Coronary Atherosclerosis and Ischemic Heart Disease

  • R. W. Wissler

Abstract

The concepts that are most important in understanding the progression and regression of clinically significant coronary atherosclerosis and the ways in which this disease process produces its most common -clinical effects have been changing rapidly.

Keywords

Permeability Estrogen Serotonin Carbon Monoxide Angiotensin 

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References

  1. 1.
    ARMSTRONG, M.L., MEGAN, M.B.: Lipid depletion in atheromatous coronary arteries in Rhesus monkeys after regression diets. Circulat Res. 30, 675–680 (1972).PubMedGoogle Scholar
  2. 2.
    ARMSTRONG, M.L., MEGAN, M.B.: Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. Circulat Res. 36, 256–261 (1975).PubMedGoogle Scholar
  3. 3.
    ARMSTRONG, M.L., WARNER, E.D., CONNOR, W.E.: Regression of coronary atheromatosis in Rhesus monkeys, Circulat Res. 27, 59–67 (1970).PubMedGoogle Scholar
  4. 4.
    BASHE, W.J., BABA, N., KELLER, M.D., GEER, J.C., ANTHONY, J.R.: Pathology of atherosclerotic heart disease in sudden death. II. The significance of myocardial infarction. Circulation 52, Suppl. III, 63 (1975).Google Scholar
  5. 5.
    BATES, S.R.: Effect of hyperlipemic serum on cholesterol accumulation in monkey aortic medial cells. Fed. Proc. 35, 7abs (1976).Google Scholar
  6. 6.
    BATES, S.R., WISSLER, R.W.: Effect of hyperlipemic serum on cholesterol accumulation in monkey aortic medial cells. Biochim. Biophys. Acta 450, 78–88, (1976).PubMedGoogle Scholar
  7. 7.
    BENDITT, E.P., BENDITT, J.M.: Evidence for a monoclonal origin of human atherosclerotic plaques. Proc. Nat. Acad. Sci. (Wash.) 70, 1753–1756 (1973).CrossRefGoogle Scholar
  8. 8.
    BERENSON, G.S., Srinivasan, S.R., Radhakrishnamurthy, B., Dalferes, E.R. Jr.: Mucopolysaccharide-lipoprotein complexes in atherosclerotic aorta. In; Arterial Mesenchyme and Arteriosclerosis (W.D. WAGNER, T.B. CLARKSON, Eds.), pp, 141–159. New York: Plenum Press 1974.Google Scholar
  9. 9.
    BJORKERUD, S., BONDJERS, G.: Arterial repair and atherosclerosis after mechanical injury. II, Tissue response after induction of a total local necrosis (deep longitudinal injury). Atherosclerosis 14, 259–276 (1971).PubMedCrossRefGoogle Scholar
  10. 10.
    BJORKERUD, S., BONDJERS, G.: Arterial repair and atherosclerosis after mechanical injury. V. Tissue response after induction of a large superficial transverse injury. Atherosclerosis 18, 235–255 (1973).PubMedCrossRefGoogle Scholar
  11. 11.
    BLANKENHORN, D.H.: Studies of regression/progression of atherosclerosis in man. In: Proceedings of the International Workshop Conference on Atherosclerosis, London, Ontario 1975Google Scholar
  12. 12.
    BOND, M.G., BULLOCK, B.C., CLARKSON, T.B., LEHNER, N.D.M.: The effect of plasma cholesterol concentrations on “regression” of primate atherosclerosis. Am, J. Pathol. 82, 89abs (1976).Google Scholar
  13. 13.
    BONDJERS, G., BJORKERUD, S,: Arterial repair and atherosclerosis after mechanical injury. IV. Uptake and composition of cholesteryl ester in morphologically defined regions of atherosclerotic lesions. Atherosclerosis 15, 273–284 (1972).PubMedCrossRefGoogle Scholar
  14. 14.
    BROWN, M.S., GOLDSTEIN, J.L.: Receptor-mediated control of cholesterol metabolism. Science 191, 150–154 (1976).PubMedCrossRefGoogle Scholar
  15. 15.
    BUCHWALD, H., MOORE, R.B., VARCO, R.L.: The partial ileal by-pass operation in treatment of hyperlipemias. In: Lipids, Lipoproteins and Drugs (D. KRITCHEVSKY, R. PAOLETTI, W. HOLMES, Eds.) pp. 221–230. New York: Plenum Press 1975.Google Scholar
  16. 16.
    CHANDLER, A.B.: Coronary thrombosis in myocardial infarction (Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction). Am. J. Cardiol. 34, 823 (1974).PubMedCrossRefGoogle Scholar
  17. 17.
    CHEN, R.: Effects of hyperlipemic rabbit serum and its lipoproteins on proliferation and lipid metabolism of rabbit aortic medial cells in vitro. Ph. D. Thesis, University of Chicago (1973).Google Scholar
  18. 18.
    CHEN, R., DZOGA, K., BORENSZTAJN, J., WISSLER, R.W.: Effect of hyperlipemic lipoproteins on the lipid accumulation of rabbit aortic medial cells in vitro. Circulation 46, Suppl. II, 253 (1972).Google Scholar
  19. 19.
    CHEN, R.M., Fischer-Dzoga, K., Wissler, R.W.: Influence of lysosomal enzyme stability in hyperlipemic serum-induced metabolic changes of monkey aortic medial cells. Accepted for presentation at the IVthe International Symposium on Atherosclerosis, Tokyo, Japan, 1976.Google Scholar
  20. 20.
    CHEN, R.M., GETZ, G.S., FISCHER-DZOGA, K., WISSLER, R.W.: Effects of hyperlipemic serum on proliferation and detachment rate of rabbit aortic medial cells. Fed. Proc. 33, 623abs (1974).Google Scholar
  21. 21.
    COBB, L.A., BAUM, R.S., ALVAREZ, H., SCHAFFER, W.A.: Resuscitation from out-of-hospital ventricular fibrillation: 4 years follow up. Circulation 52, Suppl. III, 223 (1975).Google Scholar
  22. 22.
    DAOUD, A.S., JARMOLYCH, J., FRITZ, K., AUGUSTYN, J.: Regression of advanced atherosclerosis in swine. Circulation 50, Suppl. III, 92 (1975).Google Scholar
  23. 23.
    DZOGA, K., VESSELINOVITCH, D., FRASER, R., WISSLER, R.W.: The effect of lipoproteins on the growth of aortic smooth muscle cells in vitro. Am. J. Path. 62. 32a, (1971).Google Scholar
  24. 24.
    FISCHER-DZOGA, K., CHEN, R., WISSLER, R.W.: Effects of serum lipoproteins on the morphology, growth and metabolism of arterial smooth muscle cells. In: Arterial Mesenchyme and Arteriosclerosis (W.D. WAGNER, T.B. CLARKSON, Eds.), p. 299. New York: Plenum Press 1974.Google Scholar
  25. 25.
    FISCHER-DZOGA, K., JONES, R.M., VESSELINOVITCH, D., WISSLER, R.W.: Ultrastructural and immunohistochemical studies of primary cultures of aortic medial cells. Exp. Mol. Path. 18, 162–176 (1973).CrossRefGoogle Scholar
  26. 26.
    FISCHER-DZOGA, K., JONES, R.M., VESSELINOVITCH, D., WISSLER, R.W.: Increased mitotic activity in primary cultures of aortic medial smooth muscle cells after exposure to hyperlipemic serum. In: Atherosclerosis (Proceedings of the Third International Symposium) (G. Schettler, A. Weizel, Eds.), vol. III, p. 193. Berlin-Heidelberg-New York: Springer 1974.Google Scholar
  27. 27.
    FISCHER-DZOGA, K., VESSELINOVITCH, D., WISSLER, R.W.: The effect of estrogen on the rabbit aortic medial tissue culture cells. Am. J. Path. 74, 52a (1974).Google Scholar
  28. 28.
    FISCHER-DZOGA, K., WISSLER, R.W.: Stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. II. Effect of varying concentrations of hyperlipemic serum and low density lipoproteins of varying dietary fat origins. Atherosclerosis 24, 515–525 (1976).PubMedCrossRefGoogle Scholar
  29. 29.
    FISCHER-DZOGA, K., WISSLER, R.W., SCANU, A.M.: Increased cell proliferation of aortic smooth muscle induced by varying degress of hyperlipemia and by lipoprotein fractions. Circulation 50, Suppl. III, 263 (1975).Google Scholar
  30. 30.
    FISCHER-DZOGA, K., WISSLER, R.W., SCANU, A.M.: The lipoproteins and arterial smooth muscle cells: Cellular proliferation and morphology. In: Proceedings of the International Workshop Conference of Atherosclerosis, London, OntarioGoogle Scholar
  31. 31.
    FISHMAN, J.A., RYAN, G.B., KARNOVSKY, M.J.: Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening. Lab. Invest. 32, 339–351 (1975).PubMedGoogle Scholar
  32. 32.
    GEER, J.C., HAUST, M.D.: Smooth muscle cells in atherosclerosis. In: Monographs on Atherosclerosis, vol. 2. Basel: Karger 1972.Google Scholar
  33. 33.
    GEER, J.C., MCGILL, H.C. Jr., STRONG, J.P.: Fine structure of human atherosclerotic lesions. Am. J. Path. 38, 263–287 (1961).PubMedGoogle Scholar
  34. 34.
    GERO, S., GERGELY, J., JAKAB, L., SZEKELY, J., VIRAG, S.: Comparative immunoelectrophoretic studies on homogenates of aorta, pulmonary arteries and inferior venacava of atherosclerotic individuals. J. Atheroscl. Res. 1, 88–91 (1961).CrossRefGoogle Scholar
  35. 35.
    GETZ, G.S., VESSELINOVITCH, D., WISSLER, R.W.: A dynamic pathology of atherosclerosis. Am. J. Med. 46, 657–673 (1969).CrossRefGoogle Scholar
  36. 36.
    GLAGOV, S., TS’AO, C.H.: Restitution of aortic wall after sustained necrotizing transmural ligation injury: Role of blood cells and artery cells. Am. J. Path. 79, 7–30 (1975).PubMedGoogle Scholar
  37. 37.
    GOLDFISCHER, S., DALY, M.M., KASAK, L.E., COLTOFF-SCHILLER, B.: Arterial lysosomes and connective tissue in primate atherosclerosis and hypertension. Circulat Res. 36, 553–564 (1975).PubMedGoogle Scholar
  38. 38.
    GOLDSTEIN, J.L.: Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proc. Nat. Acad. Sci. (Wash.) 71, 788–792 (1974).CrossRefGoogle Scholar
  39. 39.
    HAEREM, J.W.: Platelet aggregates in intramyocardial vessels of patients dying suddenly and unexpectedly of coronary artery disease. Atherosclerosis 15, 199–213 (1972).PubMedCrossRefGoogle Scholar
  40. 40.
    HANIG, M., SHAINOFF, J.R., LOWRY, A.D. Jr.: Flotational lipoproteins extracted from human atherosclerotic aortas. Science 124, 176–178 (1956).PubMedCrossRefGoogle Scholar
  41. 41.
    HARKER, L.A., ROSS, R., SLICHTER, S.J., SCOTT, C.R.: Homocystine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis. J. Clin. Invest.Google Scholar
  42. 42.
    HARKER, L., SLICHTER, S.J., SCOTT, C.R., ROSS, R.: Homocysti-nemia: Vascular injury and arterial thrombosis. New Engl. J. Med. 291, 537–543 (1974).PubMedCrossRefGoogle Scholar
  43. 43.
    HAUST, M.D., MORE, R.H., MOVAT, H.Z.: The role of the smooth muscle cell in the fibrogenesis of atherosclerosis. Am. J. Pathol. 37, 377–389 (1960).PubMedGoogle Scholar
  44. 44.
    HOFF, H.F., LIE, J.T., TITUS, J.L., BAYARDO, R.J., JACKSON, R.L., DEBAKEY, M.E., GOTTO, A.M.: Lipoproteins in atherosclerotic lesions: Localization by immunofluorescence of apo-low-density lipoproteins in human atherosclerotic arteries from normal and hyperlipoproteinemics. Arch. Path. 99, 253–258 (1975).PubMedGoogle Scholar
  45. 45.
    HOLLANDER, W., KRAMSCH, D.M., INOUNE, G.: The metabolism of cholesterol, lipoproteins and acid mucopolysaccharides in normal and atherosclerotic vessels. In: Progress in Biochemical Pharmacology (C.J. MIRAS, A.N. HOWARD, R. PAOLETTI, Eds.), vol. IV, P. 270. Basel: Karger 1968.Google Scholar
  46. 46.
    IVERIUS, P.H.: The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. J. Biol. Chem. 247, 2607–2613 (1972).PubMedGoogle Scholar
  47. 47.
    JØRGENSEN, L., HAEREM, J.W., CHANDLER, A.B., BORCHGREVINK, C.F.: The pathology of acute coronary death. Acta anaesth. scand., Suppl. 29, 193 (1968).CrossRefGoogle Scholar
  48. 48.
    KAO, V.C.Y., WISSLER, R.W.: A study of the immunohistochemi-cal localization of serum lipoproteins and other plasma proteins in human atherosclerotic lesions. Exp. Mol. Path. 4, 465–479 (1965).CrossRefGoogle Scholar
  49. 49.
    KAO, V.C.Y., WISSLER, R.W., DZOGA, K.: The influence of hyperlipemic serum on the growth of medial smooth muscle cells on Rhesus monkey aorta in vitro. Circulation 38, Suppl. 12 (1968).Google Scholar
  50. 50.
    KNIERIEM, H.J., KAO, V.C.Y., Wissler, R.W.: Actomyosin and myosin and the deposition of lipids and serum lipoproteins. Arch. Path. 84, 118–129 (1967).PubMedGoogle Scholar
  51. 51.
    MCGILL, H.C., GEER, J.C.: The human lesion, fine structure. In: Evolution of the Atherosclerotic Plaque (R.J. JONES, Ed.), p. 65. Chicago: University of Chicago Press 1963.Google Scholar
  52. 52.
    MEADOWS, R.: Coronary thrombosis and myocardial infarction. Med. J. Aug. 2, 409–411 (1965).Google Scholar
  53. 53.
    MOORE, S., FRIEDMAN, R.J., SINGAL, D.P., GAULDIE, J., BLAJCH-MAN, M.: Inhibition of injury induced thromboatherosclerotic lesions by antiplatelet serum in rabbits. Thromb. Diathes. Haemorrh.Google Scholar
  54. 54.
    PEARSON, T.A., WANG, A., SOLEZ, K., HEPTINSTALL, R.H.: Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Am. J. Path. 81, 379–388 (1975).PubMedGoogle Scholar
  55. 55.
    PETERS, T.J., TAKANO, T., DEDUVE, C.: Subcellular fractionation studies on the cell isolated from normal and atherosclerotic aorta. In: Atherogenesis: Initiating Factors (Ciba Found. Symp. 12), p. 197. Amsterdam: Elsevier 1973.Google Scholar
  56. 56.
    REICHENBACH, D.D., MOSS, N.S.: Myocardial cell necrosis and sudden death in humans. Circulation 52, Suppl. IV, 60 (1975).Google Scholar
  57. 57.
    ROBERTS, W.C.: Coronary artery pathology in fatal ischemic heart disease. In: The Myocardium: Failure and Infaction (E. Braunwald, Ed.), p. 192. New York: H.P. Publ. Co. 1974.Google Scholar
  58. 58.
    ROBERTS, W.C., BUJA, L.M.: The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction. Am. J. Med. 52, 425–443 (1972).PubMedCrossRefGoogle Scholar
  59. 59.
    ROBERTSON, A.L.: Role of circulating lipoproteins in the proliferative phase of atherogenesis. Am. J. Path. 74, 94a (1974).Google Scholar
  60. 60.
    ROBERTSON, A.L.: Functional characterization of arterial cells involved in spontaneous atheroma. In: Atherosclerosis (Proceedings of the Third International Symposium), vol. III. p. 175. Berlin-Heidelberg-New York: Springer 1974.Google Scholar
  61. 61.
    ROSS, R.: The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J. Cell Biol. 50, 172–186 (1971).PubMedCrossRefGoogle Scholar
  62. 62.
    ROSS, R., GLOMSET, J.: Atherosclerosis and the arterial smooth muscle cell. Science 180, 1332–1339 (1973).PubMedCrossRefGoogle Scholar
  63. 63.
    ROSS, R., GLOMSET, J.: Studies of primate arterial smooth muscle cells in relation to atherosclerosis. In: Arterial Mesenchyme and Arteriosclerosis (W.D. WAGNER, T.B. CLARKSON, Eds.) p. 265. New York: Plenum Press 1974.Google Scholar
  64. 64.
    ROSS, R., GLOMSET, J., KARIYA, B., HARKER, L.: A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Nat. Acad. Sci. (Wash.) 71, 1207–1210 (1974).CrossRefGoogle Scholar
  65. 65.
    ROSS, R., BARKER, L.B.: Experimental artheriosclerosis. II. The effect of mechanical injury and sustained hypercholesterolemia. New Engl. J. Med.Google Scholar
  66. 66.
    ROSS, R., KLEBANOFF, S.J.: The smooth muscle cell. I. In vivo synthesis of connective tissue proteins. J. Cell. Biol. 50, 159–171 (1971).PubMedCrossRefGoogle Scholar
  67. 67.
    ROTHBLAT, G.H.: Cellular sterol metabolism. In: Growth, Nutrition and Metabolism of Cells in Culture (G.H. ROTHBLAT, V. CRISTOFALO, Eds.), p. 297. New York: Academic Press 1973.Google Scholar
  68. 68.
    SCHWARTZ, C.J., GERRITY, R.G.: Anatomical pathology of sudden unexpected cardiac death. Circulation 52, Suppl. III, 18 (1975).Google Scholar
  69. 69.
    SCOTT, P.J., HURLEY, P.J.: The distribution of radioiodinated serum albumin and low-density lipoproteins in tissues and the arterial wall. Atherosclerosis 11, 77–103 (1970).PubMedCrossRefGoogle Scholar
  70. 70.
    SMITH, E.B., SLATER, R.J.: Lipids and low density lipoproteins in intima in relation to its morphological characteristics. In: Atherogenesis: Initiating Factors (Ciba Found. Symp. 12), p. 40. Amsterdam: Elsevier 1973.Google Scholar
  71. 71.
    SMITH, E.B., SLATER, R.S., CROTHERS, D.C.: Quantitative interrelationships between plasma constituents and normal and atherosclerotic human intimai tissue. In: Atherosclerosis (Proceedings of the Third International Symposium) (G. SCHETTLER, A. WEIZEL, Eds.), vol. III, p. 96. Berlin-Heidelberg-New York: Springer 1974.Google Scholar
  72. 72.
    SPAIN, D.M., BRADESS, V.A.: Sudden death from coronary heart disease. Survival time, frequency of thrombi and cigarette smoking. Dis. Chest. 58, 107–110 (1970).CrossRefGoogle Scholar
  73. 73.
    STARY, H.C.: Giant membrane complexes in the foam cells of regressing atherosclerotic lesions. Am. J. Path. 82, 92abs (1976).Google Scholar
  74. 74.
    ST. CLAIR, R.W., LOFLAND, H.B. Jr., PRICHARD, R.W., CLARKSON, T.B.: Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. Exp. Mol. Path. 8, 201–215 (1968).CrossRefGoogle Scholar
  75. 75.
    TRACY, R.E., DZOGA, K., WISSLER, R.W.: Sequestration of serum low-density lipoproteins in the arterial intima by complex formation. Proc. Soc. Exp. Biol. Med. 118, 1095–1098 (1965).PubMedGoogle Scholar
  76. 76.
    TRACY, R.E., MERCHANT, E.B., KAO, V.: On the antigenic identity of human serum beta and alpha-2 lipoproteins and their identification in aortic intima. Circulat Res. 9, 472–478 (1961).PubMedGoogle Scholar
  77. 77.
    VESSELINOVITCH, D., HUGHES, R., FRAZIER, L., WISSLER, R.W.: Studies of the reversal of advanced atherosclerosis in the Rhesus monkey. Am. J. Path. 70, 41a (1973).Google Scholar
  78. 78.
    VESSELINOVITCH, D., WISSLER, R.W., HUGHES, R., BORENSZTAJN, J.: Reversal of advanced atherosclerosis in Rhesus monkeys. I. Gross and light-microscopic studies. Atherosclerosis 23, 155–176 (1976).CrossRefGoogle Scholar
  79. 79.
    WALTON, K.W., WILLIAMSON, N.: Histological and immunofluores-cent studies on the evolution of the human atheromatous plaque. J. Atheroscl. Res. 8, 599–624 (1968).CrossRefGoogle Scholar
  80. 80.
    WATTS, H.F.: Role of lipoproteins in the formation of atherosclerotic lesions. In: Evolution of the Atherosclerotic Plaque (R. JONES, Ed.), p. 117. Chicago: University of Chicago Press 1963.Google Scholar
  81. 81.
    WISSLER, R.W.: The arterial medial cell, smooth muscle or multifunctional mesenchyme? J. Atheroscl. Res. 8, 201–213 (1968).CrossRefGoogle Scholar
  82. 82.
    WISSLER, R.W.: The development of the atherosclerotic plaque. In: The Myocardium: Failure and Infarction (E. BRAUNWALD, Ed.), p. 155. New York: H.P. Publ. Co. 1974.Google Scholar
  83. 83.
    WISSLER, R.W.: Atherosclerosis — Its pathogenesis in perspective. In: Comparative Pathology of the Heart (Advances in Cardiology, 13), p. 10. Basel: Karger 1974.Google Scholar
  84. 84.
    WISSLER, R.W.: Current concepts of coronary thrombosis as related to atherosclerosis and myocardial infarction. In: Proceedings of the International Workshop Conference on Atherosclerosis, London, Ontario: 1975Google Scholar
  85. 85.
    WISSLER, R.W., Vesselinovitch, D.: Evidence for prevention and regression of advanced atherosclerosis in man and experimental animals at the arterial lesion level. In: Atherosclerosis (Proceedings of the Third International Symposium) (G. SCHETTLER, A. WEIZEL, Eds.), vol III, p. 747–750. Berlin-Heidelberg-New York: Springer 1974.Google Scholar
  86. 86.
    WISSLER, R.W., Vesselinovitch, D.: Regression of atherosclerosis in experimental animals and man. Verhandlungen der Deutschen Gesellschaft für innere Medizin, p. 857. Munich: J.F. Bergmann 1975.Google Scholar
  87. 87.
    WISSLER, R.W., VESSELINOVITCH, D.: Studies of regression of advanced atherosclerosis in experimental animals and man. In: Proceedings of the First International Symposium on Atherogenesis, New York: Ann. New York Academy of Sciences 275, 363–378 (1976).Google Scholar
  88. 88.
    WISSLER, R.W., VESSELINOVITCH, D., BORENSZTAJN, J., HUGHES, R.: Regression of severe atherosclerosis in cholestyramine-treated Rhesus monkeys with or without a lowfat, low-cholesterol diet. Circulation 52, Suppl. II, 16 (1975).Google Scholar
  89. 89.
    WISSLER, R.W., VESSELINOVITCH, D., GETZ, G.S.: Abnormalities of the artery wall and its metabolism in atherogenesis. Progr. Cardiovasc. Dis. 18, 341 (1976).CrossRefGoogle Scholar
  90. 1.
    DAOUD, A.S., JARMOLYCH, J., AUGUSTYN, J.M., FRITZ, K.E., SINGH, J.K., LEE, K.T.: Regression of Advanced Atherosclerosis in Swine. Arch. Path. Lab. Med. 100, 372–379 (1976).PubMedGoogle Scholar
  91. 2.
    FRITZ, K.E., AUGUSTYN, J.M., JARMOLYCH, J., DAOUD, A.S., LEE, K.T.: Regression of Advanced Atherosclerosis in Swine. Arch. Path. Lab. Med. 100, 380–385 (1976).PubMedGoogle Scholar
  92. 3.
    WISSLER, R.W., VESSELINOVITCH, D., GETZ, G.S.: Abnormalities of the artery wall and its metabolism in atherogenesis. Progr. Cardiovasc. Dis. 18, 341 (1976).CrossRefGoogle Scholar

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  • R. W. Wissler

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