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Interactions of Drugs with Liver Microsomes

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Book cover Progress in Molecular and Subcellular Biology

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 5))

Abstract

The history of microsomes dates back to 1938 when CLAUDE first detected a new cell fraction in mammalian cells. For these particles, which could be isolated by differential centrifugation and afterward observed in a dark field microscope “as fine granules,” he proposed the term microsomes (CLAUDE, 1943). With the newly evolving technique of electron microscopy it was then proved that microsomes resembled the isolated form of endoplasmic reticulum (CLAUDE et al., 1947; PALADE and SIEKEVITZ, 1956).

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  1. Ingeborg Schuster
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  1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Schuster, I. (1977). Interactions of Drugs with Liver Microsomes. In: Hahn, F.E., Kersten, H., Kersten, W., Szybalski, W. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66626-1_2

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