Abstract
In this section we would like to describe one specific area where agents for the prevention of thrombosis and embolism may be important: cerebrovascular disease. This can be the result of a variety of disturbances and though there is rarely only one factor responsible (Yates and Hutchinson, 1961; Zülch, 1967), it is most frequently caused by local factors such as arteriosclerotic changes of the vessel wall, leading to stenosis, thrombotic occlusion of the lumen, or embolism. The latter usually occurs as macroembolism, mainly of cardiac origin, or as microembolism originating probably from ulcerated atherosclerotic neck arteries. Microemboli are at present considered as a frequent cause of Transient Ischemic Attacks, however, they play only a minor role in the pathogenesis of longer duration ischemic lesions (Fisher, 1961). The reported frequencies of embolism vary widely between 5% and 46% (Glynn, 1956; Jörgensen and Torvik, 1966). Kurtzke (1969), in reviewing several clinical, postmortem, and epidemiologic studies, suggested that about 10% of thromboembolic occlusive disease was due to embolism.
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Zülch, K.J., von Einsiedel-Lechtape, H. (1977). Thrombosis and Embolism as a Cause of Ischemic Cerebrovascular Disturbances. Analysis from a Serie of 1000 Patients. In: Agnoli, A., Fazio, C. (eds) Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66609-4_8
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DOI: https://doi.org/10.1007/978-3-642-66609-4_8
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