Skip to main content

The Assessment of the Abuse Potentiality of Sedative/Hypnotics (Depressants) (Methods Used in Animals and Man)

  • Chapter
Drug Addiction I

Abstract

In 1964, the WHO Expert Committee on Addiction-Producing Drugs recommended substitution of the term “drug dependence” for the terms “drug addiction” and “drug habituation.” The WHO Scientific Group (1964) endorsed this recommendation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Barsa, J.F., Kline, N.W.: Use of meprobamate in the treatment of psychotic patients. Amer. J. Psychiat. 112, 1023–1025 (1956)

    PubMed  CAS  Google Scholar 

  • Boyd, E.M.: Chlorpromazine tolerance and physical dependence. J. Pharmacol. exp. Ther. 128, 75–78 (1960)

    PubMed  CAS  Google Scholar 

  • Burke, G.W., Anderson, C.W.G.: Response to Librium in individuals with a propensity for addiction: A pilot study. J. La med. Soc. 114, 58–60 (1962)

    CAS  Google Scholar 

  • Colmore, J.P., Moore, J.P.: Lack of dependence and withdrawal symptoms in healthy volunteers given high doses of tybamate. J. clin. Pharmacol. 7, 319–323 (1967)

    CAS  Google Scholar 

  • Crossland, J., Leonard, B.E.: Barbiturate withdrawal convulsions in the rat. Biochem. Pharmacol. 12, Suppl. 103 (1963)

    Google Scholar 

  • Deneau, G.A., Klima, M., Wilson, M.: Evaluation of sedative hypnotic agents for barbiturate-like physiological dependence capacity in the dog. Reported to the Committee on Problems of Drug Dependence, National Research Council, Indianapolis, Ind., 1968

    Google Scholar 

  • Deneau, G.A., Weiss, S.: A substitution technique for determining barbiturate-like physiological dependence capacity in the dog. Pharmakopsychiatr. Neuropsychopharmacol. 1, 270–275 (1968)

    Google Scholar 

  • Deneau, G.A., Yanagita, T., Seevers, M.H.: Self-administration of psycho-active substances by the monkey. Psychopharmacologia (Berl.) 16, 30–48 (1969)

    Article  CAS  Google Scholar 

  • Essig, C.F.: Withdrawal convulsions in dogs following chronic meprobamate intoxication. Arch. Neurol. Psychiat. (Chic.) 80, 414–417 (1958)

    CAS  Google Scholar 

  • Essig, C.F.: Barbiturate withdrawal in white rats. Int. J. Neuropharmacol. 5, 103–107 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Essig, C.F., Fraser, H.F.: Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage. Electroenceph. clin. Neurophysiol. 10, 649–659 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Feldman, H.S., Mulinos, M.G.: Lack of addiction from high doses of meprobamate. J. clin. Pharmacol. 6, 354–360 (1966)

    Article  CAS  Google Scholar 

  • Findley, J.D., Robinson, W.W., Peligrinio, L.: Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure. Psychopharmacologia (Berl.) 26, 93–114 (1972)

    Article  CAS  Google Scholar 

  • Fraser, H.F.: Methods for testing for narcotic addiction in animals and man and their efficacy for predicting human abuse. In: Mantegazza, P., Piccinini, F. (Eds.): Methods in drug evaluation, Amsterdam: North-Holland Publishing Co., 1966

    Google Scholar 

  • Fraser, H.F., Essig, C.F., Wolbach, A.B.: Evaluation of carisoprodol and phenyramidol for addictiveness. Bull. Narcot. 13, 3–7 (1961b)

    Google Scholar 

  • Fraser, H.F., Isbell, H.: Abstinence syndrome in dogs after chronic barbiturate administration. J. Pharmacol. exp. Ther. 112, 261–267 (1954)

    PubMed  CAS  Google Scholar 

  • Fraser, H.F., Isbell, H.: Chlorpromazine and reserpine. (A) Effects of each with morphine. (B) Failure of each in treatment of abstinence from morphine. Arch. Neurol. Psychiat. (Chic.) 76, 257–262 (1956)

    CAS  Google Scholar 

  • Fraser, H.F., Isbell, H., Eisenman, A.J., Wikler, A., Pescor, F.T.: Chronic barbiturate intoxication. Further studies. Arch. intern. Med. 94, 34–41 (1954)

    Article  CAS  Google Scholar 

  • Fraser, H.F., Shaver, M.R., Maxwell, E.S., Isbell, H.: Death due to withdrawal of barbiturates. Report of a case. Ann. intern. Med. 38, 1319–1325 (1953)

    PubMed  CAS  Google Scholar 

  • Fraser, H.F., Van Horn, G.D., Martin, W.R., Wolbach, A.B., Isbell, H.: Methods for evaluating addiction liability. (A) “Attitude” of opiate addicts toward opiate-like drugs. (B) A short-term “direct” addiction test. J. Pharmacol. exp. Ther. 133, 371–387 (1961a)

    PubMed  CAS  Google Scholar 

  • Fraser, H.F., Wikler, A., Essig, C.F., Isbell, H.: Degree of physical dependence induced by secobarbital and pentobarbital. J. Amer. med. Ass. 166, 126–129 (1958)

    Article  CAS  Google Scholar 

  • Fraser, H.F., Wikler, A., Isbell, H., Johnson, N.K.: Partial equivalence of chronic alcohol and barbiturate intoxications. Quart. J. Stud. Alcohol 18, 541–551 (1957)

    PubMed  CAS  Google Scholar 

  • Goldstein, D.B.: An animal model for testing effects of drugs on alcohol withdrawal. J. Pharmacol. exp. Ther. 183, 14–22 (1972)

    PubMed  CAS  Google Scholar 

  • Haertzen, C.A.: Development of scales based on patterns of drug effects, using the Addiction Research Center Inventory (ARCI). Psychol. Rep. 18, 163–194 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Hill, H.E., Haertzen, C.A., Wolbach, A.B., Jr., Miner, E.J.: The Addiction Reserach Center Inventory: Appendix. I. Items comprising empirical scales for seven drugs. II. Items which do not differentiate placebo from any drug condition. Psychopharmacologia (Berl.) 4, 184–205 (1963)

    Article  CAS  Google Scholar 

  • Hoffmeister, F., Goldberg, S.R.: A comparison of chlorpromazine, imipramine, morphine, and Damphetamine self-administration in cocaine-dependent rhesus monkeys. J. Pharmacol. exp. Ther. 187, 8–14 (1973)

    PubMed  CAS  Google Scholar 

  • Hollister, L.E., Bennett, J.L., Kimbell, I., Jr., Savage, C., Overall, J.E.: Diazepam in newly admitted schizophrenics. Dis. nerv. Syst. 24, 746–750 (1963)

    PubMed  CAS  Google Scholar 

  • Hollister, L.E., Motzenbecker, F.P., Degan, R.O.: Withdrawal reaction with chlordiazepoxide (“Librium”). Psychopharmacologia (Berl.) 2, 63–68 (1961)

    Article  CAS  Google Scholar 

  • Isbell, H., Altschul, S., Kornetsky, C.H., Eisenman, A.J., Flanary, H.G., Fraser, H.F.: Chronic barbiturate intoxication. An experimental study. Arch. Neurol. Psychiat. (Chic.) 64, 1–28 (1950)

    CAS  Google Scholar 

  • Isbell, H., Fraser, H.F., Wikler, A., Belleville, R.E., Eisenman, A.J.: An experimental study of the etiology of “rum fits” and delirium tremens. Quart. J. Stud. Alcohol 16, 1–33 (1955)

    PubMed  CAS  Google Scholar 

  • Jasinski, D.R., Martin, W.R., Sapira, J.D.: Antagonism of the subjective, pupillary and respiratory depressant effects of cyclazocine by naloxone. Clin. Pharmacol. Ther. 9, 215–222 (1968)

    PubMed  CAS  Google Scholar 

  • Lemere, F.: Habit-forming properties of meprobamate. Arch. Neurol. Psychiat. (Chic.) 76, 205–206 (1956)

    CAS  Google Scholar 

  • Martin, W.R., Fraser, H.F., Isbell, H.: A comparison of the effects of intramuscularly administered pentobarbital sodium and morphine sulfate in man. Fed. Proc. 21, 326 (1962)

    Google Scholar 

  • Martin, W.R., Thompson, W.O., Fraser, H.F.: Comparison of graded single intramuscular doses of morphine and pentobarbital in man. Clin. Pharmacol. Ther. 15, 623–630 (1974)

    PubMed  CAS  Google Scholar 

  • McClane, T.K., Martin, W.R.: Subjective and physiologic effects of morphine, pentobarbital, and meprobamate. Clin. Pharmacol. Ther. 20, 192–198 (1976)

    PubMed  CAS  Google Scholar 

  • Pilkington, T.L.: Comparative effects of Librium and taractan on behavior disorders of mentally retarded children. Dis. nerv. Syst. 22, 573–575 (1961)

    PubMed  CAS  Google Scholar 

  • Rosenberg, H.C., Okamoto, M.: A method for producing maximal pentobarbital dependency in cats: dependency characteristics. In: Singh, J.M., Lal, H. (Eds.): Neurobiology and influences on behavior. Miami: Miami Symposium 1974.

    Google Scholar 

  • Seevers, M.H., Tatum, A.L.: Chronic experimental barbital poisoning. J. Pharmacol. exp. Ther. 42, 217–231 (1931)

    CAS  Google Scholar 

  • Tucker, K., Wilensky, H.: A clinical evaluation of meprobamate therapy in a chronic schizophrenic population. Amer. J. Psychiat. 113, 698–703 (1957)

    PubMed  CAS  Google Scholar 

  • Victor, M.: Alcohol and nutritional diseases of the nervous system. J. Amer. med. Ass. 167, 65–71 (1958)

    Article  CAS  Google Scholar 

  • Waters, D.H., Okamoto, M.: Increased central excitability in nondependent mice during chronic barbital dosing. In: Singh, J.M., Miller, L., Lal, H. (Eds.): Drug addiction: Experimental pharmacology, Vol. 1. Mount Kisco, New York: Futura Publication Co. 1972

    Google Scholar 

  • Weeks, J.R.: Experimental morphine addiction: Method for automatic intravenous injections in unrestrained rats. Science 138, 143–144 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Wikler, A., Fraser, H.F., Isbell, H., Pescor, F.T.: Electroencephalograms during cycles of addiction to barbiturates in man. Electroenceph. clin. Neurophysiol. 7, 1–14 (1955)

    Article  PubMed  CAS  Google Scholar 

  • Wulff, M.H.: The barbiturate withdrawal syndrome. A clinical and electroencephalographic study. Electroenceph. clin. Neurophysiol. Suppl. 14 (1959)

    Google Scholar 

  • World Health Organization: Expert Committee on Addiction-Producing Drugs, 13th report, Wld Hlth Org. techn. Rep. Ser. No. 273 (1964)

    Google Scholar 

  • Yanagita, T., Takahashi, S.: Development of tolerance to and physical dependence on barbiturates in rhesus monkey. J. Pharmacol. exp. Ther. 172, 163–169 (1970)

    PubMed  CAS  Google Scholar 

  • Yanagita, T., Takahashi, S.: Dependence liability of several sedative-hypnotic agents evaluated in monkeys. J. Pharmacol. exp. Ther. 185, 307–316 (1973)

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fraser, H.F., Jasinski, D.R. (1977). The Assessment of the Abuse Potentiality of Sedative/Hypnotics (Depressants) (Methods Used in Animals and Man). In: Martin, W.R. (eds) Drug Addiction I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 45 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66612-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66612-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66614-8

  • Online ISBN: 978-3-642-66612-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics