X.: Contractile responses of guinea-pig umbilical arteries to various hallucinogenic agents. Res. Commun. Chem. Path. Pharmacol. 9, 535–542 (1974)

    CAS  Google Scholar 

  • Nair, X., Dyer, D.C.: Responses of guinea-pig umbilical vasculature to vasoactive drugs. Europ. J. Pharmacol. 27, 294–304 (1974)

    Article  CAS  Google Scholar 

  • Nakanishi, H., Takeda, H.: The possible role of adenosine triphosphate in chemical transmission between the hypogastric nerve ending and seminal vesicle in the guinea-pig. Jap. J. Pharmacol. 23 (Suppl.), 19 (1973a)

    Article  Google Scholar 

  • Nakanishi, H., Takeda, H.: The possible role of adenosine triphosphate in chemical transmission between the hypogastric nerve terminal and seminal vesicle in the guinea-pig. Jap. J. Pharmacol. 23, 479–490 (1973b)

    Article  PubMed  CAS  Google Scholar 

  • Nakano, J.: Effects of prostaglandins E1, A1 and F on the coronary and peripheral circulations. Proc. Soc. exp. Biol. (N.Y.) 127, 1160–1163 (1968)

    CAS  Google Scholar 

  • Nanda, T.C.: The action of ergotamine on the response of the rabbit’s gut to adrenaline. J. Pharmacol. exp. Ther. 42, 9–16 (1931)

    CAS  Google Scholar 

  • Narebski, J., Romanowski, W., Kadziella, W.: Effect of 1-methyl-d-lysergic butanolamide (Deseril) on EEG changes due to 5-hydroxytryptamine and 5-hydroxytryptophane. Acta physiol. pol. 14, 157–170 (1963)

    PubMed  CAS  Google Scholar 

  • Nathanson, J.A., Greengard, P.: Serotonin-sensitive adenylate cyclase in neural tissue and its similarity to the serotonin receptor: a possible site of action of lysergic acid diethylamide. Proc. natl. Acad. Sci. (Wash.) 71, (3) 797–801 (1974)

    Article  CAS  Google Scholar 

  • Navratil, E.: Über die Beeinflussung der Cholinesterase durch Ergobasin. Klin. Wschr. 2, 64–65 (1937)

    Article  Google Scholar 

  • Ng, K.Y., Chase, T.N., Kopin, I.J.: Drug-induced release of 3H-norepinephrine and 3H-serotonin from brain slices. Nature (Lond.) 228, 468–469 (1970)

    Article  CAS  Google Scholar 

  • Nielsen, K.C., Owman, C.: Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res. 27, 33–42 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Nilsson, S.: Adrenergic innervation and drug responses of the oval sphincter in the swimbladder of the cod Gadus morhua. Acta physiol. scand. 83, 446–453 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Nishi, K.: The action of 5-hydroxytryptamine on chemoreceptor discharges of the cat’s carotid body. Brit. J. Pharmacol. 55, 27–40 (1975)

    CAS  Google Scholar 

  • North, R.A., Henderson, G.: Action of morphine on guinea-pig myenteric plexus and mouse vas deferens studied by intracellular recording. Life Sci. 17, 63–66 (1975)

    Article  PubMed  CAS  Google Scholar 

  • O’Brien, J.R.: A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors. J. clin. Path. 17, 275–281 (1964)

    Article  PubMed  Google Scholar 

  • Offermeier, J., Ariens, E.J.: Serotonin. I. Receptors involved in its action. Arch. int. Pharmacodyn. 164, 192–215 (1966)

    PubMed  CAS  Google Scholar 

  • Ogle, C.W., Wong, C.Y.: The inhibitory and excitatory properties of alpha adrenoceptors in the rat stomach. Life Sci. 10, 153–159 (1971)

    Article  CAS  Google Scholar 

  • O’Malley, B.W., Hardman, J.G.: Hormon action, part A: steroid hormones. Methods Enzymol. 36, 135–411 (1975)

    Article  Google Scholar 

  • Osborne, N.N., Hiripi, L., Neuhoff, V.: The in vitro uptake of biogenic amines by snail Helix pomatia nervous tissue. Biochem. Pharmacol. 24, 2141–2148 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Osswald, W., Guimarães, S.: Über den Mechanismus der Isoprenalinumkehr. Naunyn-Schmiedebergs Arch. Pharmacol. 243, 1–15 (1962)

    CAS  Google Scholar 

  • Osswald, W., Guimarães, S., Garret, J.: Influence of propranolol and ICI 50.172 on the cardiovascular actions of catecholamines as modified by ergotamine. J. Pharmacol. exp. Ther. 174, 315–322 (1970)

    PubMed  CAS  Google Scholar 

  • Owen, D.A.A., Herd, J.K., Kalberer, F., Pacha, W., Salzmann, R.: The influence of ergotamine and methysergide on the storage of biogenic amines. Headache 11, 91–92 (1971a)

    Google Scholar 

  • Owen, D.A.A., Herd, J.K., Kalberer, F., Pacha, W., Salzmann, R.: The influence of ergotamine and methysergide on the storage of biogenic amines. In: Proc. Intern. Headache Symposium, Elsinore, Denmark. Dalessio, D.J., Dalsgaard-Nielson, T., Diamond, S. (eds.), pp. 153–161. Basle: Sandoz 1971b

    Google Scholar 

  • Paasonen, M.K., Giarman, N.J.: Brain levels of 5-hydroxytryptamine after various agents. Arch. int. Pharmacodyn. 114, 189–200 (1958)

    PubMed  CAS  Google Scholar 

  • Pacha, W., Salzmann, R.: Inhibition of the re-uptake of neuronally liberated noradrenaline and α-receptor blocking action of some ergot alkaloids. Brit. J. Pharmacol. 38, 439P–440P (1970)

    CAS  Google Scholar 

  • Palmer, G.C., Burks, T.F.: Central and peripheral adrenergic blocking actions of LSD and BOL. Europ. J. Pharmacol. 16, 113–116 (1971)

    Article  CAS  Google Scholar 

  • Panigel, M.: Contribution à la physiologie de la circulation foeto-placentaire. I. Etude de la vaso-motricité des artères du cordon ombilical humain. J. Physiol. (Paris) 51, 941–969 (1959)

    CAS  Google Scholar 

  • Panigel, M.: Placental perfusion experiments. Amer. J. Obstet. Gynec. 84, 1664–1683 (1962)

    Google Scholar 

  • Parker, G.H.: The responses of catfish melanophores to ergotamine. Biol. Bull. 81, 163–167 (1941)

    Article  Google Scholar 

  • Parmley, W. W., Rabinowitz, B., Chuck, L.: The role of alpha adrenergic receptors in mediating positive inotropic effects in ventricular myocardium. Amer. J. Cardiol. 33, 161 (1974)

    Article  Google Scholar 

  • Parratt, J.R., West, G.B.: Inhibition of oedema production in the rat. J. Physiol. (Lond.) 135, 24P–25P (1957a)

    Google Scholar 

  • Parratt, J.R., West, G.B.: 5-Hydroxytryptamine and the anaphylactoid reaction in the rat. J. Physiol. (Lond.) 139, 27–41 (1957b)

    CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: Inhibition by various substances of oedema formation in the hind-paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, eggwhite and compound 48/80. Brit. J. Pharmacol. 13, 65–70 (1958)

    PubMed  CAS  Google Scholar 

  • Passow, H., Schniewind, H., Weiss, C.: Die Wirkung von 5-Hydroxytryptamin auf das Gefäßsystem der isolierten Rattenniere. Naunyn-Schmiedebergs Arch. Pharmacol. 240, 179–186 (1960)

    CAS  Google Scholar 

  • Paterson, G.: The response to transmural stimulation of isolated arterial strips and its modification by drugs. J. Pharm. Pharmacol. 17, 341–349 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Patten, B.M., Oliver, K.L., Engel, W.K.: Serotonin-induced muscle weakness. Arch. Neurol. (Chic.) 31, 347–349 (1974)

    Article  CAS  Google Scholar 

  • Paul, S.M., Halaris, A.E.: Rat brain de-acetylating activity: Stereospecific inhibition by LSD and serotonin-related compounds. Biochem. biophys. Res. Commun. 70, 207–211 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Paul, S.M., Halaris, A.E., Freedman, D.X., Hsu, L.L.: Rat brain aryl acylamidase: Stereospecific inhibition by LSD and serotonin-related compounds. J. Neurochem. 27, 625–627 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Pert, C.B., Snyder, S.H.: Properties of opiate-receptor binding in rat brain. Proc. natl. Acad. Sci. (Wash.) 70, 2243–2247 (1973)

    Article  CAS  Google Scholar 

  • Peters, D.A.V.: Comparison of the chronic and acute effects of D-lysergic acid diethylamide (LSD) treatment on rat brain serotonin and norepinephrine. Biochem. Pharmacol. 23, 231–237 (1974a)

    Article  PubMed  CAS  Google Scholar 

  • Peters, D.A.V.: Chronic lysergic acid diethylamide administration and serotonin turnover in various regions of rat brain. J. Neurochem. 23, 625–628 (1974b)

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer, Y., Sadowsky, E., Sulman, F.G.: Prevention of serotonin abortion in pregnant rats by five serotonin antagonists. Obstet. Gynecol. 33, 709–714 (1969)

    PubMed  CAS  Google Scholar 

  • Phillis, J.W., Tebecis, A.K., York, D.H.: The inhibitory action of monoamines on lateral geniculate neurones. J. Physiol. (Lond.) 190, 563–581 (1967)

    CAS  Google Scholar 

  • Pichler, E., Lazarini, W., Filippi, R.: Über schraubenförmige Struktur von Arterien. II. Mitteilung: Pharmakologische Strukturanalyse von Hirnarterien. Naunyn-Schmiedebergs Arch. Pharmacol. 219, 420–439 (1953)

    CAS  Google Scholar 

  • Pichler, E., Ostfeld, A.M., Goodell, H., Wolff, H.G.: Studies on headache: Central versus peripheral action of ergotamine tartrate and its relevance to the therapy of migraine headache. Arch. Neurol. Psychiat. (Chic.) 76, 571–577 (1956)

    Google Scholar 

  • Pijnenburg, A.J.J., van Rossum, J.M.: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens. J. Pharm. Pharmacol. 25, 1003–1004 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Pijnenburg, A.J.J., Woodruff, G.N., van Rossum, J.M.: Ergometrine induced locomotor activity following intracerebral injection into the nucleus accumbens. Brain Res. 59, 289–302 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Pik, K., Borsy, J.: The mechanism of action of GYKI-32084, a new antiserotonin agent. Naunyn-Schmiedebergs Arch. Pharmacol. 284 (Suppl.), R62 (1974)

    Google Scholar 

  • Pitzele, S., Dobell, A.R.C.: Inhibition of serotonin-induced blood cell aggregation in the dog. Surgery 73, 416–422 (1973)

    PubMed  CAS  Google Scholar 

  • Politoff, A., Macri, F.: Pharmacologic differences between isolated, perfused arteries of the choroid plexus and of the brain parenchyma. Int. J. Neuropharmacol. 5, 155–162 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Poulson, E., Robson, J.M.: Prevention by antagonists of the toxic action of 5-hydroxytryptamine on pregnancy. Brit. J. Pharmacol. 21, 150–154 (1963)

    PubMed  CAS  Google Scholar 

  • Pourrias, B.: Analyse des effets tensionels et cardiaques de la tryptine. J. Pharmacol. (Paris) 6, 153–164 (1975)

    CAS  Google Scholar 

  • Prince, W.T., Berridge, J., Rasmussen, H.: Role of calcium and adenosine-3′,5′-cyclic monophosphate in controlling fly salivary gland secretion. Proc. natl. Acad. Sci. (Wash.) 69, 553–557 (1972)

    Article  CAS  Google Scholar 

  • Proudfit, K., Anderson, E.G.: Alteration by serotonin antagonists of the effects of bulbospinal stimulation on spinal reflex pathways. Fed. Proc. 31, 270 (1972)

    Google Scholar 

  • Proudfit, H.K., Anderson, E.G.: Influence of serotonin antagonists on bulbospinal systems. Brain Res. 61, 331–341 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Przewlocki, R.: The effect of serotonin microinjections into the nuclei amygdale on EEG and behaviour in the rabbit. Pol. J. Pharmacol. Pharm. 27 (Suppl.), 209–216 (1975)

    PubMed  CAS  Google Scholar 

  • Rand, M.J., McCulloch, M.W., Story, D.F.: Pre-junctional modulation of noradrenergic transmission by noradrenaline, dopamine and acetylcholine. In: Central Action of Drugs in Blood Pressure Regulation. Davies, D.S., Reid, J.L. (eds.), pp. 94–132. Kent: Pitman Medical Publishing 1975

    Google Scholar 

  • Randic, M., Padjen, A.: Effect of N,N-dimethyltryptamine and D-lysergic acid diethylamide on the release of 5-hydroxy-indoles in rat forebrain. Nature (Lond.) 230, 532–533 (1971)

    Article  CAS  Google Scholar 

  • Rao, K.R., Fingerman, M.: Action of biogenic amines on crustacean chromatophores. II. Analysis of the responses of erythrophores in the fiddler crab, Uca pugilator, to indolealkylamines and an eyestalk hormone. Comp. gen. Pharmacol. 1, 117–126 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Regoli, D., Vane, J.R.: A sensitive method for the assay of angiotensin. Brit. J. Pharmacol. 23, 351–359 (1964)

    PubMed  CAS  Google Scholar 

  • Reichenberg, K., Wiszniowska, G., Marchaj, J.: The influence of 5-hydroxytryptophan (5-HTP) administered into the lateral brain ventricle on the behavior and body temperature in rats. Pol. J. Pharmacol. Pharm. 27 (Suppl.), 217–222 (1975)

    PubMed  CAS  Google Scholar 

  • Rico, J.M.G.T., Rico, J.T., Ferreira, J.M.C., Cravo, A.C.: L’effet des prostaglandines PGE1, PGE2 et PGF sur la perméabilité vasculaire chez le rat. C.R. Soc. Biol. (Paris) 167, 1315–1318 (1973)

    CAS  Google Scholar 

  • Roberts, M.H., Straughan, D.W.: Excitation and depression of cortical neurones by 5-hydroxytryptamine. J. Physiol. (Lond.) 193, 269–294 (1967)

    CAS  Google Scholar 

  • Rocha e Silva, M., Valle, J.R., Picarelli, Z.P.: A pharmacological analysis of the mode of action of serotonin (5-hydroxytryptamine) upon the guinea-pig ileum. Brit. J. Pharmacol. 8, 378–388 (1953)

    PubMed  Google Scholar 

  • Rossler, R., Unna, K.: Zur Pharmakologie des neuen Mutterkornalkaloides Sensibamin. Naunyn-Schmiedebergs Arch. Pharmacol. 179, 115–126 (1935)

    Article  CAS  Google Scholar 

  • Rose, J.C., Lazaro, E.J.: Pulmonary vascular responses to serotonin and effects of certain serotonin antagonists. Circulat. Res. 6, 283–288 (1958)

    PubMed  CAS  Google Scholar 

  • Rosecrans, J.A., Lovell, R.A., Freedman, D.X.: Effects of lysergic acid diethylamide on the metabolism of brain 5-hydroxytryptamine. Biochem. Pharmacol. 16, 2011–2021 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Rosenblueth, A.: The action of certain drugs on the nictitating membrane. Amer. J. Physiol. 100, 443–446 (1932)

    Google Scholar 

  • Ross, S.B., Renyi, A.L.: Accumulation of tritiated 5-hydroxytryptamine in brain slices. Life Sci. 6, 1407–1415 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Roth, J.: Peptide hormone binding to receptors: a review of direct studies in vitro. Metabolism 22, 1059–1073 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Rothlin, E.: Über die pharmakologische und therapeutische Wirkung des Ergotamins auf den Sympathicus. Klin. Wschr. 4, 1437–1443 (1925)

    Article  CAS  Google Scholar 

  • Rothlin, E.: Zur Pharmakologie des Sympathicolyticums Dihydroergotamin DHE 45. Schweiz. med. Wschr. 76, 1254–1259 (1946)

    PubMed  CAS  Google Scholar 

  • Rothlin, E.: The pharmacology of the natural and dihydrogenated alkaloids of ergot. Bull. schweiz. Akad. med. Wiss. 2, 249–273 (1946/47)

    Google Scholar 

  • Rothlin, E.: Pharmacology of lysergic acid diethylamide (LSD) and some of its related compounds. In: Psychotropic drugs. Garattini, S., Ghetti, V. (eds.), pp. 36–47. Amsterdam: Elsevier Press 1957a

    Google Scholar 

  • Rothlin, E.: Lysergic acid diethylamide and related substances. Ann. N.Y. Acad. Sci. 66, 668–676 (1957b)

    Article  PubMed  CAS  Google Scholar 

  • Rothlin, E.: Pharmacology of lysergic acid diethylamide and some of its related compounds. J. Pharm. Pharmacol. 9, 569–587 (1957c)

    Article  PubMed  CAS  Google Scholar 

  • Rothlin, E., Berde, B.: Über die Wirkung hydrierter Mutterkornalkaloide auf isolierte Muskelstreifen des menschlichen Uterus nahe am Termin, am Termin und während der Geburt. Helv. physiol. pharmacol. Acta 12, 191–205 (1954)

    PubMed  CAS  Google Scholar 

  • Rothlin, E., Brügger, J.: Quantitative Differenzierung von 4 genuinen und hydrierten Mutterkornalkaloiden am isolierten Kaninchen-Uterus und an der isolierten Samenblase des Meerschweinchens. Helv. physiol. pharmacol. Acta 3, C43–C44 (1945a)

    CAS  Google Scholar 

  • Rothlin, E., Brügger, J.: Quantitative Untersuchungen der sympathikolytischen Wirkung genuiner Mutterkornalkaloide und derer Dihydroderivate am isolierten Uterus des Kaninchens. Helv. physiol. pharmacol. Acta 3, 519–535 (1945b)

    CAS  Google Scholar 

  • Rothlin, E., Cerletti, A.: Pharmakologie des Hochdrucks. Verh. dtsch. Ges. Kreisl.-Forsch. 15, 158–185 (1949)

    Google Scholar 

  • Rothlin, E., Konzett, H., Cerletti, A.: The antagonism of ergot alkaloids towards the inhibitory response of the isolated rabbit intestine to epinephrine and norepinephrine. J. Pharmacol. exp. Ther. 112, 185–190 (1954)

    PubMed  CAS  Google Scholar 

  • Rózsa, K.S., Graul, C.: Is serotonin responsible for the stimulative effect of the extracardiac nerve in Helix pomatia? Ann. Biol. Tihany 31, 85–96 (1964)

    Google Scholar 

  • Ruch-Monachon, M.-A., Jalfre, M., Haefely, W.: Drugs and PGO waves in the lateral geniculate body of the curarized cat. II. PGO wave activity and brain 5-hydroxytryptamine. Arch. int. Pharmacodyn. 219, 269–286 (1976a)

    PubMed  CAS  Google Scholar 

  • Ruch-Monachon, M.-A., Jalfre, M., Haefely, W.: Drugs and PGO waves in the lateral geniculate body of the curarized cat. V. Miscellaneous compounds. Synopsis of the role of central neurotransmitters on PGO wave activity. Arch. int. Pharmacodyn. 219, 326–346 (1976b)

    PubMed  CAS  Google Scholar 

  • Ruckebusch, Y., Roche, M., Schurch, D.: Parallelisms des effets des psychodysleptiques majeure sur la toxicité de groupe et de taux cérébral en sérotonine. C.R. Soc. Biol. (Paris) 159, 1745–1748 (1965)

    CAS  Google Scholar 

  • Rudzik, A.D., Miller, J.W.: The mechanism of uterine inhibitory action of relaxin-containing ovarian extracts. J. Pharmacol. exp. Ther. 138, 82–87 (1962)

    PubMed  CAS  Google Scholar 

  • Saad, K.: The effect of drugs on the isolated splenic capsule of man and other animals. Quart. J. Pharm. Pharmacol. 8, 31–38 (1935)

    CAS  Google Scholar 

  • Sachs, E., Yonkman, F.F.: The pharmacological behavior of the intraocular muscles. V. The action of yohimbine and ergotamine on the dilator iridis. J. Pharmacol. exp. Ther. 75, 105–110 (1942)

    CAS  Google Scholar 

  • Salmoiraghi, G.C., McCubbin, J.W., Page, I.H.: Effects of D-lysergic acid diethylamide and its brom derivative on cardiovascular responses to serotonin and on arterial pressure. J. Pharmacol. exp. Ther. 119, 240–247 (1957)

    PubMed  CAS  Google Scholar 

  • Salmoiraghi, G.C., Bloom, F.E., Costa, E.: Adrenergic mechanisms in rabbit olfactory bulb. Amer. J. Physiol. 207, 1417–1424 (1964)

    PubMed  CAS  Google Scholar 

  • Salzmann, R., Kalberer, F.: Antimigraine drugs and storage of serotonin. In: Background to Migraine. Cumings, J.N. (ed.), pp. 63–72. London: William Heinemann Medical Books 1973

    Google Scholar 

  • Salzmann, R., Pacha, W.: Vergleichende Untersuchungen über die Beeinflussung adrenerger Reaktionen durch Ergotamin und Dihydroergotamin an verschiedenen Versuchsmodellen. Helv. physiol. pharmacol. Acta 26, CR246–CR248 (1968)

    CAS  Google Scholar 

  • Salzmann, R., Pacha, W.: The effects of ergot compounds on the release of noradrenaline and prostaglandins from the isolated perfused cat spleen during nerve stimulation. Postgrad. med. J. 52 (Suppl. 1), 24–31 (1976)

    Google Scholar 

  • Salzmann, R., Weidmann, H.: Die Wirkung von Ergotamin auf humorale und neuronale Effekte an der Nickhaut der Katze. Helv. physiol. pharmacol. Acta 24, C117 (1966)

    CAS  Google Scholar 

  • Salzmann, R., Pacha, W., Weidmann, H.: Der Einfluß von Ergotamin auf humorale und neuronale Wirkungen an der Nickhaut und an der Milz der Katze. Helv. physiol. pharmacol. Acta 25, CR433–CR435 (1967)

    PubMed  CAS  Google Scholar 

  • Salzmann, R., Pacha, W., Taeschler, M., Weidmann, H.: The effect of ergotamine on humoral and neuronal actions in the nictitating membrane and the spleen of the cat. Naunyn-Schmiedebergs Arch. Pharmacol. 261, 360–378 (1968)

    CAS  Google Scholar 

  • Sankar, D.V.S., Sankar, D.B., Phipps, E., Gold, E.: Effect of administration of lysergic acid diethylamide on serotonin levels in the body. Nature (Lond.) 191, 499–500 (1961)

    Article  CAS  Google Scholar 

  • Sankar, D.V.S., Phipps, E., Gold, E., Sankar, D.B.: Effect of LSD, BOL, and chlorpromazine on “Neurohormone” metabolism. Ann. N.Y. Acad. Sci. 96, 93–97 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Sankar, D.V.S., Broer, H.H., Cates, N., Sankar, D.B.: Studies on biogenic amines and psychoactive drug actions, with special reference to lysergic acid diethyl amide. Trans. N.Y. Acad. Sci. 26, 369–379 (1964)

    PubMed  CAS  Google Scholar 

  • Sankar, D.V.S., Cates, N.R., Domjan, M.: Comparative biochemical pharmacology of psychoactive drugs. Clin. Res. 17, 395 (1969)

    Google Scholar 

  • Sato, M., Sawada, M.: Selective blocking action of LSD on inhibitory dopamine receptors. Neuropharmacology 14, 883–886 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Savini, E.C.: The antagonism between 5-hydroxytryptamine and certain derivatives of lysergic acid. Brit. J. Pharmacol. 11, 313–317 (1956)

    PubMed  CAS  Google Scholar 

  • Saxena, P.R.: The effects of antimigraine drugs on the vascular responses by 5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: possible pharmacological implications to their antimigraine action. Headache 12, 44–45 (1972a)

    Article  PubMed  CAS  Google Scholar 

  • Saxena, P.R.: The effects of some antimigraine drugs on the vascular resistance in the external carotid bed of the dog. In: Vascular Smooth Muscle. Betz, E. (ed.), pp. 93–95. Berlin-Heidelberg-New York: Springer 1972b

    Chapter  Google Scholar 

  • Saxena, P.R.: Selective carotid vasoconstriction by ergotamine as a relevant mechanism in its antimigraine action. Arch. Neurobiol. 37 (Suppl.), 301–315 (1974a)

    Google Scholar 

  • Saxena, P.R.: Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect. Europ. J. Pharmacol. 27, 99–105 (1974b)

    Article  CAS  Google Scholar 

  • Saxena, P.R.: On the mechanism of action of methysergide in vascular headaches of migraine type. In: Headache, II. Biochemical Bases and Drug Therapy. Munch. Med. Wochenschr. (ed.), pp. 91–100, 137–138. München: O. Spatz 1975

    Google Scholar 

  • Saxena, P.R., De Vlaam-Schluter, G.M.: Role of some biogenic substances in migraine and relevant mechanism in antimigraine action of ergotamine-studies in an experimental model for migraine. Headache 13, 142–163 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Saxena, P.R., van Houwelingen, P., Bonta, I.L.: The effects of mianserin hydrochloride on the vascular responses evoked by 5-hydroxytryptamine and related vasoactive substances. Europ. J. Pharmacol. 13, 295–305 (1971)

    Article  CAS  Google Scholar 

  • Schanberg, S.M., Giarman, N.J.: Uptake of serotonin (5-HT) and 5-hydroxytryptophan (5-HTP) by brain slices. Pharmacologist 2, 67 (1960)

    Google Scholar 

  • Schanberg, S.M., Giarman, N.J.: Drug-induced alterations in the sub-cellular distribution of 5-hydroxytryptamine in rat’s brain. Biochem. Pharmacol. 11, 187–194 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Scherbel, A.: Pharmacodynamic effects of UML-491 in animal and man. Wiss. Ausstellung, 6. Int. Kongress Inn. Med., Basel, August 1960, Abstract

    Google Scholar 

  • Schild, H.O.: pA, a new scale for the measurement of drug antagonism. Brit. J. Pharmacol. 2, 189–206 (1947)

    PubMed  CAS  Google Scholar 

  • Schild, H.O.: Non-competitive antagonism. J. Physiol. (Lond.) 124, 33P–34P (1954)

    Google Scholar 

  • Schild, H.O.: Effect of adrenaline on depolarized smooth muscle. In: Ciba Foundation Symposium on Adrenergic Mechanisms. Wolstenholme, G.E.W., O’Connor, M. (eds.), pp. 288–294. London: J. and A. Churchill 1960

    Google Scholar 

  • Schild, H.O.: Parallelism of log dose-response curves in competitive antagonism. Pharmacol. Res. Commun. 1, 1–2 (1969)

    Article  CAS  Google Scholar 

  • Schild, H.O.: Some aspects of receptor pharmacology of ergotamine. Postgrad. med. J. 52 (Suppl. 1), 9–11 (1976)

    PubMed  CAS  Google Scholar 

  • Schildkraut, J.J., Schanberg, S.M., Breese, G.R., Kopin, I.J.: Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain. Biochem. Pharmacol. 18, 1971–1978 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Schlientz, W., Brunner, R., Rüegger, A., Berde, B., Stürmer, E., Hofmann, A.: β-Ergokryptin, ein neues Alkaloid der Ergotoxin-Gruppe. Pharm. Acta Helv. 43, 497–509 (1968)

    PubMed  CAS  Google Scholar 

  • Schönbaum, E., Lamar, J.-C.: Anti-serotonin drugs in nasal vessels. Sixth Internat. Congress Pharmacology, Helsinki, 1975, Abstract 698

    Google Scholar 

  • Schönbaum, E., Vargaftig, B.B., Lefort, J.: Nasal vessels and serotonin. Pharmacologist 16, 243 (1974)

    Google Scholar 

  • Schönbaum, E., Vargaftig, B.B., Lefort, J., Lamar, J.C., Hasenack, T.: An unexpected effect of serotonin antagonists on the canine nasal circulation. Headache 15, 180–187 (1975)

    Article  PubMed  Google Scholar 

  • Scholtysik, G.: Inhibition of accelerator nerve stimulation in cats by dihydroergotoxine. Sixth Internat. Congress Pharmacology, Helsinki, 1975, Abstract 742

    Google Scholar 

  • Schorderet, M.: Direct evidence for the stimulation of rabbit retina dopamine receptors by ergot alkaloids. Neurosci. Lett. 2, 87–91 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Schorderet, M., Frangaki, A.: Effects of antiparkinsonian drugs on cAMP accumulation in rabbit retina. Experientia (Basel) 32, 782 (1976)

    Google Scholar 

  • Schubert, J., Nybäck, H., Sedvall, G.: Accumulation and disappearance of 3H-5-hydroxytryptamine formed from 3H-tryptophan in mouse brain: effect of LSD 25. Europ. J. Pharmacol. 10, 215–224 (1970)

    Article  CAS  Google Scholar 

  • Schwarz, B.E., Wakim, K.G., Bickford, R.G., Lichtenheld, F.R.: Behavioural and electroencephalographic effects of hallucinogenic drugs. Arch. Neurol. Psychiat. (Chic.) 75, 83–90 (1956)

    CAS  Google Scholar 

  • Scriabine, A., Bellet, S., Kershbaum, A., Feinberg, L.J.: Effect of dihydroergotamine on plasma free fatty acids (FFA) in dogs. Life Sci. 7, 453–463 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Segal, M.: Physiological and pharmacological evidence for a serotonergic projection to the hippocampus. Brain Res. 94, 115–131 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Segal, M., Bloom, F.E.: The projection of midline raphe nuclei to the hippocampus of the rat. Fed. Proc. 33, 299 (1974)

    Google Scholar 

  • Seiler, K.-U., Wassermann, O.: MAO-inhibitory properties of anorectic drugs. J. Pharm. Pharmacol. 25, 576–578 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Shaskan, E.G., Snyder, S.H.: Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake. J. Pharm. exp. Ther. 175, 404–418 (1970)

    CAS  Google Scholar 

  • Shaw, E., Woolley, D.W.: Yohimbine and ergot alkaloids as naturally occurring antimetabolites of serotonin. J. biol. Chem. 203, 978–989 (1953)

    Google Scholar 

  • Shaw, E., Woolley, D.W.: Some serotoninlike activities of lysergic acid diethylamide. Science 124, 121–122 (1956)

    Article  PubMed  CAS  Google Scholar 

  • Shibuya, T., Anderson, E.G.: The influence of chronic cord transection on the effects of 5-hydroxytryptophan, L-tryptophan and pargyline on spinal neuronal activity. J. Pharmacol. exp. Ther. 164, 185–190 (1968)

    PubMed  CAS  Google Scholar 

  • Shields, P.J., Eccleston, D.: Evidence for the synthesis and storage of 5-hydroxytryptamine in two separate pools in the brain. J. Neurochem. 20, 881–888 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Shimahara, T., Tauc, L.: Heterosynaptic facilitation in the giant cell of Aplysia. J. Physiol. (Lond.) 247, 321–342 (1975)

    CAS  Google Scholar 

  • Sicuteri, F., Michelacci, S., Franchi, G.: Antagonism between an antiserotonin-the butanolamide of 1-methyl-lysergic acid-and the effects of a histamine-liberating substance 48/80 B.W. in man. Int. Arch. Allergy 15, 291–299 (1959)

    Article  PubMed  CAS  Google Scholar 

  • Sicuteri, F., Franchi, G., Michelacci, S.: Inhibition by lysergic acid derivatives of bronchospasm induced in guinea-pigs by serotonin aerosol. Med. Exp. 3, 89–94 (1960)

    CAS  Google Scholar 

  • Sicuteri, F., Del Bianco, P.L., Fanciullacci, M., Franchi, G.: II test della venocostrizione per la misura della sensibilita alia 5-idossitriptamina e alle catecolamine nell’uomo. Boll. Soc. ital. Biol. sper. 40, 1148–1150 (1964a)

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Fanciullacci, M., Del Bianco, P.L., Franchi, G.: Inibizione della venocostrizione da 5-idrossitriptamina nell’uomo da parte del metisergide (UML-491) e di altri antiserotoninici. Boll. Soc. ital. Biol. sper. 40, 1151–1152 (1964b)

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Franchi, G., Fanciullacci, M.: Serotonin potentiation of methysergide, LSD 25 and ergotamine in man: An informal approach to migraine pharmacology. In: Headache, II. Biochemical Bases and Drug Therapy. Munch. Med. Wochenschr. (ed.), pp. 101–104, 137–138. München: O. Spatz 1975

    Google Scholar 

  • Simon, G., Winter, M.: The effect of sympatholytic and sympathomimetic agents on acetylcholinesterase and cholinesterase activity in vitro. Biochem. Pharmacol. 25, 881–882 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Slater, I.H., Davis, K.H., Leary, D.E., Boyd, E.S.: The action of serotonin and lysergic acid diethylamide on spinal reflexes. J. Pharmacol. exp. Ther. 113, 48–49 (1955)

    Google Scholar 

  • Smith, C.B.: Relaxation of the nictitating membrane of the spinal cat by sympathomimetic amines. J. Pharmacol. exp. Ther. 142, 163–170 (1963)

    PubMed  CAS  Google Scholar 

  • Snider, S.R., Hutt, C., Stein, B., Fahn, S.: Increase in brain serotonin produced by bromocryptine. Neurosci. Lett. 1, 237–241 (1975)

    Article  CAS  Google Scholar 

  • Snider, S.R., Hutt, C., Stein, B., Prasad, A.L.N., Fahn, S.: Correlation of behavioural inhibition or excitation produced by bromocriptine with changes in brain catecholamine turnover. J. Pharm. Pharmacol. 28, 563–566 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Snyder, S.H., Bennett, J.P.: Neurotransmitter receptors in the brain: biochemical identification. Annu. Rev. Physiol. 38, 153–175 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Sofia, R.D., Vassar, H.B.: The effects of ergotamine and methysergide on serotonin metabolism in the rat brain. Arch. int. Pharmacodyn. 216, 40–50 (1975)

    PubMed  CAS  Google Scholar 

  • Sollero, L., Page, I.H., Salmoiraghi, G.C.: Brom-lysergic acid diethylamide: A highly potent serotonin antagonist. J. Pharmacol. exp. Ther. 117, 10–15 (1956)

    PubMed  CAS  Google Scholar 

  • Sollmann, T.: A Manual of Pharmacology and its Applications to Therapeutics and Toxicology, 7th ed. Philadelphia-London: W.B. Saunders 1948

    Google Scholar 

  • Sollmann, T., Brown, E.D.: Intravenous injection of ergot. J. Amer. med. Ass. 45, 229–240 (1905)

    Article  Google Scholar 

  • Sonneville, P.F.: An indirect action of dopamine on the rat fundus strip mediated by 5-hydroxytryptamine. Europ. J. Pharmacol. 2, 367–370 (1968)

    Article  CAS  Google Scholar 

  • Spano, P.F., Cattabeni, F., Govoni, S., Trabucchi, M.: Selective stimulation by d-LSD of dopamine-sensitive adenylate cyclase in various rat brain areas. Sixth Internat. Congress Pharmacol., Helsinki, 1975a, Abstract 186

    Google Scholar 

  • Spano, P.F., Kumakura, K., Tonon, G.C., Govoni, S., Trabucchi, M.: LSD and dopaminesensitive adenylate cyclase in various rat brain areas. Brain Res. 93, 164–167 (1975b)

    Article  PubMed  CAS  Google Scholar 

  • Sparber, S.B.: Neurochemical changes associated with schedule controlled behavior. Fed. Proc. 34, 1802–1812 (1975)

    PubMed  CAS  Google Scholar 

  • Stacey, R.S.: Uptake of 5-hydroxytryptamine by platelets. Brit. J. Pharmacol. 16, 284–295 (1961)

    PubMed  CAS  Google Scholar 

  • Stadler, P.A., Stürmer, E.: Comparative studies on the pharmacological properties of stereoisomers of ergotamine and dihydroergotamine. Naunyn-Schmiedebergs Arch. Pharmacol. 266, 457–458 (1970)

    CAS  Google Scholar 

  • Starke, K.: α-Sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart. Naunyn-Schmiedebergs Arch. Pharmacol. 274, 18–45 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Starke, K., Montel, H.: Sympathomimetic inhibition of noradrenaline release: mediated by prostaglandins? Naunyn-Schmiedebergs Arch. Pharmacol. 278, 111–116 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Starr, M.S., West, G.B.: The effect of bradykinin and anti-inflammatory agents on isolated arteries. J. Pharm. Pharmacol. 18, 838–840 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, R.P.: A modification of receptor theory. Brit. J. Pharmacol. 11, 379–393 (1956)

    PubMed  CAS  Google Scholar 

  • Stevens, B., Baguet, F.: Action de l’acide bromolysergique diethylamide (BOL 148) sur les propriétés mécaniques d’un muscle lisse de Lamellibranche. Arch. int. Physiol. Biochim. 76, 552–554 (1968)

    PubMed  CAS  Google Scholar 

  • Stjärne, L., Lishajko, F.: Drug-induced inhibition of noradrenaline synthesis in vitro in bovine splenic nerve tissue. Brit. J. Pharmacol. 27, 398–404 (1966)

    PubMed  Google Scholar 

  • Stjärne, L., Wennmalm, A.: Quantitative estimation of secretion and reuptake of adrenergic transmitter in the rabbit heart. Acta physiol. scand. 81, 286–288 (1971)

    Article  PubMed  Google Scholar 

  • Stolk, J.M., Barchas, J.D., Goldstein, M., Boggan, W., Freedman, D.X.: A comparison of psychotomimetic drug effects on rat brain norepinephrine metabolism. J. Pharmacol. exp. Ther. 189, 42–50 (1974)

    PubMed  CAS  Google Scholar 

  • Stoll, A., Hofmann, A.: The ergot alkaloids. In: The Alkaloids. Manske, R.H.F. (ed.), Chap. 21, Vol. VIII. New York: Academic Press 1965

    Google Scholar 

  • Stone, C.A., Wenger, H.C., Ludden, C.T., Stavorski, J.M., Ross, C.A.: Antiserotonin-antihistaminic properties of cyproheptadine. J. Pharmacol. exp. Ther. 131, 73–84 (1961)

    CAS  Google Scholar 

  • Stone, T.W.: Further evidence for a dopamine receptor stimulating action of an ergot alkaloid. Brain Res. 72, 177–180 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Straczowski, W., Kalicinski, A., Nowak, W., Malofiejew, M.: The effects of prostaglandin A2 (PGA2) on the guinea-pig isolated ileum. Pol. J. Pharmacol. Pharm. 26, 253–255 (1974)

    Google Scholar 

  • Strandhoy, J.W., Cronnelly, R., Long, J.P., Williamson, H.E.: Effects of vasoactive agents and diuretics on isolated superfused interlobar renal arteries. Proc. Soc. exp. Biol. (N.Y.) 141, 336–339 (1972)

    CAS  Google Scholar 

  • Streuli, H.: Die Wechselwirkung von inneren Sekreten und die Beziehung dieser Wirkung zum Problem der Erregung und Hemmung. Z. Biol. 66, 167–228 (1916)

    Google Scholar 

  • Strong, C.G., Bohr, D.F.: Effects of Prostaglandins E1, E2, A1 and F on isolated vascular smooth muscle. Circulation 36 (Suppl. 2), II 244–11 245 (1967a)

    Google Scholar 

  • Strong, C.G., Bohr, D.F.: Effects of prostaglandins E1, E2, A1 and F on isolated vascular smooth muscle. Amer. J. Physiol. 213, 725–733 (1967b)

    PubMed  CAS  Google Scholar 

  • Struyker Boudier, H., Van Rossum, J.M.: Dopamine-induced inhibition and excitation of neurones of the snail Helix aspersa. Arch. int. Pharmacodyn. 209, 314–324 (1974)

    PubMed  CAS  Google Scholar 

  • Struyker Boudier, H.A.J., Gielen, W., Cools, A.R., Van Rossum, J.M.: Pharmacological analysis of dopamine-induced inhibition and excitation of neurones of the snail Helix aspersa. Arch. int. Pharmacodyn. 209, 324–331 (1974)

    PubMed  CAS  Google Scholar 

  • Struyker Boudier, H., Teppema, L., Cools, A., Van Rossum, J.M.: (3,4-dihydroxy-phenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition. J. Pharm. Pharmacol. 27, 882–883 (1975)

    Article  CAS  Google Scholar 

  • Sugrue, M.F.: A study of the role of noradrenaline in behavioural changes produced in the rat by psychotomimetic drugs. Brit. J. Pharmacol. 35, 243–252 (1969)

    CAS  Google Scholar 

  • Svensson, T.H., Bunney, B.S., Aghajanian, G.K.: Noradrenergic regulation of brain serotonergic neurons: Evidence from single unit studies with clonidine. Pharmacologist 16, 244 (1974)

    Google Scholar 

  • Swank, R.L., Fellman, J.H.: Blood cell aggregation and biological agents. Bibl. anat. (Basel) 8–9, 98–103 (1966)

    Google Scholar 

  • Swank, R.L., Fellman, J.H., Hissen, W.W.: Aggregation of blood cells by 5-hydroxytryptamine (serotonin). Circulat. Res. 13, 392–400 (1963)

    PubMed  CAS  Google Scholar 

  • Szabadi, E., Bradshaw, C.M.: The role of physical and biological factors in determining the time course of neuronal responses. Neuropharmacology 13, 537–545 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Szara, S., Morton, D.M., Aikens, A.: Comparison of hallucinogenic and nonhallucinogenic congeners on regional serotonin metabolism in brain. Pharmacologist 9, 250 (1967)

    Google Scholar 

  • Takeuchi, H., Mori, A., Kohsaka, M.: Effets des indolamines et de leurs analogues sur l’activité électrique d’un neurone géant identifié d’Achatina fulica Ferussac. C.R. Soc. Biol. (Paris) 186, 658–663 (1974)

    Google Scholar 

  • Tardos, L., Adam, V.: The chronotropic activity of serotonin. Naunyn-Schmiedebergs Arch. Pharmacol. 248 (Suppl.), R81 (1974)

    Google Scholar 

  • Tebécis, A.K., DiMaria, A.: A re-evaluation of the mode of action of 5-hydroxytryptamine on lateral geniculate neurones: Comparison with catecholamines and LSD. Exp. Brain Res. 14, 480–493 (1972)

    Article  PubMed  Google Scholar 

  • Teraki, Y.: A study on the action mechanism of foetal death with 5-HT and the influence of its antagonists. Acta obstet. gynaec. Jap. 17, 142 (1970)

    Google Scholar 

  • Thierry, A.M., Blanc, G., Sobel, A., Stinus, L., Glowinski, J.: Dopaminergic terminals in rat cortex. Science 182, 499–501 (1973a)

    Article  PubMed  CAS  Google Scholar 

  • Thierry, A.M., Stinus, L., Blanc, G., Glowinski, J.: Some evidence for the existence of dopaminergic neurones in the rat cortex. Brain Res. 50, 230–234 (1973b)

    Article  PubMed  CAS  Google Scholar 

  • Thoenen, H., Hürlimann, A., Haefely, W.: Dual site of action of phenoxybenzamine in the cat’s spleen: Blockade of α-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine. Experientia (Basel) 20, 272–273 (1964a)

    Article  CAS  Google Scholar 

  • Thoenen, H., Hürlimann, A., Haefely, W.: Wirkungen von Phenoxybenzamin, Phentolamin und Azapetin auf adrenergische Synapsen der Katzenmilz. Helv. physiol. pharmacol. Acta 22, 148–161 (1964b)

    PubMed  CAS  Google Scholar 

  • Thompson, J.H., Campbell, L.B.: The influence of 1-methyl-d-lysergic acid butanolamide on gastrointestinal serotonin in the Sprague-Dawley rat. Biochem. Pharmacol. 16, 1377–1380 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Thompson, J.W.: Studies on the responses of the isolated nictitating membrane of the cat. J. Physiol. (Lond.) 141, 46–72 (1958)

    CAS  Google Scholar 

  • Thompson, M.R.: Some properties of ergostetrine. J. Amer. Pharm. Ass. 24, 748–753 (1935)

    Article  CAS  Google Scholar 

  • Thompson, R.H.S., Tickner, A., Webster, G.R.: Cholinesterase inhibition by lysergic acid diethylamide. Biochem. J. 58, XIX–XX (1954)

    PubMed  CAS  Google Scholar 

  • Thompson, R.H.S., Tickner, A., Webster, G.R.: The action of lysergic acid diethylamide on mammalian cholinesterases. Brit. J. Pharmacol. 10, 61–65 (1955)

    PubMed  CAS  Google Scholar 

  • Thulin, A.: Motor and secretory effects of autonomic nerves and drugs in the rat submaxillary gland. Acta physiol. scand. 92, 217–223 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Thulin, A.: Influence of autonomic nerves and drugs on myoepithelial cells in parotid gland of cat. Acta physiol. scand. 93, 477–482 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Tilson, H.A., Sparber, S.B.: Studies on the concurrent behavioral and neurochemical effects of psychoactive drugs using the push-pull cannula. J. Pharmacol. exp. Ther. 181, 387–398 (1972)

    PubMed  CAS  Google Scholar 

  • Toda, N.: Influence of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated cerebral arteries. Jap. J. Pharmacol. 24 (Suppl.), 68 (1974)

    PubMed  Google Scholar 

  • Toda, N.: Analysis of the effect of 5-hydroxykynurenamine, a serotonin metabolite, on isolated cerebral arteries, aortas and atria. J. Pharmacol. exp. Ther. 193, 385–392 (1975)

    PubMed  CAS  Google Scholar 

  • Toda, N., Goldberg, L.I.: Dopamine-induced relaxation of isolated arterial strips. J. Pharm. Pharmacol. 25, 587–589 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Toda, N., Goldberg, L.I.: Effects of dopamine on isolated canine coronary arteries. Cardiovasc. Res. 9, 384–389 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Toda, N., Goldberg, L.I., Fujiwara, M.: Dopamine-induced relaxation of isolated blood vessels. Jap. J. Pharmacol. 23 (Suppl.), 45 (1973)

    Article  Google Scholar 

  • Toda, N., Tokuyama, T., Senoh, S., Hirata, F., Hayaishi, O.: Effects of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated dog basilar arteries. Proc. natl. Acad. Sci. (Wash.) 71, 122–124 (1974)

    Article  CAS  Google Scholar 

  • Toda, N., Hayashi, S., Fu, W.L.H., Nagasaka, Y.: Serotonin antagonism in isolated canine cerebral arteries. Jap. J. Pharmacol. 26, 57–63 (1976)

    Article  CAS  Google Scholar 

  • Tomosky, T.K., Bennett, J.L., Bueding, E.: Tryptaminergic and dopaminergic responses of Schistosoma mansoni. J. Pharmacol. exp. Ther. 190, 260–271 (1974)

    PubMed  CAS  Google Scholar 

  • Tonge, S.R., Leonard, B.E.: The effects of some hallucinogenic drugs upon the metabolism of 5-hydroxy-tryptamine in the brain. Life Sci. 8 (I), 805–814 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Tonge, S.R., Leonard, B.E.: The effect of some hallucinogenic drugs on the amino acid precursors of brain monoamines. Life Sci. 9 (I), 1327–1335 (1970)

    Article  CAS  Google Scholar 

  • Torre, M., Bogetto, F., Torre, E.: Effect of LSD-25 and 1-methyl-d-lysergic acid butanolamide on rat brain and platelet serotonin levels. Psychopharmacologia 36, 117–122 (1974a)

    Article  PubMed  CAS  Google Scholar 

  • Torre, M., Torre, E., Bogetto, F.: Somministrazione di etanolo a varie dosi: livelli di serotonina cerebrale nel ratto. Somministrazione contemporanea di LSD-25 e UML: Livelli di serotonina cerebrale e comportamento condizionato nel ratto. Boll. Soc. ital. Biol. sper. 50, 1639–1645 (1974b)

    PubMed  Google Scholar 

  • Tothill, A.: Investigation of adrenaline reversal in the rat uterus by the induction of resistance to isoprenaline. Brit. J. Pharmacol. 29, 291–301 (1967)

    PubMed  CAS  Google Scholar 

  • Trabucchi, M., Spano, P.F., Tonon, G.C., Frattola, L.: Effects of bromocriptine on central dopaminergic receptors. Life Sci. 19, 225–232 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Trenchard, A., Turner, P., Pare, C.M.B., Hills, M.: The effects of protryptiline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma. Psychopharmacologia 43, 89–93 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Trendelenburg, U.: The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J. Pharmacol. exp. Ther. 130, 450–460 (1960)

    PubMed  CAS  Google Scholar 

  • Türker, K., Kiran, B.K., Kaymakcalan, S.: Distribution of adrenergic receptors in the cat ileum. Arch. int. Pharmacodyn. 156, 130–142 (1965)

    PubMed  Google Scholar 

  • Türker, R.K., Khairallah, P.A.: Prostaglandin E1 action on canine isolated tracheal muscle. J. Pharm. Pharmacol. 21, 498–501 (1969)

    Article  PubMed  Google Scholar 

  • Tuomisto, J.: Inhibition of noradrenaline (NA), dopamine (DA) and 5-HT uptake in synaptosomes by reserpine, 6-hydroxy-1,2,3,4-tetrahydroharmane (6HTH), LSD and ergotamine. J. Pharmacol. (Paris) 5 (Suppl. 2), 100 (1974)

    Google Scholar 

  • Turner, P.: Some pharmacological studies on drugs used in the prophylactic treatment of migraine. In: Background to Migraine. Cumings, J.N. (ed.), pp. 170–173. London: William Heinemann Medical Books 1973

    Google Scholar 

  • Twarog, B.M.: Responses of a molluscan smooth muscle to acetylcholine and 5-hydroxytryptamine. J. cell. comp. Physiol. 44, 141–164 (1954)

    Article  CAS  Google Scholar 

  • Ungar, F., Hitri, A., Alivisatos, S.G.A.: Drug antagonism and reversibility of the binding of indole amines in brain. Europ. J. Pharmacol. 36, 115–125 (1976)

    Article  CAS  Google Scholar 

  • Urquilla, P.R., Marco, E., Lluch, S.: Pharmacological receptors of the cerebral blood vessels of the goat. Fed. Proc. 33, 568 (1974)

    Google Scholar 

  • Urquilla, P.R., Marco, E.J., Lluch, S.: Pharmacological receptors of the cerebral arteries of the goat. Blood Vessels 12, 53–67 (1975)

    PubMed  CAS  Google Scholar 

  • Uzunov, P., Weiss, B.: Psychopharmacological agents and the cyclic AMP system of rat brain. Adv. Cyclic Nucleotide Res. 1, 435–451 (1972)

    PubMed  CAS  Google Scholar 

  • Valdecasas, F.G., Calvet, F., Cuenca, E., Salva, J.A.: Die potenzierende Wirkung verschiedener psychoaktiver Substanzen auf Adrenalin und Serotonin. Arzneimittel-Forsch. 6, 594–596 (1956)

    CAS  Google Scholar 

  • Vane, J.R.: A sensitive method for the assay of 5-hydroxytryptamine. Brit. J. Pharmacol. 12, 344–349 (1957)

    PubMed  CAS  Google Scholar 

  • Vane, J.R.: The actions of sympathomimetic amines on tryptamine receptors. In: Ciba Foundation Symposium on Adrenergic Mechanisms, pp. 356–372. London: J. and A. Churchill 1960

    Google Scholar 

  • Van Rossum, J.M.: Cumulative dose-response curves. II. Technique for the making of doseresponse curves in isolated organs and the evaluation of drug parameters. Arch. int. Pharmacodyn. 143, 299–330 (1963)

    Google Scholar 

  • Van Rossum, J.M., Pijnenburg, A.J.J., Cools, A.R., Broekkamp, C.L.E., Struyker Boudier, H.A.J.: Behavioural pharmacology of the neostriatum and the limbic striatum. In: Neuropharmacology. Excerpta Medica Int. Congress Series No. 359, pp. 505–516. Amsterdam 1975

    Google Scholar 

  • Vargaftig, B.B., Lefort, J.: Pharmacological evidence for a vasodilator receptor to serotonin in the nasal vessels of the dog. Europ. J. Pharmacol. 25, 216–225 (1974)

    Article  CAS  Google Scholar 

  • Vidrio, H., Hong, E.: Vascular tone and reactivity to serotonin in the internal and external carotid vascular beds of the dog. J. Pharmacol. exp. Ther. 197, 49–56 (1976)

    PubMed  CAS  Google Scholar 

  • Vogel, G., Marek, M.L.: Über die Hemmung verschiedener Rattenpfoten-Oedeme durch Serotonin-Antagonisten. Arzneimittel-Forsch. 11, 1051–1054 (1961)

    CAS  Google Scholar 

  • Vogt, M.: Drugs interfering with central actions of 5-hydroxytryptamine. In: Ciba Foundation Symposium on Hypertension, pp. 209–213. London: J. and A. Churchill 1954

    Google Scholar 

  • Vogt, M., Gunn, C.G., Sawyer, Ch.: Electroencephalographic effects of intraventricular 5-HT and LSD in the cat. Neurology (Minneap.) 7, 559–566 (1957)

    CAS  Google Scholar 

  • Von Hungen, K., Roberts, S., Hill, D.F.: Serotonin and catecholamine activation of brain adenylate cyclase: Effects of psychoactive drugs. Trans. Amer. Soc. Neurochem. 5, 150 (1974a)

    Google Scholar 

  • Von Hungen, K., Roberts, S., Hill, D.F.: LSD as an antagonist at central dopamine receptors. Nature (Lond.) 252, 588–589 (1974b)

    Article  Google Scholar 

  • Von Hungen, K., Roberts, S., Hill, D.F.: Serotonin-sensitive adenylate cyclase activity in immature rat brain. Brain Res. 84, 257–267 (1975)

    Article  Google Scholar 

  • Votava, Z., Lamplová, I.: Antiserotonin effect of derivatives of d-lysergic acid (cycloalkylamides, LSD, ergometrine) and chlorpromazine in rats. Activ. nerv. sup. (Praha) 1, 269–275 (1959)

    CAS  Google Scholar 

  • Votava, Z., Podvalová, I., Semonský, M.: Oxytocic effect of some d-lysergic acid cycloalkylamides. Nature (Lond.) 179, 474–475 (1957)

    Article  CAS  Google Scholar 

  • Votava, Z., Podvalová, I., Semonský, M.: Studies on the pharmacology of d-lysergic acid cycloalkylamides. Arch. int. Pharmacodyn. 115, 114–130 (1958)

    PubMed  CAS  Google Scholar 

  • Walker, R.J., Woodruff, G.N., Glaizner, B., Sedden, C.B., Kerkut, G.A.: The pharmacology of Helix dopamine receptor of specific neurones in the snail, Helix aspersa. Comp. Biochem. Physiol. 24, 455–469 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Walsh, J.A.: Antagonism by methysergide of vascular effects of 5-hydroxytryptamine in man. Brit. J. Pharmacol. 30, 518–530 (1967)

    PubMed  CAS  Google Scholar 

  • Walters, J.R., Roth, R.H., Aghajanian, G.K.: Dopaminergic neurons, similar biochemical and histochemical effects of γ-hydroxybutyrate and acute lesions of the nigro-striatal pathway. J. Pharmacol. exp. Ther. 186, 630–639 (1973)

    PubMed  CAS  Google Scholar 

  • Watson, P.J.: Drug receptor sites in the isolated superior cervical ganglion of the rat. Europ. J. Pharmacol. 12, 183–193 (1970)

    Article  CAS  Google Scholar 

  • Weber, H.P., Petcher, T.J.: unpublished observations 1976

    Google Scholar 

  • Weidmann, H.: Die Wirkung von D-Lysergsäure-diäthylamid und 5-Hydroxytryptamin auf spinale Reflexe. Helv. physiol. pharmacol. Acta 15, C43–C44 (1957)

    CAS  Google Scholar 

  • Weidmann, H., Cerletti, A.: Die Wirkung von D-Lysergsäurediäthylamid und 5-Hydroxytryptamin (Serotonin) auf spinale Reflexe der Katze. Helv. physiol. pharmacol. Acta 15, 376–383 (1957)

    PubMed  CAS  Google Scholar 

  • Weidmann, H., Taeschler, M.: Influence des substances antimigraineuses sur les effets des catécholamines, de la sérotonine et de la stimulation des nerfs sympathiques. Extrait du Symposium International sur les Céphalées vasculaires, pp. 33–40. St-Germain-en-Laye 1966

    Google Scholar 

  • Weiss, B.L., Aghajanian, G.K.: Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons. Brain Res. 26, 37–48 (1971)

    Article  CAS  Google Scholar 

  • Wellens, D., Szigetvari, E., Wauters, E.: Reflex vasodilation, ergotamine and uptake of circulating norepinephrine. Arch. int. Pharmacodyn. 183, 412–415 (1970)

    PubMed  CAS  Google Scholar 

  • Welsh, J.H.: Excitation of the heart of Venus mercenaria. Naunyn-Schmiedebergs Arch. Pharmacol. 219, 23–29 (1953)

    CAS  Google Scholar 

  • Welsh, J.H.: Hydroxytryptamine: A neurohormone in the invertebrates. Fed. Proc. 13, 162–163 (1954a)

    Google Scholar 

  • Welsh, J.H.: Marine invertebrate preparations useful in the bioassay of acetylcholine and 5-hydroxytryptamine. Nature (Lond.) 173, 955–956 (1954b)

    Article  CAS  Google Scholar 

  • Welsh, J.H.: Neurohormones. In: The Hormones. Pincus, G., Thimann, K.V. (eds.), Chap. 3. New York: Academic Press 1955

    Google Scholar 

  • Welsh, J.H.: Neurohormones of invertebrates. 1. Cardioregulators of Cyprina and Buccinum. J. Marine Biol. Assoc. United Kingdom 35, 193–201 (1956)

    Article  CAS  Google Scholar 

  • Welsh, J.H.: Serotonin as a possible neurohumoral agent: Evidence obtained in lower animals. Ann. N.Y. Acad. Sci. 66, 618–630 (1957)

    Article  PubMed  CAS  Google Scholar 

  • Welsh, J.H., McCoy, A.C.: Actions of d-lysergic acid diethylamide and its 2-bromo derivative on heart of Venus mercenaria. Science 125, 348 (1957I)

    Article  PubMed  CAS  Google Scholar 

  • Wennmalm, Å.: Quantitative evaluation of release and reuptake of adrenergic transmitter in the rabbit heart. Acta physiol. scand. 82, 532–538 (1971a)

    Article  PubMed  CAS  Google Scholar 

  • Wennmalm, Å.: Studies on mechanisms controlling the secretion of neurotransmitters in the rabbit heart. Acta physiol. scand. (Suppl.) 365, 1–36 (1971b)

    CAS  Google Scholar 

  • Wenzel, D.G., Su, J.L.: Interactions of nicotine and tyramine with adrenergic blocking agents on ventricle strips. Arch. int. Pharmacodyn. 162, 180–185 (1966a)

    PubMed  CAS  Google Scholar 

  • Wenzel, D.G., Su, J.L.: Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip. Arch. int. Pharmacodyn. 160, 379–389 (1966b)

    PubMed  CAS  Google Scholar 

  • West, G.B.: 5-Hydroxytryptamine, tissue mast cells and skin oedema. Int. Arch. Allergy 10, 257–275 (1957)

    Article  PubMed  CAS  Google Scholar 

  • White, R.P., Denton, I.C., Robertson, J.T.: Differential effects of prostaglandins A1, E1 and F on cerebrovascular tone in dogs and rhesus monkeys. Fed. Proc. 30, 625 (1971a)

    Google Scholar 

  • White, R.P., Heaton, J.A., Denton, I.C.: Pharmacological comparison of prostaglandin F, serotonin and norepinephrine on cerebrovascular tone of monkey. Europ. J. Pharmacol. 15, 300–309 (1971b)

    Article  CAS  Google Scholar 

  • Whitney, B.: A preliminary investigation of the pharmacology of longitudinal muscle strips from human isolated jejunum. J. Pharm. Pharmacol. 17, 465–473 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Wilhelmi, G.: Ueber die ulcerogene Wirkung von 5-Hydroxytryptamin am Rattenmagen und deren Beeinflussung durch verschiedene Pharmaka. Helv. physiol. pharmacol. Acta 15, C83–C84 (1957)

    CAS  Google Scholar 

  • Wilhelmi, G., Schindler, W.: Über die gastrotrope Wirkung von 5-Hydroxytryptamin (HTA), seiner Vorstufen und der entsprechenden Isomeren bei der Ratte. Naunyn-Schmiedebergs Arch. Pharmacol. 236, 49–51 (1959)

    CAS  Google Scholar 

  • Williams, L.T., Lefkowitz, R.J.: Alpha-adrenergic receptor identification by [3H]dihydroergocryptine binding. Science 192, 791–793 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Wiqvist, N.: Immediate and prolonged effects of relaxin on the spontaneous activity of the mouse and rat uterus. Acta endocr. (Kbh.) 32 (Suppl. 46), 3–32 (1959)

    Google Scholar 

  • Wise, C.D., Ruelius, H.W.: The binding of serotonin in brain: A study in vitro of the influence of physicochemical factors and drugs. Biochem. Pharmacol. 17, 617–631 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Woodruff, G.N., Agar, J., Albani, M.J., Allen, K.A., Folkard, J.: Observations on some actions of ergometrine, noradrenaline and dopamine on the guinea-pig vas deferens and on the rabbit jejunum. J. Pharm. Pharmacol. 21, 860–861 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Woodruff, G.N., Walker, R.J.: The effect of dopamine and other compounds on the activity of neurones of Helix aspersa. Structure-activity relationships. Int. J. Neuropharmacol. 8, 279–289 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Woodruff, G.N., Walker, J.R., Kerkut, G.A.: Actions of ergometrine on catecholamine receptors in the guinea-pig vas deferens and in the snail brain. Comp. gen. Pharmacol. 1, 54–60 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Woodruff, G.N., Walker, R.J., Kerkut, G.A.: Antagonism by derivatives of lysergic acid of the effect of dopamine on Helix neurones. Europ. J. Pharmacol. 14, 77–80 (1971)

    Article  CAS  Google Scholar 

  • Woolley, D.W., Shaw, E.: Yohimbine and ergotoxin as naturally occurring antimetabolites of serotonin. Fed. Proc. 12, 293 (1953)

    Google Scholar 

  • Woolley, D.W., Shaw, E.: A biochemical and pharmacological suggestion about certain mental disorders. Science 119, 587 (1954a)

    Google Scholar 

  • Woolley, D.W., Shaw, E.: Some neurophysiological aspects of serotonin. Brit. med. J. 2, 122–126 (1954b)

    Article  PubMed  CAS  Google Scholar 

  • Wright, A.M., Moorehead, M., Welsh, J.H.: Actions of derivatives of lysergic acid on the heart of Venus mercenaria. Brit. J. Pharmacol. 18, 440–450 (1962)

    PubMed  CAS  Google Scholar 

  • Wurzel, M.: Serotonin receptor in rabbit artery. Amer. J. Physiol. 211, 1424–1428 (1966)

    PubMed  CAS  Google Scholar 

  • Yamaguchi, T.: Effects of 5-hydroxytryptamine on isolated strips of the guinea-pig stomach. Brit. J. Pharmacol. 44, 100–108 (1972)

    CAS  Google Scholar 

  • York, D.H.: Dopamine receptor blockade — a central action of chlorpromazine on striatal neurones. Brain Res. 37, 91–100 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Zakusov, V.V.: Principles of pharmacological influence on coronary chemoreflexes. Arch. int. Pharmacodyn. 140, 646–654 (1962)

    PubMed  CAS  Google Scholar 

  • Zarolinski, J.F., Browne, R.K.: Effects of dopamine on canine renal artery. Pharmacologist 13, 22 (1971)

    Google Scholar 

  • Zatz, M., Roth, R.H.: Electroconvulsive shock raises prostaglandins F in rat cerebral cortex. Biochem. Pharmacol. 24, 2101–2103 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Zhabin, Y.M., Urazaeva, Z.V.: Influence of intravenous administration to pregnant rabbits of the diethylamide of lysergic acid on the content of serotonin, histamine and acetyl choline in mothers and young. Farmakol.i Toksikol. 38, 93–95 (1975)

    CAS  Google Scholar 

  • Ziegler, M.G., Lovell, R.A., Freedman, D.X.: Effects of lysergic acid diethylamide on the uptake and retention of brain 5-hydroxytryptamine in vivo and in vitro. Biochem. Pharmacol. 22, 2183–2193 (1973)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Müller-Schweinitzer, E., Weidmann, H. (1978). Basic Pharmacological Properties. In: Berde, B., Schild, H.O. (eds) Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66775-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66775-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66777-0

  • Online ISBN: 978-3-642-66775-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics