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Heme and Hemoproteins pp 255–271Cite as

The Influence of Hormonal and Nutritional Factors on the Regulation of Liver Heme Biosynthesis

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Abstract

The liver plays a major role in maintaining the chemical homeostasis of the organism. It does this by a variety of mechanisms. Some compounds of both endogenous and exogenous origin are chemically modified for eventual excretion in the urine and others are excreted into the gut before or after modification by the liver. In addition to its excretory functions the liver also serves as a sort of “chemical valve” between materials ingested from the environment and the “internal milieu.” In this capacity it handles the standard components of the diet, adjusting their composition to the needs of the body as well as modifying other foreign compounds for excretion. Some of the reactions involved in these processes are catalyzed by heme-containing enzymes. Since the demands for these reactions vary with changing conditions of diet, drug intake, and hormonal changes, it would seem that the most efficient way for the liver to adjust to these changing needs would be through the development of control mechanisms which can appropriately alter the activities of the enzymes involved. Such changes in carbohydrate-metabolizing enzymes have been studied extensively and for the most part the changes fit rather nicely into a logical or readily understood pattern. The heme biosynthetic pathway would also be expected to respond to various demands, which it clearly does. The changes, however, do not always fit into simple logical patterns, as will be shown by the subsequent discussion, which will be mainly restricted to the effect of hormonal and nutritional factors in the liver.

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Tschudy, D.P. (1978). The Influence of Hormonal and Nutritional Factors on the Regulation of Liver Heme Biosynthesis. In: De Matteis, F., Aldridge, W.N. (eds) Heme and Hemoproteins. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66763-3_9

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