Hepatic Porphyrias

Caused by 2-Allyl-2-isopropylacetamide, 3,5-Diethoxycarbonyl-1,4-dihydrocollidine, Griseofulvin and Related Compounds
  • F. De Matteis
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 44)

Abstract

The liver is an important site of synthesis of heme, which is then utilized as the prosthetic groups for the various hepatic cytochromes and hemoproteins (see chapter by Tait for a detailed coverage of these aspects). Under normal conditions the intermediates of the pathway (the porphyrins and their precursors 5-aminolevulinate and porphobilinogen) accumulate or are excreted only in very small amounts. This indicates clearly that the biosynthetic pathway is very efficiently regulated to provide the amount of heme required for the turnover of the various hemoproteins of the liver cell with little waste of the intermediates. There are conditions, however, in which the control mechanism breaks down and far more porphyrin and earlier precursors are synthesized than are turned into heme, so that they accumulate and are excreted in excess. These conditions are known as porphyrias. The hepatic porphyrias, where the liver is the site of the metabolic abnormality, should therefore be regarded as disorders of the regulation of liver heme biosynthesis.

Keywords

Cobalt Bilirubin Allyl Phenobarbital Acetamide 

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References

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  • F. De Matteis

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