Abstract
It was first noted by Schweitzer and Wright that acetylcholine (ACh) might be involved in carotid body chemoreception, but it was Eyzaguirre and co-workers (4) who later studied this problem systematically and concluded that ACh might be a sensory transmitter released from the glomus (type I) cells to excite neighboring afferent nerve terminals. However, ACh has never been chemically identified in carotid body tissue, although bioassays have suggested the presence of an ACh-like substance in carotid body extracts (5,8). Furthermore, Osborne and Butler (9), proceeding from Biscoe’s (1) suggestion that the synapses on the glomus cells are efferent, not afferent, have recently proposed that ACh is the transmitter at this junction and that consequently this substance is contained in the nerve terminals, not in the glomus cells.
This work was supported by U.S. Public Health Service grants NS-12636, NS-05666, NS-07938, and MH-25168.
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References
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Fidone, S., Weintraub, S., Stavinoha, W., Stirling, C., Jones, L. (1977). Endogenous Acetylcholine Levels in Cat Carotid Body and the Autoradiographic Localization of a High Affinity Component of Choline Uptake. In: Acker, H., Fidone, S., Pallot, D., Eyzaguirre, C., Lübbers, D.W., Torrance, R.W. (eds) Chemoreception in the Carotid Body. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66755-8_16
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