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General Pharmacology of Amphetamine-Like Drugs

  • E. Änggård
  • T. Lewander
  • L.-M. Gunne
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 45 / 2)

Abstract

Amphetamine and related central stimulant drugs are derivatives of β-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general β-phenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itself has central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the α-methyl group, much less affinity for MAO and therefore has a longer half-life.

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